PERSPECTIVES IN PHARMACOLOGY:

Hyoung-gon Lee, Xiongwei Zhu, Rudy J. Castellani, Akihiko Nunomura, George Perry, and Mark A. Smith

Amyloid- in Alzheimer Disease: The Null versus the Alternate Hypotheses
J Pharmacol Exp Ther 2007 321: 823-829. Published online January 17, 2007; 10.1124/jpet.106.114009 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Zachary A. Rodd, Victoria E. Gryszowka, Jamie E. Toalston, Scott M. Oster, Dong Ji, Richard L. Bell, and William J. McBride

The Reinforcing Actions of a Serotonin-3 Receptor Agonist within the Ventral Tegmental Area: Evidence for Subregional and Genetic Differences and Involvement of Dopamine Neurons
J Pharmacol Exp Ther 2007 321: 1003-1012. Published online February 26, 2007; 10.1124/jpet.106.112607 [Abstract] [Full Text] [PDF]  

Marcello Solinas, Maria Scherma, Gianluigi Tanda, Carrie E. Wertheim, Walter Fratta, and Steven R. Goldberg

Nicotinic Facilitation of 9-Tetrahydrocannabinol Discrimination Involves Endogenous Anandamide
J Pharmacol Exp Ther 2007 321: 1127-1134. Published online March 9, 2007; 10.1124/jpet.106.116830 [Abstract] [Full Text] [PDF]  

James K. Rowlett, Donna M. Platt, Wei-Dong Yao, and Roger D. Spealman

Modulation of Heroin and Cocaine Self-Administration by Dopamine D1- and D2-Like Receptor Agonists in Rhesus Monkeys
J Pharmacol Exp Ther 2007 321: 1135-1143. Published online March 9, 2007; 10.1124/jpet.107.120766 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Jun Guo, Hamid Massaeli, Wentao Li, Jianmin Xu, Tao Luo, James Shaw, Lorrie A. Kirshenbaum, and Shetuan Zhang

Identification of I_Kr and Its Trafficking Disruption Induced by Probucol in Cultured Neonatal Rat Cardiomyocytes
J Pharmacol Exp Ther 2007 321: 911-920. Published online March 21, 2007; 10.1124/jpet.107.120931 [Abstract] [Full Text] [PDF]  

Marnie L. Olson, Margaret E. Kargacin, Christopher A. Ward, and Gary J. Kargacin

Effects of Phloretin and Phloridzin on Ca²⁺ Handling, the Action Potential, and Ion Currents in Rat Ventricular Myocytes
J Pharmacol Exp Ther 2007 321: 921-929. Published online March 21, 2007; 10.1124/jpet.107.121111 [Abstract] [Full Text] [PDF]  

Kristina Danielyan, Bi-Sen Ding, Claudia Gottstein, Douglas B. Cines, and Vladimir R. Muzykantov

Delivery of Anti-Platelet-Endothelial Cell Adhesion Molecule Single-Chain Variable Fragment-Urokinase Fusion Protein to the Cerebral Vasculature Lyses Arterial Clots and Attenuates Postischemic Brain Edema
J Pharmacol Exp Ther 2007 321: 947-952. Published online March 26, 2007; 10.1124/jpet.107.120535 [Abstract] [Full Text] [PDF]  

Rie Schultz Hansen, Søren-Peter Olesen, and Morten Grunnet

Pharmacological Activation of Rapid Delayed Rectifier Potassium Current Suppresses Bradycardia-Induced Triggered Activity in the Isolated Guinea Pig Heart
J Pharmacol Exp Ther 2007 321: 996-1002. Published online February 26, 2007; 10.1124/jpet.106.118448 [Abstract] [Full Text] [PDF]  

Wenqi Yang, Blythe B. Holmes, V. Raj Gopal, R. V. Krishna Kishore, Bhavani Sangras, Xiu-Yu Yi, J. R. Falck, and William B. Campbell

Characterization of 14,15-Epoxyeicosatrienoyl-Sulfonamides as 14,15-Epoxyeicosatrienoic Acid Agonists: Use for Studies of Metabolism and Ligand Binding
J Pharmacol Exp Ther 2007 321: 1023-1031. Published online February 27, 2007; 10.1124/jpet.107.119651 [Abstract] [Full Text] [PDF]  

