BEHAVIORAL PHARMACOLOGY:

Kuldip D. Dave, John A. Harvey, and Vincent J. Aloyo

The Time-Course for Up- and Down-Regulation of the Cortical 5-Hydroxytryptamine (5-HT)_2A Receptor Density Predicts 5-HT_2A Receptor-Mediated Behavior in the Rabbit
J Pharmacol Exp Ther 2007 323: 327-335. Published online July 19, 2007; 10.1124/jpet.107.121707 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

A. Elizabeth Linder, Keshari M. Thakali, Janice M. Thompson, Stephanie W. Watts, R. Clinton Webb, and Romulo Leite

Methyl--cyclodextrin Prevents Angiotensin II-Induced Tachyphylactic Contractile Responses in Rat Aorta
J Pharmacol Exp Ther 2007 323: 78-84. Published online July 16, 2007; 10.1124/jpet.107.123463 [Abstract] [Full Text] [PDF]  

Rajarsi Mandal, Vijay Kumar Kutala, Mahmood Khan, Iyyapu K. Mohan, Saradhadevi Varadharaj, Arun Sridhar, Cynthia A. Carnes, Tamás Kálai, Kálmán Hideg, and Periannan Kuppusamy

N-Hydroxy-pyrroline Modification of Verapamil Exhibits Antioxidant Protection of the Heart against Ischemia/Reperfusion-Induced Cardiac Dysfunction without Compromising Its Calcium Antagonistic Activity
J Pharmacol Exp Ther 2007 323: 119-127. Published online July 23, 2007; 10.1124/jpet.107.127167 [Abstract] [Full Text] [PDF]  

Erij Messadi-Laribi, Violaine Griol-Charhbili, Anne Pizard, Marie-Pascale Vincent, Didier Heudes, Pierre Meneton, François Alhenc-Gelas, and Christine Richer

Tissue Kallikrein Is Involved in the Cardioprotective Effect of AT1-Receptor Blockade in Acute Myocardial Ischemia
J Pharmacol Exp Ther 2007 323: 210-216. Published online July 16, 2007; 10.1124/jpet.107.124859 [Abstract] [Full Text] [PDF]  

Ryan M. Fryer, Jason A. Segreti, Deborah L. Widomski, Pamela H. Franklin, Patricia N. Banfor, Kristin A. Koch, Masaki Nakane, J. Ruth Wu-Wong, Bryan F. Cox, and Glenn A. Reinhart

Systemic Activation of the Calcium Sensing Receptor Produces Acute Effects on Vascular Tone and Circulatory Function in Uremic and Normal Rats: Focus on Central versus Peripheral Control of Vascular Tone and Blood Pressure by Cinacalcet
J Pharmacol Exp Ther 2007 323: 217-226. Published online July 16, 2007; 10.1124/jpet.107.123901 [Abstract] [Full Text] [PDF]  

Fatou Nsoure Obame, Roland Zini, Rachid Souktani, Alain Berdeaux, and Didier Morin

Peripheral Benzodiazepine Receptor-Induced Myocardial Protection is Mediated by Inhibition of Mitochondrial Membrane Permeabilization
J Pharmacol Exp Ther 2007 323: 336-345. Published online July 19, 2007; 10.1124/jpet.107.124255 [Abstract] [Full Text] [PDF]  

Olga Ostrovskaya, Ravi Goyal, Noah Osman, Claire E. McAllister, Isaac N. Pessah, Joseph R. Hume, and Sean M. Wilson

Inhibition of Ryanodine Receptors by 4-(2-Aminopropyl)-3,5-dichloro-N,N-dimethylaniline (FLA 365) in Canine Pulmonary Arterial Smooth Muscle Cells
J Pharmacol Exp Ther 2007 323: 381-390. Published online July 19, 2007; 10.1124/jpet.107.122119 [Abstract] [Full Text] [PDF]  

Xiao-Hui Sun, Jiu-Ping Ding, Hui Li, Na Pan, Lu Gan, Xiang-Liang Yang, and Hui-Bi Xu

