PERSPECTIVES IN PHARMACOLOGY:

Rennolds S. Ostrom, Steven R. Post, and Paul A. Insel

Stoichiometry and Compartmentation in G Protein-Coupled Receptor Signaling: Implications for Therapeutic Interventions Involving G_s
J Pharmacol Exp Ther 2000 294: 407-412. [Abstract] [Full Text] [PDF]  

Vadivel Ganapathy, Puttur D. Prasad, Malliga E. Ganapathy, and Frederick H. Leibach

Placental Transporters Relevant to Drug Distribution across the Maternal-Fetal Interface
J Pharmacol Exp Ther 2000 294: 413-420. [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Shigehiro Ohdo, De-Sheng Wang, Satoru Koyanagi, Hiroshi Takane, Kouichi Inoue, Hironori Aramaki, Eiji Yukawa, and Shun Higuchi

Basis for Dosing Time-Dependent Changes in the Antiviral Activity of Interferon- in Mice
J Pharmacol Exp Ther 2000 294: 488-493. [Abstract] [Full Text] [PDF]  

Nathan S. Teuscher, Alexander Novotny, Richard F. Keep, and David E. Smith

Functional Evidence for Presence of PEPT2 in Rat Choroid Plexus: Studies with Glycylsarcosine
J Pharmacol Exp Ther 2000 294: 494-499. [Abstract] [Full Text] [PDF]  

Noriko Okudaira, Tomoko Tatebayashi, Graham C. Speirs, Izumi Komiya, and Yuichi Sugiyama

A Study of the Intestinal Absorption of an Ester-Type Prodrug, ME3229, in Rats: Active Efflux Transport as a Cause of Poor Bioavailability of the Active Drug
J Pharmacol Exp Ther 2000 294: 580-587. [Abstract] [Full Text] [PDF]  

Abba J. Kastin and Victoria Akerstrom

Mahogany (1377-1428) Enters Brain by a Saturable Transport System
J Pharmacol Exp Ther 2000 294: 633-636. [Abstract] [Full Text] [PDF]  

Sophie Le Lamer, Patrick Poucheret, Gérard Cros, Renaud Kiesgen de Richter, Pierre-Antoine Bonnet, and Françoise Bressolle

Pharmacokinetics of Sodium Tungstate in Rat and Dog: A Population Approach
J Pharmacol Exp Ther 2000 294: 714-721. [Abstract] [Full Text] [PDF]  

Abdul E. Mutlib, John Shockcor, Robert Espina, Nilsa Graciani, Alicia Du, and Liang-Shang Gan

Disposition of Glutathione Conjugates in Rats by a Novel Glutamic Acid Pathway: Characterization of Unique Peptide Conjugates by Liquid Chromatography/Mass Spectrometry and Liquid Chromatography/NMR
J Pharmacol Exp Ther 2000 294: 735-745. [Abstract] [Full Text] [PDF]  

Jan N. M. Commandeur, Ioanna Andreadou, Martijn Rooseboom, Marcel Out, Laurens J. de Leur, Ed Groot, and Nico P. E. Vermeulen

Bioactivation of Selenocysteine Se-Conjugates by a Highly Purified Rat Renal Cysteine Conjugate -Lyase/Glutamine Transaminase K
J Pharmacol Exp Ther 2000 294: 753-761. [Abstract] [Full Text] [PDF]  

Martijn Rooseboom, Nico P. E. Vermeulen, Ioanna Andreadou, and Jan N. M. Commandeur

Evaluation of the Kinetics of -Elimination Reactions of Selenocysteine Se-Conjugates in Human Renal Cytosol: Possible Implications for the Use as Kidney Selective Prodrugs
J Pharmacol Exp Ther 2000 294: 762-769. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Ryan M. Fryer, Anna K. Hsu, Hiroshi Nagase, and Garrett J. Gross

Opioid-Induced Cardioprotection against Myocardial Infarction and Arrhythmias: Mitochondrial versus Sarcolemmal ATP-Sensitive Potassium Channels
J Pharmacol Exp Ther 2000 294: 451-457. [Abstract] [Full Text] [PDF]  

Jian-Bing Shen, Bin Jiang, and Achilles J. Pappano

Comparison of L-Type Calcium Channel Blockade by Nifedipine and/or Cadmium in Guinea Pig Ventricular Myocytes
J Pharmacol Exp Ther 2000 294: 562-570. [Abstract] [Full Text] [PDF]  

Amber Russell and Stephanie Watts

Vascular Reactivity of Isolated Thoracic Aorta of the C57BL/6J Mouse
J Pharmacol Exp Ther 2000 294: 598-604. [Abstract] [Full Text] [PDF]  

