PERSPECTIVES IN PHARMACOLOGY:

A. Farhadi, A. Keshavarzian, Z. Ranjbaran, J. Z. Fields, and A. Banan

The Role of Protein Kinase C Isoforms in Modulating Injury and Repair of the Intestinal Barrier
J Pharmacol Exp Ther 2006 316: 1-7. Published online July 7, 2005; 10.1124/jpet.105.085449 [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Jie Su, Li He, Ningning Zhang, and Paul C. Ho

Evaluation of Tributyrin Lipid Emulsion with Affinity to Low-Density Lipoprotein: Pharmacokinetics in Adult Male Wistar Rats and Cellular Activity on Caco-2 and HepG2 Cell Lines
J Pharmacol Exp Ther 2006 316: 62-70. Published online September 27, 2005; 10.1124/jpet.105.090464 [Abstract] [Full Text] [PDF]  

Ravindra N. Dhir, Wojciech Dworakowski, Chellappagounder Thangavel, and Bernard H. Shapiro

Sexually Dimorphic Regulation of Hepatic Isoforms of Human Cytochrome P450 by Growth Hormone
J Pharmacol Exp Ther 2006 316: 87-94. Published online September 13, 2005; 10.1124/jpet.105.093773 [Abstract] [Full Text] [PDF]  

Zhifeng Yu, Wing Ping Fong, and Christopher H. K. Cheng

The Dual Actions of Morin (3,5,7,2',4'-Pentahydroxyflavone) as a Hypouricemic Agent: Uricosuric Effect and Xanthine Oxidase Inhibitory Activity
J Pharmacol Exp Ther 2006 316: 169-175. Published online September 16, 2005; 10.1124/jpet.105.092684 [Abstract] [Full Text] [PDF]  

Chiaki Ebihara, Masuo Kondoh, Naoki Hasuike, Motoki Harada, Hiroyuki Mizuguchi, Yasuhiko Horiguchi, Makiko Fujii, and Yoshiteru Watanabe

Preparation of a Claudin-Targeting Molecule Using a C-Terminal Fragment of Clostridium perfringens Enterotoxin
J Pharmacol Exp Ther 2006 316: 255-260. Published online September 23, 2005; 10.1124/jpet.105.093351 [Abstract] [Full Text] [PDF]  

Linda B. von Weymarn, Kathryn M. Brown, and Sharon E. Murphy

Inactivation of CYP2A6 and CYP2A13 during Nicotine Metabolism
J Pharmacol Exp Ther 2006 316: 295-303. Published online September 27, 2005; 10.1124/jpet.105.091306 [Abstract] [Full Text] [PDF]  

R. Scott Obach, Robert L. Walsky, Karthik Venkatakrishnan, Emily A. Gaman, J. Brian Houston, and Larry M. Tremaine

The Utility of in Vitro Cytochrome P450 Inhibition Data in the Prediction of Drug-Drug Interactions
J Pharmacol Exp Ther 2006 316: 336-348. Published online September 28, 2005; 10.1124/jpet.105.093229 [Abstract] [Full Text] [PDF] [Data Supplement]   

Daniel A. J. Bow, Jennifer L. Perry, John D. Simon, and John B. Pritchard

The Impact of Plasma Protein Binding on the Renal Transport of Organic Anions
J Pharmacol Exp Ther 2006 316: 349-355. Published online September 29, 2005; 10.1124/jpet.105.093070 [Abstract] [Full Text] [PDF]  

Liping Du, Valery Yermalitsky, David L. Hachey, Setti G. Jagadeesh, John R. Falck, and Diane S. Keeney

A Biosynthetic Pathway Generating 12-Hydroxy-5,8,14-eicosatrienoic Acid from Arachidonic Acid Is Active in Mouse Skin Microsomes
J Pharmacol Exp Ther 2006 316: 371-379. Published online September 16, 2005; 10.1124/jpet.105.093922 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

