PERSPECTIVES IN PHARMACOLOGY:

Philip S. Burton, Jay T. Goodwin, Thomas J. Vidmar, and Benny M. Amore

Predicting Drug Absorption: How Nature Made It a Difficult Problem
J Pharmacol Exp Ther 2002 303: 889-895. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Irène Brigger, Jackie Morizet, Geneviève Aubert, Hélène Chacun, Marie-José Terrier-Lacombe, Patrick Couvreur, and Gilles Vassal

Poly(ethylene glycol)-Coated Hexadecylcyanoacrylate Nanospheres Display a Combined Effect for Brain Tumor Targeting
J Pharmacol Exp Ther 2002 303: 928-936. [Abstract] [Full Text] [PDF]  

Sudha R. Kondraganti, Weiwu Jiang, and Bhagavatula Moorthy

Differential Regulation of Expression of Hepatic and Pulmonary Cytochrome P4501A Enzymes by 3-Methylcholanthrene in Mice Lacking the CYP1A2 Gene
J Pharmacol Exp Ther 2002 303: 945-951. [Abstract] [Full Text] [PDF]  

Kerry B. Goralski, Ganlu Lou, Matthew T. Prowse, Valentin Gorboulev, Christopher Volk, Hermann Koepsell, and Daniel S. Sitar

The Cation Transporters rOCT1 and rOCT2 Interact with Bicarbonate but Play Only a Minor Role for Amantadine Uptake into Rat Renal Proximal Tubules
J Pharmacol Exp Ther 2002 303: 959-968. [Abstract] [Full Text] [PDF]  

Sanjeev Kumar, Koppara Samuel, Ramaswamy Subramanian, Matthew P. Braun, Ralph A. Stearns, Shuet-Hing Lee Chiu, David C. Evans, and Thomas A. Baillie

Extrapolation of Diclofenac Clearance from in Vitro Microsomal Metabolism Data: Role of Acyl Glucuronidation and Sequential Oxidative Metabolism of the Acyl Glucuronide
J Pharmacol Exp Ther 2002 303: 969-978. [Abstract] [Full Text] [PDF]  

Kelly M. Mahar Doan, Joan E. Humphreys, Lindsey O. Webster, Stephen A. Wring, Larry J. Shampine, Cosette J. Serabjit-Singh, Kimberly K. Adkison, and Joseph W. Polli

Passive Permeability and P-Glycoprotein-Mediated Efflux Differentiate Central Nervous System (CNS) and Non-CNS Marketed Drugs
J Pharmacol Exp Ther 2002 303: 1029-1037. [Abstract] [Full Text] [PDF]  

Aiming Yu, Byron M. Kneller, Allan E. Rettie, and Robert L. Haining

Expression, Purification, Biochemical Characterization, and Comparative Function of Human Cytochrome P450 2D6.1, 2D6.2, 2D6.10, and 2D6.17 Allelic Isoforms
J Pharmacol Exp Ther 2002 303: 1291-1300. [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Zachary A. Rodd-Henricks, David L. McKinzie, Ting-Kai Li, James M. Murphy, and William J. McBride

Cocaine Is Self-Administered into the Shell but Not the Core of the Nucleus Accumbens of Wistar Rats
J Pharmacol Exp Ther 2002 303: 1216-1226. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

John J. McGuire, Jiazhen Dai, Patricia Andrade-Gordon, Chris R. Triggle, and Morley D. Hollenberg

Proteinase-Activated Receptor-2 (PAR2): Vascular Effects of a PAR2-Derived Activating Peptide via a Receptor Different than PAR2
J Pharmacol Exp Ther 2002 303: 985-992. [Abstract] [Full Text] [PDF]  

Pancras C. Wong, Earl J. Crain, Carol A. Watson, Alverna M. Zaspel, Matthew R. Wright, Patrick Y. Lam, Donald J. P. Pinto, Ruth R. Wexler, and Robert M. Knabb

