PERSPECTIVES IN PHARMACOLOGY:

Marc K. Hellerstein

Exploiting Complexity and the Robustness of Network Architecture for Drug Discovery
J Pharmacol Exp Ther 2008 325: 1-9. Published online January 17, 2008; 10.1124/jpet.107.131276 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Clifford C. Michaels and Stephen G. Holtzman

Early Postnatal Stress Alters Place Conditioning to Both µ- and -Opioid Agonists
J Pharmacol Exp Ther 2008 325: 313-318. Published online January 18, 2008; 10.1124/jpet.107.129908 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Sabine Télémaque, Swapnil Sonkusare, Terrie Grain, Sung W. Rhee, Joseph R. Stimers, Nancy J. Rusch, and James D. Marsh

Design of Mutant β₂ Subunits as Decoy Molecules to Reduce the Expression of Functional Ca²⁺ Channels in Cardiac Cells
J Pharmacol Exp Ther 2008 325: 37-46. Published online January 9, 2008; 10.1124/jpet.107.128215 [Abstract] [Full Text] [PDF] [Data Supplement]   

Takuji Machida, Yukihiro Hamaya, Sachiko Izumi, Yumika Hamaya, Kenji Iizuka, Yasuyuki Igarashi, Masaru Minami, Roberto Levi, and Masahiko Hirafuji

Sphingosine 1-Phosphate Inhibits Nitric Oxide Production Induced by Interleukin-1β in Rat Vascular Smooth Muscle Cells
J Pharmacol Exp Ther 2008 325: 200-209. Published online January 2, 2008; 10.1124/jpet.107.127290 [Abstract] [Full Text] [PDF]  

Anthony Y. H. Woo, Mary M. Y. Waye, Stephen K. W. Tsui, Sandy T. W. Yeung, and Christopher H. K. Cheng

Andrographolide Up-Regulates Cellular-Reduced Glutathione Level and Protects Cardiomyocytes against Hypoxia/Reoxygenation Injury
J Pharmacol Exp Ther 2008 325: 226-235. Published online January 3, 2008; 10.1124/jpet.107.133918 [Abstract] [Full Text] [PDF]  

Satoshi Masutani, Heng-Jie Cheng, Minja Hyttilä-Hopponen, Jouko Levijoki, Aira Heikkilä, Arja Vuorela, William C. Little, and Che-Ping Cheng

Orally Available Levosimendan Dose-Related Positive Inotropic and Lusitropic Effect in Conscious Chronically Instrumented Normal and Heart Failure Dogs
J Pharmacol Exp Ther 2008 325: 236-247. Published online January 3, 2008; 10.1124/jpet.107.134940 [Abstract] [Full Text] [PDF]  

Jason A. Segreti, Kennan C. Marsh, James S. Polakowski, and Ryan M. Fryer

Evoked Changes in Cardiovascular Function in Rats by Infusion of Levosimendan, OR-1896 [(R)-N-(4-(4-Methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)acetamide], OR-1855 [(R)-6-(4-Aminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one], Dobutamine, and Milrinone: Comparative Effects on Peripheral Resistance, Cardiac Output, dP/dt, Pulse Rate, and Blood Pressure
J Pharmacol Exp Ther 2008 325: 331-340. Published online January 2, 2008; 10.1124/jpet.107.132530 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Cibele Pinto, Dan Papa, Melanie Hübner, Tung-Chung Mou, Gerald H. Lushington, and Roland Seifert

Activation and Inhibition of Adenylyl Cyclase Isoforms by Forskolin Analogs
J Pharmacol Exp Ther 2008 325: 27-36. Published online January 9, 2008; 10.1124/jpet.107.131904 [Abstract] [Full Text] [PDF]  

Emmanuel P. Bessay, Mitsi A. Blount, Roya Zoraghi, Alfreda Beasley, Kennard A. Grimes, Sharron H. Francis, and Jackie D. Corbin

