CENTENNIAL PERSPECTIVE:

James E. Barrett and Jack Bergman

Peter B. Dews and Pharmacological Studies on Behavior
J Pharmacol Exp Ther 2008 326: 683-690. Published online June 10, 2008; 10.1124/jpet.108.139261 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Roberto Coccurello, Antonio Caprioli, Roberto Conti, Orlando Ghirardi, Franco Borsini, Paolo Carminati, and Anna Moles

Olanzapine (LY170053, 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] Benzodiazepine), but Not the Novel Atypical Antipsychotic ST2472 (9-Piperazin-1-ylpyrrolo[2,1-b][1,3]benzothiazepine), Chronic Administration Induces Weight Gain, Hyperphagia, and Metabolic Dysregulation in Mice
J Pharmacol Exp Ther 2008 326: 905-911. Published online June 20, 2008; 10.1124/jpet.108.137240 [Abstract] [Full Text] [PDF]  

Ziva D. Cooper, Yen Nhu-Thi Truong, Yong-Gong Shi, and James H. Woods

Morphine Deprivation Increases Self-Administration of the Fast- and Short-Acting µ-Opioid Receptor Agonist Remifentanil in the Rat
J Pharmacol Exp Ther 2008 326: 920-929. Published online May 30, 2008; 10.1124/jpet.108.139196 [Abstract] [Full Text] [PDF]  

Gail Pereira Do Carmo, Robin Polt, Edward J. Bilsky, Kenner C. Rice, and S. Stevens Negus

Behavioral Pharmacology of the µ/ Opioid Glycopeptide MMP2200 in Rhesus Monkeys
J Pharmacol Exp Ther 2008 326: 939-948. Published online May 29, 2008; 10.1124/jpet.108.138180 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Keiichi Kuwano, Asami Hashino, Kumiko Noda, Keiji Kosugi, and Kenji Kuwabara

A Long-Acting and Highly Selective Prostacyclin Receptor Agonist Prodrug, 2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), Ameliorates Rat Pulmonary Hypertension with Unique Relaxant Responses of Its Active Form, {4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic Acid (MRE-269), on Rat Pulmonary Artery
J Pharmacol Exp Ther 2008 326: 691-699. Published online June 13, 2008; 10.1124/jpet.108.138305 [Abstract] [Full Text] [PDF]  

Lorraine Yau, Peter Molnar, Michael C. Moon, Shelly Buhay, Jeffrey P. Werner, Katerina Molnar, Laura Saward, Dario Del Rizzo, and Peter Zahradka

meta-Iodobenzylguanidine, an Inhibitor of Arginine-Dependent Mono(ADP-ribosyl)ation, Prevents Neointimal Hyperplasia
J Pharmacol Exp Ther 2008 326: 717-724. Published online June 3, 2008; 10.1124/jpet.108.137513 [Abstract] [Full Text] [PDF]  

Qinghua Zeng, Qingwei Zhou, Fanrong Yao, Stephen T. O'Rourke, and Chengwen Sun

Endothelin-1 Regulates Cardiac L-Type Calcium Channels via NAD(P)H Oxidase-Derived Superoxide
J Pharmacol Exp Ther 2008 326: 732-738. Published online June 6, 2008; 10.1124/jpet.108.140301 [Abstract] [Full Text] [PDF]  

Huige Li, Marcus Hortmann, Andreas Daiber, Matthias Oelze, Mir Abolfazl Ostad, Petra M. Schwarz, Hui Xu, Ning Xia, Andrei L. Kleschyov, Christian Mang, Ascan Warnholtz, Thomas Münzel, and Ulrich Förstermann

Cyclooxygenase 2-Selective and Nonselective Nonsteroidal Anti-Inflammatory Drugs Induce Oxidative Stress by Up-Regulating Vascular NADPH Oxidases
J Pharmacol Exp Ther 2008 326: 745-753. Published online June 11, 2008; 10.1124/jpet.108.139030 [Abstract] [Full Text] [PDF]  

Wieslaw Kozak, Anna Kozak, Maribeth H. Johnson, Hazem F. Elewa, and Susan C. Fagan

Vascular Protection with Candesartan after Experimental Acute Stroke in Hypertensive Rats: A Dose-Response Study
J Pharmacol Exp Ther 2008 326: 773-782. Published online June 17, 2008; 10.1124/jpet.108.139618 [Abstract] [Full Text] [PDF]  

Julie L. Hawkins, Michael D. Robbins, Laurie C. Warren, Donghui Xia, Stephen F. Petras, James J. Valentine, Alison H. Varghese, Ing-Kae Wang, Timothy A. Subashi, Lorraine D. Shelly, Bruce A. Hay, Katherine T. Landschulz, Kieran F. Geoghegan, and H. James Harwood, Jr.

