PERSPECTIVES IN PHARMACOLOGY:

Ronald S. Duman, Jessica Malberg, and Shin Nakagawa

Regulation of Adult Neurogenesis by Psychotropic Drugs and Stress
J Pharmacol Exp Ther 2001 299: 401-407. [Abstract] [Full Text] [PDF]  

Scott M. Belcher and Attila Zsarnovszky

Estrogenic Actions in the Brain: Estrogen, Phytoestrogens, and Rapid Intracellular Signaling Mechanisms
J Pharmacol Exp Ther 2001 299: 408-414. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Elena V. Batrakova, Shu Li, Sergey V. Vinogradov, Valery Yu Alakhov, Donald W. Miller, and Alexander V. Kabanov

Mechanism of Pluronic Effect on P-Glycoprotein Efflux System in Blood-Brain Barrier: Contributions of Energy Depletion and Membrane Fluidization
J Pharmacol Exp Ther 2001 299: 483-493. [Abstract] [Full Text] [PDF]  

William A. Banks, Susan A. Farr, Michael E. La Scola, and John E. Morley

Intravenous Human Interleukin-1 Impairs Memory Processing in Mice: Dependence on Blood-Brain Barrier Transport into Posterior Division of the Septum
J Pharmacol Exp Ther 2001 299: 536-541. [Abstract] [Full Text] [PDF]  

Grace L. Guo and Curtis D. Klaassen

Protein Kinase C Suppresses Rat Organic Anion Transporting Polypeptide 1- and 2-Mediated Uptake
J Pharmacol Exp Ther 2001 299: 551-557. [Abstract] [Full Text] [PDF]  

David S. Miller

Nucleoside Phosphonate Interactions with Multiple Organic Anion Transporters in Renal Proximal Tubule
J Pharmacol Exp Ther 2001 299: 567-574. [Abstract] [Full Text] [PDF]  

Xiao-Yan Chu, Gloria P. Sánchez-Castaño, Kazutaka Higaki, Doo-Man Oh, Cheng-Pang Hsu, and Gordon L. Amidon

Correlation between Epithelial Cell Permeability of Cephalexin and Expression of Intestinal Oligopeptide Transporter
J Pharmacol Exp Ther 2001 299: 575-582. [Abstract] [Full Text] [PDF]  

Joseph W. Polli, Stephen A. Wring, Joan E. Humphreys, Liyue Huang, Jonathon B. Morgan, Lindsey O. Webster, and Cosette S. Serabjit-Singh

Rational Use of in Vitro P-glycoprotein Assays in Drug Discovery
J Pharmacol Exp Ther 2001 299: 620-628. [Abstract] [Full Text] [PDF]  

Ronald P. Santini, Scott Myrand, Cornelis Elferink, and John J. Reiners, Jr.

Regulation of Cyp1a1 Induction by Dioxin as a Function of Cell Cycle Phase
J Pharmacol Exp Ther 2001 299: 718-728. [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Michael R. Brandt, M. Scott Furness, Kenner C. Rice, Bradford D. Fischer, and S. Stevens Negus

Studies of Tolerance and Dependence with the -Opioid Agonist SNC80 in Rhesus Monkeys Responding under a Schedule of Food Presentation
J Pharmacol Exp Ther 2001 299: 629-637. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Ryan M. Fryer, Yigang Wang, Anna K. Hsu, Hiroshi Nagase, and Garrett J. Gross

Dependence of ₁-Opioid Receptor-Induced Cardioprotection on a Tyrosine Kinase-Dependent but Not a Src-Dependent Pathway
J Pharmacol Exp Ther 2001 299: 477-482. [Abstract] [Full Text] [PDF]  

Wilfried Roethy, Eduard Fiehn, Kotaro Suehiro, Anguo Gu, Geng Hua Yi, Juichiro Shimizu, Jie Wang, Geping Zhang, John Ranieri, Rama Akella, Sarah E. Funk, E. Helene Sage, James Benedict, and Daniel Burkhoff

A Growth Factor Mixture That Significantly Enhances Angiogenesis in Vivo
J Pharmacol Exp Ther 2001 299: 494-500. [Abstract] [Full Text] [PDF]  

Guan-Ying Wang, Jing Jun Zhou, Jian Shan, and Tak-Ming Wong

Protein Kinase C- Is a Trigger of Delayed Cardioprotection against Myocardial Ischemia of -Opioid Receptor Stimulation in Rat Ventricular Myocytes
J Pharmacol Exp Ther 2001 299: 603-610. [Abstract] [Full Text] [PDF]  

Michael Balazy, Takafumi Iesaki, James L. Park, Houli Jiang, Pawel M. Kaminski, and Michael S. Wolin