William A. Carlezon, Jr., Cécile Béguin, Jennifer A. DiNieri, Michael H. Baumann, Michele R. Richards, Mark S. Todtenkopf, Richard B. Rothman, Zhongze Ma, David Y.-W. Lee, and Bruce M. Cohen

Depressive-Like Effects of the -Opioid Receptor Agonist Salvinorin A on Behavior and Neurochemistry in Rats
J Pharmacol Exp Ther 2006 316: 440-447. Published online October 13, 2005; 10.1124/jpet.105.092304 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Yi-Nan Liu, Shiow-Lin Pan, Chieh-Yu Peng, Jih-Hwa Guh, Dong-Ming Huang, Ya-Ling Chang, Chun-Hung Lin, Hui-Chen Pai, Sheng-Chu Kuo, Fang-Yu Lee, and Che-Ming Teng

YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole] Inhibits Neointima Formation in Balloon-Injured Rat Carotid through Suppression of Expressions and Activities of Matrix Metalloproteinases 2 and 9
J Pharmacol Exp Ther 2006 316: 35-41. Published online September 23, 2005; 10.1124/jpet.105.090563 [Abstract] [Full Text] [PDF]  

Francesc Jiménez-Altayó, Ana M. Briones, Jesús Giraldo, Anna M. Planas, Mercedes Salaices, and Elisabet Vila

Increased Superoxide Anion Production by Interleukin-1 Impairs Nitric Oxide-Mediated Relaxation in Resistance Arteries
J Pharmacol Exp Ther 2006 316: 42-52. Published online September 23, 2005; 10.1124/jpet.105.088435 [Abstract] [Full Text] [PDF]  

John T. Liles, Paul A. Dabisch, Keith E. Hude, Leena Pradhan, Kurt J. Varner, Johnny R. Porter, Alissa R. Hicks, Conni Corll, Syed R. Baber, and Philip J. Kadowitz

Pressor Responses to Ephedrine Are Mediated by a Direct Mechanism in the Rat
J Pharmacol Exp Ther 2006 316: 95-105. Published online July 7, 2005; 10.1124/jpet.105.090035 [Abstract] [Full Text] [PDF]  

Zoltán Giricz, Manoj M. Lalu, Csaba Csonka, Péter Bencsik, Richard Schulz, and Péter Ferdinandy

Hyperlipidemia Attenuates the Infarct Size-Limiting Effect of Ischemic Preconditioning: Role of Matrix Metalloproteinase-2 Inhibition
J Pharmacol Exp Ther 2006 316: 154-161. Published online September 15, 2005; 10.1124/jpet.105.091140 [Abstract] [Full Text] [PDF]  

Virginie Bito, Dieter Dauwe, Fons Verdonck, Kanigula Mubagwa, and Karin R. Sipido

The Amiodarone Derivative KB130015 [2-Methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran] Induces an Na⁺-Dependent Increase of [Ca²⁺] in Ventricular Myocytes
J Pharmacol Exp Ther 2006 316: 162-168. Published online September 16, 2005; 10.1124/jpet.105.092221 [Abstract] [Full Text] [PDF]  

Masahiko Nozawa, Koh-ichi Sugimoto, Masami Ohmori, Hitoshi Ando, and Akio Fujimura

Dosing Time-Dependent Effect of Temocapril on the Mortality of Stroke-Prone Spontaneously Hypertensive Rats
J Pharmacol Exp Ther 2006 316: 176-181. Published online September 20, 2005; 10.1124/jpet.105.092080 [Abstract] [Full Text] [PDF]  

Toshiaki Sato, Alexandre D. T. Costa, Tomoaki Saito, Takehiko Ogura, Hideyuki Ishida, Keith D. Garlid, and Haruaki Nakaya

Bepridil, an Antiarrhythmic Drug, Opens Mitochondrial K_ATP Channels, Blocks Sarcolemmal K_ATP Channels, and Confers Cardioprotection
J Pharmacol Exp Ther 2006 316: 182-188. Published online September 20, 2005; 10.1124/jpet.105.094029 [Abstract] [Full Text] [PDF]  

