PERSPECTIVES IN PHARMACOLOGY:

Noura S. Abul-Husn and Lakshmi A. Devi

Neuroproteomics of the Synapse and Drug Addiction
J Pharmacol Exp Ther 2006 318: 461-468. Published online April 27, 2006; 10.1124/jpet.105.091520 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Giuseppe Astarita, Barbara Di Giacomo, Silvana Gaetani, Fariba Oveisi, Timothy R. Compton, Silvia Rivara, Giorgio Tarzia, Marco Mor, and Daniele Piomelli

Pharmacological Characterization of Hydrolysis-Resistant Analogs of Oleoylethanolamide with Potent Anorexiant Properties
J Pharmacol Exp Ther 2006 318: 563-570. Published online May 15, 2006; 10.1124/jpet.106.105221 [Abstract] [Full Text] [PDF]  

Michael A. Ansonoff, Jiwen Zhang, Traci Czyzyk, Richard B. Rothman, Jeremy Stewart, Heng Xu, Jordan Zjwiony, Daniel J. Siebert, Feng Yang, Bryan L. Roth, and John E. Pintar

Antinociceptive and Hypothermic Effects of Salvinorin A Are Abolished in a Novel Strain of -Opioid Receptor-1 Knockout Mice
J Pharmacol Exp Ther 2006 318: 641-648. Published online May 3, 2006; 10.1124/jpet.106.101998 [Abstract] [Full Text] [PDF]  

Lance R. McMahon, Lisa R. Gerak, and Charles P. France

Efficacy and the Discriminative Stimulus Effects of Negative GABA_A Modulators, or Inverse Agonists, in Diazepam-Treated Rhesus Monkeys
J Pharmacol Exp Ther 2006 318: 907-913. Published online May 16, 2006; 10.1124/jpet.106.103168 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Aihua Hu, Xiangying Jiao, Erhe Gao, Walter J. Koch, Said Sharifi-Azad, Zvi Grunwald, Xin L. Ma, and Jian-Zhong Sun

Chronic -Adrenergic Receptor Stimulation Induces Cardiac Apoptosis and Aggravates Myocardial Ischemia/Reperfusion Injury by Provoking Inducible Nitric-Oxide Synthase-Mediated Nitrative Stress
J Pharmacol Exp Ther 2006 318: 469-475. Published online March 30, 2006; 10.1124/jpet.106.102160 [Abstract] [Full Text] [PDF]  

Dorota Zolkowska, Richard B. Rothman, and Michael H. Baumann

Amphetamine Analogs Increase Plasma Serotonin: Implications for Cardiac and Pulmonary Disease
J Pharmacol Exp Ther 2006 318: 604-610. Published online April 27, 2006; 10.1124/jpet.106.101618 [Abstract] [Full Text] [PDF]  

Carlos R. Tirapelli, Débora A. Casolari, Augusto C. Montezano, Alvaro Yogi, Rita C. Tostes, Eurode Legros, Pedro D'Orléans-Juste, Vera L. Lanchote, Sérgio A. Uyemura, and Ana M. de Oliveira

Ethanol Consumption Enhances Endothelin-1-Induced Contraction in the Isolated Rat Carotid
J Pharmacol Exp Ther 2006 318: 819-827. Published online May 1, 2006; 10.1124/jpet.106.103010 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Young Chai Lim, Lang Li, Zeruesenay Desta, Qianqian Zhao, James M. Rae, David A. Flockhart, and Todd C. Skaar

Endoxifen, a Secondary Metabolite of Tamoxifen, and 4-OH-Tamoxifen Induce Similar Changes in Global Gene Expression Patterns in MCF-7 Breast Cancer Cells
J Pharmacol Exp Ther 2006 318: 503-512. Published online May 11, 2006; 10.1124/jpet.105.100511 [Abstract] [Full Text] [PDF]  

