AUTONOMIC PHARMACOLOGY:

Katsunari Taguchi, Minori Saitoh, Shuichi Sato, Masaharu Asano, and Martin C. Michel

Effects of Tamsulosin Metabolites at Alpha-1 Adrenoceptor Subtypes
J Pharmacol Exp Ther 1997 280: 1-5. [Abstract] [Full Text] [PDF]  

Rennolds S. Ostrom and Frederick J. Ehlert

M₂ Muscarinic Receptor Inhibition of Agonist-induced Cyclic Adenosine Monophosphate Accumulation and Relaxation in the Guinea Pig Ileum
J Pharmacol Exp Ther 1997 280: 189-199. [Abstract] [Full Text] [PDF]  

Daniel E. Wachsman, Jill P. Kavaler, István P. Sugár, E. Neil Schachter, Waldemar Gonsiorek, and Saul Maayani

Kinetic Studies of Desensitization and Resensitization of the Relaxation Response to Beta-2 Adrenoceptor Agonists in Isolated Guinea Pig Trachea
J Pharmacol Exp Ther 1997 280: 332-345. [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Jeffrey M. Witkin, Thomas D. Steele, and Lawrence G. Sharpe

Effects of Strychnine-Insensitive Glycine Receptor Ligands in Rats Discriminating Dizocilpine or Phencyclidine from Saline
J Pharmacol Exp Ther 1997 280: 46-52. [Abstract] [Full Text] [PDF]  

James K. Rowlett and William L. Woolverton

Discriminative Stimulus Effects of Zolpidem in Pentobarbital-Trained Subjects: I. Comparison with Triazolam in Rhesus Monkeys and Rats
J Pharmacol Exp Ther 1997 280: 162-173. [Abstract] [Full Text] [PDF]  

Craig R. Rush, Sudhakar Madakasira, Nancy H. Goldman, William L. Woolverton, and James K. Rowlett

Discriminative Stimulus Effects of Zolpidem in Pentobarbital-Trained Subjects: II. Comparison with Triazolam and Caffeine in Humans
J Pharmacol Exp Ther 1997 280: 174-188. [Abstract] [Full Text] [PDF]  

J. Auta, P. J. Winsauer, W. B. Faust, P. Lambert, and J. M. Moerschbaecher

Effects of Negative Allosteric Modulators of -Aminobutyric Acid_A Receptors on Complex Behavioral Processes in Monkeys
J Pharmacol Exp Ther 1997 280: 316-325. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR PHARMACOLOGY:

Ritchie Audet, Francis Rioux, Guy Drapeau, and François Marceau

Cardiovascular Effects of Sar-[D-Phe⁸]des-Arg⁹-Bradykinin, a Metabolically Protected Agonist of B₁ Receptor for Kinins, in the Anesthetized Rabbit Pretreated with a Sublethal Dose of Bacterial Lipopolysaccharide
J Pharmacol Exp Ther 1997 280: 6-15. [Abstract] [Full Text] [PDF]  

J. V. Rabadán, M. V. Milanés, and M. L. Laorden

Effects of Chronic Morphine Treatment on Catecholamines Content and Mechanical Response in the Rat Hearts
J Pharmacol Exp Ther 1997 280: 32-37. [Abstract] [Full Text] [PDF]  

Juraj Culman, Sabine Klee, Christina Ohlendorf, and Thomas Unger

Effect of Tachykinin Receptor Inhibition in the Brain on Cardiovascular and Behavioral Responses to Stress
J Pharmacol Exp Ther 1997 280: 238-246. [Abstract] [Full Text] [PDF]  

Roger J. Hajjar, Ulrich Schmidt, Patrick Helm, and Judith K. Gwathmey

Ca⁺⁺ Sensitizers Impair Cardiac Relaxation in Failing Human Myocardium
J Pharmacol Exp Ther 1997 280: 247-254. [Abstract] [Full Text] [PDF]  

