ARTICLES:

Eva Ludwig, Jochen Schmid, Klaus Beschke, and Thomas Ebner

Activation of Human Cytochrome P-450 3A4-Catalyzed Meloxicam 5'-Methylhydroxylation by Quinidine and Hydroquinidine In Vitro
J Pharmacol Exp Ther 1999 290: 1-8. [Abstract] [Full Text] [PDF]  

Andy N. Mead and David N. Stephens

CNQX but not NBQX Prevents Expression of Amphetamine-Induced Place Preference Conditioning: A Role for the Glycine Site of the NMDA Receptor, but not AMPA Receptors
J Pharmacol Exp Ther 1999 290: 9-15. [Abstract] [Full Text] [PDF]  

Yeong Jen Chiu, Shu-Hui Hu, and Ian A. Reid

Inhibition of Phosphodiesterase III with Milrinone Increases Renin Secretion in Human Subjects
J Pharmacol Exp Ther 1999 290: 16-19. [Abstract] [Full Text] [PDF]  

Anton Yu. Bespalov, Robert L. Balster, and Patrick M. Beardsley

N-Methyl-D-Aspartate Receptor Antagonists and the Development of Tolerance to the Discriminative Stimulus Effects of Morphine in Rats
J Pharmacol Exp Ther 1999 290: 20-27. [Abstract] [Full Text] [PDF]  

Zhuo-Wei Hu, Xiao-You Shi, Richard Z. Lin, Jin Chen, and Brian B. Hoffman

₁-Adrenergic Receptor Stimulation of Mitogenesis in Human Vascular Smooth Muscle Cells: Role of Tyrosine Protein Kinases and Calcium in Activation of Mitogen-Activated Protein Kinase
J Pharmacol Exp Ther 1999 290: 28-37. [Abstract] [Full Text] [PDF]  

Richard M. Edwards, Elwood J. Stack, and Walter Trizna

Transport of [³H]Losartan across Isolated Perfused Rabbit Proximal Tubule
J Pharmacol Exp Ther 1999 290: 38-42. [Abstract] [Full Text] [PDF]  

Gottfried J. Locker, Robert M. Mader, Blanka Rizovski, Sylvia Knapp, Hans Domanovits, Marcus Muellner, Christoph Hoeller, Guenther G. Steger, Fritz Sterz, Michael Freissmuth, Michael Frass, and Anton N. Laggner

Negative Chronotropic Effects of Fentanyl Attenuate Beneficial Effects of Dobutamine on Oxygen Metabolism: Hemodynamic and Pharmacokinetic Interactions
J Pharmacol Exp Ther 1999 290: 43-50. [Abstract] [Full Text] [PDF]  

Mitsuo Murata, Ikumi Tamai, Hiroshi Kato, Osamu Nagata, Hideo Kato, and Akira Tsuji

Efflux Transport of a New Quinolone Antibacterial Agent, HSR-903, across the Blood-Brain Barrier
J Pharmacol Exp Ther 1999 290: 51-57. [Abstract] [Full Text] [PDF]  

Lynn E. Witherow and J. Brian Houston

Sigmoidal Kinetics of CYP3A Substrates: An Approach for Scaling Dextromethorphan Metabolism in Hepatic Microsomes and Isolated Hepatocytes to Predict In Vivo Clearance in Rat
J Pharmacol Exp Ther 1999 290: 58-65. [Abstract] [Full Text] [PDF]  

Jo-Ann E. T. Fox-Threlkeld, Thomas J. McDonald, Zofia Woskowska, Keigo Iesaki, and Edwin E. Daniel

Pituitary Adenylate Cyclase-Activating Peptide as a Neurotransmitter in the Canine Ileal Circular Muscle
J Pharmacol Exp Ther 1999 290: 66-75. [Abstract] [Full Text] [PDF]  

Steven J. Coultrap, Hongwei Sun, Thomas E. Tenner, Jr., and Tina K. Machu

Competitive Antagonism of the Mouse 5-Hydroxytryptamine₃ Receptor by Bisindolylmaleimide I, a "Selective" Protein Kinase C Inhibitor
J Pharmacol Exp Ther 1999 290: 76-82. [Abstract] [Full Text] [PDF]  

