PERSPECTIVES IN PHARMACOLOGY:

Mark J. Millan

Improving the Treatment of Schizophrenia: Focus on Serotonin (5-HT)_1A Receptors
J Pharmacol Exp Ther 2000 295: 853-861. [Abstract] [Full Text] [PDF]  

Geoffrey Burnstock and Michael Williams

P2 Purinergic Receptors: Modulation of Cell Function and Therapeutic Potential
J Pharmacol Exp Ther 2000 295: 862-869. [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Alfonso Lampen, Silke Meyer, Thomas Arnhold, and Heinz Nau

Metabolism of Vitamin A and Its Active Metabolite All-trans-retinoic Acid in Small Intestinal Enterocytes
J Pharmacol Exp Ther 2000 295: 979-985. [Abstract] [Full Text] [PDF]  

Hideyuki Yamada, Hiromi Matsunaga, Kazuhiro Tsuji, Sanae Matsumoto, Midori Yamamoto, Yuji Ishii, Curtis J. Omiecinski, and Kazuta Oguri

Sequence Analyses of CYP2B Genes and Catalytic Profiles for P450s in Qdj:Sprague-Dawley Rats That Lack Response to the Phenobarbital-Mediated Induction of CYP2B2
J Pharmacol Exp Ther 2000 295: 986-993. [Abstract] [Full Text] [PDF]  

Safaa Ibrahim, James Peggins, Alan Knapton, Thomas Licht, and Adorjan Aszalos

Influence of Antipsychotic, Antiemetic, and Ca²⁺ Channel Blocker Drugs on the Cellular Accumulation of the Anticancer Drug Daunorubicin: P-glycoprotein Modulation
J Pharmacol Exp Ther 2000 295: 1276-1283. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Jiale He, Yuhui Xiao, Carlos A. Casiano, and Lubo Zhang

Role of Mitochondrial Cytochrome c in Cocaine-Induced Apoptosis in Coronary Artery Endothelial Cells
J Pharmacol Exp Ther 2000 295: 896-903. [Abstract] [Full Text] [PDF]  

Charles V. Jackson, Blanche D. Bailey, and Timothy J. Shetler

Pharmacological Profile of Recombinant, Human Activated Protein C (LY203638) in a Canine Model of Coronary Artery Thrombosis
J Pharmacol Exp Ther 2000 295: 967-971. [Abstract] [Full Text] [PDF]  

Paola Dorigo, Maura Floreani, Giovanni Santostasi, Ildebrando Maragno, Daniela Danieli-Betto, Elena Germinario, Sebastiano Marciani Magno, Gianpaolo Primofiore, Anna Maria Marini, and Federico Da Settimo

Pharmacological Characterization of a New Ca²⁺ Sensitizer
J Pharmacol Exp Ther 2000 295: 994-1004. [Abstract] [Full Text] [PDF]  

Rui M. V. Abreu, Dario J. S. L. Santos, and António J. M. Moreno

Effects of Carvedilol and Its Analog BM-910228 on Mitochondrial Function and Oxidative Stress
J Pharmacol Exp Ther 2000 295: 1022-1030. [Abstract] [Full Text] [PDF]  

Eiji Sasaki, Yasutaka Tanahashi, Yasundo Yamasaki, Nobuyuki Oda, Yoshihisa Nozawa, Hiroshi Terakawa, Kazuhisa Miyoshi, Yoshiyuki Muranaka, Hidekazu Miyake, and Naosuke Matsuura

Inhibitory Effect of TAS-301, a New Synthesized Constrictive Remodeling Regulator, on Renarrowing after Balloon Overstretch Injury of Porcine Coronary Artery
J Pharmacol Exp Ther 2000 295: 1043-1050. [Abstract] [Full Text] [PDF]  

Klara Brixius, Uwe Mehlhorn, Wilhelm Bloch, and Robert H. G. Schwinger

Different Effect of the Ca²⁺ Sensitizers EMD 57033 and CGP 48506 on Cross-Bridge Cycling in Human Myocardium
J Pharmacol Exp Ther 2000 295: 1284-1290. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Asavari Wagle and Jai Pal Singh

