PERSPECTIVES IN PHARMACOLOGY:

James E. Gibson and David A. Taylor

Can Claims, Misleading Information, and Manufacturing Issues Regarding Dietary Supplements Be Improved in the United States?
J Pharmacol Exp Ther 2005 314: 939-944. Published online April 15, 2005; 10.1124/jpet.105.085712 [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Soichiro Matsushima, Kazuya Maeda, Chihiro Kondo, Masaru Hirano, Makoto Sasaki, Hiroshi Suzuki, and Yuichi Sugiyama

Identification of the Hepatic Efflux Transporters of Organic Anions Using Double-Transfected Madin-Darby Canine Kidney II Cells Expressing Human Organic Anion-Transporting Polypeptide 1B1 (OATP1B1)/Multidrug Resistance-Associated Protein 2, OATP1B1/Multidrug Resistance 1, and OATP1B1/Breast Cancer Resistance Protein
J Pharmacol Exp Ther 2005 314: 1059-1067. Published online May 18, 2005; 10.1124/jpet.105.085589 [Abstract] [Full Text] [PDF]  

Rajinder K. Bhardwaj, Dea Herrera-Ruiz, Patrick J. Sinko, Olafur S. Gudmundsson, and Gregory Knipp

Delineation of Human Peptide Transporter 1 (hPepT1)-Mediated Uptake and Transport of Substrates with Varying Transporter Affinities Utilizing Stably Transfected hPepT1/Madin-Darby Canine Kidney Clones and Caco-2 Cells
J Pharmacol Exp Ther 2005 314: 1093-1100. Published online May 18, 2005; 10.1124/jpet.105.087148 [Abstract] [Full Text] [PDF]  

Hidemasa Katsumi, Makiya Nishikawa, Fumiyoshi Yamashita, and Mitsuru Hashida

Development of Polyethylene Glycol-Conjugated Poly-S-Nitrosated Serum Albumin, a Novel S-Nitrosothiol for Prolonged Delivery of Nitric Oxide in the Blood Circulation in Vivo
J Pharmacol Exp Ther 2005 314: 1117-1124. Published online May 18, 2005; 10.1124/jpet.105.087429 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Kirsten M. Raehal, Julia K. L. Walker, and Laura M. Bohn

Morphine Side Effects in -Arrestin 2 Knockout Mice
J Pharmacol Exp Ther 2005 314: 1195-1201. Published online May 25, 2005; 10.1124/jpet.105.087254 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Jian Zhang and Abdel A. Abdel-Rahman

Mitogen-Activated Protein Kinase Phosphorylation in the Rostral Ventrolateral Medulla Plays a Key Role in Imidazoline (I₁)-Receptor-Mediated Hypotension
J Pharmacol Exp Ther 2005 314: 945-952. Published online May 18, 2005; 10.1124/jpet.105.087510 [Abstract] [Full Text] [PDF]  

Wei Ni, Claudia S. Wilhelm, Michael Bader, Dennis L. Murphy, Keith Lookingland, and Stephanie W. Watts

(+)-Norfenfluramine-Induced Arterial Contraction Is Not Dependent on Endogenous 5-Hydroxytryptamine or 5-Hydroxytryptamine Transporter
J Pharmacol Exp Ther 2005 314: 953-960. Published online May 18, 2005; 10.1124/jpet.105.087080 [Abstract] [Full Text] [PDF]  

Jiale He, Shumei Yang, and Lubo Zhang

Effects of Cocaine on Nitric Oxide Production in Bovine Coronary Artery Endothelial Cells
J Pharmacol Exp Ther 2005 314: 980-986. Published online May 26, 2005; 10.1124/jpet.105.087452 [Abstract] [Full Text] [PDF]  

Edwin K. Jackson, Liping Gao, and Chongxue Zhu

Mechanism of the Vascular Angiotensin II/₂-Adrenoceptor Interaction
J Pharmacol Exp Ther 2005 314: 1109-1116. Published online May 18, 2005; 10.1124/jpet.105.086074 [Abstract] [Full Text] [PDF]  

Rocío Vera, Milagros Galisteo, Inmaculada Concepción Villar, Manuel Sánchez, Antonio Zarzuelo, Francisco Pérez-Vizcaíno, and Juan Duarte