Gareth W. John, Petrus J. Pauwels, Michel Perez, Serge Halazy, Bruno Le Grand, Yvan Verscheure, Jean-Pierre Valentin, Christiane Palmier, Thierry Wurch, Philippe Chopin, Marc Marien, Mark S. Kleven, Wouter Koek, Marie-Bernadette Assié, Elisabeth Carilla-Durand, Jean-Pierre Tarayre, and Francis C. Colpaert

F 11356, a Novel 5-Hydroxytryptamine (5-HT) Derivative with Potent, Selective, and Unique High Intrinsic Activity at 5-HT_1B/1D Receptors in Models Relevant to Migraine
J Pharmacol Exp Ther 1999 290: 83-95. [Abstract] [Full Text] [PDF]  

Kalina Venkova, Jeffrey M. Palmer, and Beverley Greenwood-Van Meerveld

Nematode-Induced Jejunal Inflammation in the Ferret Causes Long-Term Changes in Excitatory Neuromuscular Responses
J Pharmacol Exp Ther 1999 290: 96-103. [Abstract] [Full Text] [PDF]  

Jiang Hong Ye, Rebecca Schaefer, Wen-Hsien Wu, Philip L. Liu, Vlasta K. Zbuzek, and Joseph J. Mcardle

Inhibitory Effect of Ondansetron on Glycine Response of Dissociated Rat Hippocampal Neurons
J Pharmacol Exp Ther 1999 290: 104-111. [Abstract] [Full Text] [PDF]  

Jason W. Allen, Svetlana A. Ivanova, Lei Fan, Michael G. Espey, Anthony S. Basile, and Alan I. Faden

Group II Metabotropic Glutamate Receptor Activation Attenuates Traumatic Neuronal Injury and Improves Neurological Recovery after Traumatic Brain Injury
J Pharmacol Exp Ther 1999 290: 112-120. [Abstract] [Full Text] [PDF]  

I. Sáenz de Tejada, D. S. Garvey, J. D. Schroeder, T. Shelekhin, L. G. Letts, A. Fernández, B. Cuevas, S. Gabancho, V. Martínez, J. Angulo, M. Trocha, P. Marek, P. Cuevas, and S. W. Tam

Design and Evaluation of Nitrosylated -Adrenergic Receptor Antagonists as Potential Agents for the Treatment of Impotence
J Pharmacol Exp Ther 1999 290: 121-128. [Abstract] [Full Text] [PDF]  

Hongwei Sun, Elizabeth A. McCardy, Tina K. Machu, and Michael P. Blanton

Characterization of Interaction of 3,4,5-Trimethoxybenzoic Acid 8-(Diethylamino)octyl Ester with Torpedo californica Nicotinic Acetylcholine Receptor and 5-Hydroxytryptamine₃ Receptor
J Pharmacol Exp Ther 1999 290: 129-135. [Abstract] [Full Text] [PDF]  

Marta Mas, Magí Farré, Rafael de la Torre, Pere N. Roset, Jordi Ortuño, Jordi Segura, and Jordi Camí

Cardiovascular and Neuroendocrine Effects and Pharmacokinetics of 3,4-Methylenedioxymethamphetamine in Humans
J Pharmacol Exp Ther 1999 290: 136-145. [Abstract] [Full Text] [PDF]  

Eugene A. Sosunov, Ravil Z. Gainullin, Peter Danilo, Jr., Evgeny P. Anyukhovsky, Michael Kirchengast, and Michael R. Rosen

Electrophysiological Effects of LU111995 on Canine Hearts: In Vivo and In Vitro Studies
J Pharmacol Exp Ther 1999 290: 146-152. [Abstract] [Full Text] [PDF]  

Jessica E. van Montfoort, Bruno Stieger, Dirk K. F. Meijer, Hanns-J. Weinmann, Peter J. Meier, and Karin E. Fattinger