Ilaria Badagnani, Richard A. Castro, Travis R. Taylor, Claire M. Brett, Conrad C. Huang, Douglas Stryke, Michiko Kawamoto, Susan J. Johns, Thomas E. Ferrin, Elaine J. Carlson, Esteban G. Burchard, and Kathleen M. Giacomini

Interaction of Methotrexate with Organic-Anion Transporting Polypeptide 1A2 and Its Genetic Variants
J Pharmacol Exp Ther 2006 318: 521-529. Published online May 15, 2006; 10.1124/jpet.106.104364 [Abstract] [Full Text] [PDF]  

Knut Kotarsky, Åke Boketoft, Jesper Bristulf, Niclas E. Nilsson, Åke Norberg, Stefan Hansson, Christer Owman, Rannar Sillard, L. M. Fredrik Leeb-Lundberg, and Björn Olde

Lysophosphatidic Acid Binds to and Activates GPR92, a G Protein-Coupled Receptor Highly Expressed in Gastrointestinal Lymphocytes
J Pharmacol Exp Ther 2006 318: 619-628. Published online May 1, 2006; 10.1124/jpet.105.098848 [Abstract] [Full Text] [PDF]  

John A. Tran, Minoru Matsui, and Frederick J. Ehlert

Differential Coupling of Muscarinic M₁, M₂, and M₃ Receptors to Phosphoinositide Hydrolysis in Urinary Bladder and Longitudinal Muscle of the Ileum of the Mouse
J Pharmacol Exp Ther 2006 318: 649-656. Published online May 4, 2006; 10.1124/jpet.106.103093 [Abstract] [Full Text] [PDF]  

Mark G. Slomiany and Steven A. Rosenzweig

Hypoxia-Inducible Factor-1-Dependent and -Independent Regulation of Insulin-Like Growth Factor-1-Stimulated Vascular Endothelial Growth Factor Secretion
J Pharmacol Exp Ther 2006 318: 666-675. Published online May 8, 2006; 10.1124/jpet.106.104158 [Abstract] [Full Text] [PDF] [Data Supplement]   

Laelie A. Snook, Graeme Milligan, Brigitte L. Kieffer, and Dominique Massotte

µ- Opioid Receptor Functional Interaction: Insight Using Receptor-G Protein Fusions
J Pharmacol Exp Ther 2006 318: 683-690. Published online May 11, 2006; 10.1124/jpet.106.101220 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Ya-Ling Hsu, Chien-Yu Cho, Po-Lin Kuo, Yu-Ting Huang, and Chun-Ching Lin

Plumbagin (5-Hydroxy-2-methyl-1,4-naphthoquinone) Induces Apoptosis and Cell Cycle Arrest in A549 Cells through p53 Accumulation via c-Jun NH₂-Terminal Kinase-Mediated Phosphorylation at Serine 15 in Vitro and in Vivo
J Pharmacol Exp Ther 2006 318: 484-494. Published online April 21, 2006; 10.1124/jpet.105.098863 [Abstract] [Full Text] [PDF]  

Kevin J. French, John J. Upson, Staci N. Keller, Yan Zhuang, Jong K. Yun, and Charles D. Smith

Antitumor Activity of Sphingosine Kinase Inhibitors
J Pharmacol Exp Ther 2006 318: 596-603. Published online April 21, 2006; 10.1124/jpet.106.101345 [Abstract] [Full Text] [PDF]  

Yoshiyuki Hattori, Shigeru Kawakami, Kazumi Nakamura, Fumiyoshi Yamashita, and Mitsuru Hashida

Efficient Gene Transfer into Macrophages and Dendritic Cells by in Vivo Gene Delivery with Mannosylated Lipoplex via the Intraperitoneal Route
J Pharmacol Exp Ther 2006 318: 828-834. Published online May 2, 2006; 10.1124/jpet.106.105098 [Abstract] [Full Text] [PDF]  