Fibroblast Growth Factor Protects Nitric Oxide-Induced Apoptosis in Neuronal SHSY-5Y Cells
J Pharmacol Exp Ther 2000 295: 889-895. [Abstract] [Full Text] [PDF]  

Anthony S. L. Chan and Yung H. Wong

Regulation of c-Jun N-Terminal Kinase by the ORL₁ Receptor through Multiple G Proteins
J Pharmacol Exp Ther 2000 295: 1094-1100. [Abstract] [Full Text] [PDF]  

Barry L. Tepperman, Qing Chang, and Brian D. Soper

Protein Kinase C Mediates Lipopolysaccharide- and Phorbol-Induced Nitric-Oxide Synthase Activity and Cellular Injury in the Rat Colon
J Pharmacol Exp Ther 2000 295: 1249-1257. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Anne-Cécile Hellin, Mohamed Bentires-Alj, Myriam Verlaet, Valérie Benoit, Jacques Gielen, Vincent Bours, and Marie-Paule Merville

Roles of Nuclear Factor-B, p53, and p21/WAF1 in Daunomycin-Induced Cell Cycle Arrest and Apoptosis
J Pharmacol Exp Ther 2000 295: 870-878. [Abstract] [Full Text] [PDF]  

Sonia Zorzet, Alberta Bergamo, Moreno Cocchietto, Alenka Sorc, Barbara Gava, Enzo Alessio, Elisabetta Iengo, and Gianni Sava

Lack of In Vitro Cytotoxicity, Associated to Increased G₂-M Cell Fraction and Inhibition of Matrigel Invasion, May Predict In Vivo-Selective Antimetastasis Activity of Ruthenium Complexes
J Pharmacol Exp Ther 2000 295: 927-933. [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Shigeki Nakamura, Takahiro Hirano, Kenji Tsujimae, Masashi Aoyama, Kazumi Kondo, Yoshitaka Yamamura, Toyoki Mori, and Michiaki Tominaga

Antidiuretic Effects of a Nonpeptide Vasopressin V₂-Receptor Agonist, OPC-51803, Administered Orally to Rats
J Pharmacol Exp Ther 2000 295: 1005-1011. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Harold G. Preiksaitis, Pawel S. Krysiak, Tom Chrones, Vaishnav Rajgopal, and Lisanne G. Laurier

Pharmacological and Molecular Characterization of Muscarinic Receptor Subtypes in Human Esophageal Smooth Muscle
J Pharmacol Exp Ther 2000 295: 879-888. [Abstract] [Full Text] [PDF]  

Ravi Malaviya, Chun-Lin Chen, Christopher Navara, Rama Malaviya, Xing-Ping Liu, Margaret Keenan, Barbara Waurzyniak, and Fatih M. Uckun

Treatment of Allergic Asthma by Targeting Janus Kinase 3-Dependent Leukotriene Synthesis in Mast Cells with 4-(3',5'-Dibromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97)
J Pharmacol Exp Ther 2000 295: 912-926. [Abstract] [Full Text] [PDF]  

Renee C. Paige, Fred H. Royce, Charles G. Plopper, and Alan R. Buckpitt

Long-Term Exposure to Ozone Increases Acute Pulmonary Centriacinar Injury by 1-Nitronaphthalene: I. Region-Specific Enzyme Activity
J Pharmacol Exp Ther 2000 295: 934-941. [Abstract] [Full Text] [PDF]  

Renee C. Paige, Viviana Wong, and Charles G. Plopper

Long-Term Exposure to Ozone Increases Acute Pulmonary Centriacinar Injury by 1-Nitronaphthalene: II. Quantitative Histopathology
J Pharmacol Exp Ther 2000 295: 942-950. [Abstract] [Full Text] [PDF]  

Motonori Aoki, Masahiro Fukunaga, Minetake Kitagawa, Kazumi Hayashi, Tatsuaki Morokata, Go Ishikawa, Satoshi Kubo, and Toshimitsu Yamada