Sohag N. Saleh, Jeff E. Angermann, William R. Sones, Normand Leblanc, and Iain A. Greenwood

Stimulation of Ca²⁺-Gated Cl^- Currents by the Calcium-Dependent K⁺ Channel Modulators NS1619 [1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one] and Isopimaric Acid
J Pharmacol Exp Ther 2007 321: 1075-1084. Published online March 8, 2007; 10.1124/jpet.106.118786 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Kelly A. Berg, Amol M. Patwardhan, Teresa A. Sanchez, Yamille M. Silva, Kenneth M. Hargreaves, and William P. Clarke

Rapid Modulation of µ-Opioid Receptor Signaling in Primary Sensory Neurons
J Pharmacol Exp Ther 2007 321: 839-847. Published online March 8, 2007; 10.1124/jpet.106.116681 [Abstract] [Full Text] [PDF]  

Yi Luo, C. Jane Dixon, John F. Hall, Pamela J. White, and Michael R. Boarder

A Role for Akt in Epidermal Growth Factor-Stimulated Cell Cycle Progression in Cultured Hepatocytes: Generation of a Hyperproliferative Window after Adenoviral Expression of Constitutively Active Akt
J Pharmacol Exp Ther 2007 321: 884-891. Published online March 19, 2007; 10.1124/jpet.107.121061 [Abstract] [Full Text] [PDF]  

Hyeon Ju Kim, Michael Rowe, Ming Ren, Jau-Shyong Hong, Po-See Chen, and De-Maw Chuang

Histone Deacetylase Inhibitors Exhibit Anti-Inflammatory and Neuroprotective Effects in a Rat Permanent Ischemic Model of Stroke: Multiple Mechanisms of Action
J Pharmacol Exp Ther 2007 321: 892-901. Published online March 19, 2007; 10.1124/jpet.107.120188 [Abstract] [Full Text] [PDF]  

LaTronya McCollum, Allyn C. Howlett, and Somnath Mukhopadhyay

Anandamide-Mediated CB₁/CB₂ Cannabinoid Receptor-Independent Nitric Oxide Production in Rabbit Aortic Endothelial Cells
J Pharmacol Exp Ther 2007 321: 930-937. Published online March 22, 2007; 10.1124/jpet.106.117549 [Abstract] [Full Text] [PDF]  

Shujun Liu, Rebecca B. Klisovic, Tamara Vukosavljevic, Jianhua Yu, Peter Paschka, Lenguyen Huynh, Jiuxia Pang, Paolo Neviani, Zhongfa Liu, William Blum, Kenneth K. Chan, Danilo Perrotti, and Guido Marcucci

Targeting AML1/ETO-Histone Deacetylase Repressor Complex: A Novel Mechanism for Valproic Acid-Mediated Gene Expression and Cellular Differentiation in AML1/ETO-Positive Acute Myeloid Leukemia Cells
J Pharmacol Exp Ther 2007 321: 953-960. Published online March 26, 2007; 10.1124/jpet.106.118406 [Abstract] [Full Text] [PDF]  

Hendrik Preuss, Prasanta Ghorai, Anja Kraus, Stefan Dove, Armin Buschauer, and Roland Seifert

Mutations of Cys-17 and Ala-271 in the Human Histamine H₂ Receptor Determine the Species Selectivity of Guanidine-Type Agonists and Increase Constitutive Activity
J Pharmacol Exp Ther 2007 321: 975-982. Published online March 8, 2007; 10.1124/jpet.107.120519 [Abstract] [Full Text] [PDF]  

Hendrik Preuss, Prasanta Ghorai, Anja Kraus, Stefan Dove, Armin Buschauer, and Roland Seifert

Constitutive Activity and Ligand Selectivity of Human, Guinea Pig, Rat, and Canine Histamine H₂ Receptors
J Pharmacol Exp Ther 2007 321: 983-995. Published online March 1, 2007; 10.1124/jpet.107.120014 [Abstract] [Full Text] [PDF]  

