ANALGESIA AND DRUGS OF ABUSE:

Jodie J. Rady, Wen Lin, and James M. Fujimoto

Pentobarbital Antagonism of Morphine Analgesia Mediated by Spinal Cholecystokinin
J Pharmacol Exp Ther 1998 284: 878-885. [Abstract] [Full Text] [PDF]  

M. I. Damaj, M. Fei-Yin, M. Dukat, W. Glassco, R. A. Glennon, and B. R. Martin

Antinociceptive Responses to Nicotinic Acetylcholine Receptor Ligands after Systemic and Intrathecal Administration in Mice
J Pharmacol Exp Ther 1998 284: 1058-1065. [Abstract] [Full Text] [PDF]  

Eugène H. Cox, Thomas Kerbusch, Pieter H. Van der Graaf, and Meindert Danhof

Pharmacokinetic-Pharmacodynamic Modeling of the Electroencephalogram Effect of Synthetic Opioids in the Rat: Correlation with the Interaction at the Mu-Opioid Receptor
J Pharmacol Exp Ther 1998 284: 1095-1103. [Abstract] [Full Text] [PDF]  

Suzanne B. Bausch, Tiffany M. Esteb, Gregory W. Terman, and Charles Chavkin

Administered and Endogenously Released Kappa Opioids Decrease Pilocarpine-Induced Seizures and Seizure-Induced Histopathology
J Pharmacol Exp Ther 1998 284: 1147-1155. [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Carla Ghelardini, Nicoletta Galeotti, Fulvio Gualtieri, Vittorio Marchese, Cristina Bellucci, and Alessandro Bartolini

Antinociceptive and Antiamnesic Properties of the Presynaptic Cholinergic Amplifier PG-9
J Pharmacol Exp Ther 1998 284: 806-816. [Abstract] [Full Text] [PDF]  

Masayuki Hiramatsu, Hiroyasu Murasawa, Toshitaka Nabeshima, and Tsutomu Kameyama

Effects of U-50,488H on Scopolamine-, Mecamylamine- and Dizocilpine-Induced Learning and Memory Impairment in Rats
J Pharmacol Exp Ther 1998 284: 858-867. [Abstract] [Full Text] [PDF]  

Marjolein Beekman, Jesse T. Ungard, Maciej Gasior, Richard B. Carter, Durk Dijkstra, Steven R. Goldberg, and Jeffrey M. Witkin

Reversal of Behavioral Effects of Pentylenetetrazol by the Neuroactive Steroid Ganaxolone
J Pharmacol Exp Ther 1998 284: 868-877. [Abstract] [Full Text] [PDF]  

Harry L. June, Dana Zuccarelli, Lucas Torres, Karen S. Craig, Jana Delong, Angela Allen, Misty R. Braun, Charity R. Cason, and James M. Murphy

High-Affinity Benzodiazepine Antagonists Reduce Responding Maintained by Ethanol Presentation in Ethanol-Preferring Rats
J Pharmacol Exp Ther 1998 284: 1006-1914. [Abstract] [Full Text] [PDF]  

Mark S. Kleven and Wouter Koek

Discriminative Stimulus Properties of Cocaine: Enhancement by Monoamine Reuptake Blockers
J Pharmacol Exp Ther 1998 284: 1015-1025. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR PHARMACOLOGY:

Frank Anastasopoulos, Randal Leung, Athena Kladis, Gail M. James, Todd A. Briscoe, Thaddeus P. Gorski, and Duncan J. Campbell

Marked Difference between Angiotensin-Converting Enzyme and Neutral Endopeptidase Inhibition in Vivo by a Dual Inhibitor of Both Enzymes
J Pharmacol Exp Ther 1998 284: 799-805. [Abstract] [Full Text] [PDF]  

Philippe Chevalier, Francis Ruffy, Peter Danilo, Jr., and Michael R. Rosen

Interaction between Alpha-1 Adrenergic and Vagal Effects on Cardiac Rate and Repolarization
J Pharmacol Exp Ther 1998 284: 832-837. [Abstract] [Full Text] [PDF]  