Soy Isoflavones Improve Endothelial Function in Spontaneously Hypertensive Rats in an Estrogen-Independent Manner: Role of Nitric-Oxide Synthase, Superoxide, and Cyclooxygenase Metabolites
J Pharmacol Exp Ther 2005 314: 1300-1309. Published online June 15, 2005; 10.1124/jpet.105.085530 [Abstract] [Full Text] [PDF]  

Hossam A. Shaltout and Abdel A. Abdel-Rahman

Mechanism of Fatty Acids Induced Suppression of Cardiovascular Reflexes in Rats
J Pharmacol Exp Ther 2005 314: 1328-1337. Published online June 3, 2005; 10.1124/jpet.105.086314 [Abstract] [Full Text] [PDF]  

Karin Przyklenk, Michelle Maynard, Chad E. Darling, and Peter Whittaker

Pretreatment with D-myo-Inositol Trisphosphate Reduces Infarct Size in Rabbit Hearts: Role of Inositol Trisphosphate Receptors and Gap Junctions in Triggering Protection
J Pharmacol Exp Ther 2005 314: 1386-1392. Published online May 26, 2005; 10.1124/jpet.105.087742 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Victor Ruiz-Velasco, Henry L. Puhl, Brad C. Fuller, and Andrew D. Sumner

Modulation of Ca²⁺ Channels by Opioid Receptor-Like 1 Receptors Natively Expressed in Rat Stellate Ganglion Neurons Innervating Cardiac Muscle
J Pharmacol Exp Ther 2005 314: 987-994. Published online June 3, 2005; 10.1124/jpet.105.089284 [Abstract] [Full Text] [PDF]  

Julia Sacher, Lukas Weigl, Martin Werner, Csaba Szegedi, and Martin Hohenegger

Delineation of Myotoxicity Induced by 3-Hydroxy-3-methylglutaryl CoA Reductase Inhibitors in Human Skeletal Muscle Cells
J Pharmacol Exp Ther 2005 314: 1032-1041. Published online May 24, 2005; 10.1124/jpet.105.086462 [Abstract] [Full Text] [PDF]  

David Soto, Jesús Pintor, Assumpta Peral, Arcadi Gual, and Xavier Gasull

Effects of Dinucleoside Polyphosphates on Trabecular Meshwork Cells and Aqueous Humor Outflow Facility
J Pharmacol Exp Ther 2005 314: 1042-1051. Published online June 9, 2005; 10.1124/jpet.105.085274 [Abstract] [Full Text] [PDF]  

Yuping Chen, Grace Kissling, Masahiko Negishi, and Joyce A. Goldstein

The Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Cross-Talk with Hepatic Nuclear Factor 4 to Synergistically Activate the Human CYP2C9 Promoter
J Pharmacol Exp Ther 2005 314: 1125-1133. Published online May 26, 2005; 10.1124/jpet.105.087072 [Abstract] [Full Text] [PDF]  

D. L. B. Winkelman, C. L. Beck, D. L. Ypey, and M. E. O'Leary

Inhibition of the A-Type K⁺ Channels of Dorsal Root Ganglion Neurons by the Long-Duration Anesthetic Butamben
J Pharmacol Exp Ther 2005 314: 1177-1186. Published online May 27, 2005; 10.1124/jpet.105.087759 [Abstract] [Full Text] [PDF]  

Yili Xie, Lunhua Liu, Xiaochun Huang, Yuewei Guo, and Liguang Lou

Scalaradial Inhibition of Epidermal Growth Factor Receptor-Mediated Akt Phosphorylation Is Independent of Secretory Phospholipase A₂
J Pharmacol Exp Ther 2005 314: 1210-1217. Published online May 27, 2005; 10.1124/jpet.105.086520 [Abstract] [Full Text] [PDF]  

Po-Lin Kuo, Ya-Ling Hsu, Cheng-Hsiung Chang, and Jiunn-Kae Chang

Osthole-Mediated Cell Differentiation through Bone Morphogenetic Protein-2/p38 and Extracellular Signal-Regulated Kinase 1/2 Pathway in Human Osteoblast Cells
J Pharmacol Exp Ther 2005 314: 1290-1299. Published online June 13, 2005; 10.1124/jpet.105.085092 [Abstract] [Full Text] [PDF]  

