PERSPECTIVES IN PHARMACOLOGY:

Ursula Sonnewald, Hong Qu, and Michael Aschner

Pharmacology and Toxicology of Astrocyte-Neuron Glutamate Transport and Cycling
J Pharmacol Exp Ther 2002 301: 1-6. [Abstract] [Full Text] [PDF]  

Wolfgang Löscher and Heidrun Potschka

Role of Multidrug Transporters in Pharmacoresistance to Antiepileptic Drugs
J Pharmacol Exp Ther 2002 301: 7-14. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Susan C. N. Buist, Nathan J. Cherrington, Supratim Choudhuri, Dylan P. Hartley, and Curtis D. Klaassen

Gender-Specific and Developmental Influences on the Expression of Rat Organic Anion Transporters
J Pharmacol Exp Ther 2002 301: 145-151. [Abstract] [Full Text] [PDF]  

Hsia-lien Lin, Ute M. Kent, and Paul F. Hollenberg

Mechanism-Based Inactivation of Cytochrome P450 3A4 by 17-Ethynylestradiol: Evidence for Heme Destruction and Covalent Binding to Protein
J Pharmacol Exp Ther 2002 301: 160-167. [Abstract] [Full Text] [PDF]  

Mary F. Paine, Louis Y. Leung, H. K. Lim, Kecheng Liao, Aram Oganesian, Mei-Yi Zhang, Kenneth E. Thummel, and Paul B. Watkins

Identification of a Novel Route of Extraction of Sirolimus in Human Small Intestine: Roles of Metabolism and Secretion
J Pharmacol Exp Ther 2002 301: 174-186. [Abstract] [Full Text] [PDF]  

Lynn O. Post, Carol V. Cope, Dorothy E. Farrell, John D. Baker, and Michael J. Myers

Influence of Porcine Actinobacillus pleuropneumoniae Infection and Dexamethasone on the Pharmacokinetic Parameters of Enrofloxacin
J Pharmacol Exp Ther 2002 301: 217-222. [Abstract] [Full Text] [PDF]  

Hiroaki Kimura, Michio Takeda, Shinichi Narikawa, Atsushi Enomoto, Kimiyoshi Ichida, and Hitoshi Endou

Human Organic Anion Transporters and Human Organic Cation Transporters Mediate Renal Transport of Prostaglandins
J Pharmacol Exp Ther 2002 301: 293-298. [Abstract] [Full Text] [PDF]  

Maohe Yan, Leslie T. Webster, Jr., and Jeffrey L. Blumer

Kinetic Interactions of Dopamine and Dobutamine with Human Catechol-O-methyltransferase and Monoamine Oxidase in Vitro
J Pharmacol Exp Ther 2002 301: 315-321. [Abstract] [Full Text] [PDF]  

M. G. Soars, B. Burchell, and R. J. Riley

In Vitro Analysis of Human Drug Glucuronidation and Prediction of in Vivo Metabolic Clearance
J Pharmacol Exp Ther 2002 301: 382-390. [Abstract] [Full Text] [PDF]  

L. Illum, P. Watts, A. N. Fisher, M. Hinchcliffe, H. Norbury, I. Jabbal-Gill, R. Nankervis, and S. S. Davis

Intranasal Delivery of Morphine
J Pharmacol Exp Ther 2002 301: 391-400. [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

A. V. Terry, Jr., V. B. Risbrough, J. J. Buccafusco, and F. Menzaghi

Effects of (±)-4-{[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio}phenol Hydrochloride (SIB-1553A), a Selective Ligand for Nicotinic Acetylcholine Receptors, in Tests of Visual Attention and Distractibility in Rats and Monkeys
J Pharmacol Exp Ther 2002 301: 284-292. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Haisong Ju, Sandhya Nerurkar, Charles F. Sauermelch, Alan R. Olzinski, Rosanna Mirabile, Dawn Zimmerman, John C. Lee, Jerry Adams, Joseph Sisko, Marinella Berova, and Robert N. Willette

