PERSPECTIVES IN PHARMACOLOGY:

Roxanne A. Vaughan

Phosphorylation and Regulation of Psychostimulant-Sensitive Neurotransmitter Transporters
J Pharmacol Exp Ther 2004 310: 1-7. Published online April 2, 2004; 10.1124/jpet.103.052423 [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Daphne Chan, Brenda Knie, Rada Boskovic, and Gideon Koren

Placental Handling of Fatty Acid Ethyl Esters: Perfusion and Subcellular Studies
J Pharmacol Exp Ther 2004 310: 75-82. Published online March 5, 2004; 10.1124/jpet.104.066597 [Abstract] [Full Text] [PDF]  

Yoshiharu Deguchi, Yu Naito, Sumio Ohtsuki, Yusaku Miyakawa, Kazuhiro Morimoto, Ken-ichi Hosoya, Shinobu Sakurada, and Tetsuya Terasaki

Blood-Brain Barrier Permeability of Novel [D-Arg²]Dermorphin (1-4) Analogs: Transport Property Is Related to the Slow Onset of Antinociceptive Activity in the Central Nervous System
J Pharmacol Exp Ther 2004 310: 177-184. Published online March 18, 2004; 10.1124/jpet.103.064006 [Abstract] [Full Text] [PDF]  

N. H. Al-Huniti, J. A. Widness, R. L. Schmidt, and P. Veng-Pedersen

Pharmacokinetic/Pharmacodynamic Analysis of Paradoxal Regulation of Erythropoietin Production in Acute Anemia
J Pharmacol Exp Ther 2004 310: 202-208. Published online February 26, 2004; 10.1124/jpet.104.066027 [Abstract] [Full Text] [PDF]  

Rong Hu, Vidya Hebbar, Bok-Ryang Kim, Chi Chen, Bozena Winnik, Brian Buckley, Patricia Soteropoulos, Peter Tolias, Ronald P. Hart, and A.-N. Tony Kong

In Vivo Pharmacokinetics and Regulation of Gene Expression Profiles by Isothiocyanate Sulforaphane in the Rat
J Pharmacol Exp Ther 2004 310: 263-271. Published online February 26, 2004; 10.1124/jpet.103.064261 [Abstract] [Full Text] [PDF]  

Anna L. Blobaum, Ute M. Kent, William L. Alworth, and Paul F. Hollenberg

Novel Reversible Inactivation of Cytochrome P450 2E1 T303A by tert-Butyl Acetylene: The Role of Threonine 303 in Proton Delivery to the Active Site of Cytochrome P450 2E1
J Pharmacol Exp Ther 2004 310: 281-290. Published online February 26, 2004; 10.1124/jpet.104.065508 [Abstract] [Full Text] [PDF]  

Anshul Gupta, Yi Zhang, Jashvant D. Unadkat, and Qingcheng Mao

HIV Protease Inhibitors Are Inhibitors but Not Substrates of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)
J Pharmacol Exp Ther 2004 310: 334-341. Published online March 8, 2004; 10.1124/jpet.104.065342 [Abstract] [Full Text] [PDF]  

Patrick J. Sinko, Jeevan R. Kunta, Helen H. Usansky, and Barbara A. Perry

Differentiation of Gut and Hepatic First Pass Metabolism and Secretion of Saquinavir in Ported Rabbits
J Pharmacol Exp Ther 2004 310: 359-366. Published online March 5, 2004; 10.1124/jpet.103.064394 [Abstract] [Full Text] [PDF]  

Eun Ju Jeong, Huimin Lin, and Ming Hu

Disposition Mechanisms of Raloxifene in the Human Intestinal Caco-2 Model
J Pharmacol Exp Ther 2004 310: 376-385. Published online March 12, 2004; 10.1124/jpet.103.063925 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Ellen A. Walker, Mitchell J. Picker, Arthur Granger, and Linda A. Dykstra

Effects of Opioids in Morphine-Treated Pigeons Trained to Discriminate among Morphine, the Low-Efficacy Agonist Nalbuphine, and Saline
J Pharmacol Exp Ther 2004 310: 150-158. Published online March 25, 2004; 10.1124/jpet.103.058503 [Abstract] [Full Text] [PDF]  