Hepatic Uptake of the Magnetic Resonance Imaging Contrast Agent Gadoxetate by the Organic Anion Transporting Polypeptide Oatp1
J Pharmacol Exp Ther 1999 290: 153-157. [Abstract] [Full Text] [PDF]  

M. Quartaroli, C. Carignani, G. Dal Forno, M. Mugnaini, A. Ugolini, R. Arban, L. Bettelini, G. Maraia, F. Belardetti, A. Reggiani, D. G. Trist, E. Ratti, R. Di Fabio, and M. Corsi

Potent Antihyperalgesic Activity without Tolerance Produced by Glycine Site Antagonist of N-Methyl-D-Aspartate Receptor GV196771A
J Pharmacol Exp Ther 1999 290: 158-169. [Abstract] [Full Text] [PDF]  

Mark A. Varney, Nicholas D. P. Cosford, Christine Jachec, Sara P. Rao, Aida Sacaan, Fen-Fen Lin, Leo Bleicher, Emily M. Santori, Peter J. Flor, Hans Allgeier, Fabrizio Gasparini, Rainer Kuhn, Stephen D. Hess, Gönül Veliçelebi, and Edwin C. Johnson

SIB-1757 and SIB-1893: Selective, Noncompetitive Antagonists of Metabotropic Glutamate Receptor Type 5
J Pharmacol Exp Ther 1999 290: 170-181. [Abstract] [Full Text] [PDF]  

Matthew A. Leff, Paul N. Epstein, Mark A. Doll, Adrian J. Fretland, Udaya-Sankar Devanaboyina, Timothy D. Rustan, and David W. Hein

Prostate-Specific Human N-Acetyltransferase 2 (NAT2) Expression in the Mouse
J Pharmacol Exp Ther 1999 290: 182-187. [Abstract] [Full Text] [PDF]  

Jia En Chin, Cheryl A. Hatfield, Greg E. Winterrowd, Raymond F. Krzesicki, Kathy L. Shull, Stephen F. Fidler, Karen P. Kolbasa, John R. Brashler, Robert L. Griffin, William E. Fleming, James M. Justen, Lee S. Banitt, Gordon L. Bundy, and Ivan M. Richards

Preclinical Evaluation of Anti-inflammatory Activities of the Novel Pyrrolopyrimidine PNU-142731A, a Potential Treatment for Asthma
J Pharmacol Exp Ther 1999 290: 188-195. [Abstract] [Full Text] [PDF]  

Larissa A. Pohorecky, Anna Skiandos, Xiaoyan Zhang, Kenner C. Rice, and Daniel Benjamin

Effect of Chronic Social Stress on -Opioid Receptor Function in the Rat
J Pharmacol Exp Ther 1999 290: 196-206. [Abstract] [Full Text] [PDF]  

M. O. Urban, S. V. Coutinho, and G. F. Gebhart

Biphasic Modulation of Visceral Nociception by Neurotensin in Rat Rostral Ventromedial Medulla
J Pharmacol Exp Ther 1999 290: 207-213. [Abstract] [Full Text] [PDF]  

Ying Lu and Karin N. Westlund

Gabapentin Attenuates Nociceptive Behaviors in an Acute Arthritis Model in Rats
J Pharmacol Exp Ther 1999 290: 214-219. [Abstract] [Full Text] [PDF]  

Scott W. Walsh, Yuping Wang, and Anthony Killian

AA-2414, an Antioxidant and Thromboxane Receptor Blocker, Completely Inhibits Peroxide-Induced Vasoconstriction in the Human Placenta
J Pharmacol Exp Ther 1999 290: 220-226. [Abstract] [Full Text] [PDF]  

Alexander Y. Antipenko, Andrew I. Spielman, and Madeleine A. Kirchberger

Interactions of 6-Gingerol and Ellagic Acid with the Cardiac Sarcoplasmic Reticulum Ca²⁺-ATPase
J Pharmacol Exp Ther 1999 290: 227-234. [Abstract] [Full Text] [PDF]  

