HIGHLIGHTED PAPERS:

PERSPECTIVES IN PHARMACOLOGY:

Gladys A. Ngoh and Steven P. Jones

New Insights into Metabolic Signaling and Cell Survival: The Role of β-O-Linkage of N-Acetylglucosamine
J Pharmacol Exp Ther 2008 327: 602-609. Published online September 3, 2008; 10.1124/jpet.108.143263 [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Bojana Zupan and Miklos Toth

Inactivation of the Maternal Fragile X Gene Results in Sensitization of GABA_B Receptor Function in the Offspring
J Pharmacol Exp Ther 2008 327: 820-826. Published online September 23, 2008; 10.1124/jpet.108.143990 [Abstract] [Full Text] [PDF]  

Paul A. Ardayfio, Mark J. Benvenga, Stephen F. Chaney, Patrick L. Love, John Catlow, Steven P. Swanson, and Gerard J. Marek

The 5-Hydroxytryptamine_2A Receptor Antagonist R-(+)--(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) Attenuates Impulsivity after Both Drug-Induced Disruption (Dizocilpine) and Enhancement (Antidepressant Drugs) of Differential-Reinforcement-of-Low-Rate 72-s Behavior in the Rat
J Pharmacol Exp Ther 2008 327: 891-897. Published online September 4, 2008; 10.1124/jpet.108.143370 [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Dean Papaliodis, William Boucher, Duraisamy Kempuraj, Margaret Michaelian, Adams Wolfberg, Michael House, and Theoharis C. Theoharides

Niacin-induced "Flush" Involves Release of Prostaglandin D₂ from Mast Cells and Serotonin from Platelets: Evidence from Human Cells in Vitro and an Animal Model
J Pharmacol Exp Ther 2008 327: 665-672. Published online September 10, 2008; 10.1124/jpet.108.141333 [Abstract] [Full Text] [PDF]  

Magnus Baumhäkel, Florian Custodis, Nils Schlimmer, Ulrich Laufs, and Michael Böhm

Improvement of Endothelial Function of the Corpus Cavernosum in Apolipoprotein E Knockout Mice Treated with Irbesartan
J Pharmacol Exp Ther 2008 327: 692-698. Published online September 23, 2008; 10.1124/jpet.108.140533 [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Rita Sarközi, Paul Perco, Kathrin Hochegger, Julia Enrich, Martin Wiesinger, Markus Pirklbauer, Susanne Eder, Michael Rudnicki, Alexander R. Rosenkranz, Bernd Mayer, Gert Mayer, and Herbert Schramek

Bortezomib-Induced Survival Signals and Genes in Human Proximal Tubular Cells
J Pharmacol Exp Ther 2008 327: 645-656. Published online September 5, 2008; 10.1124/jpet.108.142604 [Abstract] [Full Text] [PDF]  

Nina Weitl and Roland Seifert

Distinct Interactions of Human β₁- and β₂-Adrenoceptors with Isoproterenol, Epinephrine, Norepinephrine, and Dopamine
J Pharmacol Exp Ther 2008 327: 760-769. Published online September 4, 2008; 10.1124/jpet.108.143412 [Abstract] [Full Text] [PDF]  

Luis R. Gardell, Jian-Nong Ma, Jimmi Gerner Seitzberg, Anne E. Knapp, Hans H. Schiffer, Ali Tabatabaei, Christopher N. Davis, Michelle Owens, Bryan Clemons, Kenneth K. Wong, Birgitte Lund, Norman R. Nash, Yan Gao, Jelveh Lameh, Kara Schmelzer, Roger Olsson, and Ethan S. Burstein

Identification and Characterization of Novel Small-Molecule Protease-Activated Receptor 2 Agonists
J Pharmacol Exp Ther 2008 327: 799-808. Published online September 3, 2008; 10.1124/jpet.108.142570 [Abstract] [Full Text] [PDF]  

Gilles Ferry, Natacha Moulharat, Jean-Philippe Pradère, Patrice Desos, Anne Try, Annie Genton, Adeline Giganti, Monique Beucher-Gaudin, Michel Lonchampt, Marc Bertrand, Jean-Sébastien Saulnier-Blache, Gordon C. Tucker, Alex Cordi, and Jean A. Boutin