Qun Chen, Charles L. Hoppel, and Edward J. Lesnefsky

Blockade of Electron Transport before Cardiac Ischemia with the Reversible Inhibitor Amobarbital Protects Rat Heart Mitochondria
J Pharmacol Exp Ther 2006 316: 200-207. Published online September 20, 2005; 10.1124/jpet.105.091702 [Abstract] [Full Text] [PDF]  

Carlos R. Tirapelli, Johny Al-Khoury, Ghassan Bkaily, Pedro D'Orléans-Juste, Vera L. Lanchote, Sergio A. Uyemura, and Ana M. de Oliveira

Chronic Ethanol Consumption Enhances Phenylephrine-Induced Contraction in the Isolated Rat Aorta
J Pharmacol Exp Ther 2006 316: 233-241. Published online September 20, 2005; 10.1124/jpet.105.092999 [Abstract] [Full Text] [PDF]  

Andrew G. Howarth, William B. Wiehler, Malarvannan Pannirselvam, Yanfen Jiang, Joel P. Berger, David Severson, Todd J. Anderson, and Chris R. Triggle

A Nonthiazolidinedione Peroxisome Proliferator-Activated Receptor Agonist Reverses Endothelial Dysfunction in Diabetic (db/db^-/-) Mice
J Pharmacol Exp Ther 2006 316: 364-370. Published online October 25, 2005; 10.1124/jpet.105.086397 [Abstract] [Full Text] [PDF]  

Gwo-Jyh Chang, Ming-Jai Su, Sheng-Chu Kuo, Tsung-Ping Lin, and Ying-Shiung Lee

Multiple Cellular Electrophysiological Effects of a Novel Antiarrhythmic Furoquinoline Derivative HA-7 [N-Benzyl-7-methoxy-2,3,4,9-tetrahydrofuro[2,3-b]quinoline-3,4-dione] in Guinea Pig Cardiac Preparations
J Pharmacol Exp Ther 2006 316: 380-391. Published online September 20, 2005; 10.1124/jpet.105.092106 [Abstract] [Full Text] [PDF]  

Renée Germack and John M. Dickenson

Induction of ₃-Adrenergic Receptor Functional Expression following Chronic Stimulation with Noradrenaline in Neonatal Rat Cardiomyocytes
J Pharmacol Exp Ther 2006 316: 392-402. Published online September 23, 2005; 10.1124/jpet.105.090597 [Abstract] [Full Text] [PDF]  

Michael. J. Watson, Jonathon D. S. Holt, Scott J. O'Neill, Ke Wei, William Pendergast, Garrett J. Gross, Peter J. Gengo, and Kwen-Jen Chang

ARD-353 [4-((2R,5S)-4-(R)-(4-Diethylcarbamoylphenyl)(3-hydroxyphenyl)methyl)-2,5-dimethylpiperazin-1-ylmethyl)benzoic Acid], A Novel Nonpeptide Receptor Agonist, Reduces Myocardial Infarct Size without Central Effects
J Pharmacol Exp Ther 2006 316: 423-430. Published online September 27, 2005; 10.1124/jpet.105.092742 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Thomas R. Hundley and Basil Rigas

Nitric Oxide-Donating Aspirin Inhibits Colon Cancer Cell Growth via Mitogen-Activated Protein Kinase Activation
J Pharmacol Exp Ther 2006 316: 25-34. Published online September 16, 2005; 10.1124/jpet.105.091363 [Abstract] [Full Text] [PDF]  

Yvonne Neye, Martina Düfer, Gisela Drews, and Peter Krippeit-Drews

HIV Protease Inhibitors: Suppression of Insulin Secretion by Inhibition of Voltage-Dependent K⁺ Currents and Anion Currents
J Pharmacol Exp Ther 2006 316: 106-112. Published online September 14, 2005; 10.1124/jpet.105.090589 [Abstract] [Full Text] [PDF]  