Nicole R. Higdon, Sajida A. Khan, Lewis V. Buchanan, and Kaushik D. Meisheri

Tissue and Species Variation in the Vascular Receptor Binding of ³H-P1075, a Potent K_ATP Opener Vasodilator
J Pharmacol Exp Ther 1997 280: 255-260. [Abstract] [Full Text] [PDF]  

Peter Bokník, Joachim Neumann, Grit Kaspareit, Wilhelm Schmitz, Hasso Scholz, Ute Vahlensieck, and Norbert Zimmermann

Mechanisms of the Contractile Effects of Levosimendan in the Mammalian Heart
J Pharmacol Exp Ther 1997 280: 277-283. [Abstract] [Full Text] [PDF]  

James E. Jordan, Zhi-Qing Zhao, Hiroki Sato, Spencer Taft, and Jakob Vinten-Johansen

Adenosine A₂ Receptor Activation Attenuates Reperfusion Injury by Inhibiting Neutrophil Accumulation, Superoxide Generation and Coronary Endothelial Adherence
J Pharmacol Exp Ther 1997 280: 301-309. [Abstract] [Full Text] [PDF]  

John Anthony Bauer, Tim Nolan, and Ho-Leung Fung

Vascular and Hemodynamic Differences between Organic Nitrates and Nitrites
J Pharmacol Exp Ther 1997 280: 326-331. [Abstract] [Full Text] [PDF]  

F. W. Dunn, M.-H. Roux, F. Farhadian, K. Sabri, C. Ossart, J. L. Samuel, L. Rappaport, and G. Hamon

HR 720, A Novel Angiotensin Receptor Antagonist Inhibits the Angiotensin II-Induced Trophic Effects, Fibronectin Release and Fibronectin-EIIIA⁺ Expression in Rat Aortic Vascular Smooth Muscle Cells in Vitro
J Pharmacol Exp Ther 1997 280: 447-453. [Abstract] [Full Text] [PDF]  

Hélène Bachelard, Maryse Pître, and Andrée Lessard

Mechanisms of the Regional Hemodynamic Effects of a µ-Opioid Receptor Agonist Microinjected into the Hypothalamic Paraventricular Nuclei of Conscious Unrestrained Rats
J Pharmacol Exp Ther 1997 280: 460-470. [Abstract] [Full Text] [PDF]  

Masahiro Norisue, Kazuo Todoki, and Eiichiro Okabe

Inhibition by Hydroxyl Radicals of Calcitonin Gene-Related Peptide-Mediated Neurogenic Vasorelaxation in Isolated Canine Lingual Artery
J Pharmacol Exp Ther 1997 280: 492-500. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR PHARMACOLOGY:

Shiling Hu and Helen S. Kim

Modulation of ATP-Sensitive and Large-Conductance Ca⁺⁺-Activated K⁺ Channels by Zeneca ZD6169 in Guinea Pig Bladder Smooth Muscle Cells
J Pharmacol Exp Ther 1997 280: 38-45. [Abstract] [Full Text] [PDF]  

Roger J. Hill, Joseph J. Oleynek, Christopher F. Hoth, M. A. Ravi Kiron, Weifan Weng, Ronald T. Wester, W. Ross Tracey, Delvin R. Knight, R. Allan Buchholz, and Scott P. Kennedy

Cloning, Expression and Pharmacological Characterization of Rabbit Adenosine A₁ and A₃ Receptors
J Pharmacol Exp Ther 1997 280: 122-128. [Abstract] [Full Text] [PDF]  

Laura E. Chavez-Noriega, James H. Crona, Mark S. Washburn, Arturo Urrutia, Kathryn J. Elliott, and Edwin C. Johnson

Pharmacological Characterization of Recombinant Human Neuronal Nicotinic Acetylcholine Receptors h22, h24, h32, h34, h42, h44 and h7 Expressed in Xenopus Oocytes
J Pharmacol Exp Ther 1997 280: 346-356. [Abstract] [Full Text] [PDF]  

Esther Castaño, Mireia Dalmau, Mercè Martí, Félix Berrocal, Ramon Bartrons, and Joan Gil