Effect of a Novel Anti-Inflammatory Compound, YM976, on Antigen-Induced Eosinophil Infiltration into the Lungs in Rats, Mice, and Ferrets
J Pharmacol Exp Ther 2000 295: 1149-1155. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Elizabeth A. Capper, Amy K. Roshak, Brian J. Bolognese, Patricia L. Podolin, Timothy Smith, David L. Dewitt, Karen M. Anderson, and Lisa A. Marshall

Modulation of Human Monocyte Activities by Tranilast, SB 252218, a Compound Demonstrating Efficacy in Restenosis
J Pharmacol Exp Ther 2000 295: 1061-1069. [Abstract] [Full Text] [PDF]  

Michael F. Jarvis, Haixia Yu, Kathy Kohlhaas, Karen Alexander, Chih-Hung Lee, Mequin Jiang, Shripad S. Bhagwat, Michael Williams, and Elizabeth A. Kowaluk

ABT-702 (4-Amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2,3-d]pyrimidine), a Novel Orally Effective Adenosine Kinase Inhibitor with Analgesic and Anti-Inflammatory Properties: I. In Vitro Characterization and Acute Antinociceptive Effects in the Mouse
J Pharmacol Exp Ther 2000 295: 1156-1164. [Abstract] [Full Text] [PDF]  

Elizabeth A. Kowaluk, Joe Mikusa, Carol T. Wismer, Chang Z. Zhu, Edmund Schweitzer, James J. Lynch, Chih-Hung Lee, Meiqun Jiang, Shripad S. Bhagwat, Arthur Gomtsyan, Jeff McKie, Bryan F. Cox, James Polakowski, Glenn Reinhart, Michael Williams, and Michael F. Jarvis

ABT-702 (4-Amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a Novel Orally Effective Adenosine Kinase Inhibitor with Analgesic and Anti-Inflammatory Properties. II. In Vivo Characterization in the Rat
J Pharmacol Exp Ther 2000 295: 1165-1174. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Meng-Yang Zhu, Susan Shamburger, Jing Li, and Gregory A. Ordway

Regulation of the Human Norepinephrine Transporter by Cocaine and Amphetamine
J Pharmacol Exp Ther 2000 295: 951-959. [Abstract] [Full Text] [PDF]  

Iain J. McFadyen, Katarzyna Sobczyk-Kojiro, Michael J. Schaefer, Jeffrey C. Ho, John R. Omnaas, Henry I. Mosberg, and John R. Traynor

Tetrapeptide Derivatives of [D-Pen²,D-Pen⁵]-Enkephalin (DPDPE) Lacking an N-Terminal Tyrosine Residue Are Agonists at the µ-Opioid Receptor
J Pharmacol Exp Ther 2000 295: 960-966. [Abstract] [Full Text] [PDF]  

Ken A. Witt, Jason D. Huber, Richard D. Egleton, and Thomas P. Davis

Insulin Enhancement of Opioid Peptide Transport across the Blood-Brain Barrier and Assessment of Analgesic Effect
J Pharmacol Exp Ther 2000 295: 972-978. [Abstract] [Full Text] [PDF]  

Richard M. Allen and Linda A. Dykstra

Attenuation of µ-Opioid Tolerance and Cross-Tolerance by the Competitive N-Methyl-D-aspartate Receptor Antagonist LY235959 Is Related to Tolerance and Cross-Tolerance Magnitude
J Pharmacol Exp Ther 2000 295: 1012-1021. [Abstract] [Full Text] [PDF]  

Alexander Kuzmin, Johan Sandin, Lars Terenius, and Sven-Ove Ögren

Dose- and Time-Dependent Bimodal Effects of -Opioid Agonists on Locomotor Activity in Mice
J Pharmacol Exp Ther 2000 295: 1031-1042. [Abstract] [Full Text] [PDF]  

Gerard R. Dawson, Keith A. Wafford, Alison Smith, George R. Marshall, Peter J. Bayley, James M. Schaeffer, Peter T. Meinke, and R. M. McKernan

Anticonvulsant and Adverse Effects of Avermectin Analogs in Mice Are Mediated through the -Aminobutyric Acid_A Receptor
J Pharmacol Exp Ther 2000 295: 1051-1060. [Abstract] [Full Text] [PDF]  

