PERSPECTIVES IN PHARMACOLOGY:

Shougang Zhuang and Rick G. Schnellmann

A Death-Promoting Role for Extracellular Signal-Regulated Kinase
J Pharmacol Exp Ther 2006 319: 991-997. Published online June 26, 2006; 10.1124/jpet.106.107367 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Lance R. McMahon

Characterization of Cannabinoid Agonists and Apparent pA₂ Analysis of Cannabinoid Antagonists in Rhesus Monkeys Discriminating ⁹-Tetrahydrocannabinol
J Pharmacol Exp Ther 2006 319: 1211-1218. Published online August 30, 2006; 10.1124/jpet.106.107110 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Adam L. Kruger, Stephen J. Peterson, Michal L. Schwartzman, Heidi Fusco, John A. McClung, Melvin Weiss, Sylvia Shenouda, Alvin I. Goodman, Michael S. Goligorsky, Attallah Kappas, and Nader G. Abraham

Up-Regulation of Heme Oxygenase Provides Vascular Protection in an Animal Model of Diabetes through Its Antioxidant and Antiapoptotic Effects
J Pharmacol Exp Ther 2006 319: 1144-1152. Published online September 7, 2006; 10.1124/jpet.106.107482 [Abstract] [Full Text] [PDF]  

Zhi-Dong Ge, Jason N. Peart, Laura M. Kreckler, Tina C. Wan, Marlene A. Jacobson, Garrett J. Gross, and John A. Auchampach

Cl-IB-MECA [2-Chloro-N⁶-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide] Reduces Ischemia/Reperfusion Injury in Mice by Activating the A Adenosine Receptor
J Pharmacol Exp Ther 2006 319: 1200-1210. Published online September 19, 2006; 10.1124/jpet.106.111351 [Abstract] [Full Text] [PDF] [Data Supplement]   

Adrian R. Allen, Elizabeth J. Kelso, David Bell, YouYou Zhao, Paula Dickson, and Barbara J. McDermott

Modulation of Contractile Function through Neuropeptide Y Receptors during Development of Cardiomyocyte Hypertrophy
J Pharmacol Exp Ther 2006 319: 1286-1296. Published online September 14, 2006; 10.1124/jpet.106.110445 [Abstract] [Full Text] [PDF]  

Erin E. Mueller, Scott A. Grandy, and Susan E. Howlett

Protein Kinase A-Mediated Phosphorylation Contributes to Enhanced Contraction Observed in Mice That Overexpress -Adrenergic Receptor Kinase-1
J Pharmacol Exp Ther 2006 319: 1307-1316. Published online September 1, 2006; 10.1124/jpet.106.107888 [Abstract] [Full Text] [PDF]  

Naoyuki Matsuda, Yukio Hayashi, Yoshika Takahashi, and Yuichi Hattori

Phosphorylation of Endothelial Nitric-Oxide Synthase Is Diminished in Mesenteric Arteries from Septic Rabbits Depending on the Altered Phosphatidylinositol 3-Kinase/Akt Pathway: Reversal Effect of Fluvastatin Therapy
J Pharmacol Exp Ther 2006 319: 1348-1354. Published online September 26, 2006; 10.1124/jpet.106.109785 [Abstract] [Full Text] [PDF]  

Qun Chen, Shadi Moghaddas, Charles L. Hoppel, and Edward J. Lesnefsky

Reversible Blockade of Electron Transport during Ischemia Protects Mitochondria and Decreases Myocardial Injury following Reperfusion
J Pharmacol Exp Ther 2006 319: 1405-1412. Published online September 21, 2006; 10.1124/jpet.106.110262 [Abstract] [Full Text] [PDF]  

Christian Pinna, Chiara Bolego, Paola Sanvito, Valeria Pelosi, Roberta Baetta, Alberto Corsini, Rosa Maria Gaion, and Andrea Cignarella