Inhibition of DNA Synthesis by Aspirin in Swiss 3T3 Fibroblasts
J Pharmacol Exp Ther 1997 280: 366-372. [Abstract] [Full Text] [PDF]  

Yuji Ikegaya, Masatoshi Yoshida, Hiroshi Saito, and Nobuyoshi Nishiyama

Epileptic Activity Prevents Synapse Formation of Hippocampal Mossy Fibers via L-Type Calcium Channel Activation In Vitro
J Pharmacol Exp Ther 1997 280: 471-476. [Abstract] [Full Text] [PDF]  

Noriyoshi Teramoto and Alison F. Brading

Nicorandil Activates Glibenclamide-Sensitive K⁺ Channels in Smooth Muscle Cells of Pig Proximal Urethra
J Pharmacol Exp Ther 1997 280: 483-491. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY/GENE THERAPY:

R. Reszka, P. Beck, I. Fichtner, M. Hentschel, J. Richter, and J. Kreuter

Body Distribution of Free, Liposomal and Nanoparticle-Associated Mitoxantrone in B16-Melanoma-Bearing Mice
J Pharmacol Exp Ther 1997 280: 232-237. [Abstract] [Full Text] [PDF]  

Pierre Moine, Jean-Xavier Mazoit, Jean-Pierre Bédos, Éric Vallée, and Esther Azoulay-Dupuis

Correlation Between In Vitro and In Vivo Activity of Amoxicillin Against Streptococcus pneumoniae in a Murine Pneumonia Model
J Pharmacol Exp Ther 1997 280: 310-315. [Abstract] [Full Text] [PDF]  

DRUG METABOLISM AND DISPOSITION:

Jinping Chen and K. Sandy Pang

Effect of Flow on First-Pass Metabolism of Drugs: Single Pass Studies on 4-Methylumbelliferone Conjugation in the Serially Perfused Rat Intestine and Liver Preparations
J Pharmacol Exp Ther 1997 280: 24-31. [Abstract] [Full Text] [PDF]  

Kai O. Lindros, Teija Oinonen, Inger Johansson, and Magnus Ingelman-Sundberg

Selective Centrilobular Expression of the Aryl Hydrocarbon Receptor in Rat Liver
J Pharmacol Exp Ther 1997 280: 506-511. [Abstract] [Full Text] [PDF]  

ENDOCRINE PHARMACOLOGY:

Raymond F. Kauffman, William R. Bensch, Roger E. Roudebush, Harlan W. Cole, James S. Bean, D. Lynn Phillips, Amy Monroe, George J. Cullinan, Andrew L. Glasebrook, and Henry U. Bryant

Hypocholesterolemic Activity of Raloxifene (LY139481): Pharmacological Characterization as a Selective Estrogen Receptor Modulator
J Pharmacol Exp Ther 1997 280: 146-153. [Abstract] [Full Text] [PDF]  

Cindy C. Taylor, Dunli Wu, Yi Soong, Jenny S. Yee, and Hazel H. Szeto

Dynorphin A_1-13 Stimulates Ovine Fetal Pituitary-Adrenal Function through a Novel Nonopioid Mechanism
J Pharmacol Exp Ther 1997 280: 416-421. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL PHARMACOLOGY:

Chika Ito, Yoshihiko Isobe, Reiko Kawamura, Yoichi Kiuchi, Katsuharu Tsuchida, and Shohei Higuchi

Effect of GK-128 [2-[(2-Methylimidazol-1-yl)methyl]benzo[f]thiochromen-1-one Monohydrochloride Hemihydrate], a Selective 5-Hydroxytryptamine₃ Receptor Antagonist, on Colonic Function in Rats
J Pharmacol Exp Ther 1997 280: 67-72. [Abstract] [Full Text] [PDF]  

P. Holzer, I.Th. Lippe, A. Lotfi Tabrizi, L. Lénárd, Jr., and L. Barthó

Dual Excitatory and Inhibitory Effect of Nitric Oxide on Peristalsis in the Guinea Pig Intestine
J Pharmacol Exp Ther 1997 280: 154-161. [Abstract] [Full Text] [PDF]  

