PERSPECTIVES IN PHARMACOLOGY:

John S. Lazo and Peter Wipf

Combinatorial Chemistry and Contemporary Pharmacology
J Pharmacol Exp Ther 2000 293: 705-709. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Hyo-Jeong Kuh, Seong Hoon Jang, M. Guillaume Wientjes, and Jessie L.-S. Au

Computational Model of Intracellular Pharmacokinetics of Paclitaxel
J Pharmacol Exp Ther 2000 293: 761-770. [Abstract] [Full Text] [PDF]  

Eve M. Taylor, Rongzi Yan, Nils Hauptmann, Timothy J. Maher, Daniela Djahandideh, and Alvin J. Glasky

AIT-082, a Cognitive Enhancer, Is Transported into Brain by a Nonsaturable Influx Mechanism and out of Brain by a Saturable Efflux Mechanism
J Pharmacol Exp Ther 2000 293: 813-821. [Abstract] [Full Text] [PDF]  

Tarundeep Kakkar, Yvonne Pak, and Michael Mayersohn

Evaluation of a Minimal Experimental Design for Determination of Enzyme Kinetic Parameters and Inhibition Mechanism
J Pharmacol Exp Ther 2000 293: 861-869. [Abstract] [Full Text] [PDF]  

John R. Cashman, Clifford E. Berkman, and Gail E. Underiner

Catalytic Antibodies that Hydrolyze ()-Cocaine Obtained by a High-Throughput Procedure
J Pharmacol Exp Ther 2000 293: 952-961. [Abstract] [Full Text] [PDF]  

Peter Laverman, Adrienne H. Brouwers, Els Th. M. Dams, Wim J. G. Oyen, Gert Storm, Nico van Rooijen, Frans H. M. Corstens, and Otto C. Boerman

Preclinical and Clinical Evidence for Disappearance of Long-Circulating Characteristics of Polyethylene Glycol Liposomes at Low Lipid Dose
J Pharmacol Exp Ther 2000 293: 996-1001. [Abstract] [Full Text] [PDF]  

Arun K. Agrawal and Bernard H. Shapiro

Latent Overexpression of Hepatic CYP2C7 in Adult Male and Female Rats Neonatally Exposed to Phenobarbital: A Developmental Profile of Gender-Dependent P450s
J Pharmacol Exp Ther 2000 293: 1027-1033. [Abstract] [Full Text] [PDF]  

Ayako Takeuchi, Satohiro Masuda, Hideyuki Saito, Yukiya Hashimoto, and Ken-ichi Inui

Trans-Stimulation Effects of Folic Acid Derivatives on Methotrexate Transport by Rat Renal Organic Anion Transporter, OAT-K1
J Pharmacol Exp Ther 2000 293: 1034-1039. [Abstract] [Full Text] [PDF]  

Illana Gozes, Eliezer Giladi, Albert Pinhasov, Amos Bardea, and Douglas E. Brenneman

Activity-Dependent Neurotrophic Factor: Intranasal Administration of Femtomolar-Acting Peptides Improve Performance in a Water Maze
J Pharmacol Exp Ther 2000 293: 1091-1098. [Abstract] [Full Text] [PDF]  

Peter D. Premdas, Raymond J. Bowers, and Poh-Gek Forkert

Inactivation of Hepatic CYP2E1 by an Epoxide of Diallyl Sulfone
J Pharmacol Exp Ther 2000 293: 1112-1120. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Malin Malmsjö, Mingyan Hou, T. Kendall Harden, William Pendergast, Emil Pantev, Lars Edvinsson, and David Erlinge

Characterization of Contractile P2 Receptors in Human Coronary Arteries by Use of the Stable Pyrimidines Uridine 5'-O-Thiodiphosphate and Uridine 5'-O-3-Thiotriphosphate
J Pharmacol Exp Ther 2000 293: 755-760. [Abstract] [Full Text] [PDF]  