S32826, A Nanomolar Inhibitor of Autotaxin: Discovery, Synthesis and Applications as a Pharmacological Tool
J Pharmacol Exp Ther 2008 327: 809-819. Published online August 28, 2008; 10.1124/jpet.108.141911 [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Ze Lu, Max Tsai, Dan Lu, Jie Wang, M. Guillaume Wientjes, and Jessie L.-S. Au

Tumor-Penetrating Microparticles for Intraperitoneal Therapy of Ovarian Cancer
J Pharmacol Exp Ther 2008 327: 673-682. Published online September 9, 2008; 10.1124/jpet.108.140095 [Abstract] [Full Text] [PDF]  

Catherine Wilson, Colin Purcell, Angela Seaton, Olabode Oladipo, Pamela J. Maxwell, Joe M. O'Sullivan, Richard H. Wilson, Patrick G. Johnston, and David J. J. Waugh

Chemotherapy-Induced CXC-Chemokine/CXC-Chemokine Receptor Signaling in Metastatic Prostate Cancer Cells Confers Resistance to Oxaliplatin through Potentiation of Nuclear Factor-B Transcription and Evasion of Apoptosis
J Pharmacol Exp Ther 2008 327: 746-759. Published online September 9, 2008; 10.1124/jpet.108.143826 [Abstract] [Full Text] [PDF]  

Christopher P. Leamon, Joseph A. Reddy, Ryan Dorton, Alicia Bloomfield, Kristen Emsweller, Nikki Parker, and Elaine Westrick

Impact of High and Low Folate Diets on Tissue Folate Receptor Levels and Antitumor Responses Toward Folate-Drug Conjugates
J Pharmacol Exp Ther 2008 327: 918-925. Published online September 12, 2008; 10.1124/jpet.108.143206 [Abstract] [Full Text] [PDF]  

ENDOCRINE AND DIABETES:

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Hasibur Rehman, Venkat K. Ramshesh, Tom P. Theruvath, Insil Kim, Robert T. Currin, Shailendra Giri, John J. Lemasters, and Zhi Zhong

NIM811 (N-Methyl-4-isoleucine Cyclosporine), a Mitochondrial Permeability Transition Inhibitor, Attenuates Cholestatic Liver Injury but Not Fibrosis in Mice
J Pharmacol Exp Ther 2008 327: 699-706. Published online September 18, 2008; 10.1124/jpet.108.143578 [Abstract] [Full Text] [PDF]  

Fernanda Leve, Wanderley de Souza, and José Andrés Morgado-Díaz

A Cross-Link between Protein Kinase A and Rho-Family GTPases Signaling Mediates Cell-Cell Adhesion and Actin Cytoskeleton Organization in Epithelial Cancer Cells
J Pharmacol Exp Ther 2008 327: 777-788. Published online September 12, 2008; 10.1124/jpet.108.140798 [Abstract] [Full Text] [PDF]  

Christian I. Schwer, Aida M. Guerrero, Matjaz Humar, Martin Roesslein, Ulrich Goebel, Patrick Stoll, Klaus K. Geiger, Benedikt H. J. Pannen, Alexander Hoetzel, and Rene Schmidt

Heme Oxygenase-1 Inhibits the Proliferation of Pancreatic Stellate Cells by Repression of the Extracellular Signal-Regulated Kinase1/2 Pathway
J Pharmacol Exp Ther 2008 327: 863-871. Published online September 10, 2008; 10.1124/jpet.108.136549 [Abstract] [Full Text] [PDF]  

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:

Ronald J. Hill, Karim Dabbagh, Deborah Phippard, Ching Li, Rebecca T. Suttmann, Mary Welch, Eva Papp, Kyung W. Song, Kung-ching Chang, David Leaffer, Yong-Nam Kim, Richard T. Roberts, Tanja S. Zabka, Dee Aud, Joseph Dal Porto, Anthony M. Manning, Stanford L. Peng, David M. Goldstein, and Brian R. Wong

Pamapimod, a Novel p38 Mitogen-Activated Protein Kinase Inhibitor: Preclinical Analysis of Efficacy and Selectivity
J Pharmacol Exp Ther 2008 327: 610-619. Published online September 5, 2008; 10.1124/jpet.108.139006 [Abstract] [Full Text] [PDF] [Data Supplement]   