Herman D. Lim, Richard M. van Rijn, Ping Ling, Remko A. Bakker, Robin L. Thurmond, and Rob Leurs

Evaluation of Histamine H₁-, H₂-, and H₃-Receptor Ligands at the Human Histamine H₄ Receptor: Identification of 4-Methylhistamine as the First Potent and Selective H₄ Receptor Agonist
J Pharmacol Exp Ther 2005 314: 1310-1321. Published online June 9, 2005; 10.1124/jpet.105.087965 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Arnold S. Kristof, Gustavo Pacheco-Rodriguez, Bruno Schremmer, and Joel Moss

LY303511 (2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one) Acts via Phosphatidylinositol 3-Kinase-Independent Pathways to Inhibit Cell Proliferation via Mammalian Target of Rapamycin (mTOR)- and Non-mTOR-Dependent Mechanisms
J Pharmacol Exp Ther 2005 314: 1134-1143. Published online May 27, 2005; 10.1124/jpet.105.083550 [Abstract] [Full Text] [PDF] Data Supplement  

Andrew Owen, Omar Janneh, Ruben C. Hartkoorn, Becky Chandler, Patrick G. Bray, Phillip Martin, Stephen A. Ward, C. Anthony Hart, Saye H. Khoo, and David J. Back

In Vitro Synergy and Enhanced Murine Brain Penetration of Saquinavir Coadministered with Mefloquine
J Pharmacol Exp Ther 2005 314: 1202-1209. Published online May 27, 2005; 10.1124/jpet.105.086272 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Kirti Chaturvedi and Dipak K. Sarkar

Role of Protein Kinase C-Ras-MAPK p44/42 in Ethanol and Transforming Growth Factor-3-Induced Basic Fibroblast Growth Factor Release from Folliculostellate Cells
J Pharmacol Exp Ther 2005 314: 1346-1352. Published online June 16, 2005; 10.1124/jpet.105.088302 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Peter J. Henry, Angela D'Aprile, Glenn Self, Tracy Hong, and Tracy S. Mann

Inhibitors of Prostaglandin Transport and Metabolism Augment Protease-Activated Receptor-2-Mediated Increases in Prostaglandin E₂ Levels and Smooth Muscle Relaxation in Mouse Isolated Trachea
J Pharmacol Exp Ther 2005 314: 995-1001. Published online June 3, 2005; 10.1124/jpet.105.086124 [Abstract] [Full Text] [PDF]  

Shiva Kazerounian, Giovanni M. Pitari, Fawad J. Shah, Glen S. Frick, Muniswamy Madesh, Inez Ruiz-Stewart, Stephanie Schulz, Gyorgy Hajnóczky, and Scott A. Waldman

Proliferative Signaling by Store-Operated Calcium Channels Opposes Colon Cancer Cell Cytostasis Induced by Bacterial Enterotoxins
J Pharmacol Exp Ther 2005 314: 1013-1022. Published online June 3, 2005; 10.1124/jpet.105.089052 [Abstract] [Full Text] [PDF]  

D. Thomas Dickey, Y. Jeffrey Wu, Leslie L. Muldoon, and Edward A. Neuwelt

Protection against Cisplatin-Induced Toxicities by N-Acetylcysteine and Sodium Thiosulfate as Assessed at the Molecular, Cellular, and in Vivo Levels
J Pharmacol Exp Ther 2005 314: 1052-1058. Published online June 10, 2005; 10.1124/jpet.105.087601 [Abstract] [Full Text] [PDF]  

Nigel Irwin, Brian D. Green, Mark H. Mooney, Brett Greer, Patrick Harriott, Clifford J. Bailey, Victor A. Gault, Finbarr P. M. O'Harte, and Peter R. Flatt

A Novel, Long-Acting Agonist of Glucose-Dependent Insulinotropic Polypeptide Suitable for Once-Daily Administration in Type 2 Diabetes
J Pharmacol Exp Ther 2005 314: 1187-1194. Published online May 27, 2005; 10.1124/jpet.105.086082 [Abstract] [Full Text] [PDF]  

Hon-Wai Koon, Dezheng Zhao, Yanai Zhan, Simos Simeonidis, Mary P. Moyer, and Charalabos Pothoulakis