M. C. H. Ko, M. S. Song, T. Edwards, H. Lee, and N. N. Naughton

The Role of Central µ Opioid Receptors in Opioid-Induced Itch in Primates
J Pharmacol Exp Ther 2004 310: 169-176. Published online March 25, 2004; 10.1124/jpet.103.061101 [Abstract] [Full Text] [PDF]  

Toni L. Jones and Linda S. Sorkin

Calcium-Permeable -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/Kainate Receptors Mediate Development, but Not Maintenance, of Secondary Allodynia Evoked by First-Degree Burn in the Rat
J Pharmacol Exp Ther 2004 310: 223-229. Published online March 8, 2004; 10.1124/jpet.103.064741 [Abstract] [Full Text] [PDF]  

Todd W. Vanderah, Claudio D. Schteingart, Jerzy Trojnar, Jean-Louis Junien, Josephine Lai, and Pierre J.-M. Riviere

FE200041 (D-Phe-D-Phe-D-Nle-D-Arg-NH₂): A Peripheral Efficacious Opioid Agonist with Unprecedented Selectivity
J Pharmacol Exp Ther 2004 310: 326-333. Published online March 1, 2004; 10.1124/jpet.104.065391 [Abstract] [Full Text] [PDF]  

James K. Rowlett, Donna M. Platt, and Roger D. Spealman

Cocaine-Like Discriminative Stimulus Effects of Heroin: Modulation by Selective Monoamine Transport Inhibitors
J Pharmacol Exp Ther 2004 310: 342-348. Published online February 25, 2004; 10.1124/jpet.104.065631 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Ying Xia and Morris Karmazyn

Obligatory Role for Endogenous Endothelin in Mediating the Hypertrophic Effects of Phenylephrine and Angiotensin II in Neonatal Rat Ventricular Myocytes: Evidence for Two Distinct Mechanisms for Endothelin Regulation
J Pharmacol Exp Ther 2004 310: 43-51. Published online March 8, 2004; 10.1124/jpet.104.065185 [Abstract] [Full Text] [PDF]  

Md. Shah Amran, Keitaro Hashimoto, and Nobuo Homma

Effects of Sodium-Calcium Exchange Inhibitors, KB-R7943 and SEA0400, on Aconitine-Induced Arrhythmias in Guinea Pigs in Vivo, in Vitro, and in Computer Simulation Studies
J Pharmacol Exp Ther 2004 310: 83-89. Published online March 17, 2004; 10.1124/jpet.104.066951 [Abstract] [Full Text] [PDF]  

Christopher G. Sobey, Jane M. Weiler, Mirna Boujaoude, and Owen L. Woodman

Effect of Short-Term Phytoestrogen Treatment in Male Rats on Nitric Oxide-Mediated Responses of Carotid and Cerebral Arteries: Comparison with 17-Estradiol
J Pharmacol Exp Ther 2004 310: 135-140. Published online March 30, 2004; 10.1124/jpet.103.063255 [Abstract] [Full Text] [PDF]  

Javier Angulo, Pedro Cuevas, Begoña Cuevas, Sandeep Gupta, and Iñigo Sáenz de Tejada

Mechanisms for the Inhibition of Genital Vascular Responses by Antidepressants in a Female Rabbit Model
J Pharmacol Exp Ther 2004 310: 141-149. Published online March 19, 2004; 10.1124/jpet.103.063362 [Abstract] [Full Text] [PDF]  

Eric R. Gross, Anna K. Hsu, and Garrett J. Gross

Acute Aspirin Treatment Abolishes, whereas Acute Ibuprofen Treatment Enhances Morphine-Induced Cardioprotection: Role of 12-Lipoxygenase
J Pharmacol Exp Ther 2004 310: 185-191. Published online March 1, 2004; 10.1124/jpet.103.064667 [Abstract] [Full Text] [PDF]  

Fraser D. Russell, Philip Kearns, Istvan Toth, and Peter Molenaar

Urotensin-II-Converting Enzyme Activity of Furin and Trypsin in Human Cells in Vitro
J Pharmacol Exp Ther 2004 310: 209-214. Published online March 8, 2004; 10.1124/jpet.104.065425 [Abstract] [Full Text] [PDF]  

Bjorn C. Knollmann, Mathew C. Casimiro, Alexander N. Katchman, Syevda G. Sirenko, Tilmann Schober, Qi Rong, Karl Pfeifer, and Steven N. Ebert