Sustained Activation of p38 Mitogen-Activated Protein Kinase Contributes to the Vascular Response to Injury
J Pharmacol Exp Ther 2002 301: 15-20. [Abstract] [Full Text] [PDF]  

Christian T. Abrahamsen, Frank C. Barone, Wallace G. Campbell, Jr., Allen H. Nelson, Lisa C. Contino, Mark A. Pullen, Eugene T. Grygielko, Richard M. Edwards, Nicholas J. Laping, and David P. Brooks

The Angiotensin Type 1 Receptor Antagonist, Eprosartan, Attenuates the Progression of Renal Disease in Spontaneously Hypertensive Stroke-Prone Rats with Accelerated Hypertension
J Pharmacol Exp Ther 2002 301: 21-28. [Abstract] [Full Text] [PDF]  

Klaus Pönicke, Ingrid Heinroth-Hoffmann, and Otto-Erich Brodde

Differential Effects of Bucindolol and Carvedilol on Noradenaline-Induced Hypertrophic Response in Ventricular Cardiomyocytes of Adult Rats
J Pharmacol Exp Ther 2002 301: 71-76. [Abstract] [Full Text] [PDF]  

Sandrine N. Hardouin, Keith N. Richmond, Andrew Zimmerman, Susan E. Hamilton, Eric O. Feigl, and Neil M. Nathanson

Altered Cardiovascular Responses in Mice Lacking the M₁ Muscarinic Acetylcholine Receptor
J Pharmacol Exp Ther 2002 301: 129-137. [Abstract] [Full Text] [PDF]  

Kurt J. Varner, Brian A. Ogden, Joseph Delcarpio, and Suzanne Meleg-Smith

Cardiovascular Responses Elicited by the "Binge" Administration of Methamphetamine
J Pharmacol Exp Ther 2002 301: 152-159. [Abstract] [Full Text] [PDF]  

M. Flechtner-Mors, C. P. Jenkinson, A. Alt, G. Adler, and H. H. Ditschuneit

In Vivo ₁-Adrenergic Lipolytic Activity in Subcutaneous Adipose Tissue of Obese Subjects
J Pharmacol Exp Ther 2002 301: 229-233. [Abstract] [Full Text] [PDF]  

Chang-Her Tsai, Sheng-Fang Su, Tsai-Fwu Chou, and Tsung-Ming Lee

Differential Effects of Sarcolemmal and Mitochondrial K_ATP Channels Activated by 17-Estradiol on Reperfusion Arrhythmias and Infarct Sizes in Canine Hearts
J Pharmacol Exp Ther 2002 301: 234-240. [Abstract] [Full Text] [PDF]  

Sachin A. Gupte, Kai-Xun Li, Takao Okada, Koichi Sato, and Masahiko Oka

Inhibitors of Pentose Phosphate Pathway Cause Vasodilation: Involvement of Voltage-Gated Potassium Channels
J Pharmacol Exp Ther 2002 301: 299-305. [Abstract] [Full Text] [PDF]  

Mahmoud M. El-Mas, Elham A. Afify, Amal G. Omar, and Fouad M. Sharabi

Cyclosporine Adversely Affects Baroreflexes via Inhibition of Testosterone Modulation of Cardiac Vagal Control
J Pharmacol Exp Ther 2002 301: 346-354. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Yoshiyuki Sugimoto, Reiko Fujisawa, Ryuji Tanimura, Anne Laure Lattion, Susanna Cotecchia, Gozoh Tsujimoto, Taku Nagao, and Hitoshi Kurose

₁-Selective Agonist ()-1-(3,4-Dimethoxyphenetylamino)-3-(3,4-dihydroxy)-2-propanol [()-RO363] Differentially Interacts with Key Amino Acids Responsible for ₁-Selective Binding in Resting and Active States
J Pharmacol Exp Ther 2002 301: 51-58. [Abstract] [Full Text] [PDF]  