Activation of Large-Conductance Calcium-Activated Potassium Channels by Puerarin: The Underlying Mechanism of Puerarin-Mediated Vasodilation
J Pharmacol Exp Ther 2007 323: 391-397. Published online July 25, 2007; 10.1124/jpet.107.125567 [Abstract] [Full Text] [PDF] [Data Supplement]   

CELLULAR AND MOLECULAR:

Haiyan Liu, Judith A. Enyeart, and John J. Enyeart

Potent Inhibition of Native TREK-1 K⁺ Channels by Selected Dihydropyridine Ca²⁺ Channel Antagonists
J Pharmacol Exp Ther 2007 323: 39-48. Published online July 10, 2007; 10.1124/jpet.107.125245 [Abstract] [Full Text] [PDF]  

Karen M. Kassel, Nancy A. Schulte, Stacey M. Parker, Aaron D. Lanik, and Myron L. Toews

Lysophosphatidic Acid Decreases Epidermal Growth Factor Receptor Binding in Airway Epithelial Cells
J Pharmacol Exp Ther 2007 323: 109-118. Published online July 19, 2007; 10.1124/jpet.107.120584 [Abstract] [Full Text] [PDF] [Erratum]   

Kiyoshi Itagaki, Jong K. Yun, Jeremy A. Hengst, Atsuko Yatani, Carl J. Hauser, Zoltan Spolarics, and Edwin A. Deitch

Sphingosine 1-Phosphate Has Dual Functions in the Regulation of Endothelial Cell Permeability and Ca²⁺ Metabolism
J Pharmacol Exp Ther 2007 323: 186-191. Published online July 12, 2007; 10.1124/jpet.107.121210 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Heng-Liang Lin, Shih-Hwa Chiou, Chew-Wun Wu, Wen-Bin Lin, Li-Hsin Chen, Yi-Ping Yang, Ming-Long Tsai, Yih-Huei Uen, Jing-Ping Liou, and Chin-Wen Chi

Combretastatin A4-Induced Differential Cytotoxicity and Reduced Metastatic Ability by Inhibition of AKT Function in Human Gastric Cancer Cells
J Pharmacol Exp Ther 2007 323: 365-373. Published online July 23, 2007; 10.1124/jpet.107.124966 [Abstract] [Full Text] [PDF]  

Jing-Ping Liou, Kuo-Shun Hsu, Ching-Chuan Kuo, Chi-Yen Chang, and Jang-Yang Chang

A Novel Oral Indoline-Sulfonamide Agent, N-[1-(4-Methoxybenzenesulfonyl)-2,3-dihydro-1H-indol-7-yl]-Isonicotinamide (J30), Exhibits Potent Activity against Human Cancer Cells in Vitro and in Vivo through the Disruption of Microtubule
J Pharmacol Exp Ther 2007 323: 398-405. Published online July 27, 2007; 10.1124/jpet.107.126680 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND DIABETES:

Tobias Rydgren, Outi Vaarala, and Stellan Sandler

Simvastatin Protects against Multiple Low-Dose Streptozotocin-Induced Type 1 Diabetes in CD-1 Mice and Recurrence of Disease in Nonobese Diabetic Mice
J Pharmacol Exp Ther 2007 323: 180-185. Published online July 17, 2007; 10.1124/jpet.107.122655 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Regina Ragasa, Eiji Nakamura, Lisa Marrone, Saeko Yanaka, Shusaku Hayashi, Koji Takeuchi, and Susan J. Hagen

Isothiocyanate Inhibits Restitution and Wound Repair after Injury in the Stomach: Ex Vivo and in Vitro Studies
J Pharmacol Exp Ther 2007 323: 1-9. Published online July 3, 2007; 10.1124/jpet.107.121640 [Abstract] [Full Text] [PDF]  

Yuk Cheung Chan and Po Sing Leung

Angiotensin II Type 1 Receptor-Dependent Nuclear Factor-B Activation-Mediated Proinflammatory Actions in a Rat Model of Obstructive Acute Pancreatitis
J Pharmacol Exp Ther 2007 323: 10-18. Published online July 6, 2007; 10.1124/jpet.107.124891 [Abstract] [Full Text] [PDF]  