Pablo R. Moya, Kelly A. Berg, Manuel A. Gutiérrez-Hernandez, Patricio Sáez-Briones, Miguel Reyes-Parada, Bruce K. Cassels, and William P. Clarke

Functional Selectivity of Hallucinogenic Phenethylamine and Phenylisopropylamine Derivatives at Human 5-Hydroxytryptamine (5-HT)_2A and 5-HT_2C Receptors
J Pharmacol Exp Ther 2007 321: 1054-1061. Published online March 2, 2007; 10.1124/jpet.106.117507 [Abstract] [Full Text] [PDF]  

Tiziano Croci, Roberto Cecchi, Pietro Marini, Céline Rouget, Nunzia Viviani, Guy Germain, Fabio Guagnini, Yvon Fradin, Laurence Descamps, Marc Pascal, Charles Advenier, Michelle Breuiller-Fouché, Marie-Josèphe Leroy, and Marc Bardou

In Vitro and in Vivo Pharmacological Characterization of Ethyl-4-{trans-4-[((2S)-2-hydroxy-3-{4-hydroxy-3[(methylsulfonyl)amino]-phenoxy}propyl) Amino]cyclohexyl}benzoate Hydrochloride (SAR150640), a New Potent and Selective Human ₃-Adrenoceptor Agonist for the Treatment of Preterm Labor
J Pharmacol Exp Ther 2007 321: 1118-1126. Published online March 9, 2007; 10.1124/jpet.106.119123 [Abstract] [Full Text] [PDF]  

Michael T. Griffin, Katherine W. Figueroa, Sarah Liller, and Frederick J. Ehlert

Estimation of Agonist Activity at G Protein-Coupled Receptors: Analysis of M₂ Muscarinic Receptor Signaling through G_i/o,G_s, and G₁₅
J Pharmacol Exp Ther 2007 321: 1193-1207. Published online March 28, 2007; 10.1124/jpet.107.120857 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Lilian Amrein, Martin Loignon, Anne-Christine Goulet, Michael Dunn, Bertrand Jean-Claude, Raquel Aloyz, and Lawrence Panasci

Chlorambucil Cytotoxicity in Malignant B Lymphocytes Is Synergistically Increased by 2-(Morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-Mediated Inhibition of DNA Double-Strand Break Repair via Inhibition of DNA-Dependent Protein Kinase
J Pharmacol Exp Ther 2007 321: 848-855. Published online March 9, 2007; 10.1124/jpet.106.118356 [Abstract] [Full Text] [PDF] [Data Supplement]   

Alan Pourpak, Terry H. Landowski, and Robert T. Dorr

Ethonafide-Induced Cytotoxicity Is Mediated by Topoisomerase II Inhibition in Prostate Cancer Cells
J Pharmacol Exp Ther 2007 321: 1109-1117. Published online March 9, 2007; 10.1124/jpet.106.117457 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Teresa Gonzalo, Leonie Beljaars, Marja van de Bovenkamp, Kai Temming, Anne-Miek van Loenen, Catharina Reker-Smit, Dirk K. F. Meijer, Marie Lacombe, Frank Opdam, György Kéri, László Örfi, Klaas Poelstra, and Robbert J. Kok

Local Inhibition of Liver Fibrosis by Specific Delivery of a Platelet-Derived Growth Factor Kinase Inhibitor to Hepatic Stellate Cells
J Pharmacol Exp Ther 2007 321: 856-865. Published online March 16, 2007; 10.1124/jpet.106.114496 [Abstract] [Full Text] [PDF]  

W. A. Simon, M. Herrmann, T. Klein, J. M. Shin, R. Huber, J. Senn-Bilfinger, and S. Postius

Soraprazan: Setting New Standards in Inhibition of Gastric Acid Secretion
J Pharmacol Exp Ther 2007 321: 866-874. Published online March 16, 2007; 10.1124/jpet.107.120428 [Abstract] [Full Text] [PDF]  

Masakazu Hirakawa, Yuji Karashima, Michi Watanabe, Chiwaka Kimura, Yushi Ito, and Masahiro Oike