Mark E. Olah and Francine L. Roudabush

Down-Regulation of Vascular Endothelial Growth Factor Expression after A_2A Adenosine Receptor Activation in PC12 Pheochromocytoma Cells
J Pharmacol Exp Ther 2000 293: 779-787. [Abstract] [Full Text] [PDF]  

Mark J. Clair, Mary K. King, Aron T. Goldberg, Jennifer W. Hendrick, Riccardo Nisato, David M. Gay, Allison E. Morrison, James H. McElmurray, III, R. Stephen Krombach, Brian R. Bond, Catherine Cazaubon, Dino Nisato, and Francis G. Spinale

Selective Vasopressin, Angiotensin II, or Dual Receptor Blockade with Developing Congestive Heart Failure
J Pharmacol Exp Ther 2000 293: 852-860. [Abstract] [Full Text] [PDF]  

Denise Poisson, Marie-Odile Christen, and Frederic Sannajust

Protective Effects of I₁-Antihypertensive Agent Moxonidine against Neurogenic Cardiac Arrhythmias in Halothane-Anesthetized Rabbits
J Pharmacol Exp Ther 2000 293: 929-938. [Abstract] [Full Text] [PDF]  

Philip Solter, David Sisson, William Thomas, and Leopold Goetze

Intrarenal Effects of Ecadotril during Acute Volume Expansion in Dogs with Congestive Heart Failure
J Pharmacol Exp Ther 2000 293: 989-995. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Kurt Kristiansen, Wesley K. Kroeze, David L. Willins, Edward I. Gelber, Jason E. Savage, Richard A. Glennon, and Bryan L. Roth

A Highly Conserved Aspartic Acid (Asp-155) Anchors the Terminal Amine Moiety of Tryptamines and Is Involved in Membrane Targeting of the 5-HT_2A Serotonin Receptor But Does Not Participate in Activation via a "Salt-Bridge Disruption" Mechanism
J Pharmacol Exp Ther 2000 293: 735-746. [Abstract] [Full Text] [PDF]  

Timothy W. Lovenberg, Jayashree Pyati, Hong Chang, Sandy J. Wilson, and Mark G. Erlander

Cloning of Rat Histamine H₃ Receptor Reveals Distinct Species Pharmacological Profiles
J Pharmacol Exp Ther 2000 293: 771-778. [Abstract] [Full Text] [PDF]  

Teruo Hayashi, Tangui Maurice, and Tsung-Ping Su

Ca²⁺ Signaling via ₁-Receptors: Novel Regulatory Mechanism Affecting Intracellular Ca²⁺ Concentration
J Pharmacol Exp Ther 2000 293: 788-798. [Abstract] [Full Text] [PDF]  

Yanqiu Chen and Jochen Buck

Cannabinoids Protect Cells from Oxidative Cell Death: A Receptor-Independent Mechanism
J Pharmacol Exp Ther 2000 293: 807-812. [Abstract] [Full Text] [PDF]  

Michael Gekle, Gerald Schwerdt, Ruth Freudinger, Sigrid Mildenberger, Doris Wilflingseder, Verena Pollack, Martina Dander, and Herbert Schramek

Ochratoxin A Induces JNK Activation and Apoptosis in MDCK-C7 Cells at Nanomolar Concentrations
J Pharmacol Exp Ther 2000 293: 837-844. [Abstract] [Full Text] [PDF]  

Petra Scholze, Julia Zwach, Alexandra Kattinger, Christian Pifl, Ernst A. Singer, and Harald H. Sitte

Transporter-Mediated Release: A Superfusion Study on Human Embryonic Kidney Cells Stably Expressing the Human Serotonin Transporter
J Pharmacol Exp Ther 2000 293: 870-878. [Abstract] [Full Text] [PDF]  

Shaheen Zia, Assane Ndoye, Tou X. Lee, Robert J. Webber, and Sergei A. Grando

Receptor-Mediated Inhibition of Keratinocyte Migration by Nicotine Involves Modulations of Calcium Influx and Intracellular Concentration
J Pharmacol Exp Ther 2000 293: 973-981. [Abstract] [Full Text] [PDF]  

Keshore R. Bidasee, Anderson Maxwell, William F. Reynolds, Vimalkumar Patel, and Henry R. Besch, Jr.