Nonpeptide Factor Xa Inhibitors III: Effects of DPC423, an Orally-Active Pyrazole Antithrombotic Agent, on Arterial Thrombosis in Rabbits
J Pharmacol Exp Ther 2002 303: 993-1000. [Abstract] [Full Text] [PDF]  

Terrance D. Barrett, James K. Hennan, Rory M. Marks, and Benedict R. Lucchesi

C-Reactive-Protein-Associated Increase in Myocardial Infarct Size After Ischemia/Reperfusion
J Pharmacol Exp Ther 2002 303: 1007-1013. [Abstract] [Full Text] [PDF]  

Jean-Sébastien Silvestre, Nyam Kamsu-Kom, Michel Clergue, Micheline Duriez, and Bernard I. Lévy

Very-Low-Dose Combination of the Angiotensin-Converting Enzyme Inhibitor Perindopril and the Diuretic Indapamide Induces an Early and Sustained Increase in Neovascularization in Rat Ischemic Legs
J Pharmacol Exp Ther 2002 303: 1038-1043. [Abstract] [Full Text] [PDF]  

Xinkang Wang, Robert T. Dorsam, Adam Lauver, Hugh Wang, Frank A. Barbera, Sandra Gibbs, David Varon, Naphtali Savion, Steven M. Friedman, and Giora Z. Feuerstein

Comparative Analysis of Various Platelet Glycoprotein IIb/IIIa Antagonists on Shear-Induced Platelet Activation and Adhesion
J Pharmacol Exp Ther 2002 303: 1114-1120. [Abstract] [Full Text] [PDF]  

Ulrich Schäfer, Christof Burgdorf, Astrid Engelhardt, Thomas Kurz, and Gert Richardt

Presynaptic Effects of Moxonidine in Isolated Buffer Perfused Rat Hearts: Role of Imidazoline-1 Receptors and ₂-Adrenoceptors
J Pharmacol Exp Ther 2002 303: 1163-1170. [Abstract] [Full Text] [PDF]  

Christopher N. Berry, Gilbert Lassalle, Catherine Lunven, Jean-Michel Altenburger, Frédérique Guilbert, Alain Lalé, Jean-Pascal Hérault, Catherine Lecoffre, Christian Pfersdorff, Jean-Marc Herbert, and Stephen E. O'Connor

SSR182289A, a Novel, Orally Active Thrombin Inhibitor: In Vitro Profile and ex Vivo Anticoagulant Activity
J Pharmacol Exp Ther 2002 303: 1189-1198. [Abstract] [Full Text] [PDF]  

Dileep Kumar Rohra, Tohru Yamakuni, Ken-Ichi Furukawa, Noe Ishii, Takashi Shinkawa, Toshiaki Isobe, and Yasushi Ohizumi

Stimulated Tyrosine Phosphorylation of Phosphatidylinositol 3-Kinase Causes Acidic pH-Induced Contraction in Spontaneously Hypertensive Rat Aorta
J Pharmacol Exp Ther 2002 303: 1255-1264. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Mariana M. Belcheva, Paul D. Haas, Yun Tan, Virginia M. Heaton, and Carmine J. Coscia

The Fibroblast Growth Factor Receptor Is at the Site of Convergence between µ-Opioid Receptor and Growth Factor Signaling Pathways in Rat C6 Glioma Cells
J Pharmacol Exp Ther 2002 303: 909-918. [Abstract] [Full Text] [PDF]  

Shilpa G. Lalchandani, Longping Lei, Weiping Zheng, Mustafa M. Suni, Bob M. Moore, Stephen B. Liggett, Duane D. Miller, and Dennis R. Feller

Yohimbine Dimers Exhibiting Selectivity for the Human _2c-Adrenoceptor Subtype
J Pharmacol Exp Ther 2002 303: 979-984. [Abstract] [Full Text] [PDF]  

Pamela Esposito, Nathan Chandler, Kristiana Kandere, Subimal Basu, Stanley Jacobson, Raymond Connolly, David Tutor, and Theoharis C. Theoharides