Raloxifene Elicits Combined Rapid Vasorelaxation and Long-Term Anti-Inflammatory Actions in Rat Aorta
J Pharmacol Exp Ther 2006 319: 1444-1451. Published online August 30, 2006; 10.1124/jpet.106.106062 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Esther P. Jane, Daniel R. Premkumar, and Ian F. Pollack

Coadministration of Sorafenib with Rottlerin Potently Inhibits Cell Proliferation and Migration in Human Malignant Glioma Cells
J Pharmacol Exp Ther 2006 319: 1070-1080. Published online September 7, 2006; 10.1124/jpet.106.108621 [Abstract] [Full Text] [PDF]  

Jin-Ran Chen, Rani Lynn Haley, Mats Hidestrand, Kartik Shankar, Xiaoli Liu, Charles K. Lumpkin, Pippa M. Simpson, Thomas M. Badger, and Martin J. J. Ronis

Estradiol Protects against Ethanol-Induced Bone Loss by Inhibiting Up-Regulation of Receptor Activator of Nuclear Factor-B Ligand in Osteoblasts
J Pharmacol Exp Ther 2006 319: 1182-1190. Published online September 13, 2006; 10.1124/jpet.106.109454 [Abstract] [Full Text] [PDF] [Erratum]   

Young-Mi Ham, Jin-Hee Lim, Hye-Kyung Na, Joon-Seok Choi, Byoung-Duck Park, Hyungshin Yim, and Seung-Ki Lee

Ginsenoside-Rh2-Induced Mitochondrial Depolarization and Apoptosis Are Associated with Reactive Oxygen Species- and Ca²⁺-Mediated c-Jun NH₂-Terminal Kinase 1 Activation in HeLa Cells
J Pharmacol Exp Ther 2006 319: 1276-1285. Published online September 14, 2006; 10.1124/jpet.106.109926 [Abstract] [Full Text] [PDF]  

Stefania Ceruti, Alessia Mazzola, and Maria P. Abbracchio

Proteasome Inhibitors Potentiate Etoposide-Induced Cell Death in Human Astrocytoma Cells Bearing a Mutated p53 Isoform
J Pharmacol Exp Ther 2006 319: 1424-1434. Published online September 13, 2006; 10.1124/jpet.106.109397 [Abstract] [Full Text] [PDF]  

Donglin Bai, Cristiane del Corsso, Miduturu Srinivas, and David C. Spray

Block of Specific Gap Junction Channel Subtypes by 2-Aminoethoxydiphenyl Borate (2-APB)
J Pharmacol Exp Ther 2006 319: 1452-1458. Published online September 19, 2006; 10.1124/jpet.106.112045 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Jirapan Moungjaroen, Ubonthip Nimmannit, Patrick S. Callery, Liying Wang, Neelam Azad, Vimolmas Lipipun, Pithi Chanvorachote, and Yon Rojanasakul

Reactive Oxygen Species Mediate Caspase Activation and Apoptosis Induced by Lipoic Acid in Human Lung Epithelial Cancer Cells through Bcl-2 Down-Regulation
J Pharmacol Exp Ther 2006 319: 1062-1069. Published online September 21, 2006; 10.1124/jpet.106.110965 [Abstract] [Full Text] [PDF]  

Hania Wehbe, Roger Henson, Molly Lang, Fanyin Meng, and Tushar Patel

Pifithrin- Enhances Chemosensitivity by a p38 Mitogen-Activated Protein Kinase-Dependent Modulation of the Eukaryotic Initiation Factor 4E in Malignant Cholangiocytes
J Pharmacol Exp Ther 2006 319: 1153-1161. Published online September 18, 2006; 10.1124/jpet.106.109835 [Abstract] [Full Text] [PDF]  

Hesso Farhan, Christian Schuster, Markus Klinger, Eva Weisz, Günter Waxenecker, Manfred Schuster, Veronika Sexl, Geert C. Mudde, Michael Freissmuth, and Ralf Kircheis