Substance P-Stimulated Interleukin-8 Expression in Human Colonic Epithelial Cells Involves Protein Kinase C Activation
J Pharmacol Exp Ther 2005 314: 1393-1400. Published online May 25, 2005; 10.1124/jpet.105.088013 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Joseph J. Senn, Sebastien Burel, and Scott P. Henry

Non-CpG-Containing Antisense 2'-Methoxyethyl Oligonucleotides Activate a Proinflammatory Response Independent of Toll-Like Receptor 9 or Myeloid Differentiation Factor 88
J Pharmacol Exp Ther 2005 314: 972-979. Published online May 26, 2005; 10.1124/jpet.105.084004 [Abstract] [Full Text] [PDF]  

Peter J. Rice, Elizabeth L. Adams, Tammy Ozment-Skelton, Andres J. Gonzalez, Matthew P. Goldman, Brent E. Lockhart, Luke A. Barker, Kevin F. Breuel, Warren K. DePonti, John H. Kalbfleisch, Harry E. Ensley, Gordon D. Brown, Siamon Gordon, and David L. Williams

Oral Delivery and Gastrointestinal Absorption of Soluble Glucans Stimulate Increased Resistance to Infectious Challenge
J Pharmacol Exp Ther 2005 314: 1079-1086. Published online June 23, 2005; 10.1124/jpet.105.085415 [Abstract] [Full Text] [PDF]  

Jean-Philippe Fortin, Lajos Gera, Johanne Bouthillier, John M. Stewart, Albert Adam, and François Marceau

Endogenous Aminopeptidase N Decreases the Potency of Peptide Agonists and Antagonists of the Kinin B₁ Receptors in the Rabbit Aorta
J Pharmacol Exp Ther 2005 314: 1169-1176. Published online May 26, 2005; 10.1124/jpet.105.088799 [Abstract] [Full Text] [PDF]  

Suzanne M. Vinson, Alice Rickard, Jan S. Ryerse, and Jane McHowat

Neutrophil Adherence to Bladder Microvascular Endothelial Cells following Platelet-Activating Factor Acetylhydrolase Inhibition
J Pharmacol Exp Ther 2005 314: 1241-1247. Published online June 3, 2005; 10.1124/jpet.105.085365 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Huei-Sheng Vincent Chen and Stuart A. Lipton

Pharmacological Implications of Two Distinct Mechanisms of Interaction of Memantine with N-Methyl-D-aspartate-Gated Channels
J Pharmacol Exp Ther 2005 314: 961-971. Published online May 18, 2005; 10.1124/jpet.105.085142 [Abstract] [Full Text] [PDF]  

Xiaoying Wang, Michael H. Baumann, Heng Xu, Marisela Morales, and Richard B. Rothman

(±)-3,4-Methylenedioxymethamphetamine Administration to Rats Does Not Decrease Levels of the Serotonin Transporter Protein or Alter Its Distribution between Endosomes and the Plasma Membrane
J Pharmacol Exp Ther 2005 314: 1002-1012. Published online June 3, 2005; 10.1124/jpet.105.088476 [Abstract] [Full Text] [PDF]  

James M. Sanders, Koichi Ito, Luca Settimo, Olli T. Pentikäinen, Muneo Shoji, Makoto Sasaki, Mark S. Johnson, Ryuichi Sakai, and Geoffrey T. Swanson

Divergent Pharmacological Activity of Novel Marine-Derived Excitatory Amino Acids on Glutamate Receptors
J Pharmacol Exp Ther 2005 314: 1068-1078. Published online May 24, 2005; 10.1124/jpet.105.086389 [Abstract] [Full Text] [PDF]  

Jannine G. Truong, Diana G. Wilkins, Jakub Baudys, Dennis J. Crouch, Kamisha L. Johnson-Davis, James W. Gibb, Glen R. Hanson, and Annette E. Fleckenstein

Age-Dependent Methamphetamine-Induced Alterations in Vesicular Monoamine Transporter-2 Function: Implications for Neurotoxicity
J Pharmacol Exp Ther 2005 314: 1087-1092. Published online May 18, 2005; 10.1124/jpet.105.085951 [Abstract] [Full Text] [PDF]  

Hsiang-En Wu, Jonathan Thompson, Han-Sen Sun, Maia Terashvili, and Leon F. Tseng

Antianalgesia: Stereoselective Action of dextro-Morphine over levo-Morphine on Glia in the Mouse Spinal Cord
J Pharmacol Exp Ther 2005 314: 1101-1108. Published online May 18, 2005; 10.1124/jpet.105.087130 [Abstract] [Full Text] [PDF]  