Vicinal Nitrohydroxyeicosatrienoic Acids: Vasodilator Lipids Formed by Reaction of Nitrogen Dioxide with Arachidonic Acid
J Pharmacol Exp Ther 2001 299: 611-619. [Abstract] [Full Text] [PDF]  

Yagna P. R. Jarajapu, Fiona Johnston, Colin Berry, Andrew Renwick, John C. McGrath, Allan MacDonald, and Chris Hillier

Functional Characterization of ₁-Adrenoceptor Subtypes in Human Subcutaneous Resistance Arteries
J Pharmacol Exp Ther 2001 299: 729-734. [Abstract] [Full Text] [PDF]  

Angel L. Cogolludo, Francisco Pérez-Vizcaíno, Gustavo López-López, Manuel Ibarra, Francisco Zaragozá-Arnáez, and Juan Tamargo

Propafenone Modulates Potassium Channel Activities of Vascular Smooth Muscle from Rat Portal Veins
J Pharmacol Exp Ther 2001 299: 801-810. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Li Liu, Han Li, Tashandra Underwood, Marti Lloyd, Mary David, Gerhard Sperl, Rifat Pamukcu, and W. Joseph Thompson

Cyclic GMP-Dependent Protein Kinase Activation and Induction by Exisulind and CP461 in Colon Tumor Cells
J Pharmacol Exp Ther 2001 299: 583-592. [Abstract] [Full Text] [PDF]  

Kelly A. Berg, Brian D. Stout, Saul Maayani, and William P. Clarke

Differences in Rapid Desensitization of 5-Hydroxytryptamine_2A and 5-Hydroxytryptamine_2C Receptor-Mediated Phospholipase C Activation
J Pharmacol Exp Ther 2001 299: 593-602. [Abstract] [Full Text] [PDF]  

Carleton P. Goold, Ted B. Usdin, and Sam R. J. Hoare

Regions in Rat and Human Parathyroid Hormone (PTH) 2 Receptors Controlling Receptor Interaction with PTH and with Antagonist Ligands
J Pharmacol Exp Ther 2001 299: 678-690. [Abstract] [Full Text] [PDF]  

Karri K. Bradley and Michael E. Bradley

Purine Nucleoside-Dependent Inhibition of Cellular Proliferation in 1321N1 Human Astrocytoma Cells
J Pharmacol Exp Ther 2001 299: 748-752. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Yilong Zhang, SaeHeum Song, Fan Yang, Jessie L.-S. Au, and M. Guillaume Wientjes

Nontoxic Doses of Suramin Enhance Activity of Doxorubicin in Prostate Tumors
J Pharmacol Exp Ther 2001 299: 426-433. [Abstract] [Full Text] [PDF]  

George S. Watts, Bernard W. Futscher, Robert Isett, Mary Gleason-Guzman, Mark W. Kunkel, and Sydney E. Salmon

cDNA Microarray Analysis of Multidrug Resistance: Doxorubicin Selection Produces Multiple Defects in Apoptosis Signaling Pathways
J Pharmacol Exp Ther 2001 299: 434-441. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Ali Keshavarzian, Sandeep Choudhary, Earle W. Holmes, Sherri Yong, Ali Banan, Shriram Jakate, and Jeremy Z. Fields

Preventing Gut Leakiness by Oats Supplementation Ameliorates Alcohol-Induced Liver Damage in Rats
J Pharmacol Exp Ther 2001 299: 442-448. [Abstract] [Full Text] [PDF]  

Kazuhiko Shirota, Yukio Kato, Koukichi Suzuki, and Yuichi Sugiyama

Characterization of Novel Kidney-Specific Delivery System Using an Alkylglucoside Vector
J Pharmacol Exp Ther 2001 299: 459-467. [Abstract] [Full Text] [PDF]  

Florian Islinger, Michael Gekle, and Stephen H. Wright

Interaction of 2,3-Dimercapto-1-propane Sulfonate with the Human Organic Anion Transporter hOAT1
J Pharmacol Exp Ther 2001 299: 741-747. [Abstract] [Full Text] [PDF]  

Aiping Zhao, Carol Bossone, Victor Piñeiro-Carrero, and Terez Shea-Donohue

Colitis-Induced Alterations in Adrenergic Control of Circular Smooth Muscle in Vitro in Rats
J Pharmacol Exp Ther 2001 299: 768-774. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Sang Bae Han, Se Hyung Park, Young Jin Jeon, Young Kook Kim, Hwan Mook Kim, and Kyu Hwan Yang

Prodigiosin Blocks T Cell Activation by Inhibiting Interleukin-2R Expression and Delays Progression of Autoimmune Diabetes and Collagen-Induced Arthritis
J Pharmacol Exp Ther 2001 299: 415-425. [Abstract] [Full Text] [PDF]  