Jörg Knapp, Peter Bokník, Bettina Linck, Hartmut Lüss, Frank U. Müller, Lars Petertönjes, Wilhelm Schmitz, and Joachim Neumann

Cantharidin Enhances Norepinephrine-Induced Vasoconstriction in an Endothelium-Dependent Fashion
J Pharmacol Exp Ther 2000 294: 620-626. [Abstract] [Full Text] [PDF]  

Bettina Linck, Peter Bokník, Sabine Huke, Uwe Kirchhefer, Jörg Knapp, Hartmut Lüss, Frank U. Müller, Joachim Neumann, Zahide Tanriseven, Ute Vahlensieck, Hideo A. Baba, Larry R. Jones, Kenneth D. Philipson, and Wilhelm Schmitz

Functional Properties of Transgenic Mouse Hearts Overexpressing Both Calsequestrin and the Na⁺-Ca²⁺ Exchanger
J Pharmacol Exp Ther 2000 294: 648-657. [Abstract] [Full Text] [PDF]  

Nathalie Niederhoffer and Bela Szabo

Cannabinoids Cause Central Sympathoexcitation and Bradycardia in Rabbits
J Pharmacol Exp Ther 2000 294: 707-713. [Abstract] [Full Text] [PDF]  

Hongjiang Chen, Yuan Clare Zhang, Dayuan Li, M. Ian Phillips, Paullete Mehta, Min Shi, and Jawahar L. Mehta

Protection against Myocardial Dysfunction Induced by Global Ischemia-Reperfusion by Antisense-Oligodeoxynucleotides Directed at ₁-Adrenoceptor mRNA
J Pharmacol Exp Ther 2000 294: 722-727. [Abstract] [Full Text] [PDF]  

Nina Hoque, Michael A. Cook, and Morris Karmazyn

Inhibition of ₁-Adrenergic-Mediated Responses in Rat Ventricular Myocytes by Adenosine A₁ Receptor Activation: Role of the K_ATP Channel
J Pharmacol Exp Ther 2000 294: 770-777. [Abstract] [Full Text] [PDF]  

Nosratola D. Vaziri, Kaihui Liang, and Habib Azad

Effect of Cyclosporine on HMG-CoA Reductase, Cholesterol 7-Hydroxylase, LDL Receptor, HDL Receptor, VLDL Receptor, and Lipoprotein Lipase Expressions
J Pharmacol Exp Ther 2000 294: 778-783. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Janet F. Mackenzie, Craig J. Daly, John D. Pediani, and John C. McGrath

Quantitative Imaging in Live Human Cells Reveals Intracellular ₁-Adrenoceptor Ligand-Binding Sites
J Pharmacol Exp Ther 2000 294: 434-443. [Abstract] [Full Text] [PDF]  

Christiaan B. Brink, Susan M. Wade, and Richard R. Neubig

Agonist-Directed Trafficking of Porcine _2A-Adrenergic Receptor Signaling in Chinese Hamster Ovary Cells: l-Isoproterenol Selectively Activates G_s
J Pharmacol Exp Ther 2000 294: 539-547. [Abstract] [Full Text] [PDF]  

Branislav M. Marcic and Ervin G. Erdös

Protein Kinase C and Phosphatase Inhibitors Block the Ability of Angiotensin I-Converting Enzyme Inhibitors to Resensitize the Receptor to Bradykinin without Altering the Primary Effects of Bradykinin
J Pharmacol Exp Ther 2000 294: 605-612. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Taturo Udagawa, Jenny Yuan, Dipak Panigrahy, Yie-Hwa Chang, Jamshed Shah, and Robert J. D'Amato

Cytochalasin E, an Epoxide Containing Aspergillus-Derived Fungal Metabolite, Inhibits Angiogenesis and Tumor Growth
J Pharmacol Exp Ther 2000 294: 421-427. [Abstract] [Full Text] [PDF]  

Miechelle O'Brien, Gary D. Kruh, and Kenneth D. Tew

The Influence of Coordinate Overexpression of Glutathione Phase II Detoxification Gene Products on Drug Resistance
J Pharmacol Exp Ther 2000 294: 480-487. [Abstract] [Full Text] [PDF]  

Stefania D'Atri, Grazia Graziani, Pedro Miguel Lacal, Vittoria Nisticò, Sara Gilberti, Isabella Faraoni, Amanda J. Watson, Enzo Bonmassar, and Geoffrey P. Margison

Attenuation of O⁶-Methylguanine-DNA Methyltransferase Activity and mRNA Levels by Cisplatin and Temozolomide in Jurkat Cells
J Pharmacol Exp Ther 2000 294: 664-671. [Abstract] [Full Text] [PDF]  