N. D. Vaziri, Y. Bai, Z. Ni, Y. Quiroz, R. Pandian, and B. Rodriguez-Iturbe

Intra-Renal Angiotensin II/AT₁ Receptor, Oxidative Stress, Inflammation, and Progressive Injury in Renal Mass Reduction
J Pharmacol Exp Ther 2007 323: 85-93. Published online July 16, 2007; 10.1124/jpet.107.123638 [Abstract] [Full Text] [PDF]  

Pedro J. Gomez-Pinilla, Pedro J. Camello, and María J. Pozo

Effects of Melatonin on Gallbladder Neuromuscular Function in Acute Cholecystitis
J Pharmacol Exp Ther 2007 323: 138-146. Published online July 5, 2007; 10.1124/jpet.107.123240 [Abstract] [Full Text] [PDF]  

Alexandra Hicks, Gerald P. McCafferty, Erin Riedel, Nambi Aiyar, Mark Pullen, Christopher Evans, Trudy D. Luce, Robert W. Coatney, Gian C. Rivera, Timothy D. Westfall, and J. Paul Hieble

GW427353 (Solabegron), a Novel, Selective ₃-Adrenergic Receptor Agonist, Evokes Bladder Relaxation and Increases Micturition Reflex Threshold in the Dog
J Pharmacol Exp Ther 2007 323: 202-209. Published online July 12, 2007; 10.1124/jpet.107.125757 [Abstract] [Full Text] [PDF]  

Keiichi Ito, Kazuya Kinoshita, Atsuyuki Tomizawa, Fumi Inaba, Yuka Morikawa-Inomata, Mitsuko Makino, Keiichi Tabata, and Nobuhiko Shibakawa

Pharmacological Profile of Novel Acid Pump Antagonist 7-(4-Fluorobenzyloxy)-2,3-dimethyl-1-{[(1S,2S)-2-methyl cyclopropyl]methyl}-1H-pyrrolo[2,3-d]pyridazine (CS-526)
J Pharmacol Exp Ther 2007 323: 308-317. Published online July 13, 2007; 10.1124/jpet.107.121350 [Abstract] [Full Text] [PDF]  

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:

Hannu Kankaanranta, Xianzhi Zhang, Ritva Tumelius, Minna Ruotsalainen, Heimo Haikala, Erkki Nissinen, and Eeva Moilanen

Antieosinophilic Activity of Simendans
J Pharmacol Exp Ther 2007 323: 31-38. Published online July 9, 2007; 10.1124/jpet.107.124057 [Abstract] [Full Text] [PDF]  

Ángeles Álvarez, M. Sales Ibiza, Mario M. Andrade, Ana Blas-García, and Sara Calatayud

Gastric Antisecretory Drugs Induce Leukocyte-Endothelial Cell Interactions through Gastrin Release and Activation of CCK-2 Receptors
J Pharmacol Exp Ther 2007 323: 406-413. Published online July 24, 2007; 10.1124/jpet.107.122754 [Abstract] [Full Text] [PDF]  

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:

Pär Matsson, Gunilla Englund, Gustav Ahlin, Christel A. S. Bergström, Ulf Norinder, and Per Artursson

A Global Drug Inhibition Pattern for the Human ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (ABCG2)
J Pharmacol Exp Ther 2007 323: 19-30. Published online July 6, 2007; 10.1124/jpet.107.124768 [Abstract] [Full Text] [PDF] [Data Supplement]   

Marissa A. Schiel, Scheri-lyn Green, Wilhelmina I. Davis, Paresh C. Sanghani, William F. Bosron, and Sonal P. Sanghani

Expression and Characterization of a Human Carboxylesterase 2 Splice Variant
J Pharmacol Exp Ther 2007 323: 94-101. Published online July 17, 2007; 10.1124/jpet.107.127027 [Abstract] [Full Text] [PDF]  