Daniel C. Broom, David J. Matson, Elizabeth Bradshaw, Marianne E. Buck, Robin Meade, Susan Coombs, Michele Matchett, Kristen K. Ford, Weifeng Yu, Jun Yuan, Synthia H. Sun, Ricardo Ochoa, James E. Krause, David J. Wustrow, and Daniel N. Cortright

Characterization of N-(Adamantan-1-ylmethyl)-5-[(3R-aminopyrrolidin-1-yl)methyl]-2-chloro-benzamide, a P2X₇ Antagonist in Animal Models of Pain and Inflammation
J Pharmacol Exp Ther 2008 327: 620-633. Published online September 4, 2008; 10.1124/jpet.108.141853 [Abstract] [Full Text] [PDF]  

Kimberly L. Fife, YingMei Liu, Kara R. Schmelzer, Hsing-Ju Tsai, In-Hae Kim, Christophe Morisseau, Bruce D. Hammock, and Deanna L. Kroetz

Inhibition of Soluble Epoxide Hydrolase Does Not Protect against Endotoxin-Mediated Hepatic Inflammation
J Pharmacol Exp Ther 2008 327: 707-715. Published online September 24, 2008; 10.1124/jpet.108.142398 [Abstract] [Full Text] [PDF] [Data Supplement]   

Aida Ahmad Guemei, Nagwa Mahmoud Nour El Din, Azza Mohamed Baraka, and Inas El Said Darwish

Do Desipramine [10,11-Dihydro-5-[3-(methylamino) propyl]-5H-dibenz[b,f]azepine monohydrochloride] and Fluoxetine [N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-propan-1-amine] Ameliorate the Extent of Colonic Damage Induced by Acetic Acid in Rats?
J Pharmacol Exp Ther 2008 327: 846-850. Published online September 12, 2008; 10.1124/jpet.108.141259 [Abstract] [Full Text] [PDF]  

Abigail Morris, Gillian Kinnear, Wing-Yan Heidi Wan, Daniel Wyss, Parmjit Bahra, and Christopher S. Stevenson

Comparison of Cigarette Smoke-Induced Acute Inflammation in Multiple Strains of Mice and the Effect of a Matrix Metalloproteinase Inhibitor on These Responses
J Pharmacol Exp Ther 2008 327: 851-862. Published online September 19, 2008; 10.1124/jpet.108.140848 [Abstract] [Full Text] [PDF]  

Robbin M. Brodbeck, Daniel N. Cortright, Andrzej P. Kieltyka, Jianying Yu, Carolyn O. Baltazar, Marianne E. Buck, Robin Meade, George D. Maynard, Andrew Thurkauf, Du-Shieng Chien, Alan J. Hutchison, and James E. Krause

Identification and Characterization of NDT 9513727 [N,N-bis(1,3-Benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-imidazole-5-methanamine], a Novel, Orally Bioavailable C5a Receptor Inverse Agonist
J Pharmacol Exp Ther 2008 327: 898-909. Published online August 27, 2008; 10.1124/jpet.108.141572 [Abstract] [Full Text] [PDF] [Data Supplement]   

Martin E. Dahl, Amy Berson, Jose Lora, and Maria Fuentes

A Novel CCR5-Specific Pharmacodynamic Assay in Whole Blood Using Phosphoflow Cytometry Highlights Different Ligand-Dependent Responses but Similar Properties of Antagonists in CD8⁺ and CD4⁺ T Lymphocytes
J Pharmacol Exp Ther 2008 327: 926-933. Published online August 27, 2008; 10.1124/jpet.108.142695 [Abstract] [Full Text] [PDF]  

Masataka Oda, Atsushi Kihara, Hiroki Yoshioka, Yuki Saito, Naoyuki Watanabe, Kana Uoo, Masahiro Higashihara, Masahiro Nagahama, Naoki Koide, Takashi Yokochi, and Jun Sakurai

Effect of Erythromycin on Biological Activities Induced by Clostridium perfringens -Toxin
J Pharmacol Exp Ther 2008 327: 934-940. Published online September 15, 2008; 10.1124/jpet.108.143677 [Abstract] [Full Text] [PDF]  

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:

H. Umesha Shetty, Sami S. Zoghbi, Fabrice G. Siméon, Jeih-San Liow, Amira K. Brown, Pavitra Kannan, Robert B. Innis, and Victor W. Pike

Radiodefluorination of 3-Fluoro-5-(2-(2-[¹⁸F](fluoromethyl)-thiazol-4-yl)ethynyl)benzonitrile ([¹⁸F]SP203), a Radioligand for Imaging Brain Metabotropic Glutamate Subtype-5 Receptors with Positron Emission Tomography, Occurs by Glutathionylation in Rat Brain
J Pharmacol Exp Ther 2008 327: 727-735. Published online September 19, 2008; 10.1124/jpet.108.143347 [Abstract] [Full Text] [PDF]  

Laddawan Senggunprai, Kouichi Yoshinari, Miki Shimada, and Yasushi Yamazoe

Involvement of ST1B Subfamily of Cytosolic Sulfotransferase in Kynurenine Metabolism to Form Natriuretic Xanthurenic Acid Sulfate
J Pharmacol Exp Ther 2008 327: 789-798. Published online September 24, 2008; 10.1124/jpet.108.143164 [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Feng Liu, Steve Grauer, Cody Kelley, Rachel Navarra, Radka Graf, Guoming Zhang, Peter J. Atkinson, Michael Popiolek, Caitlin Wantuch, Xavier Khawaja, Deborah Smith, Michael Olsen, Evguenia Kouranova, Margaret Lai, Farhana Pruthi, Claudine Pulicicchio, Mark Day, Adam Gilbert, Mark H. Pausch, Nicholas J. Brandon, Chad E. Beyer, Tom A. Comery, Sheree Logue, Sharon Rosenzweig-Lipson, and Karen L. Marquis

ADX47273 [S-(4-Fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: A Novel Metabotropic Glutamate Receptor 5-Selective Positive Allosteric Modulator with Preclinical Antipsychotic-Like and Procognitive Activities
J Pharmacol Exp Ther 2008 327: 827-839. Published online August 27, 2008; 10.1124/jpet.108.136580 [Abstract] [Full Text] [PDF]  

G. Sadri-Vakili, G. C. Janis, R. C. Pierce, T. T. Gibbs, and D. H. Farb

Nanomolar Concentrations of Pregnenolone Sulfate Enhance Striatal Dopamine Overflow in Vivo
J Pharmacol Exp Ther 2008 327: 840-845. Published online September 4, 2008; 10.1124/jpet.108.143958 [Abstract] [Full Text] [PDF]  

Kun Xiang, Damien E. Earl, Kathleen M. Davis, David R. Giovannucci, L. John Greenfield, Jr., and Elizabeth I. Tietz

Chronic Benzodiazepine Administration Potentiates High Voltage-Activated Calcium Currents in Hippocampal CA1 Neurons
J Pharmacol Exp Ther 2008 327: 872-883. Published online September 23, 2008; 10.1124/jpet.108.144444 [Abstract] [Full Text] [PDF]  

Elaine A. Gay, Rebecca C. Klein, Mark A. Melton, Perry J. Blackshear, and Jerrel L. Yakel

Inhibition of Native and Recombinant Nicotinic Acetylcholine Receptors by the Myristoylated Alanine-Rich C Kinase Substrate Peptide
J Pharmacol Exp Ther 2008 327: 884-890. Published online September 23, 2008; 10.1124/jpet.108.144758 [Abstract] [Full Text] [PDF]  

Manuel Mameli, Paolo Botta, Paula A. Zamudio, Stefano Zucca, and C. Fernando Valenzuela

Ethanol Decreases Purkinje Neuron Excitability by Increasing GABA Release in Rat Cerebellar Slices
J Pharmacol Exp Ther 2008 327: 910-917. Published online August 28, 2008; 10.1124/jpet.108.144865 [Abstract] [Full Text] [PDF]  

Ashley E. Brady, Carrie K. Jones, Thomas M. Bridges, J. Phillip Kennedy, Analisa D. Thompson, Justin U. Heiman, Micah L. Breininger, Patrick R. Gentry, Huiyong Yin, Satyawan B. Jadhav, Jana K. Shirey, P. Jeffrey Conn, and Craig W. Lindsley