Peter Schemmer, Henry D. Connor, Gavin E. Arteel, James A. Raleigh, Hartwig Bunzendahl, Ronald P. Mason, and R. G. Thurman

Reperfusion Injury in Livers Due To Gentle In Situ Organ Manipulation during Harvest Involves Hypoxia and Free Radicals
J Pharmacol Exp Ther 1999 290: 235-240. [Abstract] [Full Text] [PDF]  

Latchezar D. Todorov, Svetlana T. Mihaylova-Todorova, Richard A. Bjur, and David P. Westfall

Differential Cotransmission in Sympathetic Nerves: Role of Frequency of Stimulation and Prejunctional Autoreceptors
J Pharmacol Exp Ther 1999 290: 241-246. [Abstract] [Full Text] [PDF]  

Yuri Kolesnikov and Gavril W. Pasternak

Topical Opioids in Mice: Analgesia and Reversal of Tolerance by a Topical N-Methyl-D-Aspartate Antagonist
J Pharmacol Exp Ther 1999 290: 247-252. [Abstract] [Full Text] [PDF]  

Martin F. Fromm, Dawood Darbar, Simonetta Dell'Orto, and Dan M. Roden

Modulation of Effect of Dietary Salt on Prehepatic First-Pass Metabolism: Effects of -Blockade and Intravenous Salt Loading
J Pharmacol Exp Ther 1999 290: 253-258. [Abstract] [Full Text] [PDF]  

Jeffrey A. Vivian, Michael B. DeYoung, Tina L. Sumpter, John R. Traynor, John W. Lewis, and James H. Woods

-Opioid Receptor Effects of Butorphanol in Rhesus Monkeys
J Pharmacol Exp Ther 1999 290: 259-265. [Abstract] [Full Text] [PDF]  

Juan Carlos Gomora and John J. Enyeart

Dual Pharmacological Properties of a Cyclic AMP-Sensitive Potassium Channel
J Pharmacol Exp Ther 1999 290: 266-275. [Abstract] [Full Text] [PDF]  

Maria R. Panara, Giulia Renda, Maria G. Sciulli, Giovanna Santini, Maria Di Giamberardino, Maria T. Rotondo, Stefania Tacconelli, Francesca Seta, Carlo Patrono, and Paola Patrignani

Dose-Dependent Inhibition of Platelet Cyclooxygenase-1 and Monocyte Cyclooxygenase-2 by Meloxicam in Healthy Subjects
J Pharmacol Exp Ther 1999 290: 276-280. [Abstract] [Full Text] [PDF]  

Michael A. Shultz, Prabhakara V. Choudary, and Alan R. Buckpitt

Role of Murine Cytochrome P-450 2F2 in Metabolic Activation of Naphthalene and Metabolism of Other Xenobiotics
J Pharmacol Exp Ther 1999 290: 281-288. [Abstract] [Full Text] [PDF]  

Jun-ichi Nishino, Hiroshi Suzuki, Daisuke Sugiyama, Takeo Kitazawa, Kousei Ito, Manabu Hanano, and Yuichi Sugiyama

Transepithelial Transport of Organic Anions across the Choroid Plexus: Possible Involvement of Organic Anion Transporter and Multidrug Resistance-Associated Protein
J Pharmacol Exp Ther 1999 290: 289-294. [Abstract] [Full Text] [PDF]  

Kerry B. Goralski and Daniel S. Sitar

Tetraethylammonium and Amantadine Identify Distinct Organic Cation Transporters in Rat Renal Cortical Proximal and Distal Tubules
J Pharmacol Exp Ther 1999 290: 295-302. [Abstract] [Full Text] [PDF]  

Serge Gobaille, Viviane Hechler, Christian Andriamampandry, Véronique Kemmel, and Michel Maitre

-Hydroxybutyrate Modulates Synthesis and Extracellular Concentration of -Aminobutyric Acid in Discrete Rat Brain Regions In Vivo
J Pharmacol Exp Ther 1999 290: 303-309. [Abstract] [Full Text] [PDF]  

