ARTICLES:

John Fox, Stacey H. Lowe, Barbara A. Petty, and Edward F. Nemeth

NPS R-568: A Type II Calcimimetic Compound that Acts on Parathyroid Cell Calcium Receptor of Rats to Reduce Plasma Levels of Parathyroid Hormone and Calcium
J Pharmacol Exp Ther 1999 290: 473-479. [Abstract] [Full Text] [PDF]  

John Fox, Stacey H. Lowe, Rebecca L. Conklin, Barbara A. Petty, and Edward F. Nemeth

Calcimimetic Compound NPS R-568 Stimulates Calcitonin Secretion But Selectively Targets Parathyroid Gland Ca²⁺ Receptor in Rats
J Pharmacol Exp Ther 1999 290: 480-486. [Abstract] [Full Text] [PDF]  

A. R. Renzetti, R.-M. Catalioto, M. Criscuoli, P. Cucchi, C. Ferrer, A. Giolitti, M. Guelfi, L. Rotondaro, F. J. Warner, and C. A. Maggi

Relevance of Aromatic Residues in Transmembrane Segments V to VII for Binding of Peptide and Nonpeptide Antagonists to the Human Tachykinin NK₂ Receptor
J Pharmacol Exp Ther 1999 290: 487-495. [Abstract] [Full Text] [PDF]  

Kerry B. Goralski, Donald D. Smyth, and Daniel S. Sitar

In Vivo Analysis of Amantadine Renal Clearance in the Uninephrectomized Rat: Functional Significance of In Vitro Bicarbonate-Dependent Amantadine Renal Tubule Transport
J Pharmacol Exp Ther 1999 290: 496-504. [Abstract] [Full Text] [PDF]  

E. F. Du Toit, C. A. Muller, J. McCarthy, and L. H. Opie

Levosimendan: Effects of a Calcium Sensitizer on Function and Arrhythmias and Cyclic Nucleotide Levels during Ischemia/Reperfusion in the Langendorff-Perfused Guinea Pig Heart
J Pharmacol Exp Ther 1999 290: 505-514. [Abstract] [Full Text] [PDF]  

Jose A. Sanchez-Chapula

Mechanism of Transient Outward K⁺ Channel Block by Disopyramide
J Pharmacol Exp Ther 1999 290: 515-523. [Abstract] [Full Text] [PDF]  

Shin Yoshino and Masaru Sagai

Enhancement of Collagen-Induced Arthritis in Mice by Diesel Exhaust Particles
J Pharmacol Exp Ther 1999 290: 524-529. [Abstract] [Full Text] [PDF]  

Ioan Puscas, Marcela Coltau, Michael Baican, and Gabriela Domuta

Omeprazole Has a Dual Mechanism of Action: It Inhibits Both H⁺K⁺ATPase and Gastric Mucosa Carbonic Anhydrase Enzyme in Humans (In Vitro and In Vivo Experiments)
J Pharmacol Exp Ther 1999 290: 530-534. [Abstract] [Full Text] [PDF]  

A. Kuzmin, B. Johansson, E. E. Zvartau, and B. B. Fredholm

Caffeine, Acting on Adenosine A₁ Receptors, Prevents the Extinction of Cocaine-Seeking Behavior in Mice
J Pharmacol Exp Ther 1999 290: 535-542. [Abstract] [Full Text] [PDF]  

M. B. Hesselink, H. Smolders, B. Eilbacher, A. G. De Boer, D. D. Breimer, and W. Danysz

The Role of Probenecid-Sensitive Organic Acid Transport in the Pharmacokinetics of N-Methyl-D-Aspartate Receptor Antagonists Acting at the Glycine_B-Site: Microdialysis and Maximum Electroshock Seizures Studies
J Pharmacol Exp Ther 1999 290: 543-550. [Abstract] [Full Text] [PDF]  