Protein Kinase A Inhibits Lysophosphatidic Acid-Induced Migration of Airway Smooth Muscle Cells
J Pharmacol Exp Ther 2007 321: 1102-1108. Published online March 8, 2007; 10.1124/jpet.106.118042 [Abstract] [Full Text] [PDF]  

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:

Markus Latta, Gerald Künstle, Rudolf Lucas, Hannes Hentze, and Albrecht Wendel

ATP-Depleting Carbohydrates Prevent Tumor Necrosis Factor Receptor 1-Dependent Apoptotic and Necrotic Liver Injury in Mice
J Pharmacol Exp Ther 2007 321: 875-883. Published online March 16, 2007; 10.1124/jpet.107.119958 [Abstract] [Full Text] [PDF]  

Jeffrey R. Crosby, Mausumee Guha, David Tung, Doreen A. Miller, Brianna Bender, Thomas P. Condon, Cathie York-DeFalco, Richard S. Geary, Brett P. Monia, James G. Karras, and Susan A. Gregory

Inhaled CD86 Antisense Oligonucleotide Suppresses Pulmonary Inflammation and Airway Hyper-Responsiveness in Allergic Mice
J Pharmacol Exp Ther 2007 321: 938-946. Published online March 26, 2007; 10.1124/jpet.106.119214 [Abstract] [Full Text] [PDF]  

Navin L. Rao, Paul J. Dunford, Xiaohua Xue, Xiaohui Jiang, Katherine A. Lundeen, Fawn Coles, Jason P. Riley, Kacy N. Williams, Cheryl A. Grice, James P. Edwards, Lars Karlsson, and Anne M. Fourie

Anti-Inflammatory Activity of a Potent, Selective Leukotriene A₄ Hydrolase Inhibitor in Comparison with the 5-Lipoxygenase Inhibitor Zileuton
J Pharmacol Exp Ther 2007 321: 1154-1160. Published online March 19, 2007; 10.1124/jpet.106.115436 [Abstract] [Full Text] [PDF]  

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:

Á. Pál, D. Méhn, É. Molnár, S. Gedey, P. Mészáros, T. Nagy, H. Glavinas, T. Janáky, O. von Richter, G. Báthori, L. Szente, and P. Krajcsi

Cholesterol Potentiates ABCG2 Activity in a Heterologous Expression System: Improved in Vitro Model to Study Function of Human ABCG2
J Pharmacol Exp Ther 2007 321: 1085-1094. Published online March 8, 2007; 10.1124/jpet.106.119289 [Abstract] [Full Text] [PDF]  

Elaine M. Leslie, Paul B. Watkins, Richard B. Kim, and Kim L. R. Brouwer

Differential Inhibition of Rat and Human Na⁺-Dependent Taurocholate Cotransporting Polypeptide (NTCP/SLC10A1)by Bosentan: A Mechanism for Species Differences in Hepatotoxicity
J Pharmacol Exp Ther 2007 321: 1170-1178. Published online March 20, 2007; 10.1124/jpet.106.119073 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Ying Peng, Shaofeng Xu, Guiquan Chen, Ling Wang, Yipu Feng, and Xiaoliang Wang

l-3-n-Butylphthalide Improves Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats
J Pharmacol Exp Ther 2007 321: 902-910. Published online March 20, 2007; 10.1124/jpet.106.118760 [Abstract] [Full Text] [PDF]  

Barbara Spagnolo, Giacomo Carrà, Martina Fantin, Carmela Fischetti, Chris Hebbes, John McDonald, Timothy A. Barnes, Anna Rizzi, Claudio Trapella, Giulia Fanton, Michele Morari, Dave G. Lambert, Domenico Regoli, and Girolamo Calò

Pharmacological Characterization of the Nociceptin/Orphanin FQ Receptor Antagonist SB-612111 [(–)-cis-1-Methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: In Vitro Studies
J Pharmacol Exp Ther 2007 321: 961-967. Published online February 28, 2007; 10.1124/jpet.106.116764 [Abstract] [Full Text] [PDF]  