Emilio Ruiz, Marcela Del Rio, Beatriz Somoza, Patricia Ganado, Mercedes Sanz, and Teresa Tejerina

L-Citrulline, the By-Product of Nitric Oxide Synthesis, Decreases Vascular Smooth Muscle Cell Proliferation
J Pharmacol Exp Ther 1999 290: 310-313. [Abstract] [Full Text] [PDF]  

Jing Zhang, Joe C. Burnell, Natividad Dumaual, and William F. Bosron

Binding and Hydrolysis of Meperidine by Human Liver Carboxylesterase hCE-1
J Pharmacol Exp Ther 1999 290: 314-318. [Abstract] [Full Text] [PDF]  

Robert T. Dunn, II, Bruce A. Gleason, Dylan P. Hartley, and Curtis D. Klaassen

Postnatal Ontogeny and Hormonal Regulation of Sulfotransferase SULT1B1 in Male and Female Rats
J Pharmacol Exp Ther 1999 290: 319-324. [Abstract] [Full Text] [PDF]  

Mark S. Brodie, Maureen A. McElvain, E. Bradshaw Bunney, and Sarah B. Appel

Pharmacological Reduction of Small Conductance Calcium-Activated Potassium Current (SK) Potentiates the Excitatory Effect of Ethanol on Ventral Tegmental Area Dopamine Neurons
J Pharmacol Exp Ther 1999 290: 325-333. [Abstract] [Full Text] [PDF]  

Pascal Paul, Chantal Lahaye, Philippe Delagrange, Jean-Paul Nicolas, Emmanuel Canet, and Jean A. Boutin

Characterization of 2-[¹²⁵I]Iodomelatonin Binding Sites in Syrian Hamster Peripheral Organs
J Pharmacol Exp Ther 1999 290: 334-340. [Abstract] [Full Text] [PDF]  

Ahmed Chraïbi and Jean-Daniel Horisberger

Stimulation of Epithelial Sodium Channel Activity by the Sulfonylurea Glibenclamide
J Pharmacol Exp Ther 1999 290: 341-347. [Abstract] [Full Text] [PDF]  

Mette Grønborg, Teit E. Johansen, Dan Peters, Philip K. Ahring, Jørgen Drejer, Arne Møller, and Leif H. Jensen

Neuroprotection by a Novel Compound, NS521
J Pharmacol Exp Ther 1999 290: 348-353. [Abstract] [Full Text] [PDF]  

Halina Machelska, Martina Pflüger, Werner Weber, Mojgan Piranvisseh-Völk, Jeffrey D. Daubert, Robert DeHaven, and Christoph Stein

Peripheral Effects of the -Opioid Agonist EMD 61753 on Pain and Inflammation in Rats and Humans
J Pharmacol Exp Ther 1999 290: 354-361. [Abstract] [Full Text] [PDF]  

Meng-Ya Wang, Ira J. Rampil, and Joan J. Kendig

Ethanol Directly Depresses AMPA and NMDA Glutamate Currents in Spinal Cord Motor Neurons Independent of Actions on GABA_A or Glycine Receptors
J Pharmacol Exp Ther 1999 290: 362-367. [Abstract] [Full Text] [PDF]  

Shinichi Tsunoda, Tomoyoshi Ishikawa, Yoko Yamamoto, Haruhiko Kamada, Keiichi Koizumi, Junji Matsui, Yasuo Tsutsumi, Takashi Hirano, and Tadanori Mayumi

Enhanced Antitumor Potency of Polyethylene Glycolylated Tumor Necrosis Factor-: A Novel Polymer-Conjugation Technique with a Reversible Amino-Protective Reagent
J Pharmacol Exp Ther 1999 290: 368-372. [Abstract] [Full Text] [PDF]  

Motohiro Kato, Yukio Kato, Toshikazu Nakamura, and Yuichi Sugiyama

Efficient Extraction by the Liver Governs Overall Elimination of Hepatocyte Growth Factor in Rats
J Pharmacol Exp Ther 1999 290: 373-379. [Abstract] [Full Text] [PDF]  