Inhibition of Xenograft Tumor Growth and Down-Regulation of ErbB Receptors by an Antibody Directed against Lewis Y Antigen
J Pharmacol Exp Ther 2006 319: 1459-1466. Published online September 8, 2006; 10.1124/jpet.106.107318 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND DIABETES:

Danijela Markovic, Nikolleta Papadopoulou, Thalia Teli, Harpal Randeva, Michael A. Levine, Edward W. Hillhouse, and Dimitris K. Grammatopoulos

Differential Responses of Corticotropin-Releasing Hormone Receptor Type 1 Variants to Protein Kinase C Phosphorylation
J Pharmacol Exp Ther 2006 319: 1032-1042. Published online September 6, 2006; 10.1124/jpet.106.107441 [Abstract] [Full Text] [PDF]  

Masarsu Iwai, Huan-Sheng Li, Rui Chen, Tetsuya Shiuchi, Lan Wu, Li-Juan Min, Jian-Mei Li, Masahiro Tsuda, Jun Suzuki, Yumiko Tomono, Hirokazu Tomochika, Masaki Mogi, and Masatsugu Horiuchi

Calcium Channel Blocker Azelnidipine Reduces Glucose Intolerance in Diabetic Mice via Different Mechanism Than Angiotensin Receptor Blocker Olmesartan
J Pharmacol Exp Ther 2006 319: 1081-1087. Published online September 21, 2006; 10.1124/jpet.106.108894 [Abstract] [Full Text] [PDF]  

Kazuto Yamazaki, Nobuyuki Yasuda, Takashi Inoue, Tadashi Nagakura, Kazunobu Kira, Masanobu Shinoda, Takao Saeki, and Isao Tanaka

7-But-2-ynyl-9-(6-methoxy-pyridin-3-yl)-6-piperazin-1-yl-7,9-dihydro-purin-8-one Is a Novel Competitive and Selective Inhibitor of Dipeptidyl Peptidase IV with an Antihyperglycemic Activity
J Pharmacol Exp Ther 2006 319: 1253-1257. Published online September 15, 2006; 10.1124/jpet.106.112805 [Abstract] [Full Text] [PDF]  

Dale S. Edgerton, Kathryn M. Stettler, Doss W. Neal, Melanie Scott, Larry Bowen, Warren Wilson, Charles H. Hobbs, Chet Leach, Thomas R. Strack, and Alan D. Cherrington

Inhalation of Human Insulin Is Associated with Improved Insulin Action Compared with Subcutaneous Injection and Endogenous Secretion in Dogs
J Pharmacol Exp Ther 2006 319: 1258-1264. Published online September 8, 2006; 10.1124/jpet.106.108373 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Márcio A. F. de Godoy and Satish Rattan

Translocation of AT₁- and AT₂-Receptors by Higher Concentrations of Angiotensin II in the Smooth Muscle Cells of Rat Internal Anal Sphincter
J Pharmacol Exp Ther 2006 319: 1088-1095. Published online September 19, 2006; 10.1124/jpet.106.108084 [Abstract] [Full Text] [PDF]  

H. Serna, M. Porras, and P. Vergara

Mast Cell Stabilizer Ketotifen [4-(1-Methyl-4-piperidylidene)-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one Fumarate] Prevents Mucosal Mast Cell Hyperplasia and Intestinal Dysmotility in Experimental Trichinella spiralis Inflammation in the Rat
J Pharmacol Exp Ther 2006 319: 1104-1111. Published online September 20, 2006; 10.1124/jpet.106.104620 [Abstract] [Full Text] [PDF]  

Catherine M. McKay and Jan D. Huizinga

Muscarinic Regulation of Ether-a-go-go-Related Gene K⁺ Currents in Interstitial Cells of Cajal
J Pharmacol Exp Ther 2006 319: 1112-1123. Published online August 31, 2006; 10.1124/jpet.106.109322 [Abstract] [Full Text] [PDF]  

Atsunori Nakao, Joachim Schmidt, Tomoyuki Harada, Allan Tsung, Burkhard Stoffels, Ruy J. Cruz, Jr., Junichi Kohmoto, Ximei Peng, Koji Tomiyama, Noriko Murase, Anthony J. Bauer, and Mitchell P. Fink

