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Vol. 290, Issue 1, 214-219, July 1999
Department of Anatomy and Neuroscience and The Marine
Biomedical Institute, The University of Texas Medical Branch at
Galveston, Galveston, Texas
In this study, we investigated the effectiveness of gabapentin
(Neurontin), administered spinally with a microdialysis fiber, in
reducing nociceptive behavioral responses induced by a knee joint
inflammation model. This model is produced by injection of the knee
joint with kaolin and carrageenan in rats. The resultant knee joint
inflammation produces a secondary hyperalgesia to radiant heat applied
to the hindpaw. Both pretreatment and post-treatment protocols were
examined. Spinal administration of gabapentin (10 mg/ml) infused
1.5 h before induction of knee joint inflammation, although having
no effect on the baseline, prevented the development of heat
hyperalgesia. Gabapentin also prevented the development of other
pain-related behaviors scored subjectively. Gabapentin had no effect,
however, on the joint circumference increase typical in this model. In
animals with fully developed knee joint inflammation, gabapentin
produced a reversal of heat hyperalgesia. The paw withdrawal latency
responses and subjective pain scores were no longer significantly different from baseline, but joint circumference increases remained. These data suggest that gabapentin is an effective antinociceptive agent when administered either before or after induction of knee joint
inflammation acting through a central neurogenic mechanism.
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