Jeanelle M. Martinez, Tina Sali, Ryuji Okazaki, Colleen Anna, Melinda Hollingshead, Curtis Hose, Anne Monks, Nigel J. Walker, Seung Joon Baek, and Thomas E. Eling

Drug-Induced Expression of Nonsteroidal Anti-Inflammatory Drug-Activated Gene/Macrophage Inhibitory Cytokine-1/Prostate-Derived Factor, a Putative Tumor Suppressor, Inhibits Tumor Growth
J Pharmacol Exp Ther 2006 318: 899-906. Published online May 19, 2006; 10.1124/jpet.105.100081 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND DIABETES:

Un Ju Jung, Mi-Kyung Lee, Yong Bok Park, Seon-Min Jeon, and Myung-Sook Choi

Antihyperglycemic and Antioxidant Properties of Caffeic Acid in db/db Mice
J Pharmacol Exp Ther 2006 318: 476-483. Published online April 27, 2006; 10.1124/jpet.106.105163 [Abstract] [Full Text] [PDF]  

Koji Nobe, Mari Miyatake, Tomoko Sone, and Kazuo Honda

High-Glucose-Altered Endothelial Cell Function Involves Both Disruption of Cell-to-Cell Connection and Enhancement of Force Development
J Pharmacol Exp Ther 2006 318: 530-539. Published online May 12, 2006; 10.1124/jpet.106.105015 [Abstract] [Full Text] [PDF]  

M. K. Kim, H. D. Kim, J. H. Park, J. I. Lim, J. S. Yang, W. Y. Kwak, S. Y. Sung, H. J. Kim, S. H. Kim, C. H. Lee, J. Y. Shim, M. H. Bae, Y. A. Shin, Y. Huh, T. D. Han, W. Chong, H. Choi, B. N. Ahn, S. O. Yang, and M. H. Son

An Orally Active Cathepsin K Inhibitor, Furan-2-Carboxylic Acid, 1-{1-[4-Fluoro-2-(2-oxo-pyrrolidin-1-yl)-phenyl]-3-oxo-piperidin-4-ylcarbamoyl}-cyclohexyl)-amide (OST-4077), Inhibits Osteoclast Activity in Vitro and Bone Loss in Ovariectomized Rats
J Pharmacol Exp Ther 2006 318: 555-562. Published online May 12, 2006; 10.1124/jpet.106.102798 [Abstract] [Full Text] [PDF]  

Takao Fujimura, Chiaki Kimura, Tomoya Oe, Yoko Takata, Hiroyuki Sakuma, Ichiro Aramori, and Seitaro Mutoh

A Selective Peroxisome Proliferator-Activated Receptor Modulator with Distinct Fat Cell Regulation Properties
J Pharmacol Exp Ther 2006 318: 863-871. Published online May 8, 2006; 10.1124/jpet.106.102459 [Abstract] [Full Text] [PDF]  

Brian D. Green, Kerry S. Lavery, Nigel Irwin, Finbarr P. M. O'Harte, Patrick Harriott, Brett Greer, Clifford J. Bailey, and Peter R. Flatt

Novel Glucagon-Like Peptide-1 (GLP-1) Analog (Val⁸)GLP-1 Results in Significant Improvements of Glucose Tolerance and Pancreatic -Cell Function after 3-Week Daily Administration in Obese Diabetic (ob/ob) Mice
J Pharmacol Exp Ther 2006 318: 914-921. Published online April 28, 2006; 10.1124/jpet.105.097824 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Jason R. Kovac, Tom Chrones, Harold G. Preiksaitis, and Stephen M. Sims

Tachykinin Receptor Expression and Function in Human Esophageal Smooth Muscle
J Pharmacol Exp Ther 2006 318: 513-520. Published online May 19, 2006; 10.1124/jpet.106.104034 [Abstract] [Full Text] [PDF] [Data Supplement]   