Pharmacologic Inhibition of Site 1 Protease Activity Inhibits Sterol Regulatory Element-Binding Protein Processing and Reduces Lipogenic Enzyme Gene Expression and Lipid Synthesis in Cultured Cells and Experimental Animals
J Pharmacol Exp Ther 2008 326: 801-808. Published online June 24, 2008; 10.1124/jpet.108.139626 [Abstract] [Full Text] [PDF]  

Chin-Wei Chiao, Rita C. Tostes, and R. Clinton Webb

P2X₇ Receptor Activation Amplifies Lipopolysaccharide-Induced Vascular Hyporeactivity via Interleukin-1β Release
J Pharmacol Exp Ther 2008 326: 864-870. Published online June 16, 2008; 10.1124/jpet.107.135350 [Abstract] [Full Text] [PDF]  

Christopher Morrey, Rima Estephan, Geoffrey W. Abbott, and Roberto Levi

Cardioprotective Effect of Histamine H₃-Receptor Activation: Pivotal Role of Gβ-Dependent Inhibition of Voltage-Operated Ca²⁺ Channels
J Pharmacol Exp Ther 2008 326: 871-878. Published online June 3, 2008; 10.1124/jpet.108.137919 [Abstract] [Full Text] [PDF]  

Marcella Rocchetti, Matteo Alemanni, Gaspare Mostacciuolo, Paolo Barassi, Claudia Altomare, Riccardo Chisci, Rosella Micheletti, Patrizia Ferrari, and Antonio Zaza

Modulation of Sarcoplasmic Reticulum Function by PST2744 [Istaroxime; (E,Z)-3-((2-Aminoethoxy)imino) Androstane-6,17-dione Hydrochloride)] in a Pressure-Overload Heart Failure Model
J Pharmacol Exp Ther 2008 326: 957-965. Published online June 6, 2008; 10.1124/jpet.108.138701 [Abstract] [Full Text] [PDF] [Data Supplement]   

Young Mi Seok, Inji Baek, Yong-Hoon Kim, Yeon-Shin Jeong, In-Jung Lee, Dong Hyun Shin, Young Hyun Hwang, and In Kyeom Kim

Isoflavone Attenuates Vascular Contraction through Inhibition of the RhoA/Rho-Kinase Signaling Pathway
J Pharmacol Exp Ther 2008 326: 991-998. Published online June 24, 2008; 10.1124/jpet.108.138529 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Richard R. Almon, Eric Yang, William Lai, Ioannis P. Androulakis, Debra C. DuBois, and William J. Jusko

Circadian Variations in Rat Liver Gene Expression: Relationships to Drug Actions
J Pharmacol Exp Ther 2008 326: 700-716. Published online June 18, 2008; 10.1124/jpet.108.140186 [Abstract] [Full Text] [PDF] [Data Supplement]   

Andrea Straßer, Hans-Joachim Wittmann, and Roland Seifert

Ligand-Specific Contribution of the N Terminus and E2-Loop to Pharmacological Properties of the Histamine H₁-Receptor
J Pharmacol Exp Ther 2008 326: 783-791. Published online June 24, 2008; 10.1124/jpet.108.140913 [Abstract] [Full Text] [PDF]  

Nora Bijl, Saskia Scheij, Sander Houten, Rolf G. Boot, Albert K. Groen, and Johannes M. F. G. Aerts

The Glucosylceramide Synthase Inhibitor N-(5-Adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin Induces Sterol Regulatory Element-Binding Protein-Regulated Gene Expression and Cholesterol Synthesis in HepG2 Cells
J Pharmacol Exp Ther 2008 326: 849-855. Published online June 12, 2008; 10.1124/jpet.108.139394 [Abstract] [Full Text] [PDF] [Data Supplement]   

Telma Roque, Emilie Boncoeur, Vinciane Saint-Criq, Elise Bonvin, Annick Clement, Olivier Tabary, and Jacky Jacquot

Proinflammatory Effect of Sodium 4-Phenylbutyrate in F508-Cystic Fibrosis Transmembrane Conductance Regulator Lung Epithelial Cells: Involvement of Extracellular Signal-Regulated Protein Kinase 1/2 and c-Jun-NH₂-Terminal Kinase Signaling
J Pharmacol Exp Ther 2008 326: 949-956. Published online June 23, 2008; 10.1124/jpet.107.135186 [Abstract] [Full Text] [PDF]  

Andreas Koeberle, Ulf Siemoneit, Ulrike Bühring, Hinnak Northoff, Stefan Laufer, Wolfgang Albrecht, and Oliver Werz