Lily Alvarez-Jaimes, Mara Feliciano-Rivera, Marjorie Centeno-González, and Carmen S. Maldonado-Vlaar

Contributions of the Mitogen-Activated Protein Kinase and Protein Kinase C Cascades in Spatial Learning and Memory Mediated by the Nucleus Accumbens
J Pharmacol Exp Ther 2005 314: 1144-1157. Published online May 18, 2005; 10.1124/jpet.105.086140 [Abstract] [Full Text] [PDF]  

John C. Roberts, Brent M. Grocholski, Kelley F. Kitto, and Carolyn A. Fairbanks

Pharmacodynamic and Pharmacokinetic Studies of Agmatine after Spinal Administration in the Mouse
J Pharmacol Exp Ther 2005 314: 1226-1233. Published online June 2, 2005; 10.1124/jpet.105.086173 [Abstract] [Full Text] [PDF]  

Garth T. Whiteside, Jamie M. Boulet, and Katharine Walker

The Role of Central and Peripheral µ Opioid Receptors in Inflammatory Pain and Edema: A Study Using Morphine and DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-3-yl]-acetic Acid)
J Pharmacol Exp Ther 2005 314: 1234-1240. Published online June 3, 2005; 10.1124/jpet.105.088351 [Abstract] [Full Text] [PDF]  

Robert B. McCall, Keith J. Lookingland, Paul J. Bédard, and Rita M. Huff

Sumanirole, a Highly Dopamine D₂-Selective Receptor Agonist: In Vitro and in Vivo Pharmacological Characterization and Efficacy in Animal Models of Parkinson's Disease
J Pharmacol Exp Ther 2005 314: 1248-1256. Published online June 24, 2005; 10.1124/jpet.105.084202 [Abstract] [Full Text] [PDF]  

Diane T. Stephenson, Martin D. Meglasson, Mark A. Connell, Mary A. Childs, Eva Hajos-Korcsok, and Marina E. Emborg

The Effects of a Selective Dopamine D₂ Receptor Agonist on Behavioral and Pathological Outcome in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Treated Squirrel Monkeys
J Pharmacol Exp Ther 2005 314: 1257-1266. Published online June 24, 2005; 10.1124/jpet.105.087379 [Abstract] [Full Text] [PDF]  

L. E. Schechter, D. L. Smith, S. Rosenzweig-Lipson, S. J. Sukoff, L. A. Dawson, K. Marquis, D. Jones, M. Piesla, T. Andree, S. Nawoschik, J. A. Harder, M. D. Womack, J. Buccafusco, A. V. Terry, B. Hoebel, P. Rada, M. Kelly, M. Abou-Gharbia, J. E. Barrett, and W. Childers

Lecozotan (SRA-333): A Selective Serotonin 1A Receptor Antagonist That Enhances the Stimulated Release of Glutamate and Acetylcholine in the Hippocampus and Possesses Cognitive-Enhancing Properties
J Pharmacol Exp Ther 2005 314: 1274-1289. Published online June 10, 2005; 10.1124/jpet.105.086363 [Abstract] [Full Text] [PDF]  

Olga Dergacheva, Xin Wang, Zheng-Gui Huang, Evguenia Bouairi, Christopher Stephens, Chistopher Gorini, and David Mendelowitz

Hypocretin-1 (Orexin-A) Facilitates Inhibitory and Diminishes Excitatory Synaptic Pathways to Cardiac Vagal Neurons in the Nucleus Ambiguus
J Pharmacol Exp Ther 2005 314: 1322-1327. Published online June 9, 2005; 10.1124/jpet.105.086421 [Abstract] [Full Text] [PDF]  

Refik Kanjhan, Elizabeth J. Coulson, David J. Adams, and Mark C. Bellingham

Tertiapin-Q Blocks Recombinant and Native Large Conductance K⁺ Channels in a Use-Dependent Manner
J Pharmacol Exp Ther 2005 314: 1353-1361. Published online June 9, 2005; 10.1124/jpet.105.085928 [Abstract] [Full Text] [PDF]  

