PERSPECTIVES IN PHARMACOLOGY:

Stata Norton

Experimental Therapeutics in the Renaissance
J Pharmacol Exp Ther 2003 304: 489-492. [Abstract] [Full Text] [PDF]  

Yoichi Osawa, Ezra R. Lowe, Andrew C. Everett, Anwar Y. Dunbar, and Scott S. Billecke

Proteolytic Degradation of Nitric Oxide Synthase: Effect of Inhibitors and Role of hsp90-Based Chaperones
J Pharmacol Exp Ther 2003 304: 493-497. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Markus Forsberg, Marko Lehtonen, Minna Heikkinen, Jouko Savolainen, Tomi Järvinen, and Pekka T. Männistö

Pharmacokinetics and Pharmacodynamics of Entacapone and Tolcapone after Acute and Repeated Administration: A Comparative Study in the Rat
J Pharmacol Exp Ther 2003 304: 498-506. [Abstract] [Full Text] [PDF]  

Maarten T. Huisman, Johan W. Smit, Hugh R. Wiltshire, Jos H. Beijnen, and Alfred H. Schinkel

Assessing Safety and Efficacy of Directed P-Glycoprotein Inhibition to Improve the Pharmacokinetic Properties of Saquinavir Coadministered with Ritonavir
J Pharmacol Exp Ther 2003 304: 596-602. [Abstract] [Full Text] [PDF]  

Yoshihisa Shitara, Tomoo Itoh, Hitoshi Sato, Albert P. Li, and Yuichi Sugiyama

Inhibition of Transporter-Mediated Hepatic Uptake as a Mechanism for Drug-Drug Interaction between Cerivastatin and Cyclosporin A
J Pharmacol Exp Ther 2003 304: 610-616. [Abstract] [Full Text] [PDF]  

Elaine M. Leslie, Raymond J. Bowers, Roger G. Deeley, and Susan P. C. Cole

Structural Requirements for Functional Interaction of Glutathione Tripeptide Analogs with the Human Multidrug Resistance Protein 1 (MRP1)
J Pharmacol Exp Ther 2003 304: 643-653. [Abstract] [Full Text] [PDF]  

Janne Hukkanen, Teemu Väisänen, Arja Lassila, Ritva Piipari, Sisko Anttila, Olavi Pelkonen, Hannu Raunio, and Jukka Hakkola

Regulation of CYP3A5 by Glucocorticoids and Cigarette Smoke in Human Lung-Derived Cells
J Pharmacol Exp Ther 2003 304: 745-752. [Abstract] [Full Text] [PDF]  

Seong Hoon Jang, M. Guillaume Wientjes, and Jessie L.-S. Au

Interdependent Effect of P-Glycoprotein-Mediated Drug Efflux and Intracellular Drug Binding on Intracellular Paclitaxel Pharmacokinetics: Application of Computational Modeling
J Pharmacol Exp Ther 2003 304: 773-780. [Abstract] [Full Text] [PDF]  

Banmeet S. Anand, Jignesh Patel, and Ashim K. Mitra

Interactions of the Dipeptide Ester Prodrugs of Acyclovir with the Intestinal Oligopeptide Transporter: Competitive Inhibition of Glycylsarcosine Transport in Human Intestinal Cell Line-Caco-2
J Pharmacol Exp Ther 2003 304: 781-791. [Abstract] [Full Text] [PDF]  

Maciej J. Zamek-Gliszczynski, Hao Xiong, Nita J. Patel, Ryan Z. Turncliff, Gary M. Pollack, and Kim L. R. Brouwer

Pharmacokinetics of 5 (and 6)-Carboxy-2',7'-Dichlorofluorescein and Its Diacetate Promoiety in the Liver
J Pharmacol Exp Ther 2003 304: 801-809. [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Mikhail Kalinichev and Stephen G. Holtzman

Changes in Urination/Defecation, Auditory Startle Response, and Startle-Induced Ultrasonic Vocalizations in Rats Undergoing Morphine Withdrawal: Similarities and Differences between Acute and Chronic Dependence
J Pharmacol Exp Ther 2003 304: 603-609. [Abstract] [Full Text] [PDF]  