Orna Asher, Thomas D. Cunningham, Lina Yao, Adrienne S. Gordon, and Ivan Diamond

Ethanol Stimulates cAMP-Responsive Element (CRE)-Mediated Transcription via CRE-Binding Protein and cAMP-Dependent Protein Kinase
J Pharmacol Exp Ther 2002 301: 66-70. [Abstract] [Full Text] [PDF]  

Yasuko Ishikawa, Hirokazu Iida, Mariusz T. Skowronski, and Hajime Ishida

Activation of Endogenous Nitric Oxide Synthase Coupled with Methacholine-Induced Exocytosis in Rat Parotid Acinar Cells
J Pharmacol Exp Ther 2002 301: 355-363. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Sjofn Gunnarsdottir, Marian Rucki, and Adnan A. Elfarra

Novel Glutathione-Dependent Thiopurine Prodrugs: Evidence for Enhanced Cytotoxicity in Tumor Cells and for Decreased Bone Marrow Toxicity in Mice
J Pharmacol Exp Ther 2002 301: 77-86. [Abstract] [Full Text] [PDF]  

Thomas E. Mürdter, Godehard Friedel, Janne T. Backman, Monika McClellan, Monika Schick, Manfred Gerken, Klaus Bosslet, Peter Fritz, Heikki Toomes, Heyo K. Kroemer, and Bernhard Sperker

Dose Optimization of a Doxorubicin Prodrug (HMR 1826) in Isolated Perfused Human Lungs: Low Tumor pH Promotes Prodrug Activation by -Glucuronidase
J Pharmacol Exp Ther 2002 301: 223-228. [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Pierre Broqua, Pierre J.-M. Riviere, P. Michael Conn, Jean E. Rivier, Michel L. Aubert, and Jean-Louis Junien

Pharmacological Profile of a New, Potent, and Long-Acting Gonadotropin-Releasing Hormone Antagonist: Degarelix
J Pharmacol Exp Ther 2002 301: 95-102. [Abstract] [Full Text] [PDF]  

Alok De, Nadka Boyadjieva, and Dipak K. Sarkar

Role of Protein Kinase C in Control of Ethanol-Modulated -Endorphin Release from Hypothalamic Neurons in Primary Cultures
J Pharmacol Exp Ther 2002 301: 119-128. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Hisato Igarashi, Tetsuhide Ito, Wei Hou, Samuel A. Mantey, Tapas K. Pradhan, Charles D. Ulrich, II, Simon J. Hocart, David H. Coy, and Robert T. Jensen

Elucidation of Vasoactive Intestinal Peptide Pharmacophore for VPAC₁ Receptors in Human, Rat, and Guinea Pig
J Pharmacol Exp Ther 2002 301: 37-50. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Hiroshi Nakase, Kazuichi Okazaki, Yasuhiko Tabata, Makoto Ozeki, Norihiko Watanabe, Masaya Ohana, Suguru Uose, Kazushige Uchida, Toshiki Nishi, Minoru Mastuura, Hiroyuki Tamaki, Toshiyuki Itoh, Chiharu Kawanami, and Tsutomu Chiba

New Cytokine Delivery System Using Gelatin Microspheres Containing Interleukin-10 for Experimental Inflammatory Bowel Disease
J Pharmacol Exp Ther 2002 301: 59-65. [Abstract] [Full Text] [PDF]  

Julio Girón-Calle, Kousthub Srivatsa, and Henry Jay Forman

Priming of Alveolar Macrophage Respiratory Burst by H₂O₂ Is Prevented by Phosphatidylcholine-Specific Phospholipase C Inhibitor Tricyclodecan-9-yl-xanthate (D609)
J Pharmacol Exp Ther 2002 301: 87-94. [Abstract] [Full Text] [PDF]  