Hiroshi Takane, Shigehiro Ohdo, Tomoko Yamada, Eiji Yukawa, and Shun Higuchi

Chronopharmacology of Antitumor Effect Induced by Interferon- in Tumor-Bearing Mice
J Pharmacol Exp Ther 2000 294: 746-752. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Françoise Berlioz, Jean-José Maoret, Hervé Paris, Marc Laburthe, Robert Farinotti, and Claude Rozé

₂-Adrenergic Receptors Stimulate Oligopeptide Transport in a Human Intestinal Cell Line
J Pharmacol Exp Ther 2000 294: 466-472. [Abstract] [Full Text] [PDF]  

Ke-Xin Liu, Yukio Kato, Tai-Ichi Kaku, Tomofumi Santa, Kazuhiro Imai, Akira Yagi, Takashi Ishizu, and Yuichi Sugiyama

Hydroxyprolylserine Derivatives JBP923 and JBP485 Exhibit the Antihepatitis Activities after Gastrointestinal Absorption in Rats
J Pharmacol Exp Ther 2000 294: 510-515. [Abstract] [Full Text] [PDF]  

Jay A. A. West, Alan R. Buckpitt, and Charles G. Plopper

Elevated Airway GSH Resynthesis Confers Protection to Clara Cells from Naphthalene Injury in Mice Made Tolerant by Repeated Exposures
J Pharmacol Exp Ther 2000 294: 516-523. [Abstract] [Full Text] [PDF]  

Alexander M. Starodub and Jackie D. Wood

Histamine Suppresses A-Type Potassium Current in Myenteric Neurons from Guinea Pig Small Intestine
J Pharmacol Exp Ther 2000 294: 555-561. [Abstract] [Full Text] [PDF]  

Kazuko Sagawa, Inger M. Darling, Heini Murer, and Marilyn E. Morris

Glucocorticoid-Induced Alterations of Renal Sulfate Transport
J Pharmacol Exp Ther 2000 294: 658-663. [Abstract] [Full Text] [PDF]  

Toshihide Ikemura, Jurgen Schwarze, Mika Makela, Arihiko Kanehiro, Anthony Joetham, Kenji Ohmori, and Erwin W. Gelfand

Type 4 Phosphodiesterase Inhibitors Attenuate Respiratory Syncytial Virus-Induced Airway Hyper-Responsiveness and Lung Eosinophilia
J Pharmacol Exp Ther 2000 294: 701-706. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Kenneth W. Renton and Tara E. Nicholson

Hepatic and Central Nervous System Cytochrome P450 Are Down-Regulated during Lipopolysaccharide-Evoked Localized Inflammation in Brain
J Pharmacol Exp Ther 2000 294: 524-530. [Abstract] [Full Text] [PDF]  

Young J. Jeon, Young K. Kim, Michael Lee, Sun M. Park, Sang B. Han, and Hwan M. Kim

Radicicol Suppresses Expression of Inducible Nitric-Oxide Synthase by Blocking p38 Kinase and Nuclear Factor-B/Rel in Lipopolysaccharide-Stimulated Macrophages
J Pharmacol Exp Ther 2000 294: 548-554. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Hartmut Berger, Girolamo Calo', Erika Albrecht, Remo Guerrini, and Michael Bienert

[Nphe¹]NC(1-13)NH₂ Selectively Antagonizes Nociceptin/Orphanin FQ-Stimulated G-Protein Activation in Rat Brain
J Pharmacol Exp Ther 2000 294: 428-433. [Abstract] [Full Text] [PDF]  

Maria I. Gonzalez, Mark J. Field, John Hughes, and Lakhbir Singh

Evaluation of Selective NK₁ Receptor Antagonist CI-1021 in Animal Models of Inflammatory and Neuropathic Pain
J Pharmacol Exp Ther 2000 294: 444-450. [Abstract] [Full Text] [PDF]  

Yitong Fu, Shannon G. Matta, Wenqing Gao, Victoria G. Brower, and Burt M. Sharp

Systemic Nicotine Stimulates Dopamine Release in Nucleus Accumbens: Re-evaluation of the Role of N-Methyl-D-aspartate Receptors in the Ventral Tegmental Area
J Pharmacol Exp Ther 2000 294: 458-465. [Abstract] [Full Text] [PDF]  

Gary M. Samoriski and Robert A. Gross

Functional Compartmentalization of Opioid Desensitization in Primary Sensory Neurons
J Pharmacol Exp Ther 2000 294: 500-509. [Abstract] [Full Text] [PDF]  