Ellen Fritsche, Seung Joon Baek, Lorraine M. King, Darryl C. Zeldin, Thomas E. Eling, and Douglas A. Bell

Functional Characterization of Cyclooxygenase-2 Polymorphisms
J Pharmacol Exp Ther 2001 299: 468-476. [Abstract] [Full Text] [PDF]  

Ko Hatanaka, Michiko Kawamura, Naoki Murai, Michiko Ogino, Masataka Majima, Keiko Ogino, and Yoshiteru Harada

FR167653, a Cytokine Synthesis Inhibitor, Exhibits Anti-Inflammatory Effects Early in Rat Carrageenin-Induced Pleurisy but No Effect Later
J Pharmacol Exp Ther 2001 299: 519-527. [Abstract] [Full Text] [PDF]  

Chiharu Kishimoto, Hitoshi Takada, Hiroshi Kawamata, Miho Umatake, and Hiroshi Ochiai

Immunoglobulin Treatment Prevents Congestive Heart Failure in Murine Encephalomyocarditis Viral Myocarditis Associated with Reduction of Inflammatory Cytokines
J Pharmacol Exp Ther 2001 299: 645-651. [Abstract] [Full Text] [PDF]  

Jessica Fiedler, Francis R. Simon, Mieko Iwahashi, and Robert C. Murphy

Effect of Peroxisome Proliferator-Activated Receptor Activation on Leukotriene B₄ Metabolism in Isolated Rat Hepatocytes
J Pharmacol Exp Ther 2001 299: 691-697. [Abstract] [Full Text] [PDF]  

José Luis Jimenez, Carmen Punzón, Joaquín Navarro, M. Angeles Muñoz-Fernández, and Manuel Fresno

Phosphodiesterase 4 Inhibitors Prevent Cytokine Secretion by T Lymphocytes by Inhibiting Nuclear Factor-B and Nuclear Factor of Activated T Cells Activation
J Pharmacol Exp Ther 2001 299: 753-759. [Abstract] [Full Text] [PDF]  

Alf Lamprecht, Nathalie Ubrich, Hiromitsu Yamamoto, Ulrich Schäfer, Hirofumi Takeuchi, Philippe Maincent, Yoshiaki Kawashima, and Claus-Michael Lehr

Biodegradable Nanoparticles for Targeted Drug Delivery in Treatment of Inflammatory Bowel Disease
J Pharmacol Exp Ther 2001 299: 775-781. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Régis Steinberg, Richard Alonso, Guy Griebel, Lionel Bert, Mireille Jung, Florence Oury-Donat, Martine Poncelet, Christiane Gueudet, Christophe Desvignes, Gérard Le Fur, and Philippe Soubrié

Selective Blockade of Neurokinin-2 Receptors Produces Antidepressant-Like Effects Associated with Reduced Corticotropin-Releasing Factor Function
J Pharmacol Exp Ther 2001 299: 449-458. [Abstract] [Full Text] [PDF]  

Kyu-Sang Park, Seong-Woo Jeong, Seung-Kyu Cha, Boo-Soo Lee, In Deok Kong, Stephen R. Ikeda, and Joong-Woo Lee

Modulation of N-Type Ca²⁺ Currents by A₁-Adenosine Receptor Activation in Male Rat Pelvic Ganglion Neurons
J Pharmacol Exp Ther 2001 299: 501-508. [Abstract] [Full Text] [PDF]  

Colin N. Haile and Therese A. Kosten

Differential Effects of D1- and D2-Like Compounds on Cocaine Self-Administration in Lewis and Fischer 344 Inbred Rats
J Pharmacol Exp Ther 2001 299: 509-518. [Abstract] [Full Text] [PDF]  

Hugo Gonzalez-Serratos, Ruzhang Chang, Edna F. R. Pereira, Newton G. Castro, Yasco Aracava, Paulo A. Melo, Patrícia C. Lima, Carlos A. M. Fraga, Eliezer J. Barreiro, and Edson X. Albuquerque

A Novel Thienylhydrazone, (2-Thienylidene)3,4-methylenedioxybenzoylhydrazine, Increases Inotropism and Decreases Fatigue of Skeletal Muscle
J Pharmacol Exp Ther 2001 299: 558-566. [Abstract] [Full Text] [PDF]  

Bing Sun, Simon Lockyer, Jess Li, Ruoyan Chen, Masuhiro Yoshitake, and Jun-Ichi Kambayashi

OPC-28326, a Selective Femoral Vasodilator, Is an _2C-Adrenoceptor-Selective Antagonist
J Pharmacol Exp Ther 2001 299: 652-658. [Abstract] [Full Text] [PDF]  