Corticotropin-Releasing Hormone and Brain Mast Cells Regulate Blood-Brain-Barrier Permeability Induced by Acute Stress
J Pharmacol Exp Ther 2002 303: 1061-1066. [Abstract] [Full Text] [PDF]  

Rita Motalli, Margherita D'Antuono, Jacques Louvel, Irene Kurcewicz, Giovanna D'Arcangelo, Virginia Tancredi, Mario Manfredi, René Pumain, and Massimo Avoli

Epileptiform Synchronization and GABA_B Receptor Antagonism in the Juvenile Rat Hippocampus
J Pharmacol Exp Ther 2002 303: 1102-1113. [Abstract] [Full Text] [PDF]  

Jihee Lee Kang, Hui Su Lee, Hae Jin Jung, Hee Jae Kim, Jong Sik Hah, and Vincent Castranova

Inhibition of Mitogenic Stimulant-Induced Activation of Thymocytes with Zinc Tetrakis-(N-Methyl-4'-Pyridyl) Porphyrinato
J Pharmacol Exp Ther 2002 303: 1138-1144. [Abstract] [Full Text] [PDF]  

V. J. Bennett, S. A. Perrine, and M. A. Simmons

A Novel Mechanism of Neurokinin-1 Receptor Resensitization
J Pharmacol Exp Ther 2002 303: 1155-1162. [Abstract] [Full Text] [PDF]  

Jean-Hugues Parmentier, Aftab Ahmed, Ying Ruan, Gautam K. Gandhi, Abdelwahab E. Saeed, and Kafait U. Malik

Calcium and Protein Kinase C (PKC)-Related Kinase Mediate _1A-Adrenergic Receptor-Stimulated Activation of Phospholipase D in Rat-1 Cells, Independent of PKC
J Pharmacol Exp Ther 2002 303: 1206-1215. [Abstract] [Full Text] [PDF]  

Nathalie Morin, Virgile Visentin, Denis Calise, Luc Marti, Antonio Zorzano, Xavier Testar, Philippe Valet, Yvan Fischer, and Christian Carpéné

Tyramine Stimulates Glucose Uptake in Insulin-Sensitive Tissues in Vitro and in Vivo via Its Oxidation by Amine Oxidases
J Pharmacol Exp Ther 2002 303: 1238-1247. [Abstract] [Full Text] [PDF]  

Khosrow Kashfi, Yassir Ryann, Leon L. Qiao, Jennie L. Williams, Jie Chen, Piero del Soldato, Frank Traganos, and Basil Rigas

Nitric Oxide-Donating Nonsteroidal Anti-Inflammatory Drugs Inhibit the Growth of Various Cultured Human Cancer Cells: Evidence of a Tissue Type-Independent Effect
J Pharmacol Exp Ther 2002 303: 1273-1282. [Abstract] [Full Text] [PDF]  

Mikhail Boudarine, Oleg Yegorov, Anna Sterling-Dubrovsky, Lakshmi A. Devi, and Yemiliya Berman

Developmental Changes in Opioid Peptides and Their Receptors in Cpe^fat/Cpe^fat Mice Lacking Peptide Processing Enzyme Carboxypeptidase E
J Pharmacol Exp Ther 2002 303: 1317-1324. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

R. H. Stephens, J. Tanianis-Hughes, N. B. Higgs, M. Humphrey, and G. Warhurst

Region-Dependent Modulation of Intestinal Permeability by Drug Efflux Transporters: In Vitro Studies in mdr1a(/) Mouse Intestine
J Pharmacol Exp Ther 2002 303: 1095-1101. [Abstract] [Full Text] [PDF]  

Ian Popoff, Humberto Jijon, Brett Monia, Michele Tavernini, Michael Ma, Rob McKay, and Karen Madsen