Kazuho Sakamoto, Taro Nonomura, Susumu Ohya, Katsuhiko Muraki, Tomohiko Ohwada, and Yuji Imaizumi

Molecular Mechanisms for Large Conductance Ca²⁺-Activated K⁺ Channel Activation by a Novel Opener, 12,14-Dichlorodehydroabietic Acid
J Pharmacol Exp Ther 2006 316: 144-153. Published online September 29, 2005; 10.1124/jpet.105.093856 [Abstract] [Full Text] [PDF]  

Daniel Poeckel, Lars Tausch, Sven George, Johann Jauch, and Oliver Werz

3-O-Acetyl-11-keto-boswellic Acid Decreases Basal Intracellular Ca²⁺ Levels and Inhibits Agonist-Induced Ca²⁺ Mobilization and Mitogen-Activated Protein Kinase Activation in Human Monocytic Cells
J Pharmacol Exp Ther 2006 316: 224-232. Published online September 20, 2005; 10.1124/jpet.105.089466 [Abstract] [Full Text] [PDF]  

Yuping Gong, Muralikrishna Duvvuri, Michael B. Duncan, Jian Liu, and Jeffrey P. Krise

Niemann-Pick C1 Protein Facilitates the Efflux of the Anticancer Drug Daunorubicin from Cells According to a Novel Vesicle-Mediated Pathway
J Pharmacol Exp Ther 2006 316: 242-247. Published online September 20, 2005; 10.1124/jpet.105.089482 [Abstract] [Full Text] [PDF] [Data Supplement]   

Carl P. Nelson, Stefan R. Nahorski, and R. A. John Challiss

Constitutive Activity and Inverse Agonism at the M₂ Muscarinic Acetylcholine Receptor
J Pharmacol Exp Ther 2006 316: 279-288. Published online September 27, 2005; 10.1124/jpet.105.094383 [Abstract] [Full Text] [PDF]  

Christopher N. Davis and Jeffrey K. Harrison

Proline 326 in the C Terminus of Murine CX3CR1 Prevents G-Protein and Phosphatidylinositol 3-Kinase-Dependent Stimulation of Akt and Extracellular Signal-Regulated Kinase in Chinese Hamster Ovary Cells
J Pharmacol Exp Ther 2006 316: 356-363. Published online September 15, 2005; 10.1124/jpet.105.093039 [Abstract] [Full Text] [PDF]  

Sumaya N. Hamadmad, Matthew K. Henry, and Raymond J. Hohl

Erythropoietin Receptor Signal Transduction Requires Protein Geranylgeranylation
J Pharmacol Exp Ther 2006 316: 403-409. Published online October 3, 2005; 10.1124/jpet.105.092510 [Abstract] [Full Text] [PDF]  

Raymond R. Mattingly, Janice M. Kraniak, Joshua T. Dilworth, Patricia Mathieu, Beverly Bealmear, James E. Nowak, Joyce A. Benjamins, Michael A. Tainsky, and John J. Reiners, Jr.

The Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase Inhibitor PD184352 (CI-1040) Selectively Induces Apoptosis in Malignant Schwannoma Cell Lines
J Pharmacol Exp Ther 2006 316: 456-465. Published online October 20, 2005; 10.1124/jpet.105.091454 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Gerard Crudden, Rachel E. Chitti, and Rolf J. Craven

Hpr6 (Heme-1 Domain Protein) Regulates the Susceptibility of Cancer Cells to Chemotherapeutic Drugs
J Pharmacol Exp Ther 2006 316: 448-455. Published online October 18, 2005; 10.1124/jpet.105.094631 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND DIABETES:

Oksana Kaidanovich-Beilin and Hagit Eldar-Finkelman

Long-Term Treatment with Novel Glycogen Synthase Kinase-3 Inhibitor Improves Glucose Homeostasis in ob/ob Mice: Molecular Characterization in Liver and Muscle
J Pharmacol Exp Ther 2006 316: 17-24. Published online September 16, 2005; 10.1124/jpet.105.090266 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Juliane Bolbrinker, Snezana Markovic, Markus Wehland, Wynand B. W. H. Melenhorst, Harry van Goor, and Reinhold Kreutz

Expression and Response to Angiotensin-Converting Enzyme Inhibition of Matrix Metalloproteinases 2 and 9 in Renal Glomerular Damage in Young Transgenic Rats with Renin-Dependent Hypertension
J Pharmacol Exp Ther 2006 316: 8-16. Published online September 15, 2005; 10.1124/jpet.105.093112 [Abstract] [Full Text] [PDF]  

Eleonora Distrutti, Luca Sediari, Andrea Mencarelli, Barbara Renga, Stefano Orlandi, Elisabetta Antonelli, Fiorenza Roviezzo, Antonio Morelli, Giuseppe Cirino, John L. Wallace, and Stefano Fiorucci

Evidence That Hydrogen Sulfide Exerts Antinociceptive Effects in the Gastrointestinal Tract by Activating K_ATP Channels
J Pharmacol Exp Ther 2006 316: 325-335. Published online September 28, 2005; 10.1124/jpet.105.091595 [Abstract] [Full Text] [PDF]  

B. De Smet, I. Depoortere, D. Moechars, Q. Swennen, B. Moreaux, K. Cryns, J. Tack, J. Buyse, B. Coulie, and T. L. Peeters

Energy Homeostasis and Gastric Emptying in Ghrelin Knockout Mice
J Pharmacol Exp Ther 2006 316: 431-439. Published online October 3, 2005; 10.1124/jpet.105.091504 [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Lynn Martin, Sandeep C. Pingle, Daniel M. Hallam, Leonard P. Rybak, and Vickram Ramkumar

Activation of the Adenosine A₃ Receptor in RAW 264.7 Cells Inhibits Lipopolysaccharide-Stimulated Tumor Necrosis Factor- Release by Reducing Calcium-Dependent Activation of Nuclear Factor-B and Extracellular Signal-Regulated Kinase 1/2
J Pharmacol Exp Ther 2006 316: 71-78. Published online September 27, 2005; 10.1124/jpet.105.091868 [Abstract] [Full Text] [PDF]  

Ru Zhou, Shen-Xi Zheng, Wei Tang, Pei-Lan He, Xiao-Yu Li, Yi-Fu Yang, Yuan-Chao Li, Jian-Guo Geng, and Jian-Ping Zuo

Inhibition of Inducible Nitric-Oxide Synthase Expression by (5R)-5-Hydroxytriptolide in Interferon-- and Bacterial Lipopolysaccharide-Stimulated Macrophages
J Pharmacol Exp Ther 2006 316: 121-128. Published online September 15, 2005; 10.1124/jpet.105.093179 [Abstract] [Full Text] [PDF]  

Natalia Jiménez, Margarita M. Puig, and Olga Pol

Antiexudative Effects of Opioids and Expression of - and - Opioid Receptors during Intestinal Inflammation in Mice: Involvement of Nitric Oxide
J Pharmacol Exp Ther 2006 316: 261-270. Published online September 23, 2005; 10.1124/jpet.105.091991 [Abstract] [Full Text] [PDF]  

Jeong-Hyung Lee, Haeng Sun Jung, Phan Minh Giang, Xuejun Jin, Sangku Lee, Phan Tong Son, Dongho Lee, Young-Soo Hong, Kyeong Lee, and Jung Joon Lee