A Single Intraperitoneal Dose of Carbon Monoxide-Saturated Ringer's Lactate Solution Ameliorates Postoperative Ileus in Mice
J Pharmacol Exp Ther 2006 319: 1265-1275. Published online August 30, 2006; 10.1124/jpet.106.108654 [Abstract] [Full Text] [PDF]  

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:

Sylvia Braselmann, Vanessa Taylor, Haoran Zhao, Su Wang, Catherine Sylvain, Muhammad Baluom, Kunbin Qu, Ellen Herlaar, Angela Lau, Chi Young, Brian R. Wong, Scott Lovell, Thomas Sun, Gary Park, Ankush Argade, Stipo Jurcevic, Polly Pine, Rajinder Singh, Elliott B. Grossbard, Donald G. Payan, and Esteban S. Masuda

R406, an Orally Available Spleen Tyrosine Kinase Inhibitor Blocks Fc Receptor Signaling and Reduces Immune Complex-Mediated Inflammation
J Pharmacol Exp Ther 2006 319: 998-1008. Published online August 31, 2006; 10.1124/jpet.106.109058 [Abstract] [Full Text] [PDF] [Data Supplement]   

Anne-Marie Pulichino, Steve Rowland, Tom Wu, Patsy Clark, Daigen Xu, Marie-Claude Mathieu, Denis Riendeau, and Laurent P. Audoly

Prostacyclin Antagonism Reduces Pain and Inflammation in Rodent Models of Hyperalgesia and Chronic Arthritis
J Pharmacol Exp Ther 2006 319: 1043-1050. Published online September 14, 2006; 10.1124/jpet.106.110387 [Abstract] [Full Text] [PDF]  

Sarah Main, Rachel Handy, Jane Wilton, Stephen Smith, Liz Williams, Leila Du Fou, John Andrews, Louise A. Conroy, Richard May, Ian Anderson, and Tristan J. Vaughan

A Potent Human Anti-Eotaxin1 Antibody, CAT-213: Isolation by Phage Display and in Vitro and in Vivo Efficacy
J Pharmacol Exp Ther 2006 319: 1395-1404. Published online September 14, 2006; 10.1124/jpet.106.110734 [Abstract] [Full Text] [PDF]  

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:

Sukyung Woo, Wojciech Krzyzanski, and William J. Jusko

Pharmacokinetic and Pharmacodynamic Modeling of Recombinant Human Erythropoietin after Intravenous and Subcutaneous Administration in Rats
J Pharmacol Exp Ther 2006 319: 1297-1306. Published online September 14, 2006; 10.1124/jpet.106.111377 [Abstract] [Full Text] [PDF]  

Man Tang, Madhu Mukundan, Jian Yang, Nathan Charpentier, Edward L. LeCluyse, Chris Black, Dongfang Yang, Deshi Shi, and Bingfang Yan

Antiplatelet Agents Aspirin and Clopidogrel Are Hydrolyzed by Distinct Carboxylesterases, and Clopidogrel Is Transesterificated in the Presence of Ethyl Alcohol
J Pharmacol Exp Ther 2006 319: 1467-1476. Published online August 30, 2006; 10.1124/jpet.106.110577 [Abstract] [Full Text] [PDF]  

Deshi Shi, Jian Yang, Dongfang Yang, Edward L. LeCluyse, Chris Black, Li You, Fatemeh Akhlaghi, and Bingfang Yan

Anti-Influenza Prodrug Oseltamivir Is Activated by Carboxylesterase Human Carboxylesterase 1, and the Activation Is Inhibited by Antiplatelet Agent Clopidogrel
J Pharmacol Exp Ther 2006 319: 1477-1484. Published online September 11, 2006; 10.1124/jpet.106.111807 [Abstract] [Full Text] [PDF]  