C.-C. Chan, S. Boyce, C. Brideau, S. Charleson, W. Cromlish, D. Ethier, J. Evans, A. W. Ford-Hutchinson, M. J. Forrest, J. Y. Gauthier, R. Gordon, M. Gresser, J. Guay, S. Kargman, B. Kennedy, Y. Leblanc, S. Leger, J. Mancini, G. P. O'Neill, M. Ouellet, D. Patrick, M. D. Percival, H. Perrier, P. Prasit, I. Rodger, P. Tagari, M. Therien, P. Vickers, D. Visco, Z. Wang, J. Webb, E. Wong, L.-J. Xu, R. N. Young, R. Zamboni, and D. Riendeau

Rofecoxib [Vioxx, MK-0966; 4-(4'-Methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: A Potent and Orally Active Cyclooxygenase-2 Inhibitor. Pharmacological and Biochemical Profiles
J Pharmacol Exp Ther 1999 290: 551-560. [Abstract] [Full Text] [PDF]  

Shuichi Tanabe, Yasuyuki Shimohigashi, Yasuhisa Nakayama, Takashi Makino, Tsugumi Fujita, Takeru Nose, Gozoh Tsujimoto, Teruo Yokokura, Mikihiko Naito, Takashi Tsuruo, and Tetsuya Terasaki

In Vivo and In Vitro Evidence of Blood-Brain Barrier Transport of a Novel Cationic Arginine-Vasopressin Fragment 4-9 Analog
J Pharmacol Exp Ther 1999 290: 561-568. [Abstract] [Full Text] [PDF]  

Gea-Ny Tseng

Different State Dependencies of 4-Aminopyridine Binding to rKv1.4 and rKv4.2: Role of the Cytoplasmic Halves of the Fifth and Sixth Transmembrane Segments
J Pharmacol Exp Ther 1999 290: 569-577. [Abstract] [Full Text] [PDF]  

S. Choisy, C. Huchet-Cadiou, and C. Léoty

Sarcoplasmic Reticulum Ca²⁺ Release by 4-Chloro-m-Cresol (4-CmC) in Intact and Chemically Skinned Ferret Cardiac Ventricular Fibers
J Pharmacol Exp Ther 1999 290: 578-586. [Abstract] [Full Text] [PDF]  

Alison M. Badger, Michael N. Cook, Barbara A. Swift, Tonie M. Newman-Tarr, Maxine Gowen, and Michael Lark

Inhibition of Interleukin-1-Induced Proteoglycan Degradation and Nitric Oxide Production in Bovine Articular Cartilage/Chondrocyte Cultures by the Natural Product, Hymenialdisine
J Pharmacol Exp Ther 1999 290: 587-593. [Abstract] [Full Text] [PDF]  

Jeffrey C. Stevens, Tammy L. Domanski, Greg R. Harlow, Rebecca B. White, Edward Orton, and James R. Halpert

Use of the Steroid Derivative RPR 106541 in Combination with Site-Directed Mutagenesis for Enhanced Cytochrome P-450 3A4 Structure/Function Analysis
J Pharmacol Exp Ther 1999 290: 594-602. [Abstract] [Full Text] [PDF]  

Scott D. Sorensen, Daniel A. Linseman, Edward L. McEwen, Anne M. Heacock, and Stephen K. Fisher

Inhibition of ₂-Adrenergic and Muscarinic Cholinergic Receptor Endocytosis after Depletion of Phosphatidylinositol Bisphosphate
J Pharmacol Exp Ther 1999 290: 603-610. [Abstract] [Full Text] [PDF]  

Zhi Zhong, Gavin E. Arteel, Henry D. Connor, Peter Schemmer, Shu-Chuan Chou, James A. Raleigh, Ronald P. Mason, John J. Lemasters, and Ronald G. Thurman

Binge Drinking Disturbs Hepatic Microcirculation after Transplantation: Prevention with Free Radical Scavengers
J Pharmacol Exp Ther 1999 290: 611-620. [Abstract] [Full Text] [PDF]  

Hannu Kankaanranta, Patricia M. De Souza, Peter J. Barnes, Michael Salmon, Mark A. Giembycz, and Mark A. Lindsay

