PERSPECTIVES IN PHARMACOLOGY:

Alan R. Gintzler and Sumita Chakrabarti

The Ambiguities of Opioid Tolerance Mechanisms: Barriers to Pain Therapeutics or New Pain Therapeutic Possibilities
J Pharmacol Exp Ther 2008 325: 709-713. Published online March 19, 2008; 10.1124/jpet.107.135533 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Nicolas P. Lapointe, Roth-Visal Ung, Pascal Rouleau, and Pierre A. Guertin

Effects of Spinal ₂-Adrenoceptor and I₁-Imidazoline Receptor Activation on Hindlimb Movement Induction in Spinal Cord-Injured Mice
J Pharmacol Exp Ther 2008 325: 994-1006. Published online March 25, 2008; 10.1124/jpet.107.134874 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

A. Elizabeth Linder, Wei Ni, Theodora Szasz, Robert Burnett, Jessica Diaz, Timothy J. Geddes, Donald M. Kuhn, and Stephanie W. Watts

A Serotonergic System in Veins: Serotonin Transporter-Independent Uptake
J Pharmacol Exp Ther 2008 325: 714-722. Published online March 5, 2008; 10.1124/jpet.107.135699 [Abstract] [Full Text] [PDF]  

Terry C. Major, Shantanu Dhamija, Nicole Black, Serguei Liachenko, Brandy Morenko, Gregg Sobocinski, Carlin Okerberg, Paula Tinholt, Steven Madore, and Mark C. Kowala

The T- and L-Type Calcium Channel Blocker (CCB) Mibefradil Attenuates Leg Edema Induced by the L-Type CCB Nifedipine in the Spontaneously Hypertensive Rat: A Novel Differentiating Assay
J Pharmacol Exp Ther 2008 325: 723-731. Published online March 7, 2008; 10.1124/jpet.107.133892 [Abstract] [Full Text] [PDF]  

A. R. Kompa, F. See, D. A. Lewis, A. Adrahtas, D. M. Cantwell, B. H. Wang, and H. Krum

Long-Term but Not Short-Term p38 Mitogen-Activated Protein Kinase Inhibition Improves Cardiac Function and Reduces Cardiac Remodeling Post-Myocardial Infarction
J Pharmacol Exp Ther 2008 325: 741-750. Published online March 11, 2008; 10.1124/jpet.107.133546 [Abstract] [Full Text] [PDF]  

Chaoqin Xie, Jeffrey R. Sachs, and Donna H. Wang

Interdependent Regulation of Afferent Renal Nerve Activity and Renal Function: Role of Transient Receptor Potential Vanilloid Type 1, Neurokinin 1, and Calcitonin Gene-Related Peptide Receptors
J Pharmacol Exp Ther 2008 325: 751-757. Published online March 25, 2008; 10.1124/jpet.108.136374 [Abstract] [Full Text] [PDF]  

Dong You, Clément Cochain, Céline Loinard, José Vilar, Barend Mees, Micheline Duriez, Bernard I. Lévy, and Jean-Sébastien Silvestre

Combination of the Angiotensin-Converting Enzyme Inhibitor Perindopril and the Diuretic Indapamide Activate Postnatal Vasculogenesis in Spontaneously Hypertensive Rats
J Pharmacol Exp Ther 2008 325: 766-773. Published online February 28, 2008; 10.1124/jpet.107.131532 [Abstract] [Full Text] [PDF]  

Ali Razmara, Lorraine Sunday, Chris Stirone, Xiao Bo Wang, Diana N. Krause, Sue P. Duckles, and Vincent Procaccio

Mitochondrial Effects of Estrogen Are Mediated by Estrogen Receptor in Brain Endothelial Cells
J Pharmacol Exp Ther 2008 325: 782-790. Published online March 19, 2008; 10.1124/jpet.107.134072 [Abstract] [Full Text] [PDF]  

Magnus Baumhäkel, Nils Schlimmer, Kansu Büyükafsar, Onur Arikan, and Michael Böhm