Mitchel A. Kling, Richard E. Carson, Lisa Borg, Alan Zametkin, John A. Matochik, James Schluger, Peter Herscovitch, Kenner C. Rice, Ann Ho, William C. Eckelman, and Mary Jeanne Kreek

Opioid Receptor Imaging with Positron Emission Tomography and [¹⁸F]Cyclofoxy in Long-Term, Methadone-Treated Former Heroin Addicts
J Pharmacol Exp Ther 2000 295: 1070-1076. [Abstract] [Full Text] [PDF]  

Ryan R. Metzger, Heather M. Haughey, Diana G. Wilkins, James W. Gibb, Glen R. Hanson, and Annette E. Fleckenstein

Methamphetamine-Induced Rapid Decrease in Dopamine Transporter Function: Role of Dopamine and Hyperthermia
J Pharmacol Exp Ther 2000 295: 1077-1085. [Abstract] [Full Text] [PDF]  

David J. Dooley, Cindy M. Donovan, and Thomas A. Pugsley

Stimulus-Dependent Modulation of [³H]Norepinephrine Release from Rat Neocortical Slices by Gabapentin and Pregabalin
J Pharmacol Exp Ther 2000 295: 1086-1093. [Abstract] [Full Text] [PDF]  

Maciej Gasior, Maria Jaszyna, Jamie Peters, and Steven R. Goldberg

Changes in the Ambulatory Activity and Discriminative Stimulus Effects of Psychostimulant Drugs in Rats Chronically Exposed to Caffeine: Effect of Caffeine Dose
J Pharmacol Exp Ther 2000 295: 1101-1111. [Abstract] [Full Text] [PDF]  

Vera C. Campbell, William L. Dewey, and Sandra P. Welch

Comparison of [³H]Glyburide Binding with Opiate Analgesia, Tolerance, and Dependence in ICR and Swiss-Webster Mice
J Pharmacol Exp Ther 2000 295: 1112-1119. [Abstract] [Full Text] [PDF]  

John F. Cryan and Irwin Lucki

Antidepressant-Like Behavioral Effects Mediated by 5-Hydroxytryptamine_2C Receptors
J Pharmacol Exp Ther 2000 295: 1120-1126. [Abstract] [Full Text] [PDF]  

Theodore J. Baird, Shi-Xian Deng, Donald W. Landry, Gail Winger, and James H. Woods

Natural and Artificial Enzymes Against Cocaine. I. Monoclonal Antibody 15A10 and the Reinforcing Effects of Cocaine in Rats
J Pharmacol Exp Ther 2000 295: 1127-1134. [Abstract] [Full Text] [PDF]  

Graeme L. Fraser, Amynah A. Pradhan, Paul B. S. Clarke, and Claes Wahlestedt

Supraspinal Antinociceptive Response to [D-Pen^2,5]-Enkephalin (DPDPE) Is Pharmacologically Distinct from That to Other -Agonists in the Rat
J Pharmacol Exp Ther 2000 295: 1135-1141. [Abstract] [Full Text] [PDF]  

Stacy E. Foran, Daniel B. Carr, Andrzej W. Lipkowski, Iwona Maszczynska, James E. Marchand, Aleksandra Misicka, Martin Beinborn, Alan S. Kopin, and Richard M. Kream

Inhibition of Morphine Tolerance Development by a Substance P-Opioid Peptide Chimera
J Pharmacol Exp Ther 2000 295: 1142-1148. [Abstract] [Full Text] [PDF]  

Andrew J. Grottick, Paul J. Fletcher, and Guy A. Higgins

Studies to Investigate the Role of 5-HT_2C Receptors on Cocaine- and Food-Maintained Behavior
J Pharmacol Exp Ther 2000 295: 1183-1191. [Abstract] [Full Text] [PDF]  

Mark J. Millan, Anne Dekeyne, Adrian Newman-Tancredi, Didier Cussac, Valérie Audinot, Graeme Milligan, Delphine Duqueyroix, Sylvie Girardon, Jimmy Mullot, Jean A. Boutin, Jean-Paul Nicolas, Anne Renouard-Try, Jean-Michel Lacoste, and Alex Cordi