Phosphorylation Increases Affinity of the Phosphodiesterase-5 Catalytic Site for Tadalafil
J Pharmacol Exp Ther 2008 325: 62-68. Published online January 16, 2008; 10.1124/jpet.107.133405 [Abstract] [Full Text] [PDF]  

Caroline Norez, Frédéric Bilan, Alain Kitzis, Yvette Mettey, and Frédéric Becq

Proteasome-Dependent Pharmacological Rescue of Cystic Fibrosis Transmembrane Conductance Regulator Revealed by Mutation of Glycine 622
J Pharmacol Exp Ther 2008 325: 89-99. Published online January 29, 2008; 10.1124/jpet.107.134502 [Abstract] [Full Text] [PDF]  

Paul J. Brighton, Alan Wise, Narinder B. Dass, and Gary B. Willars

Paradoxical Behavior of Neuromedin U in Isolated Smooth Muscle Cells and Intact Tissue
J Pharmacol Exp Ther 2008 325: 154-164. Published online January 7, 2008; 10.1124/jpet.107.132803 [Abstract] [Full Text] [PDF]  

J. Robert Lane, Ben Powney, Alan Wise, Stephen Rees, and Graeme Milligan

G Protein Coupling and Ligand Selectivity of the D_2L and D₃ Dopamine Receptors
J Pharmacol Exp Ther 2008 325: 319-330. Published online January 24, 2008; 10.1124/jpet.107.134296 [Abstract] [Full Text] [PDF]  

Ankur Kapur, Patrick Samaniego, Ganesh A. Thakur, Alexandros Makriyannis, and Mary E. Abood

Mapping the Structural Requirements in the CB₁ Cannabinoid Receptor Transmembrane Helix II for Signal Transduction
J Pharmacol Exp Ther 2008 325: 341-348. Published online January 3, 2008; 10.1124/jpet.107.133256 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Naohisa Katayama, Keisuke Nakajou, Hisakazu Komori, Kunitoshi Uchida, Jun-ichi Yokoe, Norikiyo Yasui, Hisashi Yamamoto, Toshiya Kai, Makoto Sato, Takenobu Nakagawa, Motohiro Takeya, Toru Maruyama, and Masaki Otagiri

Design and Evaluation of S-Nitrosylated Human Serum Albumin as a Novel Anticancer Drug
J Pharmacol Exp Ther 2008 325: 69-76. Published online January 24, 2008; 10.1124/jpet.107.132100 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND DIABETES:

Leo Thomas, Matthias Eckhardt, Elke Langkopf, Moh Tadayyon, Frank Himmelsbach, and Michael Mark

(R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a Novel Xanthine-Based Dipeptidyl Peptidase 4 Inhibitor, Has a Superior Potency and Longer Duration of Action Compared with Other Dipeptidyl Peptidase-4 Inhibitors
J Pharmacol Exp Ther 2008 325: 175-182. Published online January 25, 2008; 10.1124/jpet.107.135723 [Abstract] [Full Text] [PDF] [Data Supplement]   

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Qingyun Liu, Qi Yang, Weimei Sun, Pete Vogel, William Heydorn, Xiang-Qing Yu, Zhixiang Hu, Wangsheng Yu, Brandie Jonas, Randy Pineda, Valerie Calderon-Gay, Michael Germann, Emily O'Neill, Robert Brommage, Emily Cullinan, Ken Platt, Alan Wilson, Dave Powell, Arthur Sands, Brian Zambrowicz, and Zhi-cai Shi

Discovery and Characterization of Novel Tryptophan Hydroxylase Inhibitors That Selectively Inhibit Serotonin Synthesis in the Gastrointestinal Tract
J Pharmacol Exp Ther 2008 325: 47-55. Published online January 11, 2008; 10.1124/jpet.107.132670 [Abstract] [Full Text] [PDF] [Data Supplement]   