Ying H. Yang, William K. K. Wu, Emily K. K. Tai, Helen P. S. Wong, Emily K. Y. Lam, Wallace H. L. So, Vivian Y. Shin, and Chi H. Cho

The Cationic Host Defense Peptide rCRAMP Promotes Gastric Ulcer Healing in Rats
J Pharmacol Exp Ther 2006 318: 547-554. Published online May 2, 2006; 10.1124/jpet.106.102467 [Abstract] [Full Text] [PDF]  

Ryo Hatazawa, Ryoko Ohno, Mayu Tanigami, Akiko Tanaka, and Koji Takeuchi

Roles of Endogenous Prostaglandins and Cyclooxygenase Isozymes in Healing of Indomethacin-Induced Small Intestinal Lesions in Rats
J Pharmacol Exp Ther 2006 318: 691-699. Published online May 12, 2006; 10.1124/jpet.106.103994 [Abstract] [Full Text] [PDF]  

Márcio A. F. De Godoy and Satish Rattan

Angiotensin-Converting Enzyme and Angiotensin II Receptor Subtype 1 Inhibitors Restitute Hypertensive Internal Anal Sphincter in the Spontaneously Hypertensive Rats
J Pharmacol Exp Ther 2006 318: 725-734. Published online April 28, 2006; 10.1124/jpet.106.103366 [Abstract] [Full Text] [PDF]  

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:

Tsung H. Lin, Axel Metzger, David J. Diller, Madhuri Desai, Ian Henderson, Gulzar Ahmed, Earl F. Kimble, Elizabeth Quadros, and Maria L. Webb

Discovery and Characterization of Triaminotriazine Aniline Amides as Highly Selective p38 Kinase Inhibitors
J Pharmacol Exp Ther 2006 318: 495-502. Published online May 15, 2006; 10.1124/jpet.105.097568 [Abstract] [Full Text] [PDF]  

Tammy R. Ozment-Skelton, Matthew P. Goldman, Siamon Gordon, Gordon D. Brown, and David L. Williams

Prolonged Reduction of Leukocyte Membrane-Associated Dectin-1 Levels following -Glucan Administration
J Pharmacol Exp Ther 2006 318: 540-546. Published online April 21, 2006; 10.1124/jpet.106.102293 [Abstract] [Full Text] [PDF]  

Rafaela F. Claudino, Candida A. L. Kassuya, Juliano Ferreira, and João B. Calixto

Pharmacological and Molecular Characterization of the Mechanisms Involved in Prostaglandin E₂-Induced Mouse Paw Edema
J Pharmacol Exp Ther 2006 318: 611-618. Published online April 27, 2006; 10.1124/jpet.106.102806 [Abstract] [Full Text] [PDF]  

Mark A. Birrell, Sissie Wong, Abdel Dekkak, Jorge De Alba, Saleem Haj-Yahia, and Maria G. Belvisi

Role of Matrix Metalloproteinases in the Inflammatory Response in Human Airway Cell-Based Assays and in Rodent Models of Airway Disease
J Pharmacol Exp Ther 2006 318: 741-750. Published online May 11, 2006; 10.1124/jpet.106.105544 [Abstract] [Full Text] [PDF]  

Gerd Birkenmeier, Silke Nicklisch, Christiane Pockelt, Andualem Mossie, Volker Steger, Christiane Gläser, Sunna Hauschildt, Elke Usbeck, Klaus Huse, Ulli Sack, Michael Bauer, and Angelika Schäfer

Polymyxin B-Conjugated 2-Macroglobulin as an Adjunctive Therapy to Sepsis: Modes of Action and Impact on Lethality
J Pharmacol Exp Ther 2006 318: 762-771. Published online May 16, 2006; 10.1124/jpet.106.104265 [Abstract] [Full Text] [PDF]  

Sylvie Attucci, Alexandre Gauthier, Brice Korkmaz, Pascal Delépine, Michèle Ferrer-Di Martino, François Saudubray, Patrice Diot, and Francis Gauthier