Nebivolol, but Not Metoprolol, Improves Endothelial Function of the Corpus Cavernosum in Apolipoprotein E-Knockout Mice
J Pharmacol Exp Ther 2008 325: 818-823. Published online March 25, 2008; 10.1124/jpet.107.135681 [Abstract] [Full Text] [PDF]  

Valerie Croons, Wim Martinet, Arnold G. Herman, and Guido R. Y. De Meyer

Differential Effect of the Protein Synthesis Inhibitors Puromycin and Cycloheximide on Vascular Smooth Muscle Cell Viability
J Pharmacol Exp Ther 2008 325: 824-832. Published online March 5, 2008; 10.1124/jpet.107.132944 [Abstract] [Full Text] [PDF]  

Dong Hyun Kim, Angela P. Burgess, Ming Li, Peter L. Tsenovoy, Francesco Addabbo, John A. McClung, Nitin Puri, and Nader G. Abraham

Heme Oxygenase-Mediated Increases in Adiponectin Decrease Fat Content and Inflammatory Cytokines Tumor Necrosis Factor- and Interleukin-6 in Zucker Rats and Reduce Adipogenesis in Human Mesenchymal Stem Cells
J Pharmacol Exp Ther 2008 325: 833-840. Published online March 11, 2008; 10.1124/jpet.107.135285 [Abstract] [Full Text] [PDF]  

Wei-Qun Wang, Chelsea Robertson, Arvinder K. Dhalla, and Luiz Belardinelli

Antitorsadogenic Effects of (±)-N-(2,6-Dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (Ranolazine) in Anesthetized Rabbits
J Pharmacol Exp Ther 2008 325: 875-881. Published online March 5, 2008; 10.1124/jpet.108.137729 [Abstract] [Full Text] [PDF]  

Marie-Claude Aubin, Claude Lajoie, Robert Clément, Hugues Gosselin, Angelino Calderone, and Louis P. Perrault

Female Rats Fed a High-Fat Diet Were Associated with Vascular Dysfunction and Cardiac Fibrosis in the Absence of Overt Obesity and Hyperlipidemia: Therapeutic Potential of Resveratrol
J Pharmacol Exp Ther 2008 325: 961-968. Published online March 20, 2008; 10.1124/jpet.107.135061 [Abstract] [Full Text] [PDF]  

Jessica Diaz, Wei Ni, Janice Thompson, Andrew King, Gregory D. Fink, and Stephanie W. Watts

5-Hydroxytryptamine Lowers Blood Pressure in Normotensive and Hypertensive Rats
J Pharmacol Exp Ther 2008 325: 1031-1038. Published online February 27, 2008; 10.1124/jpet.108.136226 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Shougang Zhuang, Gilbert R. Kinsey, Yan Yan, Jiahuai Han, and Rick G. Schnellmann

Extracellular Signal-Regulated Kinase Activation Mediates Mitochondrial Dysfunction and Necrosis Induced by Hydrogen Peroxide in Renal Proximal Tubular Cells
J Pharmacol Exp Ther 2008 325: 732-740. Published online March 13, 2008; 10.1124/jpet.108.136358 [Abstract] [Full Text] [PDF]  

Meidan Ying, Chongxing Tu, Huazhou Ying, Yongzhou Hu, Qiaojun He, and Bo Yang

MSFTZ, a Flavanone Derivative, Induces Human Hepatoma Cell Apoptosis via a Reactive Oxygen Species- and Caspase-Dependent Mitochondrial Pathway
J Pharmacol Exp Ther 2008 325: 758-765. Published online March 6, 2008; 10.1124/jpet.107.135657 [Abstract] [Full Text] [PDF] [Data Supplement]   

Karen M. Kassel, Puttappa R. Dodmane, Nancy A. Schulte, and Myron L. Toews

Lysophosphatidic Acid Induces Rapid and Sustained Decreases in Epidermal Growth Factor Receptor Binding via Different Signaling Pathways in BEAS-2B Airway Epithelial Cells
J Pharmacol Exp Ther 2008 325: 809-817. Published online February 28, 2008; 10.1124/jpet.107.133736 [Abstract] [Full Text] [PDF]  