Andrew J. Hirsh, Jim Zhang, Andra Zamurs, Jacquelyn Fleegle, William R. Thelin, Ray A. Caldwell, Juan R. Sabater, William M. Abraham, Mark Donowitz, Boyoung Cha, Kevin B. Johnson, Judith A. St. George, M. Ross Johnson, and Richard C. Boucher

Pharmacological Properties of N-(3,5-Diamino-6-chloropyrazine-2-carbonyl)-N'-4-[4-(2,3-dihydroxypropoxy)phenyl]butyl-guanidine Methanesulfonate (552-02), a Novel Epithelial Sodium Channel Blocker with Potential Clinical Efficacy for Cystic Fibrosis Lung Disease
J Pharmacol Exp Ther 2008 325: 77-88. Published online January 24, 2008; 10.1124/jpet.107.130443 [Abstract] [Full Text] [PDF]  

Karnam S. Murthy

Inhibitory Phosphorylation of Soluble Guanylyl Cyclase by Muscarinic m2 Receptors via Gβ-Dependent Activation of c-Src Kinase
J Pharmacol Exp Ther 2008 325: 183-189. Published online January 7, 2008; 10.1124/jpet.107.132928 [Abstract] [Full Text] [PDF]  

Tadayoshi Mikami, Yasuo Ochi, Keiko Suzuki, Toshiyuki Saito, Yutaka Sugie, and Minoru Sakakibara

5-Amino-6-chloro-N-[(1-isobutylpiperidin-4-yl)methyl]-2-methylimidazo[1,2-]pyridine-8-carboxamide (CJ-033,466), a Novel and Selective 5-Hydroxytryptamine₄ Receptor Partial Agonist: Pharmacological Profile in Vitro and Gastroprokinetic Effect in Conscious Dogs
J Pharmacol Exp Ther 2008 325: 190-199. Published online January 15, 2008; 10.1124/jpet.107.133850 [Abstract] [Full Text] [PDF]  

Edwin K. Jackson and Zaichuan Mi

Regulation of Renal Ectophosphodiesterase by Protein Kinase C and Sodium Diet
J Pharmacol Exp Ther 2008 325: 210-216. Published online January 25, 2008; 10.1124/jpet.107.134445 [Abstract] [Full Text] [PDF]  

DaZheng Wu and ZhiBi Hu

Rutaecarpine Induces Chloride Secretion across Rat Isolated Distal Colon
J Pharmacol Exp Ther 2008 325: 256-266. Published online January 10, 2008; 10.1124/jpet.107.131961 [Abstract] [Full Text] [PDF]  

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:

Lei Guo, Caiying Ye, Wenying Chen, Hua Ye, Ru Zheng, Juan Li, Huifen Yang, Xiaoli Yu, and Dechang Zhang

Anti-Inflammatory and Analgesic Potency of Carboxyamidotriazole, a Tumorostatic Agent
J Pharmacol Exp Ther 2008 325: 10-16. Published online January 8, 2008; 10.1124/jpet.107.131888 [Abstract] [Full Text] [PDF]  

Mark A. Richardson, Akanksha Gupta, Lee A. O'Brien, David T. Berg, Bruce Gerlitz, Samreen Syed, Ganesh R. Sharma, Martin S. Cramer, Josef G. Heuer, Elizabeth J. Galbreath, and Brian W. Grinnell

Treatment of Sepsis-Induced Acquired Protein C Deficiency Reverses Angiotensin-Converting Enzyme-2 Inhibition and Decreases Pulmonary Inflammatory Response
J Pharmacol Exp Ther 2008 325: 17-26. Published online January 8, 2008; 10.1124/jpet.107.130609 [Abstract] [Full Text] [PDF] [Data Supplement]   

Javier Megías, María Isabel Guillén, Antonio Bru, Francisco Gomar, and María José Alcaraz