Isoproterenol Exacerbates a Long QT Phenotype in Kcnq1-Deficient Neonatal Mice: Possible Roles for Human-Like Kcnq1 Isoform 1 and Slow Delayed Rectifier K⁺ Current
J Pharmacol Exp Ther 2004 310: 311-318. Published online March 5, 2004; 10.1124/jpet.103.063743 [Abstract] [Full Text] [PDF]  

Mark A. Pullen, David P Brooks, and Richard M. Edwards

Characterization of the Neutralizing Activity of Digoxin-Specific Fab toward Ouabain-Like Steroids
J Pharmacol Exp Ther 2004 310: 319-325. Published online February 24, 2004; 10.1124/jpet.104.065250 [Abstract] [Full Text] [PDF]  

Travis C. Jackson, Zaichuan Mi, and Edwin K. Jackson

Modulation of Cyclic AMP Production by Signal Transduction Pathways in Preglomerular Microvessels and Microvascular Smooth Muscle Cells
J Pharmacol Exp Ther 2004 310: 349-358. Published online April 15, 2004; 10.1124/jpet.103.063081 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Peter T. Toth, Dongjun Ren, and Richard J. Miller

Regulation of CXCR4 Receptor Dimerization by the Chemokine SDF-1 and the HIV-1 Coat Protein gp120: A Fluorescence Resonance Energy Transfer (FRET) Study
J Pharmacol Exp Ther 2004 310: 8-17. Published online March 10, 2004; 10.1124/jpet.103.064956 [Abstract] [Full Text] [PDF]  

Run-Hua Liu, Masanari Mizuta, and Shigeru Matsukura

The Expression and Functional Role of Nicotinic Acetylcholine Receptors in Rat Adipocytes
J Pharmacol Exp Ther 2004 310: 52-58. Published online March 1, 2004; 10.1124/jpet.103.065037 [Abstract] [Full Text] [PDF]  

Medhane G. Cumbay and Val J. Watts

Novel Regulatory Properties of Human Type 9 Adenylate Cyclase
J Pharmacol Exp Ther 2004 310: 108-115. Published online March 2, 2004; 10.1124/jpet.104.065748 [Abstract] [Full Text] [PDF]  

Mary J. Clark, Richard R. Neubig, and John R. Traynor

Endogenous Regulator of G Protein Signaling Proteins Suppress Go-Dependent, µ-Opioid Agonist-Mediated Adenylyl Cyclase Supersensitization
J Pharmacol Exp Ther 2004 310: 215-222. Published online March 10, 2004; 10.1124/jpet.103.064824 [Abstract] [Full Text] [PDF]  

Angel Y. F. Kam, Anthony S. L. Chan, and Yung H. Wong

-Opioid Receptor Signals through Src and Focal Adhesion Kinase to Stimulate c-Jun N-Terminal Kinases in Transfected COS-7 Cells and Human Monocytic THP-1 Cells
J Pharmacol Exp Ther 2004 310: 301-310. Published online March 2, 2004; 10.1124/jpet.104.065078 [Abstract] [Full Text] [PDF]  

Guillaume Morissette, Emmanuel Moreau, René C.-Gaudreault, and François Marceau

Massive Cell Vacuolization Induced by Organic Amines Such as Procainamide
J Pharmacol Exp Ther 2004 310: 395-406. Published online March 8, 2004; 10.1124/jpet.104.066084 [Abstract] [Full Text] [PDF] VIDEO  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Manu Hegde, Jane Roscoe, Peter Cala, and Fredric Gorin

Amiloride Kills Malignant Glioma Cells Independent of Its Inhibition of the Sodium-Hydrogen Exchanger
J Pharmacol Exp Ther 2004 310: 67-74. Published online March 9, 2004; 10.1124/jpet.103.065029 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Tomasz Brzozowski, Peter C. Konturek, Anthony P. Moran, Robert Pajdo, Slawomir Kwiecien, Stanislaw J. Konturek, Zbigniew Sliwowski, Danuta Drozdowicz, Wieslaw W. Pawlik, and Eckhart G. Hahn

Involvement of Capsaicin-Sensitive Afferent Nerves and Cholecystokinin 2/Gastrin Receptors in Gastroprotection and Adaptation of Gastric Mucosa to Helicobacter pylori-Lipopolysaccharide
J Pharmacol Exp Ther 2004 310: 116-125. Published online March 15, 2004; 10.1124/jpet.104.065128 [Abstract] [Full Text] [PDF]  