EPI-hNE4, a Proteolysis-Resistant Inhibitor of Human Neutrophil Elastase and Potential Anti-Inflammatory Drug for Treating Cystic Fibrosis
J Pharmacol Exp Ther 2006 318: 803-809. Published online April 20, 2006; 10.1124/jpet.106.103440 [Abstract] [Full Text] [PDF]  

Victoria Boswell-Smith, Domenico Spina, Alec W. Oxford, Mike B. Comer, Esther A. Seeds, and Clive P. Page

The Pharmacology of Two Novel Long-Acting Phosphodiesterase 3/4 Inhibitors, RPL554 [9,10-Dimethoxy-2(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one] and RPL565 [6,7-Dihydro-2-(2,6-diisopropylphenoxy)-9,10-dimethoxy-4H-pyrimido[6,1-a]isoquinolin-4-one]
J Pharmacol Exp Ther 2006 318: 840-848. Published online May 8, 2006; 10.1124/jpet.105.099192 [Abstract] [Full Text] [PDF]  

Claudio Storini, Luigi Bergamaschini, Raffaella Gesuete, Emanuela Rossi, Diana Maiocchi, and Maria Grazia De Simoni

Selective Inhibition of Plasma Kallikrein Protects Brain from Reperfusion Injury
J Pharmacol Exp Ther 2006 318: 849-854. Published online May 16, 2006; 10.1124/jpet.106.105064 [Abstract] [Full Text] [PDF]  

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:

Qi Wang, Inger M. Darling, and Marilyn E. Morris

Transport of -Hydroxybutyrate in Rat Kidney Membrane Vesicles: Role of Monocarboxylate Transporters
J Pharmacol Exp Ther 2006 318: 751-761. Published online May 17, 2006; 10.1124/jpet.106.105965 [Abstract] [Full Text] [PDF]  

Fengyun Xu, Valerie Y. Ng, Deanna L. Kroetz, and Paul R. Ortiz de Montellano

CYP4 Isoform Specificity in the -Hydroxylation of Phytanic Acid, a Potential Route to Elimination of the Causative Agent of Refsum's Disease
J Pharmacol Exp Ther 2006 318: 835-839. Published online May 17, 2006; 10.1124/jpet.106.104976 [Abstract] [Full Text] [PDF]  

Daniel L. Gustafson, Erica L. Bradshaw-Pierce, Andrea L. Merz, and Joseph A. Zirrolli

Tissue Distribution and Metabolism of the Tyrosine Kinase Inhibitor ZD6474 (Zactima) in Tumor-Bearing Nude Mice following Oral Dosing
J Pharmacol Exp Ther 2006 318: 872-880. Published online April 27, 2006; 10.1124/jpet.106.102376 [Abstract] [Full Text] [PDF]  

Ryan Z. Turncliff, Keith A. Hoffmaster, J. Cory Kalvass, Gary M. Pollack, and Kim L. R. Brouwer

Hepatobiliary Disposition of a Drug/Metabolite Pair: Comprehensive Pharmacokinetic Modeling in Sandwich-Cultured Rat Hepatocytes
J Pharmacol Exp Ther 2006 318: 881-889. Published online May 11, 2006; 10.1124/jpet.106.102616 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Takashi Mori, Terrence Town, Jun Tan, Nobumichi Yada, Yuko Horikoshi, Junki Yamamoto, Taiji Shimoda, Yoshihisa Kamanaka, Narito Tateishi, and Takao Asano

Arundic Acid Ameliorates Cerebral Amyloidosis and Gliosis in Alzheimer Transgenic Mice
J Pharmacol Exp Ther 2006 318: 571-578. Published online May 18, 2006; 10.1124/jpet.106.105171 [Abstract] [Full Text] [PDF]  

Sergei Melnik, Michael Wright, Julian A. Tanner, Timur Tsintsadze, Vera Tsintsadze, Andrew D. Miller, and Natalia Lozovaya

