BEHAVIORAL PHARMACOLOGY:

T. B. Halene and S. J. Siegel

Antipsychotic-Like Properties of Phosphodiesterase 4 Inhibitors: Evaluation of 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone (RO-20-1724) with Auditory Event-Related Potentials and Prepulse Inhibition of Startle
J Pharmacol Exp Ther 2008 326: 230-239. Published online April 17, 2008; 10.1124/jpet.108.138586 [Abstract] [Full Text] [PDF]  

Kathleen A. Grant, Christa M. Helms, Laura S. M. Rogers, and Robert H. Purdy

Neuroactive Steroid Stereospecificity of Ethanol-Like Discriminative Stimulus Effects in Monkeys
J Pharmacol Exp Ther 2008 326: 354-361. Published online April 24, 2008; 10.1124/jpet.108.137315 [Abstract] [Full Text] [PDF] [Data Supplement]   

CARDIOVASCULAR:

Mary-Clare Cathcart, Rasa Tamosiuniene, Gang Chen, Tomas G. Neilan, Aidan Bradford, Kenneth J. O'Byrne, Desmond J. Fitzgerald, and Graham P. Pidgeon

Cyclooxygenase-2-Linked Attenuation of Hypoxia-Induced Pulmonary Hypertension and Intravascular Thrombosis
J Pharmacol Exp Ther 2008 326: 51-58. Published online March 28, 2008; 10.1124/jpet.107.134221 [Abstract] [Full Text] [PDF]  

Mika Fukasawa, Hirofumi Nishida, Toshiaki Sato, Masaru Miyazaki, and Haruaki Nakaya

6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2-(1H)quinolinone (Cilostazol), a Phosphodiesterase Type 3 Inhibitor, Reduces Infarct Size via Activation of Mitochondrial Ca²⁺-Activated K⁺ Channels in Rabbit Hearts
J Pharmacol Exp Ther 2008 326: 100-104. Published online April 1, 2008; 10.1124/jpet.108.136218 [Abstract] [Full Text] [PDF]  

Fatou Nsoure Obame, Catherine Plin-Mercier, Rana Assaly, Roland Zini, Jean Luc Dubois-Randé, Alain Berdeaux, and Didier Morin

Cardioprotective Effect of Morphine and a Blocker of Glycogen Synthase Kinase 3β, SB216763 [3-(2,4-Dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione], via Inhibition of the Mitochondrial Permeability Transition Pore
J Pharmacol Exp Ther 2008 326: 252-258. Published online April 23, 2008; 10.1124/jpet.108.138008 [Abstract] [Full Text] [PDF]  

Lie Gao, Wei Wang, and Irving H. Zucker

Simvastatin Inhibits Central Sympathetic Outflow in Heart Failure by a Nitric-Oxide Synthase Mechanism
J Pharmacol Exp Ther 2008 326: 278-285. Published online April 25, 2008; 10.1124/jpet.107.136028 [Abstract] [Full Text] [PDF]  

Houli Jiang, Angela G. Zhu, Magdalena Mamczur, Christophe Morisseau, Bruce D. Hammock, John R. Falck, and John C. McGiff

Hydrolysis of cis- and trans-Epoxyeicosatrienoic Acids by Rat Red Blood Cells
J Pharmacol Exp Ther 2008 326: 330-337. Published online April 29, 2008; 10.1124/jpet.107.134858 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Jonathan W. Wojtkowiak, Farid Fouad, Daniel T. LaLonde, Miriam D. Kleinman, Richard A. Gibbs, John J. Reiners, Jr., Richard F. Borch, and Raymond R. Mattingly

Induction of Apoptosis in Neurofibromatosis Type 1 Malignant Peripheral Nerve Sheath Tumor Cell Lines by a Combination of Novel Farnesyl Transferase Inhibitors and Lovastatin
J Pharmacol Exp Ther 2008 326: 1-11. Published online March 26, 2008; 10.1124/jpet.107.135830 [Abstract] [Full Text] [PDF] [Data Supplement]   

Caroline Sandén, Johan Enquist, Sara H. Bengtson, Heiko Herwald, and L. M. Fredrik Leeb-Lundberg