Jonathan P. Druhan, Carrie L. Walters, and Gary Aston-Jones

Behavioral Activation Induced by D₂-Like Receptor Stimulation during Opiate Withdrawal
J Pharmacol Exp Ther 2000 294: 531-538. [Abstract] [Full Text] [PDF]  

Rui Tao, Zhiyuan Ma, and Sidney B. Auerbach

Differential Effect of Local Infusion of Serotonin Reuptake Inhibitors in the Raphe versus Forebrain and the Role of Depolarization-Induced Release in Increased Extracellular Serotonin
J Pharmacol Exp Ther 2000 294: 571-579. [Abstract] [Full Text] [PDF]  

Lotta Arborelius, Kelly H. Skelton, Karacheri V. Thrivikraman, Paul M. Plotsky, David W. Schulz, and Michael J. Owens

Chronic Administration of the Selective Corticotropin-Releasing Factor 1 Receptor Antagonist CP-154,526: Behavioral, Endocrine and Neurochemical Effects in the Rat
J Pharmacol Exp Ther 2000 294: 588-597. [Abstract] [Full Text] [PDF]  

Zheng-Xiong Xi and Elliot A. Stein

Increased Mesolimbic GABA Concentration Blocks Heroin Self-Administration in the Rat
J Pharmacol Exp Ther 2000 294: 613-619. [Abstract] [Full Text] [PDF]  

Jena J. Steinle and Peter G. Smith

Presynaptic Muscarinic Facilitation of Parasympathetic Neurotransmission after Sympathectomy in the Rat Choroid
J Pharmacol Exp Ther 2000 294: 627-632. [Abstract] [Full Text] [PDF]  

Scott C. Steffensen, Zhiguo Nie, Jose R. Criado, and George R. Siggins

Ethanol Inhibition of N-Methyl-D-aspartate Responses Involves Presynaptic -Aminobutyric Acid_B Receptors
J Pharmacol Exp Ther 2000 294: 637-647. [Abstract] [Full Text] [PDF]  

William L. Bacon and Sheryl G. Beck

5-Hydroxytryptamine₇ Receptor Activation Decreases Slow Afterhyperpolarization Amplitude in CA3 Hippocampal Pyramidal Cells
J Pharmacol Exp Ther 2000 294: 672-679. [Abstract] [Full Text] [PDF]  

Taline V. Khroyan, Rita L. Barrett-Larimore, James K. Rowlett, and Roger D. Spealman

Dopamine D1- and D2-Like Receptor Mechanisms in Relapse to Cocaine-Seeking Behavior: Effects of Selective Antagonists and Agonists
J Pharmacol Exp Ther 2000 294: 680-687. [Abstract] [Full Text] [PDF]  

Kurt Rasmussen, David O. Calligaro, Janet F. Czachura, Laura J. Dreshfield-Ahmad, David C. Evans, Susan K. Hemrick-Luecke, Mary Jeanne Kallman, William T. Kendrick, J. David Leander, David L. Nelson, Carl D. Overshiner, David B. Wainscott, Mary C. Wolff, David T. Wong, Theresa A. Branchek, John M. Zgombick, and Yao-chang Xu

The Novel 5-Hydroxytryptamine_1A Antagonist LY426965: Effects on Nicotine Withdrawal and Interactions with Fluoxetine
J Pharmacol Exp Ther 2000 294: 688-700. [Abstract] [Full Text] [PDF]  

Giampaolo Mereu, Maurizio Cammalleri, Mauro Fà, Walter Francesconi, Pierluigi Saba, Maria Tattoli, Luigia Trabace, Andrea Vaccari, and Vincenzo Cuomo

Prenatal Exposure to a Low Concentration of Carbon Monoxide Disrupts Hippocampal Long-Term Potentiation in Rat Offspring
J Pharmacol Exp Ther 2000 294: 728-734. [Abstract] [Full Text] [PDF]  

Heather L. Kimmel, Wenhe Gong, Stephanie Dall Vechia, Richard G. Hunter, and Michael J. Kuhar

Intra-Ventral Tegmental Area Injection of Rat Cocaine and Amphetamine-Regulated Transcript Peptide 55-102 Induces Locomotor Activity and Promotes Conditioned Place Preference
J Pharmacol Exp Ther 2000 294: 784-792. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Tao Wang, Kartik Shankar, Martin J. J. Ronis, and Harihara M. Mehendale

Potentiation of Thioacetamide Liver Injury in Diabetic Rats Is Due to Induced CYP2E1
J Pharmacol Exp Ther 2000 294: 473-479. [Abstract] [Full Text] [PDF]  

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