Brian S. Cummings, Gilbert R. Kinsey, Laura J. C. Bolchoz, and Rick G. Schnellmann

Identification of Caspase-Independent Apoptosis in Epithelial and Cancer Cells
J Pharmacol Exp Ther 2004 310: 126-134. Published online March 17, 2004; 10.1124/jpet.104.065862 [Abstract] [Full Text] [PDF]  

Vincent Lagente, Emmanuel Naline, Isabelle Guenon, Marianne Corbel, Elisabeth Boichot, Jean-Luc Burgaud, Piero Del Soldato, and Charles Advenier

A Nitric Oxide-Releasing Salbutamol Elicits Potent Relaxant and Anti-Inflammatory Activities
J Pharmacol Exp Ther 2004 310: 367-375. Published online April 14, 2004; 10.1124/jpet.103.061739 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Stephen J. Getting, Clara Di Filippo, Connie W. Lam, Francesco Rossi, and Michele D'Amico

Investigation into the Potential Anti-Inflammatory Effects of Endothelin Antagonists in a Murine Model of Experimental Monosodium Urate Peritonitis
J Pharmacol Exp Ther 2004 310: 90-97. Published online March 2, 2004; 10.1124/jpet.104.065573 [Abstract] [Full Text] [PDF]  

Balazs Veres, Balazs Radnai, Ferenc Gallyas, Jr., Gabor Varbiro, Zoltan Berente, Erzsebet Osz, and Balazs Sumegi

Regulation of Kinase Cascades and Transcription Factors by a Poly(ADP-Ribose) Polymerase-1 Inhibitor, 4-Hydroxyquinazoline, in Lipopolysaccharide-Induced Inflammation in Mice
J Pharmacol Exp Ther 2004 310: 247-255. Published online March 3, 2004; 10.1124/jpet.104.065151 [Abstract] [Full Text] [PDF]  

Keisuke Takeshita, Kevin B. Bacon, and Florian Gantner

Critical Role of L-Selectin and Histamine H4 Receptor in Zymosan-Induced Neutrophil Recruitment from the Bone Marrow: Comparison with Carrageenan
J Pharmacol Exp Ther 2004 310: 272-280. Published online March 2, 2004; 10.1124/jpet.103.063776 [Abstract] [Full Text] [PDF]  

R. William Hipkin, Gregory Deno, Jay Fine, Yongliang Sun, Brian Wilburn, Xuedong Fan, Waldemar Gonsiorek, and Maria T. Wiekowski

Cloning and Pharmacological Characterization of CXCR1 and CXCR2 from Macaca fascicularis
J Pharmacol Exp Ther 2004 310: 291-300. Published online March 17, 2004; 10.1124/jpet.103.063131 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Sonia Carboni, Agnes Hiver, Cedric Szyndralewiez, Pascale Gaillard, Jean-Pierre Gotteland, and Pierre-Alain Vitte

AS601245 (1,3-Benzothiazol-2-yl (2-{[2-(3-pyridinyl) ethyl] amino}-4 pyrimidinyl) Acetonitrile): A c-Jun NH₂-Terminal Protein Kinase Inhibitor with Neuroprotective Properties
J Pharmacol Exp Ther 2004 310: 25-32. Published online February 26, 2004; 10.1124/jpet.103.064246 [Abstract] [Full Text] [PDF]  

Yahong Zhang, Thackery S. Gray, Deborah N. D'Souza, Gonzalo A. Carrasco, Katerina J. Damjanoska, Bertalan Dudas, Francisca Garcia, Gina M. Zainelli, Nicole R. Sullivan Hanley, George Battaglia, Nancy A. Muma, and Louis D. Van de Kar

Desensitization of 5-HT_1A Receptors by 5-HT_2A Receptors in Neuroendocrine Neurons in Vivo
J Pharmacol Exp Ther 2004 310: 59-66. Published online April 2, 2004; 10.1124/jpet.103.062224 [Abstract] [Full Text] [PDF]  

Yingxian Xiao and Kenneth J. Kellar

The Comparative Pharmacology and Up-Regulation of Rat Neuronal Nicotinic Receptor Subtype Binding Sites Stably Expressed in Transfected Mammalian Cells
J Pharmacol Exp Ther 2004 310: 98-107. Published online March 11, 2004; 10.1124/jpet.104.066787 [Abstract] [Full Text] [PDF]  