Sajida A. Khan, Nicole R. Higdon, and Kaushik D. Meisheri

Coronary Vasorelaxation by Nitroglycerin: Involvement of Plasmalemmal Calcium-Activated K⁺ Channels and Intracellular Ca⁺⁺ Stores
J Pharmacol Exp Ther 1998 284: 838-846. [Abstract] [Full Text] [PDF]  

Ricardo E. Chatelain, Rajendra D. Ghai, Angelo J. Trapani, Lynne M. Odorico, Beatriz N. Dardik, Stephane De Lombaert, Rodney W. Lappe, and Cynthia A. Fink

Antihypertensive and Natriuretic Effects of CGS 30440, a Dual Inhibitor of Angiotensin-Converting Enzyme and Neutral Endopeptidase 24.11
J Pharmacol Exp Ther 1998 284: 974-982. [Abstract] [Full Text] [PDF]  

Rhian M. Touyz, Pascal Laurant, and Ernesto L. Schiffrin

Effect of Magnesium on Calcium Responses to Vasopressin in Vascular Smooth Muscle Cells of Spontaneously Hypertensive Rats
J Pharmacol Exp Ther 1998 284: 998-1005. [Abstract] [Full Text] [PDF]  

Yi Fei Huang, Richard N. Upton, Da Zheng, Colin Mclean, Elke C. Gray, and Cliff Grant

The Enantiomer-Specific Kinetics and Dynamics of Verapamil after Rapid Intravenous Administration to Sheep: Physiological Analysis and Modeling
J Pharmacol Exp Ther 1998 284: 1048-1057. [Abstract] [Full Text] [PDF]  

Luiz Belardinelli, John C. Shryock, Stephen Snowdy, Yi Zhang, Angela Monopoli, Gianluca Lozza, Ennio Ongini, Ray A. Olsson, and Donn M. Dennis

The A_2A Adenosine Receptor Mediates Coronary Vasodilation
J Pharmacol Exp Ther 1998 284: 1066-1073. [Abstract] [Full Text] [PDF]  

Hideyuki Suzuki, George H. Caughey, Xiao-Pei Gao, and Israel Rubinstein

Mast Cell Chymase-Like Protease(s) Modulates Escherichia coli Lipopolysaccharide-Induced Vasomotor Dysfunction in Skeletal Muscle in Vivo
J Pharmacol Exp Ther 1998 284: 1156-1164. [Abstract] [Full Text] [PDF]  

Qian Li, Margaret J. Sullivan, William E. Dale, Eileen M. Hasser, Edward H. Blaine, and J. Thomas Cunningham

Fos-Like Immunoreactivity in the Medulla after Acute and Chronic Angiotensin II Infusion
J Pharmacol Exp Ther 1998 284: 1165-1173. [Abstract] [Full Text] [PDF]  

Olivier Costerousse, Jacqueline Allegrini, Jean-Paul Clozel, Joël Ménard, and François Alhenc-Gelas

Angiotensin I-Converting Enzyme Inhibition but Not Angiotensin II Suppression Alters Angiotensin I-Converting Enzyme Gene Expression in Vessels and Epithelia
J Pharmacol Exp Ther 1998 284: 1180-1187. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR PHARMACOLOGY:

M. Bencherif, J. D. Schmitt, B. S. Bhatti, P. Crooks, W. S. Caldwell, M. E. Lovette, K. Fowler, L. Reeves, and P. M. Lippiello

The Heterocyclic Substituted Pyridine Derivative (±)-2-(-3-pyridinyl)-1-Azabicyclo[2.2.2]octane (RJR-2429): A Selective Ligand at Nicotinic Acetylcholine Receptors
J Pharmacol Exp Ther 1998 284: 886-894. [Abstract] [Full Text] [PDF]  