Patrick Hindlet, André Bado, Robert Farinotti, and Marion Buyse

Long-Term Effect of Leptin on H⁺-Coupled Peptide Cotransporter 1 Activity and Expression in Vivo: Evidence in Leptin-Deficient Mice
J Pharmacol Exp Ther 2007 323: 192-201. Published online July 10, 2007; 10.1124/jpet.107.125799 [Abstract] [Full Text] [PDF]  

Caroline Henrike Storch, Robert Ehehalt, Walter Emil Haefeli, and Johanna Weiss

Localization of the Human Breast Cancer Resistance Protein (BCRP/ABCG2) in Lipid Rafts/Caveolae and Modulation of Its Activity by Cholesterol in Vitro
J Pharmacol Exp Ther 2007 323: 257-264. Published online July 24, 2007; 10.1124/jpet.107.122994 [Abstract] [Full Text] [PDF] [Data Supplement]   

NEUROPHARMACOLOGY:

E. van Duuren, G. van der Plasse, R. van der Blom, R. N. J. M. A. Joosten, A. B. Mulder, C. M. A. Pennartz, and M. G. P. Feenstra

Pharmacological Manipulation of Neuronal Ensemble Activity by Reverse Microdialysis in Freely Moving Rats: A Comparative Study of the Effects of Tetrodotoxin, Lidocaine, and Muscimol
J Pharmacol Exp Ther 2007 323: 61-69. Published online July 12, 2007; 10.1124/jpet.107.124784 [Abstract] [Full Text] [PDF]  

Fabio Cavaliere, Susanna Amadio, Klaus Dinkel, Klaus G. Reymann, and Cinzia Volonté

P2 Receptor Antagonist Trinitrophenyl-Adenosine-Triphosphate Protects Hippocampus from Oxygen and Glucose Deprivation Cell Death
J Pharmacol Exp Ther 2007 323: 70-77. Published online July 9, 2007; 10.1124/jpet.106.119024 [Abstract] [Full Text] [PDF]  

Margi E. Goldstein, Yang Cao, Tracey Fiedler, Jeremy Toyn, Lawrence Iben, Donna M. Barten, Maria Pierdomenico, Jason Corsa, C. V. C. Prasad, Richard E. Olson, Yu-Wen Li, Robert Zaczek, and Charles F. Albright

Ex Vivo Occupancy of -Secretase Inhibitors Correlates with Brain -Amyloid Peptide Reduction in Tg2576 Mice
J Pharmacol Exp Ther 2007 323: 102-108. Published online July 19, 2007; 10.1124/jpet.107.125492 [Abstract] [Full Text] [PDF]  

Narender R. Gavva, Anthony W. Bannon, David N. Hovland, Jr., Sonya G. Lehto, Lana Klionsky, Sekhar Surapaneni, David C. Immke, Charles Henley, Leyla Arik, Annette Bak, James Davis, Nadia Ernst, Gal Hever, Rongzhen Kuang, Licheng Shi, Rami Tamir, Jue Wang, Weiya Wang, Gary Zajic, Dawn Zhu, Mark H. Norman, Jean-Claude Louis, Ella Magal, and James J. S. Treanor

Repeated Administration of Vanilloid Receptor TRPV1 Antagonists Attenuates Hyperthermia Elicited by TRPV1 Blockade
J Pharmacol Exp Ther 2007 323: 128-137. Published online July 25, 2007; 10.1124/jpet.107.125674 [Abstract] [Full Text] [PDF] [Data Supplement]   

Gentaroh Suzuki, Naohiro Tsukamoto, Hiroshi Fushiki, Aki Kawagishi, Masayuki Nakamura, Hideki Kurihara, Morihiro Mitsuya, Mitsuru Ohkubo, and Hisashi Ohta

In Vitro Pharmacological Characterization of Novel Isoxazolopyridone Derivatives as Allosteric Metabotropic Glutamate Receptor 7 Antagonists
J Pharmacol Exp Ther 2007 323: 147-156. Published online July 3, 2007; 10.1124/jpet.107.124701 [Abstract] [Full Text] [PDF] [Data Supplement]   