Licofelone Suppresses Prostaglandin E₂ Formation by Interference with the Inducible Microsomal Prostaglandin E₂ Synthase-1
J Pharmacol Exp Ther 2008 326: 975-982. Published online June 11, 2008; 10.1124/jpet.108.139444 [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Kazutomo Kita, Kento Takahashi, Yumi Ohashi, Hironori Takasuka, Eitaro Aihara, and Koji Takeuchi

Phosphodiesterase Isozymes Involved in Regulation of Secretion in Isolated Mouse Stomach in Vitro
J Pharmacol Exp Ther 2008 326: 889-896. Published online June 12, 2008; 10.1124/jpet.108.138941 [Abstract] [Full Text] [PDF]  

Melissa A. Burmeister, Michael A. Ansonoff, John E. Pintar, and Daniel R. Kapusta

Nociceptin/Orphanin FQ (N/OFQ)-Evoked Bradycardia, Hypotension, and Diuresis Are Absent in N/OFQ Peptide (NOP) Receptor Knockout Mice
J Pharmacol Exp Ther 2008 326: 897-904. Published online June 6, 2008; 10.1124/jpet.107.135905 [Abstract] [Full Text] [PDF]  

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:

Daigen Xu, Steven E. Rowland, Patsy Clark, André Giroux, Bernard Côté, Sébastien Guiral, Myriam Salem, Yves Ducharme, Richard W. Friesen, Nathalie Méthot, Joseph Mancini, Laurent Audoly, and Denis Riendeau

MF63 [2-(6-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a Selective Microsomal Prostaglandin E Synthase-1 Inhibitor, Relieves Pyresis and Pain in Preclinical Models of Inflammation
J Pharmacol Exp Ther 2008 326: 754-763. Published online June 4, 2008; 10.1124/jpet.108.138776 [Abstract] [Full Text] [PDF]  

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:

Jitesh D. Kawedia, Mengmeng Jiang, Amit Kulkarni, Holly E. Waechter, Karl S. Matlin, Giovanni M. Pauletti, and Anil G. Menon

The Protein Kinase A Pathway Contributes to Hg²⁺-Induced Alterations in Phosphorylation and Subcellular Distribution of Occludin Associated with Increased Tight Junction Permeability of Salivary Epithelial Cell Monolayers
J Pharmacol Exp Ther 2008 326: 829-837. Published online June 12, 2008; 10.1124/jpet.107.135798 [Abstract] [Full Text] [PDF]  

Fetweh H. Al-Saleem, Denise M. Ancharski, Easwaran Ravichandran, Suresh G. Joshi, Ajay K. Singh, Yujing Gong, and Lance L. Simpson

The Role of Systemic Handling in the Pathophysiologic Actions of Botulinum Toxin
J Pharmacol Exp Ther 2008 326: 856-863. Published online June 6, 2008; 10.1124/jpet.108.136242 [Abstract] [Full Text] [PDF]  

Koji Abe, Arlene S. Bridges, Wei Yue, and Kim L. R. Brouwer

In Vitro Biliary Clearance of Angiotensin II Receptor Blockers and 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase Inhibitors in Sandwich-Cultured Rat Hepatocytes: Comparison with in Vivo Biliary Clearance
J Pharmacol Exp Ther 2008 326: 983-990. Published online June 23, 2008; 10.1124/jpet.108.138073 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Alan R. Gintzler, Stephen A. Schnell, Daya S. Gupta, Nai-Jiang Liu, and Martin W. Wessendorf

Relationship of Spinal Dynorphin Neurons to -Opioid Receptors and Estrogen Receptor : Anatomical Basis for Ovarian Sex Steroid Opioid Antinociception
J Pharmacol Exp Ther 2008 326: 725-731. Published online June 9, 2008; 10.1124/jpet.108.139816 [Abstract] [Full Text] [PDF] [Data Supplement]   

Hiroshi Onozuka, Akira Nakajima, Kentaro Matsuzaki, Ryong-Woon Shin, Koichi Ogino, Daisuke Saigusa, Naomi Tetsu, Akihito Yokosuka, Yutaka Sashida, Yoshihiro Mimaki, Tohru Yamakuni, and Yasushi Ohizumi

Nobiletin, a Citrus Flavonoid, Improves Memory Impairment and Aβ Pathology in a Transgenic Mouse Model of Alzheimer's Disease
J Pharmacol Exp Ther 2008 326: 739-744. Published online June 10, 2008; 10.1124/jpet.108.140293 [Abstract] [Full Text] [PDF]  

Wei Hu, Laura Saba, Katherina Kechris, Sanjiv V. Bhave, Paula L. Hoffman, and Boris Tabakoff