The Carbon Monoxide-Releasing Molecule Tricarbonyldichlororuthenium(II) Dimer Protects Human Osteoarthritic Chondrocytes and Cartilage from the Catabolic Actions of Interleukin-1β
J Pharmacol Exp Ther 2008 325: 56-61. Published online January 14, 2008; 10.1124/jpet.107.134650 [Abstract] [Full Text] [PDF]  

Tiziana Genovese, Emanuela Esposito, Emanuela Mazzon, Carmelo Muià, Rosanna Di Paola, Rosaria Meli, Placido Bramanti, and Salvatore Cuzzocrea

Evidence for the Role of Mitogen-Activated Protein Kinase Signaling Pathways in the Development of Spinal Cord Injury
J Pharmacol Exp Ther 2008 325: 100-114. Published online January 7, 2008; 10.1124/jpet.107.131060 [Abstract] [Full Text] [PDF]  

Elizabeth L. Adams, Peter J. Rice, Bridget Graves, Harry E. Ensley, Hai Yu, Gordon D. Brown, Siamon Gordon, Mario A. Monteiro, Erzsebet Papp-Szabo, Douglas W. Lowman, Trevor D. Power, Michael F. Wempe, and David L. Williams

Differential High-Affinity Interaction of Dectin-1 with Natural or Synthetic Glucans Is Dependent upon Primary Structure and Is Influenced by Polymer Chain Length and Side-Chain Branching
J Pharmacol Exp Ther 2008 325: 115-123. Published online January 2, 2008; 10.1124/jpet.107.133124 [Abstract] [Full Text] [PDF] [Data Supplement]   

Martin Roesslein, David Schibilsky, Laurent Muller, Ulrich Goebel, Christian Schwer, Matjaz Humar, Rene Schmidt, Klaus K. Geiger, Heike L. Pahl, Benedikt H. J. Pannen, and Torsten Loop

Thiopental Protects Human T Lymphocytes from Apoptosis in Vitro via the Expression of Heat Shock Protein 70
J Pharmacol Exp Ther 2008 325: 217-225. Published online January 24, 2008; 10.1124/jpet.107.133108 [Abstract] [Full Text] [PDF]  

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:

Marco H. Hofmann, Julia K. Blievernicht, Kathrin Klein, Tanja Saussele, Elke Schaeffeler, Matthias Schwab, and Ulrich M. Zanger

Aberrant Splicing Caused by Single Nucleotide Polymorphism c.516G>T [Q172H], a Marker of CYP2B6*6, Is Responsible for Decreased Expression and Activity of CYP2B6 in Liver
J Pharmacol Exp Ther 2008 325: 284-292. Published online January 2, 2008; 10.1124/jpet.107.133306 [Abstract] [Full Text] [PDF] [Data Supplement]   

NEUROPHARMACOLOGY:

Eric C. Peterson, Elizabeth M. Laurenzana, William T. Atchley, Howard P. Hendrickson, and S. Michael Owens

Development and Preclinical Testing of a High-Affinity Single-Chain Antibody against (+)-Methamphetamine
J Pharmacol Exp Ther 2008 325: 124-133. Published online January 11, 2008; 10.1124/jpet.107.134395 [Abstract] [Full Text] [PDF]  

Warren D. Hirst, Terrance H. Andree, Suzan Aschmies, Wayne E. Childers, Thomas A. Comery, Lee A. Dawson, Mark Day, Irene B. Feingold, Steven M. Grauer, Boyd L. Harrison, Zoë A. Hughes, John Kao, Michael G. Kelly, Heidi van der Lee, Sharon Rosenzweig-Lipson, Annmarie L. Saab, Deborah L. Smith, Kelly Sullivan, Stacey J. Sukoff Rizzo, Cesario Tio, Mei-Yi Zhang, and Lee E. Schechter