Paul Whiteaker, Michael J. Marks, Sean Christensen, Cheryl Dowell, Allan C. Collins, and J. Michael McIntosh

Synthesis and Characterization of ¹²⁵I--Conotoxin ArIB[V11L;V16A], a Selective 7 Nicotinic Acetylcholine Receptor Antagonist
J Pharmacol Exp Ther 2008 325: 910-919. Published online March 6, 2008; 10.1124/jpet.108.136895 [Abstract] [Full Text] [PDF] [Data Supplement]   

Vimesh A. Avlani, David J. McLoughlin, Patrick M. Sexton, and Arthur Christopoulos

The Impact of Orthosteric Radioligand Depletion on the Quantification of Allosteric Modulator Interactions
J Pharmacol Exp Ther 2008 325: 927-934. Published online March 5, 2008; 10.1124/jpet.108.136978 [Abstract] [Full Text] [PDF]  

Yuichi Hashimoto, Kanoko Morisawa, Hiroyuki Saito, Eri Jojima, Norihiro Yoshida, and Tatsuya Haga

Muscarinic M4 Receptor Recycling Requires a Motif in the Third Intracellular Loop
J Pharmacol Exp Ther 2008 325: 947-953. Published online March 12, 2008; 10.1124/jpet.107.135095 [Abstract] [Full Text] [PDF]  

Luciano De Petrocellis, Vittorio Vellani, Aniello Schiano-Moriello, Pietro Marini, Pier Cosimo Magherini, Pierangelo Orlando, and Vincenzo Di Marzo

Plant-Derived Cannabinoids Modulate the Activity of Transient Receptor Potential Channels of Ankyrin Type-1 and Melastatin Type-8
J Pharmacol Exp Ther 2008 325: 1007-1015. Published online March 19, 2008; 10.1124/jpet.107.134809 [Abstract] [Full Text] [PDF]  

Sabrina Noël, Martina Wilke, Alice G. M. Bot, Hugo R. De Jonge, and Frédéric Becq

Parallel Improvement of Sodium and Chloride Transport Defects by Miglustat (n-Butyldeoxynojyrimicin) in Cystic Fibrosis Epithelial Cells
J Pharmacol Exp Ther 2008 325: 1016-1023. Published online February 28, 2008; 10.1124/jpet.107.135582 [Abstract] [Full Text] [PDF]  

Mirella Profita, Angelo Sala, Anna Bonanno, Liboria Siena, Maria Ferraro, Rossana Di Giorgi, Angela M. Montalbano, Giusy D. Albano, Rosalia Gagliardo, and Mark Gjomarkaj

Cysteinyl Leukotriene-1 Receptor Activation in a Human Bronchial Epithelial Cell Line Leads to Signal Transducer and Activator of Transcription 1-Mediated Eosinophil Adhesion
J Pharmacol Exp Ther 2008 325: 1024-1030. Published online February 27, 2008; 10.1124/jpet.107.131649 [Abstract] [Full Text] [PDF]  

Frederick J. Ehlert and Michael T. Griffin

Two-State Models and the Analysis of the Allosteric Effect of Gallamine at the M₂ Muscarinic Receptor
J Pharmacol Exp Ther 2008 325: 1039-1060. Published online February 27, 2008; 10.1124/jpet.108.136960 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Hsueh-Ling Chang, Yang-Chang Wu, Jinu-Huang Su, Yao-Tsung Yeh, and Shyng-Shiou F. Yuan

Protoapigenone, a Novel Flavonoid, Induces Apoptosis in Human Prostate Cancer Cells through Activation of p38 Mitogen-Activated Protein Kinase and c-Jun NH₂-Terminal Kinase 1/2
J Pharmacol Exp Ther 2008 325: 841-849. Published online March 12, 2008; 10.1124/jpet.107.135442 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Juliane I. Beier, Luping Guo, Claudia von Montfort, J. Phillip Kaiser, Swati Joshi-Barve, and Gavin E. Arteel

