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February 1999; 288 (2)
[Index by Author]
[Cover Caption]
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Scheme for the pharmacological determination of the receptor selectivity of heroin given i.c.v. based
on inhibition of descending (serotonergic, GABAergic, noradrenergic) systems. The various antagonists
with dose and route of administration are given in the ellipse, and the lines connecting downward
indicate the progression of the analyses. The inbred strains, which were ultimately classified as groups
A, B, and C, are indicated in the rectangles. See the article in this issue by Rady et al.,
p.438.