Diadenosine Polyphosphate Analog Controls Postsynaptic Excitation in CA3-CA1 Synapses via a Nitric Oxide-Dependent Mechanism
J Pharmacol Exp Ther 2006 318: 579-588. Published online May 18, 2006; 10.1124/jpet.105.097642 [Abstract] [Full Text] [PDF] [Data Supplement]   

Dustin W. DuBois, Andreas Perlegas, Donald W. Floyd, Jeffery L. Weiner, and Brian A. McCool

Distinct Functional Characteristics of the Lateral/Basolateral Amygdala GABAergic System in C57BL/6J and DBA/2J Mice
J Pharmacol Exp Ther 2006 318: 629-640. Published online May 1, 2006; 10.1124/jpet.105.100552 [Abstract] [Full Text] [PDF]  

Darlene C. Deecher, Chad E. Beyer, Grace Johnston, Jenifer Bray, S. Shah, M. Abou-Gharbia, and Terrance H. Andree

Desvenlafaxine Succinate: A New Serotonin and Norepinephrine Reuptake Inhibitor
J Pharmacol Exp Ther 2006 318: 657-665. Published online May 4, 2006; 10.1124/jpet.106.103382 [Abstract] [Full Text] [PDF]  

Kristi S. Rau, Elisabeth Birdsall, Trent J. Volz, James A. Riordan, Anthony J. Baucum, II, Brian P. Adair, Rebecca Bitter, James W. Gibb, Glen R. Hanson, and Annette E. Fleckenstein

Methamphetamine Administration Reduces Hippocampal Vesicular Monoamine Transporter-2 Uptake
J Pharmacol Exp Ther 2006 318: 676-682. Published online May 10, 2006; 10.1124/jpet.105.099200 [Abstract] [Full Text] [PDF]  

Andréy Mazarati, Linda Lundström, Ulla Sollenberg, Don Shin, Ülo Langel, and Raman Sankar

Regulation of Kindling Epileptogenesis by Hippocampal Galanin Type 1 and Type 2 Receptors: The Effects of Subtype-Selective Agonists and the Role of G-Protein-Mediated Signaling
J Pharmacol Exp Ther 2006 318: 700-708. Published online May 12, 2006; 10.1124/jpet.106.104703 [Abstract] [Full Text] [PDF]  

Alvin V. Terry, Jr., Vinay Parikh, Debra A. Gearhart, Anilkumar Pillai, Elizabeth Hohnadel, Samantha Warner, Henry A. Nasrallah, and Sahebarao P. Mahadik

Time-Dependent Effects of Haloperidol and Ziprasidone on Nerve Growth Factor, Cholinergic Neurons, and Spatial Learning in Rats
J Pharmacol Exp Ther 2006 318: 709-724. Published online May 15, 2006; 10.1124/jpet.105.099218 [Abstract] [Full Text] [PDF]  

Misaki Matsumoto, Makoto Inoue, Andreas Hald, Weijiao Xie, and Hiroshi Ueda

Inhibition of Paclitaxel-Induced A-Fiber Hypersensitization by Gabapentin
J Pharmacol Exp Ther 2006 318: 735-740. Published online May 10, 2006; 10.1124/jpet.106.103614 [Abstract] [Full Text] [PDF]  

Brianne Weiss, Andrew Alt, Ann Marie Ogden, Mary Gates, Donna K. Dieckman, Amy Clemens-Smith, Ken H. Ho, Keith Jarvie, Geihan Rizkalla, Rebecca A. Wright, David O. Calligaro, Darryle Schoepp, Edward L. Mattiuz, Robert E. Stratford, Bryan Johnson, Craig Salhoff, Mary Katofiasc, Lee A. Phebus, Kathryn Schenck, Marlene Cohen, Sandra A. Filla, Paul L. Ornstein, Kirk W. Johnson, and David Bleakman