Anna Rizzi, Elaine C. Gavioli, Giuliano Marzola, Barbara Spagnolo, Silvia Zucchini, Roberto Ciccocioppo, Claudio Trapella, Domenico Regoli, and Girolamo Calò

Pharmacological Characterization of the Nociceptin/Orphanin FQ Receptor Antagonist SB-612111 [(–)-cis-1-Methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: In Vivo Studies
J Pharmacol Exp Ther 2007 321: 968-974. Published online February 28, 2007; 10.1124/jpet.106.116780 [Abstract] [Full Text] [PDF]  

Tung M. Fong, Xiao-Ming Guan, Donald J. Marsh, Chun-Pyn Shen, D. Sloan Stribling, Kim M. Rosko, Julie Lao, Hong Yu, Yue Feng, Jing C. Xiao, Lex H. T. Van der Ploeg, Mark T. Goulet, Williams K. Hagmann, Linus S. Lin, Thomas J. Lanza, Jr., James P. Jewell, Ping Liu, Shrenik K. Shah, Hongbo Qi, Xinchun Tong, Junying Wang, Suoyu S. Xu, Barbara Francis, Alison M. Strack, D. Euan MacIntyre, and Lauren P. Shearman

Antiobesity Efficacy of a Novel Cannabinoid-1 Receptor Inverse Agonist, N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), in Rodents
J Pharmacol Exp Ther 2007 321: 1013-1022. Published online February 27, 2007; 10.1124/jpet.106.118737 [Abstract] [Full Text] [PDF] [Data Supplement]   

Andrew D. Medhurst, Alan R. Atkins, Isabel J. Beresford, Kim Brackenborough, Michael A. Briggs, Andrew R. Calver, Jackie Cilia, Jane E. Cluderay, Barry Crook, John B. Davis, Rebecca K. Davis, Robert P. Davis, Lee A. Dawson, Andrew G. Foley, Jane Gartlon, M. Isabel Gonzalez, Teresa Heslop, Warren D. Hirst, Carol Jennings, Declan N. C. Jones, Laurent P. Lacroix, Abbe Martyn, Sandrine Ociepka, Alison Ray, Ciaran M. Regan, Jennifer C. Roberts, Joanne Schogger, Eric Southam, Tania O. Stean, Brenda K. Trail, Neil Upton, Graham Wadsworth, Jeffrey A. Wald, Trevor White, Jason Witherington, Marie L. Woolley, Angela Worby, and David M. Wilson

GSK189254, a Novel H₃ Receptor Antagonist That Binds to Histamine H₃ Receptors in Alzheimer's Disease Brain and Improves Cognitive Performance in Preclinical Models
J Pharmacol Exp Ther 2007 321: 1032-1045. Published online February 27, 2007; 10.1124/jpet.107.120311 [Abstract] [Full Text] [PDF]  

Feng-Yu Liu, Guo-Gang Xing, Xiao-Xiu Qu, Isabella S. Xu, Ji-Sheng Han, and You Wan

Roles of 5-Hydroxytryptamine (5-HT) Receptor Subtypes in the Inhibitory Effects of 5-HT on C-Fiber Responses of Spinal Wide Dynamic Range Neurons in Rats
J Pharmacol Exp Ther 2007 321: 1046-1053. Published online February 28, 2007; 10.1124/jpet.106.115204 [Abstract] [Full Text] [PDF]  

Kristin L. Hillman, Van A. Doze, and James E. Porter

1A-Adrenergic Receptors Are Functionally Expressed by a Subpopulation of Cornu Ammonis 1 Interneurons in Rat Hippocampus
J Pharmacol Exp Ther 2007 321: 1062-1068. Published online March 2, 2007; 10.1124/jpet.106.119297 [Abstract] [Full Text] [PDF]  

Dirk Rüsch, Boris Musset, Hinnerk Wulf, Anika Schuster, and Douglas E. Raines

Subunit-Dependent Modulation of the 5-Hydroxytryptamine Type 3 Receptor Open-Close Equilibrium by n-Alcohols
J Pharmacol Exp Ther 2007 321: 1069-1074. Published online March 7, 2007; 10.1124/jpet.106.118752 [Abstract] [Full Text] [PDF]  