SB 203580, an Inhibitor of p38 Mitogen-Activated Protein Kinase, Enhances Constitutive Apoptosis of Cytokine-Deprived Human Eosinophils
J Pharmacol Exp Ther 1999 290: 621-628. [Abstract] [Full Text] [PDF]  

Vicente Martínez, Jean Rivier, and Y. Taché

Peripheral Injection of a New Corticotropin-Releasing Factor (CRF) Antagonist, Astressin, Blocks Peripheral CRF- and Abdominal Surgery-Induced Delayed Gastric Emptying in Rats
J Pharmacol Exp Ther 1999 290: 629-634. [Abstract] [Full Text] [PDF]  

Gordon C. Ibeanu, Joyce Blaisdell, Ronald J. Ferguson, Burhan I. Ghanayem, Kim Brøsen, Simone Benhamou, Christine Bouchardy, Grant R. Wilkinson, Pierre Dayer, and Joyce A. Goldstein

A Novel Transversion in the Intron 5 Donor Splice Junction of CYP2C19 and a Sequence Polymorphism in Exon 3 Contribute to the Poor Metabolizer Phenotype for the Anticonvulsant Drug S-Mephenytoin
J Pharmacol Exp Ther 1999 290: 635-640. [Abstract] [Full Text] [PDF]  

Jian-Bing Shen, Bin Jiang, and Achilles J. Pappano

Lack of Effect of McN-A-343 on Membrane Current and Contraction in Guinea Pig Ventricular Myocytes
J Pharmacol Exp Ther 1999 290: 641-648. [Abstract] [Full Text] [PDF]  

Mari Rios Candelore, Liping Deng, Laurie Tota, Xiao-Ming Guan, Angela Amend, Yong Liu, Ron Newbold, Margaret A. Cascieri, and Ann E. Weber

Potent and Selective Human ₃-Adrenergic Receptor Antagonists
J Pharmacol Exp Ther 1999 290: 649-655. [Abstract] [Full Text] [PDF]  

Nahid Seyedi, Ryushi Maruyama, and Roberto Levi

Bradykinin Activates a Cross-Signaling Pathway between Sensory and Adrenergic Nerve Endings in the Heart: A Novel Mechanism of Ischemic Norepinephrine Release?
J Pharmacol Exp Ther 1999 290: 656-663. [Abstract] [Full Text] [PDF]  

Lena Brynne, Lennart K. Paalzow, and Mats O. Karlsson

Mechanism-Based Modeling of Rebound Tachycardia after Chronic l-Propranolol Infusion in Spontaneous Hypertensive Rats
J Pharmacol Exp Ther 1999 290: 664-671. [Abstract] [Full Text] [PDF]  

Surawat Jariyawat, Takashi Sekine, Michio Takeda, Nopporn Apiwattanakul, Yoshikatsu Kanai, Samaisukh Sophasan, and Hitoshi Endou

The Interaction and Transport of -Lactam Antibiotics with the Cloned Rat Renal Organic Anion Transporter 1
J Pharmacol Exp Ther 1999 290: 672-677. [Abstract] [Full Text] [PDF]  

Eduardo R. Butelman, Todd J. Harris, Amarilis Perez, and Mary-Jeanne Kreek

Effects of Systemically Administered Dynorphin A(1-17) in Rhesus Monkeys
J Pharmacol Exp Ther 1999 290: 678-686. [Abstract] [Full Text] [PDF]  

Chantal Gauthier, Geneviève Tavernier, Jean-Noël Trochu, Véronique Leblais, Karine Laurent, Dominique Langin, Denis Escande, and Hervé Le Marec

Interspecies Differences in the Cardiac Negative Inotropic Effects of ₃-Adrenoceptor Agonists
J Pharmacol Exp Ther 1999 290: 687-693. [Abstract] [Full Text] [PDF]  

Richard N. Upton, Yi Fei Huang, Laurence E. Mather, and David J. Doolette

The Relationship between the Myocardial Kinetics of Meperidine and Its Effect on Myocardial Contractility: Model-Independent Analysis and Optimal Regional Model
J Pharmacol Exp Ther 1999 290: 694-701. [Abstract] [Full Text] [PDF]  