Antisense Oligonucleotides to poly(ADP-ribose) Polymerase-2 Ameliorate Colitis in Interleukin-10-Deficient Mice
J Pharmacol Exp Ther 2002 303: 1145-1154. [Abstract] [Full Text] [PDF]  

Akiko Tanaka, Shoko Hase, Tohru Miyazawa, Ryoko Ohno, and Koji Takeuchi

Role of Cyclooxygenase (COX)-1 and COX-2 Inhibition in Nonsteroidal Anti-Inflammatory Drug-Induced Intestinal Damage in Rats: Relation to Various Pathogenic Events
J Pharmacol Exp Ther 2002 303: 1248-1254. [Abstract] [Full Text] [PDF]  

Flavia Mulè, Maria Carmela Baffi, Mariarita Falzone, and Maria Carmela Cerra

Signal Transduction Pathways Involved in the Mechanical Responses to Protease-Activated Receptors in Rat Colon
J Pharmacol Exp Ther 2002 303: 1265-1272. [Abstract] [Full Text] [PDF]  

Shingo Tsuji, Wei-Hao Sun, Masahiko Tsujii, Naoki Kawai, Arata Kimura, Yoshimi Kakiuchi, Shoichi Yasumaru, Masato Komori, Hiroaki Murata, Yutaka Sasaki, Sunao Kawano, and Masatsugu Hori

Lansoprazole Induces Mucosal Protection through Gastrin Receptor-Dependent Up-Regulation of Cyclooxygenase-2 in Rats
J Pharmacol Exp Ther 2002 303: 1301-1308. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Francesco Giuliano and Timothy D. Warner

Origins of Prostaglandin E₂: Involvements of Cyclooxygenase (COX)-1 and COX-2 in Human and Rat Systems
J Pharmacol Exp Ther 2002 303: 1001-1006. [Abstract] [Full Text] [PDF]  

Shigeru Fukuda, Katsuo Midoro, Takayuki Kamei, Michiyo Gyoten, Yasuhiko Kawano, Yasuko Ashida, and Hideaki Nagaya

Inhibition of Allergic Dermal Inflammation by the Novel Imidazopyridazine Derivative TAK-427 in a Guinea Pig Experimental Model of Eczema
J Pharmacol Exp Ther 2002 303: 1283-1290. [Abstract] [Full Text] [PDF]  

Stephen Rapecki and Rodger Allen

Inhibition of Human T Cell Activation by Novel Src Kinase Inhibitors Is Dependent upon the Complexity of the Signal Delivered to the Cell
J Pharmacol Exp Ther 2002 303: 1325-1333. [Abstract] [Full Text] [PDF]  

K. Lea Sewell, Richard S. Geary, Brenda F. Baker, Josephine M. Glover, Timothy G. K. Mant, Rosie Z. Yu, Joseph A. Tami, and F. Andrew Dorr

Phase I Trial of ISIS 104838, a 2'-Methoxyethyl Modified Antisense Oligonucleotide Targeting Tumor Necrosis Factor-
J Pharmacol Exp Ther 2002 303: 1334-1343. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Lidia Serova and Esther L. Sabban

Involvement of 7 Nicotinic Acetylcholine Receptors in Gene Expression of Dopamine Biosynthetic Enzymes in Rat Brain
J Pharmacol Exp Ther 2002 303: 896-903. [Abstract] [Full Text] [PDF]  

Chad J. Swanson and Darryle D. Schoepp

The Group II Metabotropic Glutamate Receptor Agonist ()-2-Oxa-4-aminobicyclo[3.1.0.]hexane-4,6-dicarboxylate (LY379268) and Clozapine Reverse Phencyclidine-Induced Behaviors in Monoamine-Depleted Rats
J Pharmacol Exp Ther 2002 303: 919-927. [Abstract] [Full Text] [PDF]  

T. L. Crowder, O. J. Ariwodola, and J. L. Weiner

Ethanol Antagonizes Kainate Receptor-Mediated Inhibition of Evoked GABA_A Inhibitory Postsynaptic Currents in the Rat Hippocampal CA1 Region
J Pharmacol Exp Ther 2002 303: 937-944. [Abstract] [Full Text] [PDF]  