Wennan Lu, David Reigada, Jean Sévigny, and Claire H. Mitchell

Stimulation of the P2Y₁ Receptor Up-Regulates Nucleoside-Triphosphate Diphosphohydrolase-1 in Human Retinal Pigment Epithelial Cells
J Pharmacol Exp Ther 2007 323: 157-164. Published online July 12, 2007; 10.1124/jpet.107.124545 [Abstract] [Full Text] [PDF]  

Jinsook Kim, Alexei Kondratyev, and Karen Gale

Antiepileptic Drug-Induced Neuronal Cell Death in the Immature Brain: Effects of Carbamazepine, Topiramate, and Levetiracetam as Monotherapy versus Polytherapy
J Pharmacol Exp Ther 2007 323: 165-173. Published online July 16, 2007; 10.1124/jpet.107.126250 [Abstract] [Full Text] [PDF]  

Lori Birder, F. Aura Kullmann, Hyosang Lee, Stacey Barrick, William de Groat, Anthony Kanai, and Michael Caterina

Activation of Urothelial Transient Receptor Potential Vanilloid 4 by 4-Phorbol 12,13-Didecanoate Contributes to Altered Bladder Reflexes in the Rat
J Pharmacol Exp Ther 2007 323: 227-235. Published online July 17, 2007; 10.1124/jpet.107.125435 [Abstract] [Full Text] [PDF]  

Wenjun Li, Xiaochun Jin, Douglas F. Covey, and Joe Henry Steinbach

Neuroactive Steroids and Human Recombinant 1 GABA Receptors
J Pharmacol Exp Ther 2007 323: 236-247. Published online July 17, 2007; 10.1124/jpet.107.127365 [Abstract] [Full Text] [PDF] [Data Supplement]   

Ju Shi, Katerina J. Damjanoska, Rakesh K. Singh, Gonzalo A. Carrasco, Francisca Garcia, Angela J. Grippo, Michelle Landry, Nicole R. Sullivan, George Battaglia, and Nancy A. Muma

Agonist Induced-Phosphorylation of G₁₁ Protein Reduces Coupling to 5-HT_2A Receptors
J Pharmacol Exp Ther 2007 323: 248-256. Published online July 23, 2007; 10.1124/jpet.107.122317 [Abstract] [Full Text] [PDF]  

Thomas M. Tzschentke, Thomas Christoph, Babette Kögel, Klaus Schiene, Hagen-Heinrich Hennies, Werner Englberger, Michael Haurand, Ulrich Jahnel, Thomas I. F. H. Cremers, Elmar Friderichs, and Jean De Vry

(–)-(1R,2R)-3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol Hydrochloride (Tapentadol HCl): a Novel µ-Opioid Receptor Agonist/Norepinephrine Reuptake Inhibitor with Broad-Spectrum Analgesic Properties
J Pharmacol Exp Ther 2007 323: 265-276. Published online July 26, 2007; 10.1124/jpet.107.126052 [Abstract] [Full Text] [PDF]  

Daniel B. Putterman, Adam C. Munhall, Laura B. Kozell, John K. Belknap, and Steven W. Johnson

Evaluation of Levodopa Dose and Magnitude of Dopamine Depletion as Risk Factors for Levodopa-Induced Dyskinesia in a Rat Model of Parkinson's Disease
J Pharmacol Exp Ther 2007 323: 277-284. Published online July 27, 2007; 10.1124/jpet.107.126219 [Abstract] [Full Text] [PDF] [Data Supplement]   

Bruce R. Bianchi, Rachid El Kouhen, Torben R. Neelands, Chih-Hung Lee, Arthur Gomtsyan, Shirish N. Raja, Sriajan N. Vaidyanathan, Bruce Surber, Heath A. McDonald, Carol S. Surowy, Connie R. Faltynek, Robert B. Moreland, Michael F. Jarvis, and Pamela S. Puttfarcken