David A. Gutman, Michael J. Owens, Kelly H. Skelton, K. V. Thrivikraman, and Charles B. Nemeroff

The Corticotropin-Releasing Factor₁ Receptor Antagonist R121919 Attenuates the Behavioral and Endocrine Responses to Stress
J Pharmacol Exp Ther 2003 304: 874-880. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Adebayo O. Oyekan

Contributions of Nitric Oxide and Prostanoids and Their Signaling Pathways to the Renal Medullary Vasodilator Effect of U46619 (9-11-Dideoxy-11,9a-Epoxymethano-Prostaglandin F_2a) in the Rat
J Pharmacol Exp Ther 2003 304: 507-512. [Abstract] [Full Text] [PDF]  

J. Lorrain, L. Millet, I. Lechaire, S. Lochot, P. Ferrari, C. Visconte, M. Sainte-Marie, C. Lunven, C. N. Berry, P. Schaeffer, J.-M. Herbert, and S. E. O'Connor

Antithrombotic Properties of SSR182289A, a New, Orally Active Thrombin Inhibitor
J Pharmacol Exp Ther 2003 304: 567-574. [Abstract] [Full Text] [PDF]  

Hongkui Jin, Renhui Yang, Wei Li, Annie K. Ogasawara, Ralph Schwall, David A. Eberhard, Zhong Zheng, David Kahn, and Nicholas F. Paoni

Early Treatment with Hepatocyte Growth Factor Improves Cardiac Function in Experimental Heart Failure Induced by Myocardial Infarction
J Pharmacol Exp Ther 2003 304: 654-660. [Abstract] [Full Text] [PDF]  

Han Choe, Yu-Kyung Lee, Yong-Tae Lee, Huhn Choe, Seong-Hoon Ko, Chan-Uhng Joo, Min-Ho Kim, Gong-Soo Kim, Jae-Soon Eun, Jong-Hyun Kim, Soo-Wan Chae, and Yong-Geun Kwak

Papaverine Blocks hKv1.5 Channel Current and Human Atrial Ultrarapid Delayed Rectifier K⁺ Currents
J Pharmacol Exp Ther 2003 304: 706-712. [Abstract] [Full Text] [PDF]  

Shailaja Kalyankrishna and Kafait U. Malik

Norepinephrine-Induced Stimulation of p38 Mitogen-Activated Protein Kinase Is Mediated by Arachidonic Acid Metabolites Generated by Activation of Cytosolic Phospholipase A₂ in Vascular Smooth Muscle Cells
J Pharmacol Exp Ther 2003 304: 761-772. [Abstract] [Full Text] [PDF]  

Shinji Takai, Hiroshi Sakonjo, Kohzo Fukuda, Denan Jin, Masato Sakaguchi, Keiichi Kamoshita, Koichi Ishida, Yoshikazu Sukenaga, and Mizuo Miyazaki

A Novel Chymase Inhibitor, 2-(5-Formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[{3,4-dioxo-1-phenyl-7-(2-pyridyloxy)}-2-heptyl]acetamide (NK3201), Suppressed Intimal Hyperplasia after Balloon Injury
J Pharmacol Exp Ther 2003 304: 841-844. [Abstract] [Full Text] [PDF]  

Claudia K. Derian, Bruce P. Damiano, Michael F. Addo, Andrew L. Darrow, Michael R. D'Andrea, Mark Nedelman, Han-Cheng Zhang, Bruce E. Maryanoff, and Patricia Andrade-Gordon

Blockade of the Thrombin Receptor Protease-Activated Receptor-1 with a Small-Molecule Antagonist Prevents Thrombus Formation and Vascular Occlusion in Nonhuman Primates
J Pharmacol Exp Ther 2003 304: 855-861. [Abstract] [Full Text] [PDF]  

Ignacio Moreno, Ricardo Caballero, Teresa González, Cristina Arias, Carmen Valenzuela, Isabel Iriepa, Enrique Gálvez, Juan Tamargo, and Eva Delpón

