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Journal of Pharmacology And Experimental Therapeutics, Vol. 72, Issue 1, 74-79, 1941
Copyright © 1941 by American Society for Pharmacology and Experimental Therapeutics

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

FRED E. D'AMOUR 1 and DONN L. SMITH 1

1 From The Biologic Research Laboratory, University of Denver

1. A simple, rapid method for determining the pain threshold in the rat is described.

2. The individual variation, under a variety of conditions, was found to be surprisingly small.

3. The method was applied to the determination of analgesic properties of several substances, including cobra venom. No analgesic property in the latter could be demonstrated.

4. A comparative assay of five opiates gave results in good agreement with clinical experience.

Submitted on January 27, 1941






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Copyright © 1941 by the American Society for Pharmacology and Experimental Therapeutics.