Genomic Insights into Acute Alcohol Tolerance
J Pharmacol Exp Ther 2008 326: 792-800. Published online June 11, 2008; 10.1124/jpet.108.137521 [Abstract] [Full Text] [PDF] [Data Supplement]   

Rosemarie Roeloffs, Alan D. Wickenden, Christopher Crean, Stephen Werness, Grant McNaughton-Smith, James Stables, James O. McNamara, Neil Ghodadra, and Greg C. Rigdon

In Vivo Profile of ICA-27243 [N-(6-Chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a Potent and Selective KCNQ2/Q3 (Kv7.2/Kv7.3) Activator in Rodent Anticonvulsant Models
J Pharmacol Exp Ther 2008 326: 818-828. Published online June 24, 2008; 10.1124/jpet.108.137794 [Abstract] [Full Text] [PDF]  

Yan Xia, Cheng Z. Wang, Jie Liu, Noelle C. Anastasio, and Kenneth M. Johnson

Lithium Protection of Phencyclidine-Induced Neurotoxicity in Developing Brain: The Role of Phosphatidylinositol-3 Kinase/Akt and Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Signaling Pathways
J Pharmacol Exp Ther 2008 326: 838-848. Published online June 10, 2008; 10.1124/jpet.107.133272 [Abstract] [Full Text] [PDF]  

Carol S. Surowy, Torben R. Neelands, Bruce R. Bianchi, Steve McGaraughty, Rachid El Kouhen, Ping Han, Katharine L. Chu, Heath A. McDonald, Melissa Vos, Wende Niforatos, Erol K. Bayburt, Arthur Gomtsyan, Chih-Hung Lee, Prisca Honore, James P. Sullivan, Michael F. Jarvis, and Connie R. Faltynek

(R)-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) Blocks Polymodal Activation of Transient Receptor Potential Vanilloid 1 Receptors in Vitro and Heat-Evoked Firing of Spinal Dorsal Horn Neurons in Vivo
J Pharmacol Exp Ther 2008 326: 879-888. Published online May 30, 2008; 10.1124/jpet.108.138511 [Abstract] [Full Text] [PDF] [Data Supplement]   

Urszula Baranowska, Manfred Göthert, Radoslaw Rudz, and Barbara Malinowska

Methanandamide Allosterically Inhibits in Vivo the Function of Peripheral Nicotinic Acetylcholine Receptors Containing the 7-Subunit
J Pharmacol Exp Ther 2008 326: 912-919. Published online June 20, 2008; 10.1124/jpet.108.140863 [Abstract] [Full Text] [PDF]  

J. M. Witkin, B. Levant, A. Zapata, R. Kaminski, and M. Gasior

The Dopamine D₃/D₂ Agonist (+)-PD-128,907 [(R-(+)-trans-3,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol)] Protects against Acute and Cocaine-Kindled Seizures in Mice: Further Evidence for the Involvement of D₃ Receptors
J Pharmacol Exp Ther 2008 326: 930-938. Published online June 19, 2008; 10.1124/jpet.108.139212 [Abstract] [Full Text] [PDF]  

Xiao Ru Chen, Valerie C. Besson, Tiphaine Beziaud, Michel Plotkine, and Catherine Marchand-Leroux

Combination Therapy with Fenofibrate, a Peroxisome Proliferator-Activated Receptor Agonist, and Simvastatin, a 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase Inhibitor, on Experimental Traumatic Brain Injury
J Pharmacol Exp Ther 2008 326: 966-974. Published online June 18, 2008; 10.1124/jpet.108.140368 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Jin Yan and Barbara F. Hales

p38 and c-Jun N-Terminal Kinase Mitogen-Activated Protein Kinase Signaling Pathways Play Distinct Roles in the Response of Organogenesis-Stage Embryos to a Teratogen
J Pharmacol Exp Ther 2008 326: 764-772. Published online June 24, 2008; 10.1124/jpet.108.139907 [Abstract] [Full Text] [PDF]  

Joseph T. Dever and Adnan A. Elfarra

L-Methionine Toxicity in Freshly Isolated Mouse Hepatocytes Is Gender-Dependent and Mediated in Part by Transamination
J Pharmacol Exp Ther 2008 326: 809-817. Published online June 13, 2008; 10.1124/jpet.108.141044 [Abstract] [Full Text] [PDF]  

ERRATUM:

Correction to "Antihyperalgesic Effects of (R,E)-N-(2-Hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a Novel Transient Receptor Potential Vanilloid Type 1 Modulator That Does Not Cause Hyperthermia in Rats"
J Pharmacol Exp Ther 2008 326: 999. [Full Text] [PDF]  

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