György Haskó, Edwin A. Deitch, Zoltán H. Németh, David G. Kuhel, and Csaba Szabó

Inhibitors of ATP-Binding Cassette Transporters Suppress Interleukin-12 p40 Production and Major Histocompatibility Complex II Up-Regulation in Macrophages
J Pharmacol Exp Ther 2002 301: 103-110. [Abstract] [Full Text] [PDF]  

Alexandre Trifilieff, Daniel Wyss, Christoph Walker, Lazzaro Mazzoni, and Rene Hersperger

Pharmacological Profile of a Novel Phosphodiesterase 4 Inhibitor, 4-(8-Benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridin-6-yl)-benzoic Acid (NVP-ABE171), a 1,7-Naphthyridine Derivative, with Anti-Inflammatory Activities
J Pharmacol Exp Ther 2002 301: 241-248. [Abstract] [Full Text] [PDF]  

Marianne Corbel, Noëlla Germain, Jérôme Lanchou, Sophie Molet, Patricia M. R. e Silva, Marco A. Martins, Elisabeth Boichot, and Vincent Lagente

The Selective Phosphodiesterase 4 Inhibitor RP 73-401 Reduced Matrix Metalloproteinase 9 Activity and Transforming Growth Factor- Release During Acute Lung Injury in Mice: The Role of the Balance Between Tumor Necrosis Factor- and Interleukin-10
J Pharmacol Exp Ther 2002 301: 258-265. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Carmina Montoliu, Marc Humet, Juan-José Canales, Jozef Burda, Rosa Planells-Cases, Francisco Sánchez-Baeza, Teresa Carbonell, Enrique Pérez-Payá, Angel Messeguer, Antonio Ferrer-Montiel, and Vicente Felipo

Prevention of in Vivo Excitotoxicity by a Family of Trialkylglycines, a Novel Class of Neuroprotectants
J Pharmacol Exp Ther 2002 301: 29-36. [Abstract] [Full Text] [PDF]  

Altaf S. Darvesh, Mahalakshmi Shankaran, and Gary A. Gudelsky

3,4-Methylenedioxymethamphetamine Produces Glycogenolysis and Increases the Extracellular Concentration of Glucose in the Rat Brain
J Pharmacol Exp Ther 2002 301: 138-144. [Abstract] [Full Text] [PDF]  

Roman Furtmüller, Michael G. Schlag, Michael Berger, Rudolf Hopf, Sigismund Huck, Werner Sieghart, and Heinz Redl

Tranexamic Acid, a Widely Used Antifibrinolytic Agent, Causes Convulsions by a -Aminobutyric Acid_A Receptor Antagonistic Effect
J Pharmacol Exp Ther 2002 301: 168-173. [Abstract] [Full Text] [PDF]  

Philippe Chopin, Francis C. Colpaert, and Marc Marien

Effects of Acute and Subchronic Administration of Dexefaroxan, an ₂-Adrenoceptor Antagonist, on Memory Performance in Young Adult and Aged Rodents
J Pharmacol Exp Ther 2002 301: 187-196. [Abstract] [Full Text] [PDF]  

Yogesh Dwivedi, Hooriyah S. Rizavi, and Ghanshyam N. Pandey

Differential Effects of Haloperidol and Clozapine on [³H]cAMP Binding, Protein Kinase A (PKA) Activity, and mRNA and Protein Expression of Selective Regulatory and Catalytic Subunit Isoforms of PKA in Rat Brain
J Pharmacol Exp Ther 2002 301: 197-209. [Abstract] [Full Text] [PDF]  

Ki Whan Hong, Ki Young Kim, Jeong Hyun Lee, Hwa Kyoung Shin, Yong Geun Kwak, Sun-Ok Kim, Hong Lim, and Sung-Eun Yoo

Neuroprotective Effect of (2S,3S,4R)-N"-cyano-N-(6-amino-3, 4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-benzylguanidine (KR-31378), a Benzopyran Analog, against Focal Ischemic Brain Damage in Rats
J Pharmacol Exp Ther 2002 301: 210-216. [Abstract] [Full Text] [PDF]  