Tectoridins Modulate Skeletal and Cardiac Muscle Sarcoplasmic Reticulum Calcium-Release Channels
J Pharmacol Exp Ther 2000 293: 1074-1083. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Raymond T. Bartus, Pamela Snodgrass, Joanne Marsh, Mary Agostino, Alexis Perkins, and Dwaine F. Emerich

Intravenous Cereport (RMP-7) Modifies Topographic Uptake Profile of Carboplatin within Rat Glioma and Brain surrounding Tumor, Elevates Platinum Levels, and Enhances Survival
J Pharmacol Exp Ther 2000 293: 903-911. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Aldo D. Mottino, Tim Hoffman, Lothar Jennes, and Mary Vore

Expression and Localization of Multidrug Resistant Protein mrp2 in Rat Small Intestine
J Pharmacol Exp Ther 2000 293: 717-723. [Abstract] [Full Text] [PDF]  

Jeffrey S. Fedan, Lyndell L. Millecchia, Richard A. Johnston, Appavoo Rengasamy, Ann Hubbs, Richard D. Dey, Long-Xing Yuan, David Watson, W. Travis Goldsmith, Jeffrey S. Reynolds, Larry Orsini, Juanita Dortch-Carnes, Deborah Cutler, and David G. Frazer

Effect of Ozone Treatment on Airway Reactivity and Epithelium-Derived Relaxing Factor in Guinea Pigs
J Pharmacol Exp Ther 2000 293: 724-734. [Abstract] [Full Text] [PDF]  

Hiroo Takeda, Yoshinobu Yamazaki, Masuo Akahane, Yasuhiko Igawa, Yukiyoshi Ajisawa, and Osamu Nishizawa

Role of the ₃-Adrenoceptor in Urine Storage in the Rat: Comparison between the Selective ₃-Adrenoceptor Agonist, CL316,243, and Various Smooth Muscle Relaxants
J Pharmacol Exp Ther 2000 293: 939-945. [Abstract] [Full Text] [PDF]  

Ahmad R. Dehpour, Hossein Rastegar, Masoumeh Jorjani, Farshad Roushanzamir, Khojasteh Joharchi, and Abolhasan Ahmadiani

Subsensitivity to Opioids Is Receptor-Specific in Isolated Guinea Pig Ileum and Mouse Vas Deferens after Obstructive Cholestasis
J Pharmacol Exp Ther 2000 293: 946-951. [Abstract] [Full Text] [PDF]  

Tomoyuki Yamasaki, Masaji Ohmagari, Isao Tamai, Kazutaka Hayashi, and Yasuo Matsumura

Inhibitory Effects of AE0047, a New Dihydropyridine Ca²⁺ Channel Blocker, on Renal Nerve Stimulation-Induced Renal Actions in Anesthetized Dogs
J Pharmacol Exp Ther 2000 293: 1040-1047. [Abstract] [Full Text] [PDF]  

Vicente Martínez, Jean Rivier, David Coy, and Yvette Taché

Intracisternal Injection of Somatostatin Receptor 5-Preferring Agonists Induces a Vagal Cholinergic Stimulation of Gastric Emptying in Rats
J Pharmacol Exp Ther 2000 293: 1099-1105. [Abstract] [Full Text] [PDF]  

Verne E. Cowles, Hugh N. Nellans, Terese R. Seifert, Leslie M. Besecke, Jason A. Segreti, Kurt M. Mohning, Ramin Faghih, Marleen H. Verlinden, and Craig D. Wegner

Effect of Novel Motilide ABT-229 versus Erythromycin and Cisapride on Gastric Emptying in Dogs
J Pharmacol Exp Ther 2000 293: 1106-1111. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