New Role of Resistin in Lipopolysaccharide-Induced Liver Damage in Mice
J Pharmacol Exp Ther 2008 325: 801-808. Published online March 13, 2008; 10.1124/jpet.108.136721 [Abstract] [Full Text] [PDF]  

Jin Ren, Zaichuan Mi, and Edwin K. Jackson

Assessment of Nerve Stimulation-Induced Release of Purines from Mouse Kidneys by Tandem Mass Spectrometry
J Pharmacol Exp Ther 2008 325: 920-926. Published online March 5, 2008; 10.1124/jpet.108.137752 [Abstract] [Full Text] [PDF]  

Alan S. Braverman, Ronald J. Tallarida, and Michael R. Ruggieri, Sr.

The Use of Occupation Isoboles for Analysis of a Response Mediated by Two Receptors: M₂ and M₃ Muscarinic Receptor Subtype-Induced Mouse Stomach Contractions
J Pharmacol Exp Ther 2008 325: 954-960. Published online March 13, 2008; 10.1124/jpet.108.137018 [Abstract] [Full Text] [PDF]  

Guie Dong, Lysa Wang, Cong-Yi Wang, Tianxin Yang, M. Vijay Kumar, and Zheng Dong

Induction of Apoptosis in Renal Tubular Cells by Histone Deacetylase Inhibitors, a Family of Anticancer Agents
J Pharmacol Exp Ther 2008 325: 978-984. Published online February 29, 2008; 10.1124/jpet.108.137398 [Abstract] [Full Text] [PDF]  

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:

Marion T. Kasaian, Xiang-Yang Tan, Macy Jin, Lori Fitz, Kimberly Marquette, Nancy Wood, Timothy A. Cook, Julie Lee, Angela Widom, Rita Agostinelli, Andrea Bree, Franklin J. Schlerman, Stephane Olland, Michael Wadanoli, Joseph Sypek, Davinder Gill, Samuel J. Goldman, and Lioudmila Tchistiakova

Interleukin-13 Neutralization by Two Distinct Receptor Blocking Mechanisms Reduces Immunoglobulin E Responses and Lung Inflammation in Cynomolgus Monkeys
J Pharmacol Exp Ther 2008 325: 882-892. Published online March 12, 2008; 10.1124/jpet.108.136515 [Abstract] [Full Text] [PDF]  

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:

Nada Abla, Leslie W. Chinn, Tsutomu Nakamura, Li Liu, Conrad C. Huang, Susan J. Johns, Michiko Kawamoto, Doug Stryke, Travis R. Taylor, Thomas E. Ferrin, Kathleen M. Giacomini, and Deanna L. Kroetz

The Human Multidrug Resistance Protein 4 (MRP4, ABCC4): Functional Analysis of a Highly Polymorphic Gene
J Pharmacol Exp Ther 2008 325: 859-868. Published online March 25, 2008; 10.1124/jpet.108.136523 [Abstract] [Full Text] [PDF]  

Cuyue Tang, Brian A. Carr, Frédéric Poignant, Bennett Ma, Stacey L. Polsky-Fisher, Yuhsin Kuo, Kristie Strong-Basalyga, Alisha Norcross, Karen Richards, Roy Eisenhandler, Edward J. Carlini, Christina Ng Di Marco, Scott D. Kuduk, Nathan X. Yu, Conrad E. Raab, Tom Rushmore, Clay B. Frederick, Mark G. Bock, and Thomayant Prueksaritanont

CYP2C75-Involved Autoinduction of Metabolism in Rhesus Monkeys of Methyl 3-Chloro-3'-fluoro-4'-{(1R)-1-[({1-[(trifluoroacetyl)amino]cyclopropyl}carbonyl)amino]ethyl}-1,1'-biphenyl-2-carboxylate (MK-0686), a Bradykinin B₁ Receptor Antagonist
J Pharmacol Exp Ther 2008 325: 935-946. Published online February 29, 2008; 10.1124/jpet.107.136044 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Shuji Maruyama, Hideo Tsukada, Shingo Nishiyama, Takeharu Kakiuchi, Dai Fukumoto, Naoto Oku, and Shizuo Yamada