Adrian Sculptoreanu, Naoki Yoshimura, and William C. de Groat

KW-7158 [(2S)-(+)-3,3,3-Trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide] Enhances A-Type K⁺ Currents in Neurons of the Dorsal Root Ganglion of the Adult Rat
J Pharmacol Exp Ther 2004 310: 159-168. Published online March 9, 2004; 10.1124/jpet.104.065409 [Abstract] [Full Text] [PDF]  

Xilong Zhao, Jay Z. Yeh, Vincent L. Salgado, and Toshio Narahashi

Fipronil Is a Potent Open Channel Blocker of Glutamate-Activated Chloride Channels in Cockroach Neurons
J Pharmacol Exp Ther 2004 310: 192-201. Published online March 10, 2004; 10.1124/jpet.104.065516 [Abstract] [Full Text] [PDF]  

D. S. Reddy, D. C. Castaneda, B. W. O'Malley, and M. A. Rogawski

Anticonvulsant Activity of Progesterone and Neurosteroids in Progesterone Receptor Knockout Mice
J Pharmacol Exp Ther 2004 310: 230-239. Published online February 24, 2004; 10.1124/jpet.104.065268 [Abstract] [Full Text] [PDF]  

Hsiang-En Wu, Jonathan Thompson, Han-Sen Sun, Randy J. Leitermann, James M. Fujimoto, and Leon F. Tseng

Nonopioidergic Mechanism Mediating Morphine-Induced Antianalgesia in the Mouse Spinal Cord
J Pharmacol Exp Ther 2004 310: 240-246. Published online March 3, 2004; 10.1124/jpet.104.065334 [Abstract] [Full Text] [PDF]  

Mária Szücs, Krisztina Boda, and Alan R. Gintzler

Dual Effects of DAMGO [D-Ala²,N-Me-Phe⁴,Gly⁵-ol]-Enkephalin and CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH₂) on Adenylyl Cyclase Activity: Implications for µ-Opioid Receptor G_s Coupling
J Pharmacol Exp Ther 2004 310: 256-262. Published online March 2, 2004; 10.1124/jpet.104.066837 [Abstract] [Full Text] [PDF]  

Michael P. Hill, Paula Ravenscroft, Erwan Bezard, Alan R. Crossman, Jonathan M. Brotchie, Anne Michel, Renee Grimée, and Henrik Klitgaard

Levetiracetam Potentiates the Antidyskinetic Action of Amantadine in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-Lesioned Primate Model of Parkinson's Disease
J Pharmacol Exp Ther 2004 310: 386-394. Published online March 5, 2004; 10.1124/jpet.104.066191 [Abstract] [Full Text] [PDF]  

Michael F. Jarvis, Bruce Bianchi, John T. Uchic, Jayne Cartmell, Chih-Hung Lee, Michael Williams, and Connie Faltynek

[³H]A-317491, a Novel High-Affinity Non-Nucleotide Antagonist That Specifically Labels Human P2X_2/3 and P2X₃ Receptors
J Pharmacol Exp Ther 2004 310: 407-416. Published online March 15, 2004; 10.1124/jpet.103.064907 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Jie Liu, Wei Qu, Joseph E. Saavedra, and Michael P. Waalkes

The Nitric Oxide Donor, O²-Vinyl 1-(Pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO), Protects against Cadmium-Induced Hepatotoxicity in Mice
J Pharmacol Exp Ther 2004 310: 18-24. Published online March 9, 2004; 10.1124/jpet.103.065003 [Abstract] [Full Text] [PDF]  

Erik J. Martin and Poh-Gek Forkert

Evidence That 1,1-Dichloroethylene Induces Apoptotic Cell Death in Murine Liver
J Pharmacol Exp Ther 2004 310: 33-42. Published online March 17, 2004; 10.1124/jpet.104.066019 [Abstract] [Full Text] [PDF]  

Amin A. Nanji, Andrew J. Dannenberg, Kalle Jokelainen, and Nathan M. Bass

Alcoholic Liver Injury in the Rat Is Associated with Reduced Expression of Peroxisome Proliferator- (PPAR)-Regulated Genes and Is Ameliorated by PPAR Activation
J Pharmacol Exp Ther 2004 310: 417-424. Published online March 11, 2004; 10.1124/jpet.103.064717 [Abstract] [Full Text] [PDF]  

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