David G. Hammond and Isao Kubo

Alkanols Inhibit Respiration of Intact Mitochondria and Display Cutoff Similar to That Measured In Vivo
J Pharmacol Exp Ther 2000 293: 822-828. [Abstract] [Full Text] [PDF]  

Angela R. Evans, Heidi Junger, Michael D. Southall, Grant D. Nicol, Linda S. Sorkin, James T. Broome, Timothy W. Bailey, and Michael R. Vasko

Isoprostanes, Novel Eicosanoids That Produce Nociception and Sensitize Rat Sensory Neurons
J Pharmacol Exp Ther 2000 293: 912-920. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Eugenia Chu, Teh-Ching Chu, and David E. Potter

Mechanisms and Sites of Ocular Action of 7-Hydroxy-2-dipropylaminotetralin: A Dopamine₃ Receptor Agonist
J Pharmacol Exp Ther 2000 293: 710-716. [Abstract] [Full Text] [PDF]  

Charles E. Weaver, Michele B. Land, Robert H. Purdy, Kyle G. Richards, Terrell T. Gibbs, and David H. Farb

Geometry and Charge Determine Pharmacological Effects of Steroids on N-Methyl-D-aspartate Receptor-Induced Ca²⁺ Accumulation and Cell Death
J Pharmacol Exp Ther 2000 293: 747-754. [Abstract] [Full Text] [PDF]  

Mary Ann Pelleymounter, Margaret Joppa, Michelle Carmouche, Mary Jane Cullen, Brock Brown, Brian Murphy, Dimitri E. Grigoriadis, Nick Ling, and Alan C. Foster

Role of Corticotropin-Releasing Factor (CRF) Receptors in the Anorexic Syndrome Induced by CRF
J Pharmacol Exp Ther 2000 293: 799-806. [Abstract] [Full Text] [PDF]  

Yumiko Ishizawa, Hai-Chun Ma, Shuji Dohi, and Hiroyuki Shimonaka

Effects of Cholinomimetic Injection into the Brain Stem Reticular Formation on Halothane Anesthesia and Antinociception in Rats
J Pharmacol Exp Ther 2000 293: 845-851. [Abstract] [Full Text] [PDF]  

Stacy L. Sell, Joanne M. Scalzitti, Mary L. Thomas, and Kathryn A. Cunningham

Influence of Ovarian Hormones and Estrous Cycle on the Behavioral Response to Cocaine in Female Rats
J Pharmacol Exp Ther 2000 293: 879-886. [Abstract] [Full Text] [PDF]  

John Daniel Pediani, Janet Fraser MacKenzie, Robert Paul Heeley, Craig James Daly, and John Christie McGrath

Single-Cell Recombinant Pharmacology: Bovine _1a-Adrenoceptors in Rat-1 Fibroblasts Release Intracellular Ca²⁺, Display Subtype-Characteristic Agonism and Antagonism, and Exhibit an Antagonist-Reversible Inverse Concentration-Response Phase
J Pharmacol Exp Ther 2000 293: 887-895. [Abstract] [Full Text] [PDF]  

Yasushi Nakada, Osamu Yokoyama, Kazuto Komatsu, Koichi Kodama, Satoshi Yotsuyanagi, Susumu Niikura, Yasuhiro Nagasaka, and Mikio Namiki

Effects of Aniracetam on Bladder Overactivity in Rats with Cerebral Infarction
J Pharmacol Exp Ther 2000 293: 921-928. [Abstract] [Full Text] [PDF]  

Susan C. Hernandez, Maria Bertolino, Yingxian Xiao, Kenneth E. Pringle, Frank S. Caruso, and Kenneth J. Kellar

Dextromethorphan and Its Metabolite Dextrorphan Block 34 Neuronal Nicotinic Receptors
J Pharmacol Exp Ther 2000 293: 962-967. [Abstract] [Full Text] [PDF]  

Amanda J. Roberts, Jeffrey S. McDonald, Charles J. Heyser, Brigitte L. Kieffer, Hans W. D. Matthes, George F. Koob, and Lisa H. Gold