P. H. Van der Graaf, E. A. Van Schaick, S. A. G. Visser, H. J. M. M. De Greef, A. P. Ijzerman, and M. Danhof

Mechanism-Based Pharmacokinetic-Pharmacodynamic Modeling of Antilipolytic Effects of Adenosine A₁ Receptor Agonists in Rats: Prediction of Tissue-Dependent Efficacy In Vivo
J Pharmacol Exp Ther 1999 290: 702-709. [Abstract] [Full Text] [PDF]  

G. Gabriëls, A. Werners, S. Mauss, and J. Greven

Evidence for Differential Regulation of Renal Proximal Tubular p-Aminohippurate and Sodium-Dependent Dicarboxylate Transport
J Pharmacol Exp Ther 1999 290: 710-715. [Abstract] [Full Text] [PDF]  

Mark A. Geyer, Neal R. Swerdlow, Virginia Lehmann-Masten, Hans-Jürgen Teschendorf, Martin Traut, and Gerhard Gross

Effects of LU-111995 in Three Models of Disrupted Prepulse Inhibition in Rats
J Pharmacol Exp Ther 1999 290: 716-724. [Abstract] [Full Text] [PDF]  

Mauro Cataldi, Agnese Secondo, Angela D'Alessio, Maurizio Taglialatela, Franz Hofmann, Norbert Klugbauer, Gianfranco Di Renzo, and Lucio Annunziato

Studies on Maitotoxin-Induced Intracellular Ca²⁺ Elevation in Chinese Hamster Ovary Cells Stably Transfected with cDNAs Encoding for L-Type Ca²⁺ Channel Subunits
J Pharmacol Exp Ther 1999 290: 725-730. [Abstract] [Full Text] [PDF]  

J. S. Schneider, John P. Tinker, Maria Van Velson, Frederique Menzaghi, and G. Kenneth Lloyd

Nicotinic Acetylcholine Receptor Agonist SIB-1508Y Improves Cognitive Functioning in Chronic Low-Dose MPTP-Treated Monkeys
J Pharmacol Exp Ther 1999 290: 731-739. [Abstract] [Full Text] [PDF]  

Salman M. Hyder, Constance Chiappetta, and George M. Stancel

Synthetic Estrogen 17-Ethinyl Estradiol Induces Pattern of Uterine Gene Expression Similar to Endogenous Estrogen 17-Estradiol
J Pharmacol Exp Ther 1999 290: 740-747. [Abstract] [Full Text] [PDF]  

Kohtarou Kodama and Hideyuki Adachi

Improvement of Mortality by Long-Term E4010 Treatment in Monocrotaline-Induced Pulmonary Hypertensive Rats
J Pharmacol Exp Ther 1999 290: 748-752. [Abstract] [Full Text] [PDF]  

Bahjat Al-Ani, Mahmoud Saifeddine, Atsufumi Kawabata, Bernard Renaux, Shalini Mokashi, and Morley D. Hollenberg

Proteinase-Activated Receptor 2 (PAR₂): Development of a Ligand-Binding Assay Correlating with Activation of PAR₂ by PAR₁- and PAR₂-Derived Peptide Ligands
J Pharmacol Exp Ther 1999 290: 753-760. [Abstract] [Full Text] [PDF]  

Filip A. Paczkowski, Lesley J. Bryan-Lluka, Peter Pörzgen, Michael Brüss, and Heinz Bönisch

Comparison of the Pharmacological Properties of Cloned Rat, Human, and Bovine Norepinephrine Transporters
J Pharmacol Exp Ther 1999 290: 761-767. [Abstract] [Full Text] [PDF]  

Kansu Büyükafsar, Emine Demirel-Yilmaz, Cemil Göçmen, and Atilla Dikmen

Depletion and Restoration of the Putative Photosensitive Materials Store Yielding Nitric Oxide in the Isolated Mouse Gastric Fundus
J Pharmacol Exp Ther 1999 290: 768-773. [Abstract] [Full Text] [PDF]  