In Vivo Quantitative Autoradiographic Analysis of Brain Muscarinic Receptor Occupancy by Antimuscarinic Agents for Overactive Bladder Treatment
J Pharmacol Exp Ther 2008 325: 774-781. Published online March 7, 2008; 10.1124/jpet.108.136390 [Abstract] [Full Text] [PDF]  

Crystal C. Walline, David E. Nichols, F. Ivy Carroll, and Eric L. Barker

Comparative Molecular Field Analysis Using Selectivity Fields Reveals Residues in the Third Transmembrane Helix of the Serotonin Transporter Associated with Substrate and Antagonist Recognition
J Pharmacol Exp Ther 2008 325: 791-800. Published online March 19, 2008; 10.1124/jpet.108.136200 [Abstract] [Full Text] [PDF]  

Hee Jung Kim, Jonathan J. Waataja, and Stanley A. Thayer

Cannabinoids Inhibit Network-Driven Synapse Loss between Hippocampal Neurons in Culture
J Pharmacol Exp Ther 2008 325: 850-858. Published online February 29, 2008; 10.1124/jpet.107.131607 [Abstract] [Full Text] [PDF]  

Hasib Salah-Uddin, David R. Thomas, Ceri H. Davies, Jim J. Hagan, Martyn D. Wood, Jeannette M. Watson, and R. A. John Challiss

Pharmacological Assessment of M₁ Muscarinic Acetylcholine Receptor-G_q/11 Protein Coupling in Membranes Prepared from Postmortem Human Brain Tissue
J Pharmacol Exp Ther 2008 325: 869-874. Published online March 5, 2008; 10.1124/jpet.108.137968 [Abstract] [Full Text] [PDF]  

Naoe Okamura, Stephen A. Habay, Joanne Zeng, A. Richard Chamberlin, and Rainer K. Reinscheid

Synthesis and Pharmacological in Vitro and in Vivo Profile of 3-Oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic Acid 4-Fluoro-benzylamide (SHA 68), a Selective Antagonist of the Neuropeptide S Receptor
J Pharmacol Exp Ther 2008 325: 893-901. Published online March 12, 2008; 10.1124/jpet.107.135103 [Abstract] [Full Text] [PDF]  

Siyuan Le, John A. Gruner, Joanne R. Mathiasen, Michael J. Marino, and Hervé Schaffhauser

Correlation between ex Vivo Receptor Occupancy and Wake-Promoting Activity of Selective H₃ Receptor Antagonists
J Pharmacol Exp Ther 2008 325: 902-909. Published online February 27, 2008; 10.1124/jpet.107.135343 [Abstract] [Full Text] [PDF]  

Samuel A. Roiko, Andrew C. Harris, Daniel E. Keyler, Mark G. LeSage, Yan Zhang, and Paul R. Pentel

Combined Active and Passive Immunization Enhances the Efficacy of Immunotherapy against Nicotine in Rats
J Pharmacol Exp Ther 2008 325: 985-993. Published online February 27, 2008; 10.1124/jpet.107.135111 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Lalana Kongkaneramit, Narong Sarisuta, Neelam Azad, Yongju Lu, Anand Krishnan V. Iyer, Liying Wang, and Yon Rojanasakul

Dependence of Reactive Oxygen Species and FLICE Inhibitory Protein on Lipofectamine-Induced Apoptosis in Human Lung Epithelial Cells
J Pharmacol Exp Ther 2008 325: 969-977. Published online March 19, 2008; 10.1124/jpet.107.136077 [Abstract] [Full Text] [PDF]  

ERRATA:

Correction to "First in Vivo Evidence for a Functional Interaction between Chemokine and Cannabinoid Systems in the Brain"
J Pharmacol Exp Ther 2008 325: 1061. [Full Text] [PDF]  

Correction to "Tetrathiomolybdate Protects against Bile Duct Ligation-Induced Cholestatic Liver Injury and Fibrosis"
J Pharmacol Exp Ther 2008 325: 1062. [Full Text] [PDF]  

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