Hiroaki Matsubayashi, Manickavasagom Alkondon, Edna F. R. Pereira, Karen L. Swanson, and Edson X. Albuquerque

Strychnine: A Potent Competitive Antagonist of -Bungarotoxin-Sensitive Nicotinic Acetylcholine Receptors In Rat Hippocampal Neurons
J Pharmacol Exp Ther 1998 284: 904-913. [Abstract] [Full Text] [PDF]  

Matthew D. Krasowski, Suzanne E. Finn, Qing Ye, and Neil L. Harrison

Trichloroethanol Modulation of Recombinant GABA_A, Glycine and GABA ₁ Receptors
J Pharmacol Exp Ther 1998 284: 934-942. [Abstract] [Full Text] [PDF]  

Iustin V. Tabarean and Toshio Narahashi

Potent Modulation of Tetrodotoxin-Sensitive and Tetrodotoxin-Resistant Sodium Channels by the Type II Pyrethroid Deltamethrin
J Pharmacol Exp Ther 1998 284: 958-965. [Abstract] [Full Text] [PDF]  

Jerry A. Stitzel, Jennifer M. Blanchette, and Allan C. Collins

Sensitivity to the Seizure-Inducing Effects of Nicotine is Associated with Strain-Specific Variants of the 5 and 7 Nicotinic Receptor Subunit Genes
J Pharmacol Exp Ther 1998 284: 1104-1111. [Abstract] [Full Text] [PDF]  

Katie J. Salter and Roland Z. Kozlowski

Differential Electrophysiological Actions of Endothelin-1 on Cl^- and K⁺ Currents in Myocytes Isolated from Aorta, Basilar and Pulmonary Artery
J Pharmacol Exp Ther 1998 284: 1122-1131. [Abstract] [Full Text] [PDF]  

Pascal Daleau

Effects of Antiarrhythmic Agents on Junctional Resistance of Guinea Pig Ventricular Cell Pairs
J Pharmacol Exp Ther 1998 284: 1174-1179. [Abstract] [Full Text] [PDF]  

DRUG METABOLISM AND DISPOSITION:

Masataka Katashima, Koujirou Yamamoto, Yoji Tokuma, Takehisa Hata, Yasufumi Sawada, and Tatsuji Iga

Pharmacokinetic and Pharmacodynamic Study of a New Nonsteroidal 5-Reductase Inhibitor, 4-[3-[3-[Bis(4-Isobutylphenyl)Methylamino]Benzoyl]-1H-Indol-1-yl]-Butyric Acid, in Rats
J Pharmacol Exp Ther 1998 284: 914-920. [Abstract] [Full Text] [PDF]  

Haruo Imawaka and Yuichi Sugiyama

Kinetic Study of the Hepatobiliary Transport of a New Prostaglandin Receptor Agonist
J Pharmacol Exp Ther 1998 284: 949-957. [Abstract] [Full Text] [PDF]  

Hiroyuki Sasabe, Akira Tsuji, and Yuichi Sugiyama

Carrier-Mediated Mechanism for the Biliary Excretion of the Quinolone Antibiotic Grepafloxacin and Its Glucuronide in Rats
J Pharmacol Exp Ther 1998 284: 1033-1039. [Abstract] [Full Text] [PDF]  

Stefan Scheuerer, Kenneth M. Williams, Roland Brugger, Andrew J. McLachlan, Kay Brune, Richard O. Day, and Gerd Geisslinger

Effect of Clofibrate on the Chiral Disposition of Ibuprofen in Rats
J Pharmacol Exp Ther 1998 284: 1132-1138. [Abstract] [Full Text] [PDF]  

Wen-Chao Song, Yueming Qian, and Albert P. Li

Estrogen Sulfotransferase Expression in the Human Liver: Marked Interindividual Variation and Lack of Gender Specificity
J Pharmacol Exp Ther 1998 284: 1197-1202. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL PHARMACOLOGY:

B. L. Tepperman, T. D. Abrahamson, and B. D. Soper

The Role of Cyclic Guanylate Monophosphate in Nitric Oxide-Induced Injury to Rat Small Intestinal Epithelial Cells
J Pharmacol Exp Ther 1998 284: 929-933. [Abstract] [Full Text] [PDF]  

IMMUNOPHARMACOLOGY:

G. Lhoëst, R. Dieden, R.K. Verbeeck, N. Maton, A. Ingendoh, and D. Latinne

In Vitro Immunosuppressive Activity, Isolation from Pig Liver Microsomes and Identification by Electrospray ms-ms of a New FK-506 C₁₉-C₂₀ Epoxide Metabolite
J Pharmacol Exp Ther 1998 284: 1074-1081. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Li Chen and Li-Yen Mae Huang

Dynorphin Block of N-Methyl-D-Aspartate Channels Increases with the Peptide Length
J Pharmacol Exp Ther 1998 284: 826-831. [Abstract] [Full Text] [PDF]  

Masaya Kato, Taiichi Katayama, Hiroshi Iwata, Michio Yamamura, Yuzo Matsuoka, and Hiroshi Narita

In Vivo Characterization of T-794, a Novel Reversible Inhibitor of Monoamine Oxidase-A, as an Antidepressant with a Wide Safety Margin
J Pharmacol Exp Ther 1998 284: 983-990. [Abstract] [Full Text]  

Aygul Balcioglu and Richard J. Wurtman

Dexfenfluramine Enhances Striatal Dopamine Release in Conscious Rats via a Serotoninergic Mechanism
J Pharmacol Exp Ther 1998 284: 991-997. [Abstract] [Full Text] [PDF]  

Edwin M. Meyer, Ee Tein Tay, John A. Zoltewicz, Craig Meyers, Michael A. King, Roger L. Papke, and Christopher M. De Fiebre

Neuroprotective and Memory-Related Actions of Novel Alpha-7 Nicotinic Agents with Different Mixed Agonist/Antagonist Properties
J Pharmacol Exp Ther 1998 284: 1026-1032. [Abstract] [Full Text] [PDF]  

Yossef Itzhak, Carlos Gandia, Paul L. Huang, and Syed F. Ali

Resistance of Neuronal Nitric Oxide Synthase-Deficient Mice to Methamphetamine-Induced Dopaminergic Neurotoxicity
J Pharmacol Exp Ther 1998 284: 1040-1047. [Abstract] [Full Text] [PDF]  

Jean De Vry, Rudolf Schohe-Loop, Hans-Georg Heine, Joachim M. Greuel, Frank Mauler, Bernard Schmidt, Henning Sommermeyer, and Thomas Glaser

Characterization of the Aminomethylchroman Derivative BAY × 3702 as a Highly Potent 5-Hydroxytryptamine_1A Receptor Agonist
J Pharmacol Exp Ther 1998 284: 1082-1094. [Abstract] [Full Text] [PDF]  

Yitong Fu, Shannon G. Matta, Tressa J. James, and Burt M. Sharp

Nicotine-Induced Norepinephrine Release in the Rat Amygdala and Hippocampus is Mediated through Brainstem Nicotinic Cholinergic Receptors
J Pharmacol Exp Ther 1998 284: 1188-1196. [Abstract] [Full Text] [PDF]  

I. B. Adams, D. R. Compton, and B. R. Martin

Assessment of Anandamide Interaction with the Cannabinoid Brain Receptor: SR 141716A Antagonism Studies in Mice and Autoradiographic Analysis of Receptor Binding in Rat Brain
J Pharmacol Exp Ther 1998 284: 1209-1217. [Abstract] [Full Text] [PDF]  