Kinin B₂ Receptor-Mediated Bradykinin Internalization and Metalloendopeptidase EP24.15-Dependent Intracellular Bradykinin Degradation
J Pharmacol Exp Ther 2008 326: 24-32. Published online April 22, 2008; 10.1124/jpet.108.136911 [Abstract] [Full Text] [PDF]  

Bin Sun, Xiaoling Zhang, Sonia Talathi, and Brian S. Cummings

Inhibition of Ca²⁺-Independent Phospholipase A₂ Decreases Prostate Cancer Cell Growth by p53-Dependent and Independent Mechanisms
J Pharmacol Exp Ther 2008 326: 59-68. Published online April 25, 2008; 10.1124/jpet.108.138958 [Abstract] [Full Text] [PDF]  

Mary P. Horn, Sharmon M. Knecht, Frances L. Rushing, Julie Birdsong, C. Parker Siddall, Charron M. Johnson, Terri N. Abraham, Amy Brown, Catherine B. Volk, Kelly Gammon, Derron L. Bishop, John L. McKillip, and Susan A. McDowell

Simvastatin Inhibits Staphylococcus aureus Host Cell Invasion through Modulation of Isoprenoid Intermediates
J Pharmacol Exp Ther 2008 326: 135-143. Published online April 3, 2008; 10.1124/jpet.108.137927 [Abstract] [Full Text] [PDF]  

Aida Salameh, Silke Krautblatter, Sabine Baeβler, Sebastian Karl, Diana Rojas Gomez, Stefan Dhein, and Dietrich Pfeiffer

Signal Transduction and Transcriptional Control of Cardiac Connexin43 Up-Regulation after ₁-Adrenoceptor Stimulation
J Pharmacol Exp Ther 2008 326: 315-322. Published online April 29, 2008; 10.1124/jpet.108.136663 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Maryse Rapp, Jean C. Maurizis, Janine Papon, Pierre Labarre, Ting-Di Wu, Alain Croisy, Jean L. Guerquin-Kern, Jean C. Madelmont, and Emmanuelle Mounetou

A New O⁶-Alkylguanine-DNA Alkyltransferase Inhibitor Associated with a Nitrosourea (Cystemustine) Validates a Strategy of Melanoma-Targeted Therapy in Murine B16 and Human-Resistant M4Beu Melanoma Xenograft Models
J Pharmacol Exp Ther 2008 326: 171-177. Published online April 14, 2008; 10.1124/jpet.108.137737 [Abstract] [Full Text] [PDF]  

Zsuzsanna Szöcs, Barbara Brunmair, Karin Stadlbauer, Peter Nowotny, Leonhardt Bauer, Anton Luger, and Clemens Fürnsinn

Age-Dependent Development of Metabolic Derangement and Effects of Intervention with Pioglitazone in Zucker Diabetic Fatty Rats
J Pharmacol Exp Ther 2008 326: 323-329. Published online April 29, 2008; 10.1124/jpet.108.136465 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Xuan Liu, William K. K. Wu, Le Yu, Zhi J. Li, Joseph J. Y. Sung, Shu T. Zhang, and Chi H. Cho

Epidermal Growth Factor-Induced Esophageal Cancer Cell Proliferation Requires Transactivation of β-Adrenoceptors
J Pharmacol Exp Ther 2008 326: 69-75. Published online March 27, 2008; 10.1124/jpet.107.134528 [Abstract] [Full Text] [PDF]  

Tomasz Brzozowski, Peter C. Konturek, Stefan Chlopicki, Zbigniew Sliwowski, Michal Pawlik, Agata Ptak-Belowska, Slawomir Kwiecien, Danuta Drozdowicz, Robert Pajdo, Ewa Slonimska, Stanislaw J. Konturek, and Wieslaw W. Pawlik

Therapeutic Potential of 1-Methylnicotinamide against Acute Gastric Lesions Induced by Stress: Role of Endogenous Prostacyclin and Sensory Nerves
J Pharmacol Exp Ther 2008 326: 105-116. Published online April 2, 2008; 10.1124/jpet.108.136457 [Abstract] [Full Text] [PDF]  