Effects of Irbesartan on Cloned Potassium Channels Involved in Human Cardiac Repolarization
J Pharmacol Exp Ther 2003 304: 862-873. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Baoyong Sun, Carol R. Sterling, and A. William Tank

Chronic Nicotine Treatment Leads to Sustained Stimulation of Tyrosine Hydroxylase Gene Transcription Rate in Rat Adrenal Medulla
J Pharmacol Exp Ther 2003 304: 575-588. [Abstract] [Full Text] [PDF]  

Rita Pepponi, Giancarlo Marra, Maria Pia Fuggetta, Sabrina Falcinelli, Elena Pagani, Enzo Bonmassar, Josef Jiricny, and Stefania D'Atri

The Effect of O⁶-Alkylguanine-DNA Alkyltransferase and Mismatch Repair Activities on the Sensitivity of Human Melanoma Cells to Temozolomide, 1,3-bis(2-Chloroethyl)1-nitrosourea, and Cisplatin
J Pharmacol Exp Ther 2003 304: 661-668. [Abstract] [Full Text] [PDF]  

Peter D. Ward, Hui Ouyang, and Dhiren R. Thakker

Role of Phospholipase C- in the Modulation of Epithelial Tight Junction Permeability
J Pharmacol Exp Ther 2003 304: 689-698. [Abstract] [Full Text] [PDF]  

Efstathia Giannopoulou, Panagiotis Katsoris, Dimitris Kardamakis, and Evangelia Papadimitriou

Amifostine Inhibits Angiogenesis in Vivo
J Pharmacol Exp Ther 2003 304: 729-737. [Abstract] [Full Text] [PDF]  

Min Huang, Yanhong Wang, Susan B. Cogut, Beverly S. Mitchell, and Lee M. Graves

Inhibition of Nucleoside Transport by Protein Kinase Inhibitors
J Pharmacol Exp Ther 2003 304: 753-760. [Abstract] [Full Text] [PDF]  

Dirk Gründemann, Christian Hahne, Reinhard Berkels, and Edgar Schömig

Agmatine Is Efficiently Transported by Non-Neuronal Monoamine Transporters Extraneuronal Monoamine Transporter (EMT) and Organic Cation Transporter 2 (OCT2)
J Pharmacol Exp Ther 2003 304: 810-817. [Abstract] [Full Text] [PDF]  

Stefanie De Schepper, Hélène Bruwiere, Tinne Verhulst, Ulf Steller, Luc Andries, Walter Wouters, Michel Janicot, Janine Arts, and Jim Van heusden

Inhibition of Histone Deacetylases by Chlamydocin Induces Apoptosis and Proteasome-Mediated Degradation of Survivin
J Pharmacol Exp Ther 2003 304: 881-888. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Satoru Koyanagi, Hiroo Nakagawa, Yukako Kuramoto, Shigehiro Ohdo, Shinji Soeda, and Hiroshi Shimeno

Optimizing the Dosing Schedule of TNP-470 [O-(Chloroacetyl-carbamoyl) Fumagillol] Enhances Its Antitumor and Antiangiogenic Efficacies
J Pharmacol Exp Ther 2003 304: 669-674. [Abstract] [Full Text] [PDF]  

Monika Wierdl, Christopher L. Morton, Linda C. Harris, Mary K. Danks, John D. Schuetz, and Philip M. Potter

p53-Mediated Regulation of Expression of a Rabbit Liver Carboxylesterase Confers Sensitivity to 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11)
J Pharmacol Exp Ther 2003 304: 699-705. [Abstract] [Full Text] [PDF]  

Lynn O. Post, Dorothy E. Farrell, Carol V. Cope, John D. Baker, and Michael J. Myers

The Effect of Endotoxin and Dexamethasone on Enrofloxacin Pharmacokinetic Parameters in Swine
J Pharmacol Exp Ther 2003 304: 889-895. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Monika Hitzl, Kathrin Klein, Ulrich M. Zanger, Peter Fritz, Andreas K. Nüssler, Peter Neuhaus, and Martin F. Fromm