Blockade of Nuclear Factor-B Signaling Pathway and Anti-Inflammatory Activity of Cardamomin, a Chalcone Analog from Alpinia conchigera
J Pharmacol Exp Ther 2006 316: 271-278. Published online September 23, 2005; 10.1124/jpet.105.092486 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Véronique Josserand, Hélène Pélerin, Béatrice de Bruin, Benoît Jego, Bertrand Kuhnast, Françoise Hinnen, Frédéric Ducongé, Raphaël Boisgard, Frédéric Beuvon, Francine Chassoux, Catherine Daumas-Duport, Eric Ezan, Frédéric Dollé, Aloïse Mabondzo, and Bertrand Tavitian

Evaluation of Drug Penetration into the Brain: A Double Study by in Vivo Imaging with Positron Emission Tomography and Using an in Vitro Model of the Human Blood-Brain Barrier
J Pharmacol Exp Ther 2006 316: 79-86. Published online October 6, 2005; 10.1124/jpet.105.089102 [Abstract] [Full Text] [PDF]  

Hana Hammad and John J. Wagner

Dopamine-Mediated Disinhibition in the CA1 Region of Rat Hippocampus via D₃ Receptor Activation
J Pharmacol Exp Ther 2006 316: 113-120. Published online September 14, 2005; 10.1124/jpet.105.091579 [Abstract] [Full Text] [PDF]  

Gianluigi D'Agostino, Anna M. Condino, Paola Gallinari, Gian P. Franceschetti, and Marcello Tonini

Characterization of Prejunctional Serotonin Receptors Modulating [³H]Acetylcholine Release in the Human Detrusor
J Pharmacol Exp Ther 2006 316: 129-135. Published online September 15, 2005; 10.1124/jpet.105.092551 [Abstract] [Full Text] [PDF]  

R. Danzeisen, B. Schwalenstoecker, F. Gillardon, E. Buerger, V. Krzykalla, K. Klinder, L. Schild, B. Hengerer, A. C. Ludolph, C. Dorner-Ciossek, and L. Kussmaul

Targeted Antioxidative and Neuroprotective Properties of the Dopamine Agonist Pramipexole and Its Nondopaminergic Enantiomer SND919CL2x [(+)2-Amino-4,5,6,7-tetrahydro-6-Lpropylamino-benzathiazole Dihydrochloride]
J Pharmacol Exp Ther 2006 316: 189-199. Published online September 27, 2005; 10.1124/jpet.105.092312 [Abstract] [Full Text] [PDF]  

Robert I. Westphalen and Hugh C. Hemmings, Jr.

Volatile Anesthetic Effects on Glutamate versus GABA Release from Isolated Rat Cortical Nerve Terminals: Basal Release
J Pharmacol Exp Ther 2006 316: 208-215. Published online September 20, 2005; 10.1124/jpet.105.090647 [Abstract] [Full Text] [PDF]  

Robert I. Westphalen and Hugh C. Hemmings, Jr.

Volatile Anesthetic Effects on Glutamate versus GABA Release from Isolated Rat Cortical Nerve Terminals: 4-Aminopyridine-Evoked Release
J Pharmacol Exp Ther 2006 316: 216-223. Published online September 20, 2005; 10.1124/jpet.105.090662 [Abstract] [Full Text] [PDF]  

Jennifer R. Paulson, Karen E. Roder, Ghia McAfee, David D. Allen, Cornelis J. Van der Schyf, and Thomas J. Abbruscato

Tobacco Smoke Chemicals Attenuate Brain-to-Blood Potassium Transport Mediated by the Na,K,2Cl-Cotransporter during Hypoxia-Reoxygenation
J Pharmacol Exp Ther 2006 316: 248-254. Published online September 20, 2005; 10.1124/jpet.105.090738 [Abstract] [Full Text] [PDF]  

Christina R. Maxwell, Richard S. Ehrlichman, Yuling Liang, Danielle Trief, Stephen J. Kanes, Jonathan Karp, and Steven J. Siegel

Ketamine Produces Lasting Disruptions in Encoding of Sensory Stimuli
J Pharmacol Exp Ther 2006 316: 315-324. Published online September 28, 2005; 10.1124/jpet.105.091199 [Abstract] [Full Text] [PDF]  