J. R. Pappenheimer, M. L. Karnovsky, and J. E. Maggio

Absorption and Excretion of Undegradable Peptides: Role of Lipid Solubility and Net Charge
J Pharmacol Exp Ther 1997 280: 292-300. [Abstract] [Full Text] [PDF]  

IMMUNOPHARMACOLOGY:

Florian Gantner, Sabine Küsters, Albrecht Wendel, Armin Hatzelmann, Christian Schudt, and Gisa Tiegs

Protection from T Cell-Mediated Murine Liver Failure by Phosphodiesterase Inhibitors
J Pharmacol Exp Ther 1997 280: 53-60. [Abstract] [Full Text] [PDF]  

Eric D. Stanulis, Ray A. Matulka, Stephen D. Jordan, John A. Rosecrans, and Michael P. Holsapple

Role of Corticosterone in the Enhancement of the Antibody Response after Acute Cocaine Administration
J Pharmacol Exp Ther 1997 280: 284-291. [Abstract] [Full Text] [PDF]  

Pierluigi Navarra, Ursula Grohmann, Giuseppe Nocentini, Giuseppe Tringali, Paolo Puccetti, Carlo Riccardi, and Paolo Preziosi

Hydroxyurea Induces the Gene Expression and Synthesis of Proinflammatory Cytokines In Vivo
J Pharmacol Exp Ther 1997 280: 477-482. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

C. J. Malanga, Jianzhong Meng, William W. Fleming, and David A. Taylor

Chronic Morphine Treatment of Guinea Pigs Induces Nonspecific Sensitivity Changes in the Nucleus Tractus Solitarius In Vitro
J Pharmacol Exp Ther 1997 280: 16-23. [Abstract] [Full Text] [PDF]  

Ling-Yuan Kong, Michael K. McMillian, Pearlie M. Hudson, Lei Jin, and Jau-Shyong Hong

Inhibition of Lipopolysaccharide-Induced Nitric Oxide and Cytokine Production by Ultralow Concentrations of Dynorphins in Mixed Glia Cultures
J Pharmacol Exp Ther 1997 280: 61-66. [Abstract] [Full Text] [PDF]  

Gh. Perrault, R. Depoortere, E. Morel, D. J. Sanger, and B. Scatton

Psychopharmacological Profile of Amisulpride: An Antipsychotic Drug with Presynaptic D₂/D₃ Dopamine Receptor Antagonist Activity and Limbic Selectivity
J Pharmacol Exp Ther 1997 280: 73-82. [Abstract] [Full Text] [PDF]  

H. Schoemaker, Y. Claustre, D. Fage, L. Rouquier, K. Chergui, O. Curet, A. Oblin, F. Gonon, C. Carter, J. Benavides, and B. Scatton

Neurochemical Characteristics of Amisulpride, an Atypical Dopamine D₂/D₃ Receptor Antagonist with Both Presynaptic and Limbic Selectivity
J Pharmacol Exp Ther 1997 280: 83-97. [Abstract] [Full Text] [PDF]  

Wayne A. Cass

Decreases in Evoked Overflow of Dopamine in Rat Striatum after Neurotoxic Doses of Methamphetamine
J Pharmacol Exp Ther 1997 280: 105-113. [Abstract] [Full Text] [PDF]  

Shingo Shoji, Debra Simms, Wesley C. McDaniel, and Joel P. Gallagher

Chronic Cocaine Enhances -Aminobutyric Acid and Glutamate Release by Altering Presynaptic and not Postsynaptic -Aminobutyric Acid_B Receptors within the Rat Dorsolateral Septal Nucleus
J Pharmacol Exp Ther 1997 280: 129-137. [Abstract] [Full Text] [PDF]  

Theresa M. Cabrera-Vera, Francisca Garcia, Wilfred Pinto, and George Battaglia

Effect of Prenatal Fluoxetine (Prozac) Exposure on Brain Serotonin Neurons in Prepubescent and Adult Male Rat Offspring
J Pharmacol Exp Ther 1997 280: 138-145. [Abstract] [Full Text] [PDF]  