Ana I. Galán, M. Eugenia Muñoz, and Rafael Jiménez

S-Adenosylmethionine Protects Against Cyclosporin A-Induced Alterations in Rat Liver Plasma Membrane Fluidity and Functions
J Pharmacol Exp Ther 1999 290: 774-781. [Abstract] [Full Text] [PDF]  

E. von Dobschuetz, T. Hoffmann, and K. Messmer

Inhibition of Neutrophil Proteinases by Recombinant Serpin Lex032 Reduces Capillary No-Reflow in Ischemia/Reperfusion-Induced Acute Pancreatitis
J Pharmacol Exp Ther 1999 290: 782-788. [Abstract] [Full Text] [PDF]  

Y. Li, H. Y. Wang, and C. H. Cho

Association of Heparin with Basic Fibroblast Growth Factor, Epidermal Growth Factor, and Constitutive Nitric Oxide Synthase on Healing of Gastric Ulcer in Rats
J Pharmacol Exp Ther 1999 290: 789-796. [Abstract] [Full Text] [PDF]  

Stephanie A. Kushner, Stephen L. Dewey, and Conan Kornetsky

The Irreversible -Aminobutyric Acid (GABA) Transaminase Inhibitor -Vinyl-GABA Blocks Cocaine Self-Administration in Rats
J Pharmacol Exp Ther 1999 290: 797-802. [Abstract] [Full Text] [PDF]  

Xiaoping Zhou and James J. Galligan

Synaptic Activation and Properties of 5-Hydroxytryptamine₃ Receptors in Myenteric Neurons of Guinea Pig Intestine
J Pharmacol Exp Ther 1999 290: 803-810. [Abstract] [Full Text] [PDF]  

Bo Rum Ryu, Dennis W. Choi, Dean M. Hartley, Erminio Costa, Ilo Jou, and Byoung Joo Gwag

Attenuation of Cortical Neuronal Apoptosis by Gangliosides
J Pharmacol Exp Ther 1999 290: 811-816. [Abstract] [Full Text] [PDF]  

Chiara Florio, Fabiana Frausin, Rodolfo Vertua, and Rosa Maria Gaion

Amplification of the Cyclic AMP Response to Forskolin in Pheochromocytoma PC12 Cells through Adenosine A_2A Purinoceptors
J Pharmacol Exp Ther 1999 290: 817-824. [Abstract] [Full Text] [PDF]  

Yongbei Yu and William C. de Groat

Effects of ZD6169, a K_ATP Channel Opener, on the Micturition Reflex in the Rat
J Pharmacol Exp Ther 1999 290: 825-831. [Abstract] [Full Text] [PDF]  

Guy J. L. Lagaud, Peter L. Skarsgard, Ismail Laher, and Cornelis van Breemen

Heterogeneity of Endothelium-Dependent Vasodilation in Pressurized Cerebral and Small Mesenteric Resistance Arteries of the Rat
J Pharmacol Exp Ther 1999 290: 832-839. [Abstract] [Full Text] [PDF]  

Martine Clozel, Henri Ramuz, Jean-Paul Clozel, Volker Breu, Patrick Hess, Bernd-Michael Löffler, Philippe Coassolo, and Sébastien Roux

Pharmacology of Tezosentan, New Endothelin Receptor Antagonist Designed for Parenteral Use
J Pharmacol Exp Ther 1999 290: 840-846. [Abstract] [Full Text] [PDF]  

Amer M. Johri and Luke J. Janssen

N-Type Ca²⁺ Channels Trigger Release of Excitatory and Inhibitory Neurotransmitter from Nerve Endings in Canine Bronchi
J Pharmacol Exp Ther 1999 290: 847-853. [Abstract] [Full Text] [PDF]  

A. H. Dantzig, R. L. Shepard, K. L. Law, L. Tabas, S. Pratt, J. S. Gillespie, S. N. Binkley, M. T. Kuhfeld, J. J. Starling, and S. A. Wrighton