S18616, a Highly Potent, Spiroimidazoline Agonist at ₂-Adrenoceptors: I. Receptor Profile, Antinociceptive and Hypothermic Actions in Comparison with Dexmedetomidine and Clonidine
J Pharmacol Exp Ther 2000 295: 1192-1205. [Abstract] [Full Text] [PDF]  

Mark J. Millan, Françoise Lejeune, Alain Gobert, Mauricette Brocco, Agnés Auclair, Catherine Bosc, Jean-Michel Rivet, Jean-Michel Lacoste, Alex Cordi, and Anne Dekeyne

S18616, a Highly Potent Spiroimidazoline Agonist at ₂-Adrenoceptors: II. Influence on Monoaminergic Transmission, Motor Function, and Anxiety in Comparison with Dexmedetomidine and Clonidine
J Pharmacol Exp Ther 2000 295: 1206-1222. [Abstract] [Full Text] [PDF]  

Gregg D. Stanwood, Roman P. Artymyshyn, Mei-Ping Kung, Hank F. Kung, Irwin Lucki, and Paul McGonigle

Quantitative Autoradiographic Mapping of Rat Brain Dopamine D3 Binding with [¹²⁵I]7-OH-PIPAT: Evidence for the Presence of D3 Receptors on Dopaminergic and Nondopaminergic Cell Bodies and Terminals
J Pharmacol Exp Ther 2000 295: 1223-1231. [Abstract] [Full Text] [PDF]  

Gregg D. Stanwood, Irwin Lucki, and Paul McGonigle

Differential Regulation of Dopamine D2 and D3 Receptors by Chronic Drug Treatments
J Pharmacol Exp Ther 2000 295: 1232-1240. [Abstract] [Full Text] [PDF]  

Doodipala S. Reddy and Michael A. Rogawski

Chronic Treatment with the Neuroactive Steroid Ganaxolone in the Rat Induces Anticonvulsant Tolerance to Diazepam but Not to Itself
J Pharmacol Exp Ther 2000 295: 1241-1248. [Abstract] [Full Text] [PDF]  

Lance R. Molnar, William W. Fleming, and David A. Taylor

Alterations in Neuronal -Aminobutyric Acid_A Receptor Responsiveness in Genetic Models of Seizure Susceptibility with Different Expression Patterns
J Pharmacol Exp Ther 2000 295: 1258-1266. [Abstract] [Full Text] [PDF]  

Will P. J. M. Spooren, Annick Vassout, Hans C. Neijt, Rainer Kuhn, Fabrizio Gasparini, Silvain Roux, Roger D. Porsolt, and Conrad Gentsch

Anxiolytic-Like Effects of the Prototypical Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)pyridine in Rodents
J Pharmacol Exp Ther 2000 295: 1267-1275. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Norisato Ikebe, Takaaki Akaike, Yoichi Miyamoto, Kazuyuki Hayashida, Jun Yoshitake, Michio Ogawa, and Hiroshi Maeda

Protective Effect of S-Nitrosylated ₁-Protease Inhibitor on Hepatic Ischemia-Reperfusion Injury
J Pharmacol Exp Ther 2000 295: 904-911. [Abstract] [Full Text] [PDF]  

Lisa Imamura, Hiroshi Hasegawa, Kaori Kurashina, Ayako Hamanishi, Akiko Tabuchi, and Masaaki Tsuda

Repression of Activity-Dependent c-fos and Brain-Derived Neurotrophic Factor mRNA Expression by Pyrethroid Insecticides Accompanying a Decrease in Ca²⁺ Influx into Neurons
J Pharmacol Exp Ther 2000 295: 1175-1182. [Abstract] [Full Text] [PDF]  

ASPET MEETING REPORT:

Anthony R. Porcari and Ronald J. Shebuski

Meeting Report of the ASPET Colloquium: Functional Genomics
J Pharmacol Exp Ther 2000 295: 1291-1295. [Full Text] [PDF]  

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