Hirofumi Tsuga, Eriko Okuno, Kimihiko Kameyama, and Tatsuya Haga

Sequestration of Human Muscarinic Acetylcholine Receptor hm1hm5 Subtypes: Effect of G Protein-Coupled Receptor Kinases GRK2, GRK4, GRK5 and GRK6
J Pharmacol Exp Ther 1998 284: 1218-1226. [Abstract] [Full Text] [PDF]  

Dayne Y. Okuhara and Sheryl G. Beck

Corticosteroids Alter 5-Hydroxytryptamine_1A Receptor-effector Pathway in Hippocampal Subfield CA3 Pyramidal Cells
J Pharmacol Exp Ther 1998 284: 1227-1233. [Abstract] [Full Text] [PDF]  

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS:

T. R. Hundley, L. A. Marshall, W. C. Hubbard, and D. W. Macglashan Jr.

Characteristics of Arachidonic Acid Generation in Human Basophils: Relationship Between the Effects of Inhibitors of Secretory Phospholipase A₂ Activity and Leukotriene C₄ Release
J Pharmacol Exp Ther 1998 284: 847-857. [Abstract] [Full Text] [PDF]  

Metiner Tosun, Richard J. Paul, and Robert M. Rapoport

Role of Extracellular Ca⁺⁺ Influx via L-Type and Non-L-Type Ca⁺⁺ Channels in Thromboxane A₂ Receptor-Mediated Contraction in Rat Aorta
J Pharmacol Exp Ther 1998 284: 921-928. [Abstract] [Full Text] [PDF]  

Mong-Heng Wang, Elimor Brand-Schieber, Barbara A. Zand, Xuandai Nguyen, John R. Falck, Narayanan Balu, and Michal Laniado Schwartzman

Cytochrome P450-Derived Arachidonic Acid Metabolism in the Rat Kidney: Characterization of Selective Inhibitors
J Pharmacol Exp Ther 1998 284: 966-973. [Abstract] [Full Text] [PDF]  

Peitan Liu, Kingsley Yin, Robert Nagele, and Patrick Y-K Wong

Inhibition of Nitric Oxide Synthase Attenuates Peroxynitrite Generation, but Augments Neutrophil Accumulation in Hepatic Ischemia-Reperfusion in Rats
J Pharmacol Exp Ther 1998 284: 1139-1146. [Abstract] [Full Text] [PDF]  

PULMONARY PHARMACOLOGY:

Cheryl C. Docherty and Margaret R. Maclean

Endothelin_B Receptors in Rabbit Pulmonary Resistance Arteries: Effect of Left Ventricular Dysfunction
J Pharmacol Exp Ther 1998 284: 895-903. [Abstract] [Full Text] [PDF]  

RENAL PHARMACOLOGY:

Carlotta E. Groves, Mark Morales, and Stephen H. Wright

Peritubular Transport of Ochratoxin A in Rabbit Renal Proximal Tubules
J Pharmacol Exp Ther 1998 284: 943-948. [Abstract] [Full Text] [PDF]  

Lief Eric Olsson, Marcia A. Wheeler, William C. Sessa, and Robert M. Weiss

Bladder Instillation and Intraperitoneal Injection of Escherichia coli Lipopolysaccharide Up-regulate Cytokines and iNOS in Rat Urinary Bladder
J Pharmacol Exp Ther 1998 284: 1203-1208. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Armin Wolf, Ursula Schramm, Alfred Fahr, Lothar Aicher, André Cordier, Wolfgang E. Trommer, and Gert Fricker

Hepatocellular Effects of Cyclosporine A and its Derivative SDZ IMM 125 in Vitro
J Pharmacol Exp Ther 1998 284: 817-825. [Abstract] [Full Text] [PDF]  

Liliana Brambilla, Piero Sestili, Andrea Guidarelli, Letizia Palomba, and Orazio Cantoni

Electron Transport-Mediated Wasteful Consumption of NADH Promotes the Lethal Response of U937 Cells to Tert-Butylhydroperoxide
J Pharmacol Exp Ther 1998 284: 1112-1121. [Abstract] [Full Text] [PDF]  

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