José Eduardo da Silva-Santos and Jamil Assreuy

Long-Lasting Changes of Rat Blood Pressure to Vasoconstrictors and Vasodilators Induced by Nitric Oxide Donor Infusion: Involvement of Potassium Channels
J Pharmacol Exp Ther 1999 290: 380-387. [Abstract] [Full Text] [PDF]  

Hiroshi Mizuuchi, Toshiya Katsura, Hideyuki Saito, Yukiya Hashimoto, and Ken-Ichi Inui

Transport Characteristics of Diphenhydramine in Human Intestinal Epithelial Caco-2 Cells: Contribution of pH-Dependent Transport System
J Pharmacol Exp Ther 1999 290: 388-392. [Abstract] [Full Text] [PDF]  

Jillian H. Broadbear, Gail Winger, Theodore J. Cicero, and James H. Woods

Effects of Response Contingent and Noncontingent Cocaine Injection on Hypothalamic-Pituitary-Adrenal Activity in Rhesus Monkeys
J Pharmacol Exp Ther 1999 290: 393-402. [Abstract] [Full Text] [PDF]  

Carolyn A. Fairbanks and George L. Wilcox

Moxonidine, a Selective ₂-Adrenergic and Imidazoline Receptor Agonist, Produces Spinal Antinociception in Mice
J Pharmacol Exp Ther 1999 290: 403-412. [Abstract] [Full Text] [PDF]  

Yoseph Caraco, James Sheller, and Alastair J. J. Wood

Impact of Ethnic Origin and Quinidine Coadministration on Codeine's Disposition and Pharmacodynamic Effects
J Pharmacol Exp Ther 1999 290: 413-422. [Abstract] [Full Text] [PDF]  

Anna Pittaluga, Roberto Pattarini, Gian Carlo Andrioli, Concetta Viola, Claudio Munari, and Maurizio Raiteri

Activity of Putative Cognition Enhancers in Kynurenate Test Performed with Human Neocortex Slices
J Pharmacol Exp Ther 1999 290: 423-428. [Abstract] [Full Text] [PDF]  

Sean Ekins, Gianpaolo Bravi, Shelly Binkley, Jennifer S. Gillespie, Barbara J. Ring, James H. Wikel, and Steven A Wrighton

Three- and Four-Dimensional Quantitative Structure Activity Relationship Analyses of Cytochrome P-450 3A4 Inhibitors
J Pharmacol Exp Ther 1999 290: 429-438. [Abstract] [Full Text] [PDF]  

Frederick W. Berman and Thomas F. Murray

Brevetoxins Cause Acute Excitotoxicity in Primary Cultures of Rat Cerebellar Granule Neurons
J Pharmacol Exp Ther 1999 290: 439-444. [Abstract] [Full Text] [PDF]  

Sharon M. Strobel, Grazyna D. Szklarz, You qun He, Maryam Foroozesh, William L. Alworth, Elizabeth S. Roberts, Paul F. Hollenberg, and James R. Halpert

Identification of Selective Mechanism-Based Inactivators of Cytochromes P-450 2B4 and 2B5, and Determination of the Molecular Basis for Differential Susceptibility
J Pharmacol Exp Ther 1999 290: 445-451. [Abstract] [Full Text] [PDF]  

Sandra L. Hrometz, Stephanie E. Edelmann, Dan F. McCune, Jennifer R. Olges, Robert W. Hadley, Dianne M. Perez, and Michael T. Piascik

Expression of Multiple ₁-Adrenoceptors on Vascular Smooth Muscle: Correlation with the Regulation of Contraction
J Pharmacol Exp Ther 1999 290: 452-463. [Abstract] [Full Text] [PDF]  

Renée Miceli, Melissa Hubert, Gemma Santiago, Da-Lin Yao, Timothy A. Coleman, Kathleen A. Huddleston, and Kevin Connolly

Efficacy of Keratinocyte Growth Factor-2 in Dextran Sulfate Sodium-Induced Murine Colitis
J Pharmacol Exp Ther 1999 290: 464-471. [Abstract] [Full Text] [PDF]  

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