Matthew J. Hansard, Lance A. Smith, Michael J. Jackson, Sharon C. Cheetham, and Peter Jenner

Dopamine, but Not Norepinephrine or Serotonin, Reuptake Inhibition Reverses Motor Deficits in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Treated Primates
J Pharmacol Exp Ther 2002 303: 952-958. [Abstract] [Full Text] [PDF]  

Maria Paola Mascia, Francesca Biggio, Luisa Mancuso, Stefano Cabras, Pier Luigi Cocco, Giorgio Gorini, Annalisa Manca, Carla Marra, Robert H. Purdy, Paolo Follesa, and Giovanni Biggio

Changes in GABA_A Receptor Gene Expression Induced by Withdrawal of, but Not by Long-Term Exposure to, Ganaxolone in Cultured Rat Cerebellar Granule Cells
J Pharmacol Exp Ther 2002 303: 1014-1020. [Abstract] [Full Text] [PDF]  

Ghous M. Khan, De-Pei Li, Shao-Rui Chen, and Hui-Lin Pan

Role of Spinal Nitric Oxide in the Inhibitory Effect of [D-Pen², D-Pen⁵]-Enkephalin on Ascending Dorsal Horn Neurons in Normal and Diabetic Rats
J Pharmacol Exp Ther 2002 303: 1021-1028. [Abstract] [Full Text] [PDF]  

Jeffery J. Anderson, Sara P. Rao, Blake Rowe, Darlene R. Giracello, Greg Holtz, Deborah F. Chapman, Lida Tehrani, Margaret J. Bradbury, Nicholas D. P. Cosford, and Mark A. Varney

[³H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine Binding to Metabotropic Glutamate Receptor Subtype 5 in Rodent Brain: In Vitro and in Vivo Characterization
J Pharmacol Exp Ther 2002 303: 1044-1051. [Abstract] [Full Text] [PDF]  

Guy R. Seabrook, Kathy G. Sutton, Wolfgang Jarolimek, Gregory J. Hollingworth, Simon Teague, Janine Webb, Natalie Clark, Susan Boyce, Julie Kerby, Zahid Ali, Margaret Chou, Richard Middleton, Gregory Kaczorowski, and A. Brian Jones

Functional Properties of the High-Affinity TRPV1 (VR1) Vanilloid Receptor Antagonist (4-Hydroxy-5-iodo-3-methoxyphenylacetate ester) Iodo-Resiniferatoxin
J Pharmacol Exp Ther 2002 303: 1052-1060. [Abstract] [Full Text] [PDF]  

Amy C. Arai, Yan-Fang Xia, Gary Rogers, Gary Lynch, and Markus Kessler

Benzamide-Type AMPA Receptor Modulators Form Two Subfamilies with Distinct Modes of Action
J Pharmacol Exp Ther 2002 303: 1075-1085. [Abstract] [Full Text] [PDF]  

Gabriele Campana, Claudio Bucolo, Giovanna Murari, and Santi Spampinato

Ocular Hypotensive Action of Topical Flunarizine in the Rabbit: Role of ₁ Recognition Sites
J Pharmacol Exp Ther 2002 303: 1086-1094. [Abstract] [Full Text] [PDF]  

Klaas P. Zuideveld, Jasna Rusiç-Pavletiç, Hugo J. Maas, Lambertus A. Peletier, Piet H. Van der Graaf, and Meindert Danhof

Pharmacokinetic-Pharmacodynamic Modeling of Buspirone and Its Metabolite 1-(2-Pyrimidinyl)-piperazine in Rats
J Pharmacol Exp Ther 2002 303: 1130-1137. [Abstract] [Full Text] [PDF]  