Maciej J. Zamek-Gliszczynski, Ken-ichi Nezasa, Xianbin Tian, Arlene S. Bridges, Kun Lee, Martin G. Belinsky, Gary D. Kruh, and Kim L. R. Brouwer

Evaluation of the Role of Multidrug Resistance-Associated Protein (Mrp) 3 and Mrp4 in Hepatic Basolateral Excretion of Sulfate and Glucuronide Metabolites of Acetaminophen, 4-Methylumbelliferone, and Harmol in Abcc3^–/– and Abcc4^–/– Mice
J Pharmacol Exp Ther 2006 319: 1485-1491. Published online September 20, 2006; 10.1124/jpet.106.110106 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Nicole E. Pardo, Ravindra K. Hajela, and William D. Atchison

Acetylcholine Release at Neuromuscular Junctions of Adult Tottering Mice Is Controlled by N-(Ca_v2.2) and R-Type (Ca_v2.3) but Not L-Type (Ca_v1.2) Ca²⁺ Channels
J Pharmacol Exp Ther 2006 319: 1009-1020. Published online September 18, 2006; 10.1124/jpet.106.108670 [Abstract] [Full Text] [PDF]  

Dawn S. Carter, S. Naqeeb Haider, Robert E. Blair, Laxmikant S. Deshpande, Sompong Sombati, and Robert J. DeLorenzo

Altered Calcium/Calmodulin Kinase II Activity Changes Calcium Homeostasis That Underlies Epileptiform Activity in Hippocampal Neurons in Culture
J Pharmacol Exp Ther 2006 319: 1021-1031. Published online September 13, 2006; 10.1124/jpet.106.110403 [Abstract] [Full Text] [PDF]  

Jesse LoVerme, Roberto Russo, Giovanna La Rana, Jin Fu, Jesse Farthing, Giuseppina Mattace-Raso, Rosaria Meli, Andrea Hohmann, Antonio Calignano, and Daniele Piomelli

Rapid Broad-Spectrum Analgesia through Activation of Peroxisome Proliferator-Activated Receptor-
J Pharmacol Exp Ther 2006 319: 1051-1061. Published online September 22, 2006; 10.1124/jpet.106.111385 [Abstract] [Full Text] [PDF]  

Chung-Ren Lin, Fumimasa Amaya, Lee Barrett, Haibin Wang, Junji Takada, Tarek A. Samad, and Clifford J. Woolf

Prostaglandin E₂ Receptor EP4 Contributes to Inflammatory Pain Hypersensitivity
J Pharmacol Exp Ther 2006 319: 1096-1103. Published online September 11, 2006; 10.1124/jpet.106.105569 [Abstract] [Full Text] [PDF]  

Liqin Zhao, Kathleen O'Neill, and Roberta Diaz Brinton

Estrogenic Agonist Activity of ICI 182,780 (Faslodex) in Hippocampal Neurons: Implications for Basic Science Understanding of Estrogen Signaling and Development of Estrogen Modulators with a Dual Therapeutic Profile
J Pharmacol Exp Ther 2006 319: 1124-1132. Published online September 1, 2006; 10.1124/jpet.106.109504 [Abstract] [Full Text] [PDF]  

Lynn A. Hyde, Nansie A. McHugh, Joseph Chen, Qi Zhang, Denise Manfra, Amin A. Nomeir, Hubert Josien, Thomas Bara, John W. Clader, Lili Zhang, Eric M. Parker, and Guy A. Higgins

Studies to Investigate the in Vivo Therapeutic Window of the -Secretase Inhibitor N²-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N¹-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY411,575) in the CRND8 Mouse
J Pharmacol Exp Ther 2006 319: 1133-1143. Published online August 31, 2006; 10.1124/jpet.106.111716 [Abstract] [Full Text] [PDF]  

Mahalakshmi Shankaran, Chelsea King, Jean Lee, Robert Busch, Mary Wolff, and Marc K. Hellerstein