Keiichi Ito, Kazuya Kinoshita, Atsuyuki Tomizawa, Yuka Morikawa-Inomata, Fumi Inaba, Yoshifumi Fujita, Keiichi Tabata, and Nobuhiko Shibakawa

The Effect of Subchronic Administration of 7-(4-Fluorobenzyloxy)-2,3-dimethyl-1-{[(1S,2S)-2-methylcyclopropyl]methyl}-1H-pyrrolo[2,3-d]pyridazine (CS-526), a Novel Acid Pump Antagonist, on Gastric Acid Secretion and Gastrin Levels in Rats
J Pharmacol Exp Ther 2008 326: 163-170. Published online April 14, 2008; 10.1124/jpet.108.137299 [Abstract] [Full Text] [PDF]  

Lisa A. Leon, Bryan E. Hoffman, Scott D. Gardner, Nicholas J. Laping, Christopher Evans, Erin S. R. Lashinger, and Xin Su

Effects of the β3-Adrenergic Receptor Agonist Disodium 5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL-316243) on Bladder Micturition Reflex in Spontaneously Hypertensive Rats
J Pharmacol Exp Ther 2008 326: 178-185. Published online April 15, 2008; 10.1124/jpet.108.138651 [Abstract] [Full Text] [PDF]  

Yi Jing, Janet A. Dowdy, Michael R. Van Scott, and Jeffrey S. Fedan

Hyperosmolarity-Induced Dilation and Epithelial Bioelectric Responses of Guinea Pig Trachea in Vitro: Role of Kinase Signaling
J Pharmacol Exp Ther 2008 326: 186-195. Published online April 15, 2008; 10.1124/jpet.107.135871 [Abstract] [Full Text] [PDF]  

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:

James G. Conway, Heather Pink, Mandy L. Bergquist, Bajin Han, Scott Depee, Sarva Tadepalli, Peiyuan Lin, R. Christian Crumrine, Jane Binz, Richard L. Clark, Jeffrey L. Selph, Stephen A. Stimpson, Jeff T. Hutchins, Stanley D. Chamberlain, and Thomas A. Brodie

Effects of the cFMS Kinase Inhibitor 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in Normal and Arthritic Rats
J Pharmacol Exp Ther 2008 326: 41-50. Published online April 23, 2008; 10.1124/jpet.107.129429 [Abstract] [Full Text] [PDF] [Data Supplement]   

Matthew C. Catley, Mark A. Birrell, Elizabeth L. Hardaker, Jorge de Alba, Stuart Farrow, Saleem Haj-Yahia, and Maria G. Belvisi

Estrogen Receptor β: Expression Profile and Possible Anti-Inflammatory Role in Disease
J Pharmacol Exp Ther 2008 326: 83-88. Published online March 28, 2008; 10.1124/jpet.108.136275 [Abstract] [Full Text] [PDF]  

Lasse Dissing-Olesen, Morten Thaysen-Andersen, Michael Meldgaard, Peter Højrup, and Bente Finsen

The Function of the Human Interferon-β1a Glycan Determined in Vivo
J Pharmacol Exp Ther 2008 326: 338-347. Published online April 29, 2008; 10.1124/jpet.108.138263 [Abstract] [Full Text] [PDF]  

Linda B. Kidd, Gernot A. Schabbauer, James P. Luyendyk, Todd D. Holscher, Rachel E. Tilley, Michael Tencati, and Nigel Mackma

Insulin Activation of the Phosphatidylinositol 3-Kinase/Protein Kinase B (Akt) Pathway Reduces Lipopolysaccharide-Induced Inflammation in Mice
J Pharmacol Exp Ther 2008 326: 348-353. Published online April 29, 2008; 10.1124/jpet.108.138891 [Abstract] [Full Text] [PDF]  

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:

Yang Liu, Youyun Yang, Jing Qi, Hui Peng, and Jian-Ting Zhang

Effect of Cysteine Mutagenesis on the Function and Disulfide Bond Formation of Human ABCG2
J Pharmacol Exp Ther 2008 326: 33-40. Published online April 22, 2008; 10.1124/jpet.108.138115 [Abstract] [Full Text] [PDF]  