John R. Atack, Keith A. Wafford, Spencer J. Tye, Susan M. Cook, Bindi Sohal, Andrew Pike, Cyrille Sur, David Melillo, Linda Bristow, Fran Bromidge, Ian Ragan, Julie Kerby, Les Street, Robert Carling, José L. Castro, Paul Whiting, Gerard R. Dawson, and Ruth M. McKernan

TPA023 [7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an Agonist Selective for 2- and 3-Containing GABA_A Receptors, Is a Nonsedating Anxiolytic in Rodents and Primates
J Pharmacol Exp Ther 2006 316: 410-422. Published online September 23, 2005; 10.1124/jpet.105.089920 [Abstract] [Full Text] [PDF]  

Tony L. Yaksh, George Kokotos, Camilla I. Svensson, Daren Stephens, Christoforos G. Kokotos, Bethany Fitzsimmons, Dimitra Hadjipavlou-Litina, Xiao-Ying Hua, and Edward A. Dennis

Systemic and Intrathecal Effects of a Novel Series of Phospholipase A₂ Inhibitors on Hyperalgesia and Spinal Prostaglandin E₂ Release
J Pharmacol Exp Ther 2006 316: 466-475. Published online October 3, 2005; 10.1124/jpet.105.091686 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

João Paulo Capela, Andreas Meisel, Artur Reis Abreu, Paula Sério Branco, Luísa Maria Ferreira, Ana Maria Lobo, Fernando Remião, Maria Lurdes Bastos, and Félix Carvalho

Neurotoxicity of Ecstasy Metabolites in Rat Cortical Neurons, and Influence of Hyperthermia
J Pharmacol Exp Ther 2006 316: 53-61. Published online September 23, 2005; 10.1124/jpet.105.092577 [Abstract] [Full Text] [PDF]  

Lisa Imamura, Makoto Yasuda, Kozue Kuramitsu, Daichi Hara, Akiko Tabuchi, and Masaaki Tsuda

Deltamethrin, a Pyrethroid Insecticide, Is a Potent Inducer for the Activity-Dependent Gene Expression of Brain-Derived Neurotrophic Factor in Neurons
J Pharmacol Exp Ther 2006 316: 136-143. Published online September 15, 2005; 10.1124/jpet.105.092478 [Abstract] [Full Text] [PDF]  

Xiaoyan Zhang, Jason C. Lambert, Mark A. Doll, Jason M. Walraven, Gavin E. Arteel, and David W. Hein

4,4'-Methylenedianiline-Induced Hepatotoxicity Is Modified by N-Acetyltransferase 2 (NAT2) Acetylator Polymorphism in the Rat
J Pharmacol Exp Ther 2006 316: 289-294. Published online September 28, 2005; 10.1124/jpet.105.093302 [Abstract] [Full Text] [PDF]  

Anthony Lemarie, Claudie Morzadec, Delphine Mérino, Olivier Micheau, Olivier Fardel, and Laurent Vernhet

Arsenic Trioxide Induces Apoptosis of Human Monocytes during Macrophagic Differentiation through Nuclear Factor-B-Related Survival Pathway Down-Regulation
J Pharmacol Exp Ther 2006 316: 304-314. Published online September 20, 2005; 10.1124/jpet.105.092874 [Abstract] [Full Text] [PDF]  

LETTERS TO THE EDITOR:

J. Ignacio Lorenzo and Paula Sánchez-Marín

Comments on "Isobolographic Analysis for Combinations of a Full and Partial Agonist: Curved Isoboles"
J Pharmacol Exp Ther 2006 316: 476-478. [Full Text] [PDF]  

Ronald J. Tallarida

Response to Comments on "Isobolographic Analysis for Combinations of a Full and Partial Agonist: Curved Isoboles"
J Pharmacol Exp Ther 2006 316: 479. [Full Text] [PDF]  

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