Centrally Active Allosteric Potentiators of the M₄ Muscarinic Acetylcholine Receptor Reverse Amphetamine-Induced Hyperlocomotor Activity in Rats
J Pharmacol Exp Ther 2008 327: 941-953. Published online September 4, 2008; 10.1124/jpet.108.140350 [Abstract] [Full Text] [PDF] [Data Supplement]   

N. R. Mirza, J. S. Larsen, C. Mathiasen, T. A. Jacobsen, G. Munro, H. K. Erichsen, A. N. Nielsen, K. B. Troelsen, E. Ø. Nielsen, and P. K. Ahring

NS11394 [3'-[5-(1-Hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile], a Unique Subtype-Selective GABA_A Receptor Positive Allosteric Modulator: In Vitro Actions, Pharmacokinetic Properties and in Vivo Anxiolytic Efficacy
J Pharmacol Exp Ther 2008 327: 954-968. Published online September 12, 2008; 10.1124/jpet.108.138859 [Abstract] [Full Text] [PDF]  

G. Munro, J. A. Lopez-Garcia, I. Rivera-Arconada, H. K. Erichsen, E. Ø. Nielsen, J. S. Larsen, P. K. Ahring, and N. R. Mirza

Comparison of the Novel Subtype-Selective GABA_A Receptor-Positive Allosteric Modulator NS11394 [3'-[5-(1-Hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with Diazepam, Zolpidem, Bretazenil, and Gaboxadol in Rat Models of Inflammatory and Neuropathic Pain
J Pharmacol Exp Ther 2008 327: 969-981. Published online September 12, 2008; 10.1124/jpet.108.144568 [Abstract] [Full Text] [PDF]  

Subbu Apparsundaram, Daniel J. Stockdale, Robert A. Henningsen, Marcos E. Milla, and Renee S. Martin

Antidepressants Targeting the Serotonin Reuptake Transporter Act via a Competitive Mechanism
J Pharmacol Exp Ther 2008 327: 982-990. Published online September 18, 2008; 10.1124/jpet.108.142315 [Abstract] [Full Text] [PDF]  

Renee S. Martin, Robert A. Henningsen, Alexander Suen, Subbu Apparsundaram, Becky Leung, Zhongjiang Jia, Rama K. Kondru, and Marcos E. Milla

Kinetic and Thermodynamic Assessment of Binding of Serotonin Transporter Inhibitors
J Pharmacol Exp Ther 2008 327: 991-1000. Published online September 18, 2008; 10.1124/jpet.108.142307 [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Xiaomin Deng, Michael J. Liguori, Erica M. Sparkenbaugh, Jeffrey F. Waring, Eric A. G. Blomme, Patricia E. Ganey, and Robert A. Roth

Gene Expression Profiles in Livers from Diclofenac-Treated Rats Reveal Intestinal Bacteria-Dependent and -Independent Pathways Associated with Liver Injury
J Pharmacol Exp Ther 2008 327: 634-644. Published online September 18, 2008; 10.1124/jpet.108.140335 [Abstract] [Full Text] [PDF] [Data Supplement]   

Wendy L. Imlach, Sarah C. Finch, James Dunlop, Andrea L. Meredith, Richard W. Aldrich, and Julie E. Dalziel

The Molecular Mechanism of "Ryegrass Staggers," a Neurological Disorder of K⁺ Channels
J Pharmacol Exp Ther 2008 327: 657-664. Published online September 18, 2008; 10.1124/jpet.108.143933 [Abstract] [Full Text] [PDF] [Data Supplement]   

Islam R. Younis, Meenal Elliott, Cody J. Peer, Arthur J. L. Cooper, John T. Pinto, Gregory W. Konat, Michal Kraszpulski, William P. Petros, and Patrick S. Callery

Dehydroalanine Analog of Glutathione: An Electrophilic Busulfan Metabolite That Binds to Human Glutathione S-Transferase A1-1
J Pharmacol Exp Ther 2008 327: 770-776. Published online September 12, 2008; 10.1124/jpet.108.142208 [Abstract] [Full Text] [PDF]  

ERRATUM:

Correction to "Conotoxin Arenatus IB[V11l,V16D] Is a Potent and Selective Antagonist at Rat and Human Native 7 Nicotinic Acetylcholine Receptors"
J Pharmacol Exp Ther 2008 327: 1001. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.