Xavier Emonds-Alt, Vincenzo Proietto, Régis Steinberg, Florence Oury-Donat, Xavier Vigé, Pol Vilain, Emmanuel Naline, Samira Daoui, Charles Advenier, Gérard Le Fur, Jean-Pierre Maffrand, Philippe Soubrié, and Marc Pascal

SSR240600 [(R)-2-(1-{2-[4-{2-[3,5-Bis(trifluoromethyl)phenyl]acetyl}-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl}- 4-piperidinyl)-2-methylpropanamide], a Centrally Active Nonpeptide Antagonist of the Tachykinin Neurokinin-1 Receptor: I. Biochemical and Pharmacological Characterization
J Pharmacol Exp Ther 2002 303: 1171-1179. [Abstract] [Full Text] [PDF]  

Régis Steinberg, Richard Alonso, Liliane Rouquier, Christophe Desvignes, Jean-Claude Michaud, Annie Cudennec, Mireille Jung, Jacques Simiand, Guy Griebel, Xavier Emonds-Alt, Gérard Le Fur, and Philippe Soubrié

SSR240600 [(R)-2-(1-{2-[4-{2-[3,5-Bis(trifluoromethyl)phenyl]acetyl}-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl}-4-piperidinyl)-2-methylpropanamide], a Centrally Active Nonpeptide Antagonist of the Tachykinin Neurokinin 1 Receptor: II. Neurochemical and Behavioral Characterization
J Pharmacol Exp Ther 2002 303: 1180-1188. [Abstract] [Full Text] [PDF]  

Z. D. Luo, N. A. Calcutt, E. S. Higuera, C. R. Valder, Y.-H. Song, C. I. Svensson, and R. R. Myers

Injury Type-Specific Calcium Channel ₂-1 Subunit Up-Regulation in Rat Neuropathic Pain Models Correlates with Antiallodynic Effects of Gabapentin
J Pharmacol Exp Ther 2002 303: 1199-1205. [Abstract] [Full Text] [PDF]  

Minoru Takebayashi, Teruo Hayashi, and Tsung-Ping Su

Nerve Growth Factor-Induced Neurite Sprouting in PC12 Cells Involves -1 Receptors: Implications for Antidepressants
J Pharmacol Exp Ther 2002 303: 1227-1237. [Abstract] [Full Text] [PDF]  

Marko Huotari, Miklos Santha, Louis R. Lucas, Maria Karayiorgou, Joseph A. Gogos, and Pekka T. Männistö

Effect of Dopamine Uptake Inhibition on Brain Catecholamine Levels and Locomotion in Catechol-O-methyltransferase-Disrupted Mice
J Pharmacol Exp Ther 2002 303: 1309-1316. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Daniel S. Perrien, Elizabeth C. Brown, Terry W. Fletcher, David J. Irby, James Aronson, Guan G. Gao, Robert A. Skinner, William R. Hogue, Ulrich Feige, Larry J. Suva, Martin J. J. Ronis, Thomas M. Badger, and Charles K. Lumpkin, Jr.

Interleukin-1 and Tumor Necrosis Factor Antagonists Attenuate Ethanol-Induced Inhibition of Bone Formation in a Rat Model of Distraction Osteogenesis
J Pharmacol Exp Ther 2002 303: 904-908. [Abstract] [Full Text] [PDF]  

Emilio Salceda, Anoland Garateix, and Enrique Soto

The Sea Anemone Toxins BgII and BgIII Prolong the Inactivation Time Course of the Tetrodotoxin-Sensitive Sodium Current in Rat Dorsal Root Ganglion Neurons
J Pharmacol Exp Ther 2002 303: 1067-1074. [Abstract] [Full Text] [PDF]  

Laura J. C. Bolchoz, Andrew K. Gelasco, David J. Jollow, and David C. McMillan

Primaquine-Induced Hemolytic Anemia: Formation of Free Radicals in Rat Erythrocytes Exposed to 6-Methoxy-8-hydroxylaminoquinoline
J Pharmacol Exp Ther 2002 303: 1121-1129. [Abstract] [Full Text] [PDF]  

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