Huadong Sun, Li Zhang, Edwin Chiu Yuen Chow, Ge Lin, Zhong Zuo, and K. Sandy Pang

A Catenary Model to Study Transport and Conjugation of Baicalein, a Bioactive Flavonoid, in the Caco-2 Cell Monolayer: Demonstration of Substrate Inhibition
J Pharmacol Exp Ther 2008 326: 117-126. Published online April 2, 2008; 10.1124/jpet.108.137463 [Abstract] [Full Text] [PDF]  

Pablo González and James E. Polli

Impact of Impurity on Kinetic Estimates from Transport and Inhibition Studies
J Pharmacol Exp Ther 2008 326: 296-305. Published online April 28, 2008; 10.1124/jpet.107.135863 [Abstract] [Full Text] [PDF] [Data Supplement]   

NEUROPHARMACOLOGY:

Tiziana Genovese, Emanuela Esposito, Emanuela Mazzon, Rosanna Di Paola, Rosaria Meli, Placido Bramanti, Daniele Piomelli, Antonio Calignano, and Salvatore Cuzzocrea

Effects of Palmitoylethanolamide on Signaling Pathways Implicated in the Development of Spinal Cord Injury
J Pharmacol Exp Ther 2008 326: 12-23. Published online March 26, 2008; 10.1124/jpet.108.136903 [Abstract] [Full Text] [PDF]  

Mia Ericson, Elin Löf, Rosita Stomberg, PeiPei Chau, and Bo Söderpalm

Nicotinic Acetylcholine Receptors in the Anterior, but Not Posterior, Ventral Tegmental Area Mediate Ethanol-Induced Elevation of Accumbal Dopamine Levels
J Pharmacol Exp Ther 2008 326: 76-82. Published online March 27, 2008; 10.1124/jpet.108.137489 [Abstract] [Full Text] [PDF]  

Patrick L. Sheets, Cara Heers, Thomas Stoehr, and Theodore R. Cummins

Differential Block of Sensory Neuronal Voltage-Gated Sodium Channels by Lacosamide [(2R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide], Lidocaine, and Carbamazepine
J Pharmacol Exp Ther 2008 326: 89-99. Published online March 31, 2008; 10.1124/jpet.107.133413 [Abstract] [Full Text] [PDF] [Data Supplement]   

Feng Han, Norifumi Shioda, Shigeki Moriguchi, Yui Yamamoto, Alisa Y. Ali Raie, Yoshimasa Yamaguchi, Masataka Hino, and Kohji Fukunaga

Spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one (ZSET1446/ST101) Treatment Rescues Olfactory Bulbectomy-Induced Memory Impairment by Activating Ca²⁺/Calmodulin Kinase II and Protein Kinase C in Mouse Hippocampus
J Pharmacol Exp Ther 2008 326: 127-134. Published online April 3, 2008; 10.1124/jpet.108.137471 [Abstract] [Full Text] [PDF]  

Y. Dai, N. L. Dudek, T. B. Patel, and N. A. Muma

Transglutaminase-Catalyzed Transamidation: A Novel Mechanism for Rac1 Activation by 5-Hydroxytryptamine_2A Receptor Stimulation
J Pharmacol Exp Ther 2008 326: 153-162. Published online April 9, 2008; 10.1124/jpet.107.135046 [Abstract] [Full Text] [PDF]  

Aynun N. Begum, Mychica R. Jones, Giselle P. Lim, Takashi Morihara, Peter Kim, Dennis D. Heath, Cheryl L. Rock, Mila A. Pruitt, Fusheng Yang, Beverly Hudspeth, Shuxin Hu, Kym F. Faull, Bruce Teter, Greg M. Cole, and Sally A. Frautschy

Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer's Disease
J Pharmacol Exp Ther 2008 326: 196-208. Published online April 16, 2008; 10.1124/jpet.108.137455 [Abstract] [Full Text] [PDF]  