Influence of Omeprazole on Multidrug Resistance Protein 3 Expression in Human Liver
J Pharmacol Exp Ther 2003 304: 524-530. [Abstract] [Full Text] [PDF]  

Carlotta E. Groves, Lynn Muñoz, Andrew Bahn, Gerhard Burckhardt, and Stephen H. Wright

Interaction of Cysteine Conjugates with Human and Rabbit Organic Anion Transporter 1
J Pharmacol Exp Ther 2003 304: 560-566. [Abstract] [Full Text] [PDF]  

Peter W. Stengel and Marlene L. Cohen

M₁ Receptor-Mediated Nitric Oxide-Dependent Relaxation Unmasked in Stomach Fundus from M₃ Receptor Knockout Mice
J Pharmacol Exp Ther 2003 304: 675-682. [Abstract] [Full Text] [PDF]  

Kenta Nishiki, Shuichi Tsuruoka, Atsuhiro Kawaguchi, Kohichi Sugimoto, George J. Schwartz, Makoto Suzuki, Masashi Imai, and Akio Fujimura

Inhibition of Rho-Kinase Reduces Renal Na-H Exchanger Activity and Causes Natriuresis in Rat
J Pharmacol Exp Ther 2003 304: 723-728. [Abstract] [Full Text] [PDF]  

Tong Wang

The Effects of the Potassium Channel Opener Minoxidil on Renal Electrolytes Transport in the Loop of Henle
J Pharmacol Exp Ther 2003 304: 833-840. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

David M. Aronoff, Olivier Boutaud, Lawrence J. Marnett, and John A. Oates

Inhibition of Prostaglandin H₂ Synthases by Salicylate Is Dependent on the Oxidative State of the Enzymes
J Pharmacol Exp Ther 2003 304: 589-595. [Abstract] [Full Text] [PDF]  

Toshihiko Morichika, Hideo Kohka Takahashi, Hiromi Iwagaki, Tadashi Yoshino, Ryuji Tamura, Minori Yokoyama, Shuji Mori, Tadaatsu Akagi, Masahiro Nishibori, and Noriaki Tanaka

Histamine Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor- Production in an Intercellular Adhesion Molecule-1- and B7.1-Dependent Manner
J Pharmacol Exp Ther 2003 304: 624-633. [Abstract] [Full Text] [PDF]  

Hideo Kohka Takahashi, Toshihiko Morichika, Hiromi Iwagaki, Tadashi Yoshino, Ryuji Tamura, Shinnya Saito, Shuji Mori, Tadaatsu Akagi, Noriaki Tanaka, and Masahiro Nishibori

Effect of 2-Adrenergic Receptor Stimulation on Interleukin-18-Induced Intercellular Adhesion Molecule-1 Expression and Cytokine Production
J Pharmacol Exp Ther 2003 304: 634-642. [Abstract] [Full Text] [PDF]  

Douglas C. McVey, Patricia C. Schmid, Harald H. O. Schmid, and Steven R. Vigna

Endocannabinoids Induce Ileitis in Rats via the Capsaicin Receptor (VR1)
J Pharmacol Exp Ther 2003 304: 713-722. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Satoshi Takeo, Tomoko Fukatsu, Keiko Miyake-Takagi, Norio Takagi, Makiko Niimura, Akira Nagakura, Tsuyoshi Ando, and Kouichi Tanonaka

Persistent Effects of Delayed Treatment with Nefiracetam on the Water Maze Task in Rats with Sustained Cerebral Ischemia
J Pharmacol Exp Ther 2003 304: 513-523. [Abstract] [Full Text] [PDF]  

J. P. Beekwilder, M. E. O'Leary, L. P. van den Broek, G. Th. H. Van Kempen, D. L. Ypey, and R. J. Van den Berg

Kv1.1 Channels of Dorsal Root Ganglion Neurons Are Inhibited by n-Butyl-p-aminobenzoate, a Promising Anesthetic for the Treatment of Chronic Pain
J Pharmacol Exp Ther 2003 304: 531-538. [Abstract] [Full Text] [PDF]  