Jonathan A. Prince, Mohammed S. Yassin, and Lars Oreland

Neuroleptic-Induced Mitochondrial Enzyme Alterations in the Rat Brain
J Pharmacol Exp Ther 1997 280: 261-267. [Abstract] [Full Text] [PDF]  

Nuo-Yu Huang, Richard M. Kostrzewa, Chuanfu Li, Kenneth W. Perry, and Ray W. Fuller

Persistent Spontaneous Oral Dyskinesias in Haloperidol-Withdrawn Rats Neonatally Lesioned with 6-Hydroxydopamine: Absence of an Association with the B_max for [³H]Raclopride Binding to Neostriatal Homogenates
J Pharmacol Exp Ther 1997 280: 268-276. [Abstract] [Full Text] [PDF]  

Vijay K. Shukla and Simon Lemaire

N-Methyl-D-aspartate Antagonist Activity of - and -Sulfallorphans
J Pharmacol Exp Ther 1997 280: 357-365. [Abstract] [Full Text] [PDF]  

Aida I. Sacaan, Richard T. Reid, Emily M. Santori, Pamala Adams, Lucia D. Correa, Lorrence S. Mahaffy, Leo Bleicher, Nicholas D. P. Cosford, Kenneth A. Stauderman, Ian A. McDonald, Tadimeti S. Rao, and G. Kenneth Lloyd

Pharmacological Characterization of SIB-1765F: A Novel Cholinergic Ion Channel Agonist
J Pharmacol Exp Ther 1997 280: 373-383. [Abstract] [Full Text] [PDF]  

Frédérique Menzaghi, Kevin T. Whelan, Victoria B. Risbrough, Tadimeti S. Rao, and G. Kenneth Lloyd

Effects of a Novel Cholinergic Ion Channel Agonist SIB-1765F on Locomotor Activity in Rats
J Pharmacol Exp Ther 1997 280: 384-392. [Abstract] [Full Text] [PDF]  

Frédérique Menzaghi, Kevin T. Whelan, Victoria B. Risbrough, Tadimeti S. Rao, and G. Kenneth Lloyd

Interactions between a Novel Cholinergic Ion Channel Agonist, SIB-1765F and L-DOPA in the Reserpine Model of Parkinson's Disease in Rats
J Pharmacol Exp Ther 1997 280: 393-401. [Abstract] [Full Text] [PDF]  

Thomas J. Abbruscato, Sarah A. Thomas, Victor J. Hruby, and Thomas P. Davis

Blood-Brain Barrier Permeability and Bioavailability of a Highly Potent and µ-Selective Opioid Receptor Antagonist, CTAP: Comparison with Morphine
J Pharmacol Exp Ther 1997 280: 402-409. [Abstract] [Full Text] [PDF]  

Ikumi Tamai, Yoshimichi Sai, Hiroyuki Kobayashi, Makoto Kamata, Tateaki Wakamiya, and Akira Tsuji

Structure-Internalization Relationship for Adsorptive-Mediated Endocytosis of Basic Peptides at the Blood-Brain Barrier
J Pharmacol Exp Ther 1997 280: 410-415. [Abstract] [Full Text] [PDF]  

L.-M. Zhou, Z.-Q. Gu, A. M. Costa, K. A. Yamada, P. E. Mansson, T. Giordano, P. Skolnick, and K. A. Jones

(2S,4R)-4-Methylglutamic Acid (SYM 2081): A Selective, High-Affinity Ligand for Kainate Receptors
J Pharmacol Exp Ther 1997 280: 422-427. [Abstract] [Full Text] [PDF]  

O. Delbono, M. Gopalakrishnan, M. Renganathan, L. M. Monteggia, M. L. Messi, and J. P. Sullivan

Activation of the Recombinant Human ₇ Nicotinic Acetylcholine Receptor Significantly Raises Intracellular Free Calcium
J Pharmacol Exp Ther 1997 280: 428-438. [Abstract] [Full Text] [PDF]  