Selectivity of the Multidrug Resistance Modulator, LY335979, for P-Glycoprotein and Effect on Cytochrome P-450 Activities
J Pharmacol Exp Ther 1999 290: 854-862. [Abstract] [Full Text] [PDF]  

Tracey A. Ignatowski and Jean M. Bidlack

Differential -Opioid Receptor Expression on Mouse Lymphocytes at Varying Stages of Maturation and on Mouse Macrophages after Selective Elicitation
J Pharmacol Exp Ther 1999 290: 863-870. [Abstract] [Full Text] [PDF]  

Hyo-Jeong Kuh, Seong H. Jang, M. Guillaume Wientjes, Jean R. Weaver, and Jessie L.-S. Au

Determinants of Paclitaxel Penetration and Accumulation in Human Solid Tumor
J Pharmacol Exp Ther 1999 290: 871-880. [Abstract] [Full Text] [PDF]  

Stéphanie Caillé, Emilio F. Espejo, Jean-Philippe Reneric, Martine Cador, George F. Koob, and Luis Stinus

Total Neurochemical Lesion of Noradrenergic Neurons of the Locus Ceruleus Does Not Alter Either Naloxone-Precipitated or Spontaneous Opiate Withdrawal nor Does It Influence Ability of Clonidine To Reverse Opiate Withdrawal
J Pharmacol Exp Ther 1999 290: 881-892. [Abstract] [Full Text] [PDF]  

M. Kurjak, D. Sattler, V. Schusdziarra, and H. D. Allescher

Characterization of Prejunctional and Postjunctional Muscarinic Receptors of the Ascending Reflex Contraction in Rat Ileum
J Pharmacol Exp Ther 1999 290: 893-900. [Abstract] [Full Text] [PDF]  

Harlan E. Shannon, John C. Hart, Frank P. Bymaster, David O. Calligaro, Neil W. DeLapp, Charles H. Mitch, John S. Ward, Anders Fink-Jensen, Per Sauerberg, Lone Jeppesen, Malcolm J. Sheardown, and Michael D.B. Swedberg

Muscarinic Receptor Agonists, Like Dopamine Receptor Antagonist Antipsychotics, Inhibit Conditioned Avoidance Response in Rats
J Pharmacol Exp Ther 1999 290: 901-907. [Abstract] [Full Text] [PDF]  

Jurgen F. M. Vanhauwe, Norbert Fraeyman, Bart J. B. Francken, Walter H. M. L. Luyten, and Josée E. Leysen

Comparison of the Ligand Binding and Signaling Properties of Human Dopamine D₂ and D₃ Receptors in Chinese Hamster Ovary Cells
J Pharmacol Exp Ther 1999 290: 908-916. [Abstract] [Full Text] [PDF]  

Sven Sihver, Wiebke Sihver, Mats Bergström, A. Urban Höglund, Pernilla Sjöberg, Bengt Långström, and Yasuyoshi Watanabe

Quantitative Autoradiography with Short-Lived Positron Emission Tomography Tracers: A Study on Muscarinic Acetylcholine Receptors with N-[¹¹C]methyl-4-piperidylbenzilate
J Pharmacol Exp Ther 1999 290: 917-922. [Abstract] [Full Text] [PDF]  

Masami Ishido, Tsuguyoshi Suzuki, Tatsumi Adachi, and Manabu Kunimoto

Zinc Stimulates DNA Synthesis during Its Antiapoptotic Action Independently with Increments of an Antiapoptotic Protein, Bcl-2, in Porcine Kidney LLC-PK₁ Cells
J Pharmacol Exp Ther 1999 290: 923-928. [Abstract] [Full Text] [PDF]  

Yasuaki Nakao, Jun Gotoh, Tang-Yong Kuang, David M. Cohen, Karen D. Pettigrew, and Louis Sokoloff

Cerebral Blood Flow Responses to Somatosensory Stimulation Are Unaffected by Scopolamine in Unanesthetized Rat
J Pharmacol Exp Ther 1999 290: 929-934. [Abstract] [Full Text] [PDF]  

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