[³H]A-778317 [1-((R)-5-tert-Butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a Novel, Stereoselective, High-Affinity Antagonist Is a Useful Radioligand for the Human Transient Receptor Potential Vanilloid-1 (TRPV1) Receptor
J Pharmacol Exp Ther 2007 323: 285-293. Published online July 27, 2007; 10.1124/jpet.107.124305 [Abstract] [Full Text] [PDF] [Data Supplement]   

Daniel B. Timmermann, Jens Halvard Grønlien, Kathy L. Kohlhaas, Elsebet Ø. Nielsen, Eva Dam, Tino D. Jørgensen, Philip K. Ahring, Dan Peters, Dorte Holst, Jeppe K. Chrsitensen, John Malysz, Clark A. Briggs, Murali Gopalakrishnan, and Gunnar M. Olsen

An Allosteric Modulator of the 7 Nicotinic Acetylcholine Receptor Possessing Cognition-Enhancing Properties in Vivo
J Pharmacol Exp Ther 2007 323: 294-307. Published online July 11, 2007; 10.1124/jpet.107.120436 [Abstract] [Full Text] [PDF]  

Xuebing Cao, Li Liang, John R. Hadcock, Philip A. Iredale, David A. Griffith, Frank S. Menniti, Stewart Factor, J. Timothy Greenamyre, and Stella M. Papa

Blockade of Cannabinoid Type 1 Receptors Augments the Antiparkinsonian Action of Levodopa without Affecting Dyskinesias in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Treated Rhesus Monkeys
J Pharmacol Exp Ther 2007 323: 318-326. Published online July 13, 2007; 10.1124/jpet.107.125666 [Abstract] [Full Text] [PDF]  

J. Cory Kalvass, Emily R. Olson, Michael P. Cassidy, Dana E. Selley, and Gary M. Pollack

Pharmacokinetics and Pharmacodynamics of Seven Opioids in P-Glycoprotein-Competent Mice: Assessment of Unbound Brain EC_50,u and Correlation of in Vitro, Preclinical, and Clinical Data
J Pharmacol Exp Ther 2007 323: 346-355. Published online July 23, 2007; 10.1124/jpet.107.119560 [Abstract] [Full Text] [PDF]  

M. Katherine Kelm, Hugh E. Criswell, and George R. Breese

Calcium Release from Presynaptic Internal Stores Is Required for Ethanol to Increase Spontaneous -Aminobutyric Acid Release onto Cerebellum Purkinje Neurons
J Pharmacol Exp Ther 2007 323: 356-364. Published online July 25, 2007; 10.1124/jpet.107.126144 [Abstract] [Full Text] [PDF]  

Ewa D. Marczak, Yunden Jinsmaa, Tingyou Li, Sharon D. Bryant, Yuko Tsuda, Yoshio Okada, and Lawrence H. Lazarus

[N-Allyl-Dmt¹]-Endomorphins Are µ-Opioid Receptor Antagonists Lacking Inverse Agonist Properties
J Pharmacol Exp Ther 2007 323: 374-380. Published online July 12, 2007; 10.1124/jpet.107.125807 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Paul W. Buehler, Felice D'Agnillo, Victoria Hoffman, and Abdu I. Alayash

Effects of Endogenous Ascorbate on Oxidation, Oxygenation, and Toxicokinetics of Cell-Free Modified Hemoglobin after Exchange Transfusion in Rat and Guinea Pig
J Pharmacol Exp Ther 2007 323: 49-60. Published online July 10, 2007; 10.1124/jpet.107.126409 [Abstract] [Full Text] [PDF]  

K. T. LePage, J. D. Rainier, H. W. B. Johnson, D. G. Baden, and T. F. Murray

Gambierol Acts as a Functional Antagonist of Neurotoxin Site 5 on Voltage-Gated Sodium Channels in Cerebellar Granule Neurons
J Pharmacol Exp Ther 2007 323: 174-179. Published online July 3, 2007; 10.1124/jpet.107.124271 [Abstract] [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.