Piu Chan, Donato A. Di Monte, J. William Langston, and Ann Marie Janson

(+)MK-801 Does Not Prevent MPTP-Induced Loss of Nigral Neurons in Mice
J Pharmacol Exp Ther 1997 280: 439-446. [Abstract] [Full Text] [PDF]  

Hermann Ammer and Rüdiger Schulz

Chronic Morphine Treatment Increases Stimulatory Beta-2 Adrenoceptor Signaling in A431 Cells Stably Expressing the Mu Opioid Receptor
J Pharmacol Exp Ther 1997 280: 512-520. [Abstract] [Full Text] [PDF]  

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS:

Manabu Musashi, Keisuke Sakurada, Ken-Ichi Kawamura, Hiroshi Iwasaki, Yuzo Tsuda, Masanobu Kobayashi, Makie Sasaki, Keiko Kato, Eiji Tanaka, Tetsuo Sudo, Masahiro Asaka, and Tamotsu Miyazaki

Phorbol Ester Enhancement of IL-3-Dependent Proliferation of Primitive Hematopoietic Progenitors of Mice in Culture
J Pharmacol Exp Ther 1997 280: 225-231. [Abstract] [Full Text] [PDF]  

J. P. De La Cruz, A. Moreno, M. Muñoz, J. M. García Campos, and F. Sánchez De La Cuesta

Effect of Aspirin Plus Dipyridamole on the Retinal Vascular Pattern in Experimental Diabetes Mellitus
J Pharmacol Exp Ther 1997 280: 454-459. [Abstract] [Full Text] [PDF]  

PULMONARY PHARMACOLOGY:

Manuel Merlos, Marta Giral, Dolors Balsa, Rosa Ferrando, Mireia Queralt, Anna Puigdemont, Julián García-Rafanell, and Javier Forn

Rupatadine, a New Potent, Orally Active Dual Antagonist of Histamine and Platelet-Activating Factor (PAF)
J Pharmacol Exp Ther 1997 280: 114-121. [Abstract] [Full Text] [PDF]  

David C. Underwood, Jane K. Matthews, Ruth R. Osborn, Steven Bochnowicz, and Theodore J. Torphy

The Influence of Endogenous Catecholamines on the Inhibitory Effects of Rolipram Against Early- and Late-Phase Response to Antigen in the Guinea Pig
J Pharmacol Exp Ther 1997 280: 210-219. [Abstract] [Full Text] [PDF]  

RENAL PHARMACOLOGY:

Thomas H. Maren, Curtis W. Conroy, George C. Wynns, and David R. Godman

Renal and Cerebrospinal Fluid Formation Pharmacology of a High Molecular Weight Carbonic Anhydrase Inhibitor
J Pharmacol Exp Ther 1997 280: 98-104. [Abstract] [Full Text] [PDF]  

Matthias Zingerle, Stefan Silbernagl, and Michael Gekle

Reabsorption of the Nephrotoxin Ochratoxin A Along the Rat Nephron In Vivo
J Pharmacol Exp Ther 1997 280: 220-224. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Perry M. Kim, Louise M. Winn, Toufan Parman, and Peter G. Wells

UDP-Glucuronosyltransferase-mediated Protection Against In Vitro DNA Oxidation and Micronucleus Formation Initiated by Phenytoin and Its Embryotoxic Metabolite 5-(p-Hydroxyphenyl)-5-phenylhydantoin
J Pharmacol Exp Ther 1997 280: 200-209. [Abstract] [Full Text] [PDF]  

Neil R. Pumford, N. Christine Halmes, Brian M. Martin, Robert J. Cook, Conrad Wagner, and Jack A. Hinson

Covalent Binding of Acetaminophen to N-10-Formyl-Tetrahydrofolate Dehydrogenase in Mice
J Pharmacol Exp Ther 1997 280: 501-505. [Abstract] [Full Text] [PDF]  

ERRATA:

Correction for vol. 279, p. 247
J Pharmacol Exp Ther 1997 280: 520. [Full Text]  

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