Correlating Efficacy in Rodent Cognition Models with in Vivo 5-Hydroxytryptamine_1A Receptor Occupancy by a Novel Antagonist, (R)-N-(2-Methyl-(4-indolyl-1-piperazinyl)ethyl)-N-(2-pyridinyl)-cyclohexane Carboxamide (WAY-101405)
J Pharmacol Exp Ther 2008 325: 134-145. Published online January 8, 2008; 10.1124/jpet.107.133082 [Abstract] [Full Text] [PDF]  

Yasuji Matsuoka, Yan Jouroukhin, Audrey J. Gray, Li Ma, Chiho Hirata-Fukae, Hui-Fang Li, Li Feng, Laurent Lecanu, Benjamin R. Walker, Emmanuel Planel, Ottavio Arancio, Illana Gozes, and Paul S. Aisen

A Neuronal Microtubule-Interacting Agent, NAPVSIPQ, Reduces Tau Pathology and Enhances Cognitive Function in a Mouse Model of Alzheimer's Disease
J Pharmacol Exp Ther 2008 325: 146-153. Published online January 16, 2008; 10.1124/jpet.107.130526 [Abstract] [Full Text] [PDF]  

Ke-Yong Li, Cheng Xiao, Ming Xiong, Ellise Delphin, and Jiang-Hong Ye

Nanomolar Propofol Stimulates Glutamate Transmission to Dopamine Neurons: A Possible Mechanism of Abuse Potential?
J Pharmacol Exp Ther 2008 325: 165-174. Published online January 23, 2008; 10.1124/jpet.107.132472 [Abstract] [Full Text] [PDF]  

B. J. Van der Schueren, A. Rogiers, F. H. Vanmolkot, A. Van Hecken, M. Depré, S. A. Kane, I. De Lepeleire, S. R. Sinclair, and J. N. de Hoon

Calcitonin Gene-Related Peptide_8-37 Antagonizes Capsaicin-Induced Vasodilation in the Skin: Evaluation of a Human in Vivo Pharmacodynamic Model
J Pharmacol Exp Ther 2008 325: 248-255. Published online January 23, 2008; 10.1124/jpet.107.133868 [Abstract] [Full Text] [PDF]  

Fang Luo, Cheng Yang, Yan Chen, Pradeep Shukla, Lei Tang, Lili X. Wang, and Zaijie Jim Wang

Reversal of Chronic Inflammatory Pain by Acute Inhibition of Ca²⁺/Calmodulin-Dependent Protein Kinase II
J Pharmacol Exp Ther 2008 325: 267-275. Published online January 4, 2008; 10.1124/jpet.107.132167 [Abstract] [Full Text] [PDF]  

Mohamed Rafiuddin Ahmed, Vsevolod V. Gurevich, Kevin N. Dalby, Jeffrey L. Benovic, and Eugenia V. Gurevich

Haloperidol and Clozapine Differentially Affect the Expression of Arrestins, Receptor Kinases, and Extracellular Signal-Regulated Kinase Activation
J Pharmacol Exp Ther 2008 325: 276-283. Published online January 4, 2008; 10.1124/jpet.107.131987 [Abstract] [Full Text] [PDF]  

Devadoss J. Samuvel, Lankupalle D. Jayanthi, Senthilvelan Manohar, Kolanjiappan Kaliyaperumal, Ronald E. See, and Sammanda Ramamoorthy

Dysregulation of Dopamine Transporter Trafficking and Function after Abstinence from Cocaine Self-Administration in Rats: Evidence for Differential Regulation in Caudate Putamen and Nucleus Accumbens
J Pharmacol Exp Ther 2008 325: 293-301. Published online January 15, 2008; 10.1124/jpet.107.130534 [Abstract] [Full Text] [PDF]  

K. J. Jackson, B. R. Martin, J. P. Changeux, and M. I. Damaj

Differential Role of Nicotinic Acetylcholine Receptor Subunits in Physical and Affective Nicotine Withdrawal Signs
J Pharmacol Exp Ther 2008 325: 302-312. Published online January 9, 2008; 10.1124/jpet.107.132977 [Abstract] [Full Text] [PDF]  

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