Discovery of Novel Hippocampal Neurogenic Agents by Using an in Vivo Stable Isotope Labeling Technique
J Pharmacol Exp Ther 2006 319: 1172-1181. Published online September 14, 2006; 10.1124/jpet.106.110510 [Abstract] [Full Text] [PDF]  

Sandra J. Hewett, Janna M. Silakova, and James A. Hewett

Oral Treatment with Rofecoxib Reduces Hippocampal Excitotoxic Neurodegeneration
J Pharmacol Exp Ther 2006 319: 1219-1224. Published online September 8, 2006; 10.1124/jpet.106.109876 [Abstract] [Full Text] [PDF]  

Mahmoud M. Iravani, Kayhan Tayarani-Binazir, Wing B. Chu, Michael J. Jackson, and Peter Jenner

In 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Treated Primates, the Selective 5-Hydroxytryptamine 1a Agonist (R)-(+)-8-OHDPAT Inhibits Levodopa-Induced Dyskinesia but Only with\ Increased Motor Disability
J Pharmacol Exp Ther 2006 319: 1225-1234. Published online September 7, 2006; 10.1124/jpet.106.110429 [Abstract] [Full Text] [PDF]  

Vanja Duric and Kenneth E. McCarson

Effects of Analgesic or Antidepressant Drugs on Pain- or Stress-Evoked Hippocampal and Spinal Neurokinin-1 Receptor and Brain-Derived Neurotrophic Factor Gene Expression in the Rat
J Pharmacol Exp Ther 2006 319: 1235-1243. Published online September 6, 2006; 10.1124/jpet.106.109470 [Abstract] [Full Text] [PDF]  

Piotr Popik, Emmanuel Kostakis, Martyna Krawczyk, Gabriel Nowak, Bernadeta Szewczyk, Philip Krieter, Zhengming Chen, Shelley J. Russek, Terrell T. Gibbs, David H. Farb, Phil Skolnick, Arnold S. Lippa, and Anthony S. Basile

The Anxioselective Agent 7-(2-Chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) Is More Efficacious Than Diazepam at Enhancing GABA-Gated Currents at ₁ Subunit-Containing GABA_A Receptors
J Pharmacol Exp Ther 2006 319: 1244-1252. Published online September 13, 2006; 10.1124/jpet.106.107201 [Abstract] [Full Text] [PDF]  

Laura H. Jacobson, Bernhard Bettler, Klemens Kaupmann, and John F. Cryan

GABA_B(1) Receptor Subunit Isoforms Exert a Differential Influence on Baseline but Not GABA_B Receptor Agonist-Induced Changes in Mice
J Pharmacol Exp Ther 2006 319: 1317-1326. Published online September 21, 2006; 10.1124/jpet.106.111971 [Abstract] [Full Text] [PDF]  

David M. Devilbiss and Craig W. Berridge

Low-Dose Methylphenidate Actions on Tonic and Phasic Locus Coeruleus Discharge
J Pharmacol Exp Ther 2006 319: 1327-1335. Published online September 15, 2006; 10.1124/jpet.106.110015 [Abstract] [Full Text] [PDF]  

Christopher Katnik, Waldo R. Guerrero, Keith R. Pennypacker, Yelenis Herrera, and Javier Cuevas

Sigma-1 Receptor Activation Prevents Intracellular Calcium Dysregulation in Cortical Neurons during in Vitro Ischemia
J Pharmacol Exp Ther 2006 319: 1355-1365. Published online September 20, 2006; 10.1124/jpet.106.107557 [Abstract] [Full Text] [PDF]  

S. Kumar, B. M. Lane, and A. L. Morrow

Differential Effects of Systemic Ethanol Administration on Protein Kinase C, , and Isoform Expression, Membrane Translocation, and Target Phosphorylation: Reversal by Chronic Ethanol Exposure
J Pharmacol Exp Ther 2006 319: 1366-1375. Published online September 22, 2006; 10.1124/jpet.106.110890 [Abstract] [Full Text] [PDF]  