Matthew J. Fell, Kjell A. Svensson, Bryan G. Johnson, and Darryle D. Schoepp

Evidence for the Role of Metabotropic Glutamate (mGlu)2 Not mGlu3 Receptors in the Preclinical Antipsychotic Pharmacology of the mGlu2/3 Receptor Agonist (–)-(1R,4S,5S,6S)-4-Amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic Acid (LY404039)
J Pharmacol Exp Ther 2008 326: 209-217. Published online April 18, 2008; 10.1124/jpet.108.136861 [Abstract] [Full Text] [PDF]  

Sonya G. Lehto, Rami Tamir, Hong Deng, Lana Klionsky, Rongzhen Kuang, April Le, Doo Lee, Jean-Claude Louis, Ella Magal, Barton H. Manning, John Rubino, Sekhar Surapaneni, Nuria Tamayo, Tingrong Wang, Judy Wang, Jue Wang, Weiya Wang, Brad Youngblood, Maosheng Zhang, Dawn Zhu, Mark H. Norman, and Narender R. Gavva

Antihyperalgesic Effects of (R,E)-N-(2-Hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a Novel Transient Receptor Potential Vanilloid Type 1 Modulator That Does Not Cause Hyperthermia in Rats
J Pharmacol Exp Ther 2008 326: 218-229. Published online April 17, 2008; 10.1124/jpet.107.132233 [Abstract] [Full Text] [PDF] [Erratum]   

Blake A. Rowe, Hervé Schaffhauser, Sylvia Morales, Laura S. Lubbers, Celine Bonnefous, Theodore M. Kamenecka, Jeffrey McQuiston, and Lorrie P. Daggett

Transposition of Three Amino Acids Transforms the Human Metabotropic Glutamate Receptor (mGluR)-3-Positive Allosteric Modulation Site to mGluR2, and Additional Characterization of the mGluR2-Positive Allosteric Modulation Site
J Pharmacol Exp Ther 2008 326: 240-251. Published online April 22, 2008; 10.1124/jpet.108.138271 [Abstract] [Full Text] [PDF]  

Takafumi Horishita and R. Adron Harris

n-Alcohols Inhibit Voltage-Gated Na⁺ Channels Expressed in Xenopus Oocytes
J Pharmacol Exp Ther 2008 326: 270-277. Published online April 23, 2008; 10.1124/jpet.108.138370 [Abstract] [Full Text] [PDF]  

Joseph J. Pariser, John S. Partilla, Christina M. Dersch, Subramaniam Ananthan, and Richard B. Rothman

Studies of the Biogenic Amine Transporters. 12. Identification of Novel Partial Inhibitors of Amphetamine-Induced Dopamine Release
J Pharmacol Exp Ther 2008 326: 286-295. Published online April 25, 2008; 10.1124/jpet.108.139675 [Abstract] [Full Text] [PDF]  

Neil E. Paterson, Styliani Vlachou, Sebastien Guery, Klemens Kaupmann, Wolfgang Froestl, and Athina Markou

Positive Modulation of GABA_B Receptors Decreased Nicotine Self-Administration and Counteracted Nicotine-Induced Enhancement of Brain Reward Function in Rats
J Pharmacol Exp Ther 2008 326: 306-314. Published online April 29, 2008; 10.1124/jpet.108.139204 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Xiaomin Deng, Jingtao Lu, Lois D. Lehman-McKeeman, Ernst Malle, David L. Crandall, Patricia E. Ganey, and Robert A. Roth

p38 Mitogen-Activated Protein Kinase-Dependent Tumor Necrosis Factor--Converting Enzyme Is Important for Liver Injury in Hepatotoxic Interaction between Lipopolysaccharide and Ranitidine
J Pharmacol Exp Ther 2008 326: 144-152. Published online April 4, 2008; 10.1124/jpet.108.137497 [Abstract] [Full Text] [PDF]  

Olga Popelová, Martin Sterba, Tomás Simunek, Yvona Mazurová, Ivana Guncová, Milos Hroch, Michaela Adamcová, and Vladimír Gersl

Deferiprone Does Not Protect against Chronic Anthracycline Cardiotoxicity in Vivo
J Pharmacol Exp Ther 2008 326: 259-269. Published online April 23, 2008; 10.1124/jpet.108.137604 [Abstract] [Full Text] [PDF]  

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