Ai-Ming Yu, Camille P. Granvil, Robert L. Haining, Kristopher W. Krausz, Javier Corchero, Adrian Küpfer, Jeffrey R. Idle, and Frank J. Gonzalez

The Relative Contribution of Monoamine Oxidase and Cytochrome P450 Isozymes to the Metabolic Deamination of the Trace Amine Tryptamine
J Pharmacol Exp Ther 2003 304: 539-546. [Abstract] [Full Text] [PDF]  

Sonya G. Wilson, Shad B. Smith, Elissa J. Chesler, Kimberly A. Melton, Jeremiah J. Haas, Bryan Mitton, Kate Strasburg, Lawrence Hubert, Sandra L. Rodriguez-Zas, and Jeffrey S. Mogil

The Heritability of Antinociception: Common Pharmacogenetic Mediation of Five Neurochemically Distinct Analgesics
J Pharmacol Exp Ther 2003 304: 547-559. [Abstract] [Full Text] [PDF]  

Leela Cherian, Geeta Chacko, Clay Goodman, and Claudia S. Robertson

Neuroprotective Effects of L-Arginine Administration after Cortical Impact Injury in Rats: Dose Response and Time Window
J Pharmacol Exp Ther 2003 304: 617-623. [Abstract] [Full Text] [PDF]  

Keiko Hosohata, Eva V. Varga, Josue Alfaro-Lopez, Xuejun Tang, Todd W. Vanderah, Frank Porreca, Victor J. Hruby, William R. Roeske, and Henry I. Yamamura

(2S,3R)-Methyl-2',6'-dimethyltyrosine-L-tetrahydroisoquinoline-3-carboxylic acid [(2S,3R)TMT-L-Tic-OH] Is a Potent, Selective -Opioid Receptor Antagonist in Mouse Brain
J Pharmacol Exp Ther 2003 304: 683-688. [Abstract] [Full Text] [PDF]  

Daya S. Gupta and Alan R. Gintzler

Influence of Ovarian Sex Steroids on Spinal Methionine-Enkephalin Release: Comparison with Dynorphin Reveals Asymmetrical Regulation
J Pharmacol Exp Ther 2003 304: 738-744. [Abstract] [Full Text] [PDF]  

Catherine Mytilineou, Ruth H. Walker, Ruth JnoBaptiste, and C. Warren Olanow

Levodopa Is Toxic to Dopamine Neurons in an in Vitro but Not an in Vivo Model of Oxidative Stress
J Pharmacol Exp Ther 2003 304: 792-800. [Abstract] [Full Text] [PDF]  

Shigeyuki Chaki, Shiho Hirota, Takeo Funakoshi, Yoshiko Suzuki, Sayoko Suetake, Taketoshi Okubo, Takaaki Ishii, Atsuro Nakazato, and Shigeru Okuyama

Anxiolytic-Like and Antidepressant-Like Activities of MCL0129 (1-[(S)-2-(4-Fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine), a Novel and Potent Nonpeptide Antagonist of the Melanocortin-4 Receptor
J Pharmacol Exp Ther 2003 304: 818-826. [Abstract] [Full Text] [PDF]  

Camilla I. Svensson, Yosup Rew, Shelle Malkmus, Peter W. Schiller, Joseph P. Taulane, Murray Goodman, and Tony L. Yaksh

Systemic and Spinal Analgesic Activity of a -Opioid-Selective Lanthionine Enkephalin Analog
J Pharmacol Exp Ther 2003 304: 827-832. [Abstract] [Full Text] [PDF]  

Elena V. Batrakova, Shu Li, Valery Yu Alakhov, Donald W. Miller, and Alexander V. Kabanov

Optimal Structure Requirements for Pluronic Block Copolymers in Modifying P-glycoprotein Drug Efflux Transporter Activity in Bovine Brain Microvessel Endothelial Cells
J Pharmacol Exp Ther 2003 304: 845-854. [Abstract] [Full Text] [PDF]  

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