Pharmacological Characterization of the Competitive GLU_K5 Receptor Antagonist Decahydroisoquinoline LY466195 in Vitro and in Vivo
J Pharmacol Exp Ther 2006 318: 772-781. Published online May 11, 2006; 10.1124/jpet.106.101428 [Abstract] [Full Text] [PDF]  

Sridhar Natesan, Kjell A. Svensson, Greg E. Reckless, José N. Nobrega, Karen B. L. Barlow, Anette M. Johansson, and Shitij Kapur

The Dopamine Stabilizers (S)-(-)-(3-Methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-Methanesulfonylphenyl)-1-propyl-piperidine (ACR16) Show High in Vivo D₂ Receptor Occupancy, Antipsychotic-Like Efficacy, and Low Potential for Motor Side Effects in the Rat
J Pharmacol Exp Ther 2006 318: 810-818. Published online April 28, 2006; 10.1124/jpet.106.102905 [Abstract] [Full Text] [PDF]  

Tada Utsuki, Qian-sheng Yu, Diane Davidson, Demao Chen, Harold W. Holloway, Arnold Brossi, Kumar Sambamurti, Debomoy K. Lahiri, Nigel H. Greig, and Tony Giordano

Identification of Novel Small Molecule Inhibitors of Amyloid Precursor Protein Synthesis as a Route to Lower Alzheimer's Disease Amyloid- Peptide
J Pharmacol Exp Ther 2006 318: 855-862. Published online May 11, 2006; 10.1124/jpet.106.103309 [Abstract] [Full Text] [PDF]  

Adrienne E. Dorr and Guy Debonnel

Effect of Vagus Nerve Stimulation on Serotonergic and Noradrenergic Transmission
J Pharmacol Exp Ther 2006 318: 890-898. Published online May 11, 2006; 10.1124/jpet.106.104166 [Abstract] [Full Text] [PDF]  

A. S. Adewale, D. M. Platt, and R. D. Spealman

Pharmacological Stimulation of Group II Metabotropic Glutamate Receptors Reduces Cocaine Self-Administration and Cocaine-Induced Reinstatement of Drug Seeking in Squirrel Monkeys
J Pharmacol Exp Ther 2006 318: 922-931. Published online May 4, 2006; 10.1124/jpet.106.105387 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Myrtle A. Davis, Douglas Hinerfeld, Sajan Joseph, Yu-Hua Hui, Naijia H. Huang, John Leszyk, Jennifer Rutherford-Bethard, and Sun W. Tam

Proteomic Analysis of Rat Liver Phosphoproteins after Treatment with Protein Kinase Inhibitor H89 (N-(2-[p-Bromocinnamylamino-]ethyl)-5-isoquinolinesulfonamide)
J Pharmacol Exp Ther 2006 318: 589-595. Published online May 10, 2006; 10.1124/jpet.105.100032 [Abstract] [Full Text] [PDF]  

Natascha A. Wolff, Marouan Abouhamed, Pierre J. Verroust, and Frank Thévenod

Megalin-Dependent Internalization of Cadmium-Metallothionein and Cytotoxicity in Cultured Renal Proximal Tubule Cells
J Pharmacol Exp Ther 2006 318: 782-791. Published online May 11, 2006; 10.1124/jpet.106.102574 [Abstract] [Full Text] [PDF]  

B. Alex Merrick, Maribel E. Bruno, Jennifer H. Madenspacher, Barbara A. Wetmore, Julie Foley, Rembert Pieper, Ming Zhao, Anthony J. Makusky, Andrew M. McGrath, Jeff X. Zhou, John Taylor, and Kenneth B. Tomer

Alterations in the Rat Serum Proteome during Liver Injury from Acetaminophen Exposure
J Pharmacol Exp Ther 2006 318: 792-802. Published online May 10, 2006; 10.1124/jpet.106.102681 [Abstract] [Full Text] [PDF]  

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