Prisca Honore, Diana Donnelly-Roberts, Marian T. Namovic, Gin Hsieh, Chang Z. Zhu, Joe P. Mikusa, Gricelda Hernandez, Chengmin Zhong, Donna M. Gauvin, Prasant Chandran, Richard Harris, Arturo Perez Medrano, William Carroll, Kennan Marsh, James P. Sullivan, Connie R. Faltynek, and Michael F. Jarvis

A-740003 [N-(1-{[(Cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a Novel and Selective P2X₇ Receptor Antagonist, Dose-Dependently Reduces Neuropathic Pain in the Rat
J Pharmacol Exp Ther 2006 319: 1376-1385. Published online September 18, 2006; 10.1124/jpet.106.111559 [Abstract] [Full Text] [PDF]  

Adebola C. Fabiyi and Alison F. Brading

The Use of the Isolated Mouse Whole Bladder for Investigating Bladder Overactivity
J Pharmacol Exp Ther 2006 319: 1386-1394. Published online August 30, 2006; 10.1124/jpet.106.108902 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Liping Du, Mark M. Neis, Patricia A. Ladd, and Diane S. Keeney

Differentiation-Specific Factors Modulate Epidermal CYP1–4 Gene Expression in Human Skin in Response to Retinoic Acid and Classic Aryl Hydrocarbon Receptor Ligands
J Pharmacol Exp Ther 2006 319: 1162-1171. Published online September 19, 2006; 10.1124/jpet.106.111724 [Abstract] [Full Text] [PDF]  

Xiaomin Deng, Robert F. Stachlewitz, Michael J. Liguori, Eric A. G. Blomme, Jeffrey F. Waring, James P. Luyendyk, Jane F. Maddox, Patricia E. Ganey, and Robert A. Roth

Modest Inflammation Enhances Diclofenac Hepatotoxicity in Rats: Role of Neutrophils and Bacterial Translocation
J Pharmacol Exp Ther 2006 319: 1191-1199. Published online September 21, 2006; 10.1124/jpet.106.110247 [Abstract] [Full Text] [PDF]  

Martin Sterba, Olga Popelová, Tomás Simunek, Yvona Mazurová, Anna Potácová, Michaela Adamcová, Helena Kaiserová, Premysl Ponka, and Vladimír Gersl

Cardioprotective Effects of a Novel Iron Chelator, Pyridoxal 2-Chlorobenzoyl Hydrazone, in the Rabbit Model of Daunorubicin-Induced Cardiotoxicity
J Pharmacol Exp Ther 2006 319: 1336-1347. Published online September 26, 2006; 10.1124/jpet.106.111468 [Abstract] [Full Text] [PDF]  

Katri Maria Waldhauser, Michael Török, Huy-Riem Ha, Urs Thomet, Daniel Konrad, Karin Brecht, Ferenc Follath, and Stephan Krähenbühl

Hepatocellular Toxicity and Pharmacological Effect of Amiodarone and Amiodarone Derivatives
J Pharmacol Exp Ther 2006 319: 1413-1423. Published online September 13, 2006; 10.1124/jpet.106.108993 [Abstract] [Full Text] [PDF]  

Jingxiang Bai and Arthur I. Cederbaum

Cycloheximide Protects HepG2 Cells from Serum Withdrawal-Induced Apoptosis by Decreasing p53 and Phosphorylated p53 Levels
J Pharmacol Exp Ther 2006 319: 1435-1443. Published online September 13, 2006; 10.1124/jpet.106.110007 [Abstract] [Full Text] [PDF]  

ERRATUM:

Correction to "A Novel Phospholipid Derivative of Indomethacin, DP-155 [Mixture of 1-Steroyl and 1-Palmitoyl-2-{4-[1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl acetamido]butanoyl}-sn-glycero-3-phosophatidyl Choline], Shows Superior Safety and Similar Efficacy in Reducing Brain Amyloid in an Alzheimer's Disease Model"
J Pharmacol Exp Ther 2006 319: 1492. [Full Text] [PDF]  

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