Gentaroh Suzuki, Toshifumi Kimura, Akio Satow, Naoki Kaneko, Junko Fukuda, Hirohiko Hikichi, Naoko Sakai, Shunsuke Maehara, Hiroko Kawagoe-Takaki, Mikiko Hata, Tomoko Azuma, Satoru Ito, Hiroshi Kawamoto, and Hisashi Ohta

Pharmacological Characterization of a New, Orally Active and Potent Allosteric Metabotropic Glutamate Receptor 1 Antagonist, 4-[1-(2-Fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide (FTIDC)
J Pharmacol Exp Ther 2007 321: 1144-1153. Published online March 14, 2007; 10.1124/jpet.106.116574 [Abstract] [Full Text] [PDF] [Data Supplement]   

M. I. Damaj, C. Fonck, M. J. Marks, P. Deshpande, C. Labarca, H. A. Lester, A. C. Collins, and B. R. Martin

Genetic Approaches Identify Differential Roles for ₄₂^* Nicotinic Receptors in Acute Models of Antinociception in Mice
J Pharmacol Exp Ther 2007 321: 1161-1169. Published online March 19, 2007; 10.1124/jpet.106.112649 [Abstract] [Full Text] [PDF]  

Maibritt B. Andersen, Thomas Werge, and Anders Fink-Jensen

The Acetylcholinesterase Inhibitor Galantamine Inhibits d-Amphetamine-Induced Psychotic-Like Behavior in Cebus Monkeys
J Pharmacol Exp Ther 2007 321: 1179-1182. Published online March 20, 2007; 10.1124/jpet.107.119677 [Abstract] [Full Text] [PDF]  

Martin J. Gunthorpe, Sara Luis Hannan, Darren Smart, Jeffrey C. Jerman, Sandra Arpino, Graham D. Smith, Stephen Brough, Jim Wright, Julie Egerton, Sarah C. Lappin, Vicky A. Holland, Kim Winborn, Mervyn Thompson, Harshad K. Rami, Andrew Randall, and John B. Davis

Characterization of SB-705498, a Potent and Selective Vanilloid Receptor-1 (VR1/TRPV1) Antagonist That Inhibits the Capsaicin-, Acid-, and Heat-Mediated Activation of the Receptor
J Pharmacol Exp Ther 2007 321: 1183-1192. Published online March 28, 2007; 10.1124/jpet.106.116657 [Abstract] [Full Text] [PDF]  

Anthony S. Basile, Aaron Janowsky, Krystyna Golembiowska, Magdalena Kowalska, Eyal Tam, Morris Benveniste, Piotr Popik, Agnieszka Nikiforuk, Martyna Krawczyk, Gabriel Nowak, Philip A. Krieter, Arnold S. Lippa, Phil Skolnick, and Elena Koustova

Characterization of the Antinociceptive Actions of Bicifadine in Models of Acute, Persistent, and Chronic Pain
J Pharmacol Exp Ther 2007 321: 1208-1225. Published online February 26, 2007; 10.1124/jpet.106.116483 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Karen C. Thomas, Ashwini S. Sabnis, Mark E. Johansen, Diane L. Lanza, Philip J. Moos, Garold S. Yost, and Christopher A. Reilly

Transient Receptor Potential Vanilloid 1 Agonists Cause Endoplasmic Reticulum Stress and Cell Death in Human Lung Cells
J Pharmacol Exp Ther 2007 321: 830-838. Published online March 1, 2007; 10.1124/jpet.107.119412 [Abstract] [Full Text] [PDF] [Data Supplement]   

Adnan A. Elfarra and Renee J. Krause

S-(1,2,2-Trichlorovinyl)-L-cysteine Sulfoxide, a Reactive Metabolite of S-(1,2,2-Trichlorovinyl)-L-cysteine Formed in Rat Liver and Kidney Microsomes, Is a Potent Nephrotoxicant
J Pharmacol Exp Ther 2007 321: 1095-1101. Published online March 8, 2007; 10.1124/jpet.107.120444 [Abstract] [Full Text] [PDF]  

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