Guibao Gu, Ichiro Kondo, Xiao-Ying Hua, and Tony L. Yaksh

Resting and Evoked Spinal Substance P Release during Chronic Intrathecal Morphine Infusion: Parallels with Tolerance and Dependence
J Pharmacol Exp Ther 2005 314: 1362-1369. Published online May 20, 2005; 10.1124/jpet.105.087718 [Abstract] [Full Text] [PDF]  

Luciene B. Vieira, Christopher Kushmerick, Michael E. Hildebrand, Esperanza Garcia, Antony Stea, Marta N. Cordeiro, Michael Richardson, Marcus Vinicius Gomez, and Terrance P. Snutch

Inhibition of High Voltage-Activated Calcium Channels by Spider Toxin PnTx3-6
J Pharmacol Exp Ther 2005 314: 1370-1377. Published online June 2, 2005; 10.1124/jpet.105.087023 [Abstract] [Full Text] [PDF] Data supplement  

Isao Shimizu, Tohko Iida, Nobuhiko Horiuchi, and Michael J. Caterina

5-Iodoresiniferatoxin Evokes Hypothermia in Mice and Is a Partial Transient Receptor Potential Vanilloid 1 Agonist in Vitro
J Pharmacol Exp Ther 2005 314: 1378-1385. Published online June 9, 2005; 10.1124/jpet.105.084277 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

James P. Luyendyk, Patrick J. Shaw, Christopher D. Green, Jane F. Maddox, Patricia E. Ganey, and Robert A. Roth

Coagulation-Mediated Hypoxia and Neutrophil-Dependent Hepatic Injury in Rats Given Lipopolysaccharide and Ranitidine
J Pharmacol Exp Ther 2005 314: 1023-1031. Published online June 2, 2005; 10.1124/jpet.105.087981 [Abstract] [Full Text] [PDF]  

Rudolfs K. Zalups and Sarfaraz Ahmad

Transport of N-Acetylcysteine S-Conjugates of Methylmercury in Madin-Darby Canine Kidney Cells Stably Transfected with Human Isoform of Organic Anion Transporter 1
J Pharmacol Exp Ther 2005 314: 1158-1168. Published online May 20, 2005; 10.1124/jpet.105.086645 [Abstract] [Full Text] [PDF]  

Jacqueline Arp, Michael J. Rieder, Brad Urquhart, David Freeman, M. Jane Tucker, Adriana Krizova, David Lehmann, and Gregory A. Dekaban

Hypersensitivity of HIV-1-Infected Cells to Reactive Sulfonamide Metabolites Correlated to Expression of the HIV-1 Viral Protein Tat
J Pharmacol Exp Ther 2005 314: 1218-1225. Published online June 2, 2005; 10.1124/jpet.105.085050 [Abstract] [Full Text] [PDF]  

Werner Klingler, James J. A. Heffron, Karin Jurkat-Rott, Grainne O'Sullivan, Andreas Alt, Friedrich Schlesinger, Johannes Bufler, and Frank Lehmann-Horn

3,4-Methylenedioxymethamphetamine (Ecstasy) Activates Skeletal Muscle Nicotinic Acetylcholine Receptors
J Pharmacol Exp Ther 2005 314: 1267-1273. Published online June 9, 2005; 10.1124/jpet.105.086629 [Abstract] [Full Text] [PDF]  

Krishnan Prabhakaran, Li Li, Edward M. Mills, Joseph L. Borowitz, and Gary E. Isom

Up-Regulation of Uncoupling Protein 2 by Cyanide Is Linked with Cytotoxicity in Mesencephalic Cells
J Pharmacol Exp Ther 2005 314: 1338-1345. Published online June 3, 2005; 10.1124/jpet.105.088625 [Abstract] [Full Text] [PDF]  

LETTERS TO THE EDITOR:

Hartmut Jaeschke

Comments on "Glycogen Synthase Kinase-3 Mediates Acetaminophen-Induced Apoptosis in Human Hepatoma Cells"
J Pharmacol Exp Ther 2005 314: 1401-1402. [Full Text] [PDF]  

George E. N. Kass

Response: Comments on "Glycogen Synthase Kinase-3 Mediates Acetaminophen-Induced Apoptosis in Human Hepatoma Cells"
J Pharmacol Exp Ther 2005 314: 1403-1404. [Full Text] [PDF]  

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