µ-Opioid Receptor Knockout Mice Do Not Self-Administer Alcohol
J Pharmacol Exp Ther 2000 293: 1002-1008. [Abstract] [Full Text] [PDF]  

Douglas F. Covey, Devi Nathan, Melissa Kalkbrenner, Kent R. Nilsson, Yuefei Hu, Charles F. Zorumski, and Alex S. Evers

Enantioselectivity of Pregnanolone-Induced -Aminobutyric Acid_A Receptor Modulation and Anesthesia
J Pharmacol Exp Ther 2000 293: 1009-1016. [Abstract] [Full Text] [PDF]  

Donna M. Platt, James K. Rowlett, and Roger D. Spealman

Dissociation of Cocaine-Antagonist Properties and Motoric Effects of the D1 Receptor Partial Agonists SKF 83959 and SKF 77434
J Pharmacol Exp Ther 2000 293: 1017-1026. [Abstract] [Full Text] [PDF]  

Mark J. Millan, Alain Gobert, Adrian Newman-Tancredi, Françoise Lejeune, Didier Cussac, Jean-Michel Rivet, Valérie Audinot, Thierry Dubuffet, and Gilbert Lavielle

S33084, a Novel, Potent, Selective, and Competitive Antagonist at Dopamine D₃-Receptors: I. Receptorial, Electrophysiological and Neurochemical Profile Compared with GR218,231 and L741,626
J Pharmacol Exp Ther 2000 293: 1048-1062. [Abstract] [Full Text] [PDF]  

Mark J. Millan, Anne Dekeyne, Jean-Michel Rivet, Thierry Dubuffet, Gilbert Lavielle, and Mauricette Brocco

S33084, a Novel, Potent, Selective, and Competitive Antagonist at Dopamine D₃-Receptors: II. Functional and Behavioral Profile Compared with GR218,231 and L741,626
J Pharmacol Exp Ther 2000 293: 1063-1073. [Abstract] [Full Text] [PDF]  

Marike Lancel and Anke Langebartels

-Aminobutyric Acid_A (GABA_A) Agonist 4,5,6,7-Tetrahydroisoxazolo[4,5-c]pyridin-3-ol Persistently Increases Sleep Maintenance and Intensity during Chronic Administration to Rats
J Pharmacol Exp Ther 2000 293: 1084-1090. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Maurizio Viale, Maria Ornella Vannozzi, Ilaria Pastrone, Maria A. Mariggiò, Antonio Zicca, Angela Cadoni, Sergio Cafaggi, Giuseppina Tolino, Gianluigi Lunardi, Dario Civalleri, W. Edward Lindup, and Mauro Esposito

Reduction of Cisplatin Nephrotoxicity by Procainamide: Does the Formation of a Cisplatin-Procainamide Complex Play a Role?
J Pharmacol Exp Ther 2000 293: 829-836. [Abstract] [Full Text] [PDF]  

Weihua Xie, Judith A. Stribley, Arnaud Chatonnet, Phillip J. Wilder, Angie Rizzino, Rodney D. McComb, Palmer Taylor, Steven H. Hinrichs, and Oksana Lockridge

Postnatal Developmental Delay and Supersensitivity to Organophosphate in Gene-Targeted Mice Lacking Acetylcholinesterase
J Pharmacol Exp Ther 2000 293: 896-902. [Abstract] [Full Text] [PDF]  

Chaojie Zhang, Lisa M. Walker, Jack A. Hinson, and Philip R. Mayeux

Oxidant Stress in Rat Liver after Lipopolysaccharide Administration: Effect of Inducible Nitric-Oxide Synthase Inhibition
J Pharmacol Exp Ther 2000 293: 968-972. [Abstract] [Full Text] [PDF]  

Li-Jun Zhou and Xing-Zu Zhu

Reactive Oxygen Species-Induced Apoptosis in PC12 Cells and Protective Effect of Bilobalide
J Pharmacol Exp Ther 2000 293: 982-988. [Abstract] [Full Text] [PDF]  

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