Jodie J. Rady and James M. Fujimoto

Confluence of Antianalgesic Action of Diverse Agents through Brain Interleukin₁ in Mice
J Pharmacol Exp Ther 2001 299: 659-665. [Abstract] [Full Text] [PDF]  

Subbu Apparsundaram, Uhna Sung, Raymond D. Price, and Randy D. Blakely

Trafficking-Dependent and -Independent Pathways of Neurotransmitter Transporter Regulation Differentially Involving p38 Mitogen-Activated Protein Kinase Revealed in Studies of Insulin Modulation of Norepinephrine Transport in SK-N-SH Cells
J Pharmacol Exp Ther 2001 299: 666-677. [Abstract] [Full Text] [PDF]  

V. Gene Erwin, Richard Radcliffe, and Richard A. Deitrich

Neurotensin Levels in Specific Brain Regions and Hypnotic Sensitivity to Ethanol and Pentobarbital as a Function of Time after Haloperidol Administration in Selectively Bred Rat Lines
J Pharmacol Exp Ther 2001 299: 698-704. [Abstract] [Full Text] [PDF]  

Michael S. Gold and Paul D. Thut

Lithium Increases Potency of Lidocaine-Induced Block of Voltage-Gated Na⁺ Currents in Rat Sensory Neurons in Vitro
J Pharmacol Exp Ther 2001 299: 705-711. [Abstract] [Full Text] [PDF]  

Xavier Langlois, Paula te Riele, Cindy Wintmolders, Josée E. Leysen, and Mirek Jurzak

Use of the -Imager for Rapid ex Vivo Autoradiography Exemplified with Central Nervous System Penetrating Neurokinin 3 Antagonists
J Pharmacol Exp Ther 2001 299: 712-717. [Abstract] [Full Text] [PDF]  

Jian Yi Li, Ruben J. Boado, and William M. Pardridge

Differential Kinetics of Transport of 2',3'-Dideoxyinosine and Adenosine via Concentrative Na⁺ Nucleoside Transporter CNT2 Cloned from Rat Blood-Brain Barrier
J Pharmacol Exp Ther 2001 299: 735-740. [Abstract] [Full Text] [PDF]  

Donna M. Platt, James K. Rowlett, and Roger D. Spealman

Discriminative Stimulus Effects of Intravenous Heroin and Its Metabolites in Rhesus Monkeys: Opioid and Dopaminergic Mechanisms
J Pharmacol Exp Ther 2001 299: 760-767. [Abstract] [Full Text] [PDF]  

K. J. Stanhope, N. R. Mirza, M. J. Bickerdike, J. L. Bright, N. R. Harrington, M. B. Hesselink, G. A. Kennett, S. Lightowler, M. J. Sheardown, R. Syed, R. L. Upton, G. Wadsworth, S. M. Weiss, and A. Wyatt

The Muscarinic Receptor Agonist Xanomeline Has an Antipsychotic-Like Profile in the Rat
J Pharmacol Exp Ther 2001 299: 782-792. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Ellen G. Duysen, Bin Li, Weihua Xie, Lawrence M. Schopfer, Robert S. Anderson, Clarence A. Broomfield, and Oksana Lockridge

Evidence for Nonacetylcholinesterase Targets of Organophosphorus Nerve Agent: Supersensitivity of Acetylcholinesterase Knockout Mouse to VX Lethality
J Pharmacol Exp Ther 2001 299: 528-535. [Abstract] [Full Text] [PDF]  

Lisa A. Howard, Alina L. Micu, Edward M. Sellers, and Rachel F. Tyndale

Low Doses of Nicotine and Ethanol Induce CYP2E1 and Chlorzoxazone Metabolism in Rat Liver
J Pharmacol Exp Ther 2001 299: 542-550. [Abstract] [Full Text] [PDF]  

Amin A. Nanji, Kalle Jokelainen, George L. Tipoe, Amir Rahemtulla, and Andrew J. Dannenberg

Dietary Saturated Fatty Acids Reverse Inflammatory and Fibrotic Changes in Rat Liver Despite Continued Ethanol Administration
J Pharmacol Exp Ther 2001 299: 638-644. [Abstract] [Full Text] [PDF]  

Alain Berson, Véronique Descatoire, Angela Sutton, Daniel Fau, Béatrice Maulny, Nathalie Vadrot, Gérard Feldmann, Brigitte Berthon, Thierry Tordjmann, and Dominique Pessayre

Toxicity of Alpidem, a Peripheral Benzodiazepine Receptor Ligand, but Not Zolpidem, in Rat Hepatocytes: Role of Mitochondrial Permeability Transition and Metabolic Activation
J Pharmacol Exp Ther 2001 299: 793-800. [Abstract] [Full Text] [PDF]  

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