Katsura Tottori, Masami Nakai, Yasufumi Uwahodo, Takashi Miwa, Sakiko Yamada, Yasuo Oshiro, Tetsuro Kikuchi, and C. Anthony Altar

Attenuation of Scopolamine-Induced and Age-Associated Memory Impairments by the Sigma and 5-Hydroxytryptamine_1A Receptor Agonist OPC-14523 (1-{3-[4-(3-chlorophenyl)-1-piperazinyl]propyl}-5-methoxy-3,4-dihydro-2[1H]-quinolinone monomethanesulfonate)
J Pharmacol Exp Ther 2002 301: 249-257. [Abstract] [Full Text] [PDF]  

Sandra D. Comer, Eric D. Collins, and Marian W. Fischman

Intravenous Buprenorphine Self-Administration by Detoxified Heroin Abusers
J Pharmacol Exp Ther 2002 301: 266-276. [Abstract] [Full Text] [PDF]  

George K. Acquaah-Mensah, James P. Kehrer, and Steven W. Leslie

In Utero Ethanol Suppresses Cerebellar Activator Protein-1 and Nuclear Factor-B Transcriptional Activation in a Rat Fetal Alcohol Syndrome Model
J Pharmacol Exp Ther 2002 301: 277-283. [Abstract] [Full Text] [PDF]  

Alicia E. Derbez, Rupal M. Mody, and Linda L. Werling

₂-Receptor Regulation of Dopamine Transporter via Activation of Protein Kinase C
J Pharmacol Exp Ther 2002 301: 306-314. [Abstract] [Full Text] [PDF]  

Danielle Gully, Michel Geslin, Laurence Serva, Evelyne Fontaine, Pierre Roger, Christine Lair, Valerie Darre, Claudine Marcy, Pierre-Eric Rouby, Jacques Simiand, Josette Guitard, Georgette Gout, Regis Steinberg, Daniel Rodier, Guy Griebel, Philippe Soubrie, Marc Pascal, Rebecca Pruss, Bernard Scatton, Jean-Pierre Maffrand, and Gerard Le Fur

4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1,3-thiazol-2-amine Hydrochloride (SSR125543A): A Potent and Selective Corticotrophin-Releasing Factor₁ Receptor Antagonist. I. Biochemical and Pharmacological Characterization
J Pharmacol Exp Ther 2002 301: 322-332. [Abstract] [Full Text] [PDF]  

Guy Griebel, Jacques Simiand, Régis Steinberg, Mireille Jung, Danielle Gully, Pierre Roger, Michel Geslin, Bernard Scatton, Jean-Pierre Maffrand, and Philippe Soubrié

4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1, 3-thiazol-2-amine Hydrochloride (SSR125543A), a Potent and Selective Corticotrophin-Releasing Factor₁ Receptor Antagonist. II. Characterization in Rodent Models of Stress-Related Disorders
J Pharmacol Exp Ther 2002 301: 333-345. [Abstract] [Full Text] [PDF]  

Leslie C. Newman, Steven S. Sands, David R. Wallace, and Craig W. Stevens

Characterization of µ, , and Opioid Binding in Amphibian Whole Brain Tissue Homogenates
J Pharmacol Exp Ther 2002 301: 364-370. [Abstract] [Full Text] [PDF]  

Michael S. Turner, Laurence Mignon, and T. Celeste Napier

Alterations in Responses of Ventral Pallidal Neurons to Excitatory Amino Acids after Long-Term Dopamine Depletion
J Pharmacol Exp Ther 2002 301: 371-381. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Montserrat Marí, Jingxiang Bai, and Arthur I. Cederbaum

Adenovirus-Mediated Overexpression of Catalase in the Cytosolic or Mitochondrial Compartment Protects against Toxicity Caused by Glutathione Depletion in HepG2 Cells Expressing CYP2E1
J Pharmacol Exp Ther 2002 301: 111-118. [Abstract] [Full Text] [PDF]  

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