JPET -- Table of Contents (331 [2])

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):
Year:		Vol:		Page:

Receive this page by email each issue: [Sign up for eTOCs]

Other Issues:
November 2009; 331 (2)   [Index by Author] [Cover Caption]

       HIGHLIGHTED PAPER

       PERSPECTIVES IN PHARMACOLOGY

       BEHAVIORAL PHARMACOLOGY

       CARDIOVASCULAR

       CELLULAR AND MOLECULAR

       CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

       ENDOCRINE AND DIABETES

       GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

       INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

       METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

       NEUROPHARMACOLOGY

       TOXICOLOGY

Find articles in this issue containing these words:
[Search ALL Issues]

Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

HIGHLIGHTED PAPER:

: Inflammation Gender Differences in Heart Disease Patients
J Pharmacol Exp Ther 2009 331: 339. [Full Text] [PDF]

PERSPECTIVES IN PHARMACOLOGY:

Liyun Wang, Bronwen Martin, Randall Brenneman, Louis M. Luttrell, and Stuart Maudsley: Allosteric Modulators of G Protein-Coupled Receptors: Future Therapeutics for Complex Physiological Disorders
J Pharmacol Exp Ther 2009 331: 340-348. Published online August 10, 2009; 10.1124/jpet.109.156380 [Abstract] [Full Text] [PDF]

BEHAVIORAL PHARMACOLOGY:

Tara A. Macey, Erin N. Bobeck, Deborah M. Hegarty, Sue A. Aicher, Susan L. Ingram, and Michael M. Morgan: Extracellular Signal-Regulated Kinase 1/2 Activation Counteracts Morphine Tolerance in the Periaqueductal Gray of the Rat
J Pharmacol Exp Ther 2009 331: 412-418. Published online August 14, 2009; 10.1124/jpet.109.152157 [Abstract] [Full Text] [PDF]

Gregory T. Collins, Remy L. Brim, Diwahar Narasimhan, Mei-Chuan Ko, Roger K. Sunahara, Chang-Guo Zhan, and James H. Woods: Cocaine Esterase Prevents Cocaine-Induced Toxicity and the Ongoing Intravenous Self-Administration of Cocaine in Rats
J Pharmacol Exp Ther 2009 331: 445-455. Published online August 26, 2009; 10.1124/jpet.108.150029 [Abstract] [Full Text] [PDF]

Jun-Xu Li, Alison Unzeitig, Martin A. Javors, Kenner C. Rice, Wouter Koek, and Charles P. France: Discriminative Stimulus Effects of 1-(2,5-Dimethoxy-4-methylphenyl)-2-aminopropane (DOM), Ketanserin, and (R)-(+)- ${alpha}$ -(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol (MDL100907) in Rats
J Pharmacol Exp Ther 2009 331: 671-679. Published online August 17, 2009; 10.1124/jpet.109.157560 [Abstract] [Full Text] [PDF]

Anbrin Masood, Ying Huang, Hassan Hajjhussein, Lan Xiao, Hao Li, Wei Wang, Adel Hamza, Chang-Guo Zhan, and James M. O'Donnell: Anxiolytic Effects of Phosphodiesterase-2 Inhibitors Associated with Increased cGMP Signaling
J Pharmacol Exp Ther 2009 331: 690-699. Published online August 14, 2009; 10.1124/jpet.109.156729 [Abstract] [Full Text] [PDF]

K. S. Murnane, N. Murai, L. L. Howell, and W. E. Fantegrossi: Discriminative Stimulus Effects of Psychostimulants and Hallucinogens in S(+)-3,4-Methylenedioxymethamphetamine (MDMA) and R(–)-MDMA Trained Mice
J Pharmacol Exp Ther 2009 331: 717-723. Published online August 14, 2009; 10.1124/jpet.109.156174 [Abstract] [Full Text] [PDF]

CARDIOVASCULAR:

J. Andrew Wasserstrom, Rohan Sharma, Matthew J. O'Toole, Jiabo Zheng, James E. Kelly, John Shryock, Luiz Belardinelli, and Gary L. Aistrup: Ranolazine Antagonizes the Effects of Increased Late Sodium Current on Intracellular Calcium Cycling in Rat Isolated Intact Heart
J Pharmacol Exp Ther 2009 331: 382-391. Published online August 12, 2009; 10.1124/jpet.109.156471 [Abstract] [Full Text] [PDF]

Vladimir V. Shuvaev, Melpo Christofidou-Solomidou, Faiz Bhora, Karine Laude, Hua Cai, Sergei Dikalov, Evguenia Arguiri, Charalambos C. Solomides, Steven M. Albelda, David G. Harrison, and Vladimir R. Muzykantov: Targeted Detoxification of Selected Reactive Oxygen Species in the Vascular Endothelium
J Pharmacol Exp Ther 2009 331: 404-411. Published online August 19, 2009; 10.1124/jpet.109.156877 [Abstract] [Full Text] [PDF]

Brinda K. Rana, Jennifer Wessel, Vafa Mahboubi, Fangwen Rao, Jeannine Haeller, Jiaur R. Gayen, Eleazar Eskin, Anne M. Valle, Madhusudan Das, Sushil K. Mahata, Laurent Taupenot, Mats Stridsberg, Todd T. Talley, Michael G. Ziegler, Douglas W. Smith, Nicholas J. Schork, Daniel T. O'Connor, and Palmer Taylor: Natural Variation within the Neuronal Nicotinic Acetylcholine Receptor Cluster on Human Chromosome 15q24: Influence on Heritable Autonomic Traits in Twin Pairs
J Pharmacol Exp Ther 2009 331: 419-428. Published online August 11, 2009; 10.1124/jpet.109.157271 [Abstract] [Full Text] [PDF] [Data Supplement]

Francesc Jiménez-Altayó, Laura Caracuel, Fernando J. Pérez-Asensio, Sonia Martínez-Revelles, Ángel Messeguer, Anna M. Planas, and Elisabet Vila: Participation of Oxidative Stress on Rat Middle Cerebral Artery Changes Induced by Focal Cerebral Ischemia: Beneficial Effects of 3,4-Dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran (CR-6)
J Pharmacol Exp Ther 2009 331: 429-436. Published online August 19, 2009; 10.1124/jpet.109.157131 [Abstract] [Full Text] [PDF]

Angela Amoruso, Claudio Bardelli, Luigia G. Fresu, Alessandra Palma, Matteo Vidali, Valeria Ferrero, Flavio Ribichini, Corrado Vassanelli, and Sandra Brunelleschi: Enhanced Peroxisome Proliferator-Activated Receptor- ${gamma}$ Expression in Monocyte/Macrophages from Coronary Artery Disease Patients and Possible Gender Differences
J Pharmacol Exp Ther 2009 331: 531-538. Published online July 30, 2009; 10.1124/jpet.109.154419 [Abstract] [Full Text] [PDF] [Highlight]

CELLULAR AND MOLECULAR:

Samuel D. Robinson, Jacqueline F. Aitken, Richard J. Bailey, David R. Poyner, and Debbie L. Hay: Novel Peptide Antagonists of Adrenomedullin and Calcitonin Gene-Related Peptide Receptors: Identification, Pharmacological Characterization, and Interactions with Position 74 in Receptor Activity-Modifying Protein 1/3
J Pharmacol Exp Ther 2009 331: 513-521. Published online July 30, 2009; 10.1124/jpet.109.156448 [Abstract] [Full Text] [PDF]

Daniela Ponce-Balbuena, Angélica López-Izquierdo, Tania Ferrer, Aldo A. Rodríguez-Menchaca, Iván A. Aréchiga-Figueroa, and José A. Sánchez-Chapula: Tamoxifen Inhibits Inward Rectifier K⁺ 2.x Family of Inward Rectifier Channels by Interfering with Phosphatidylinositol 4,5-Bisphosphate-Channel Interactions
J Pharmacol Exp Ther 2009 331: 563-573. Published online August 4, 2009; 10.1124/jpet.109.156075 [Abstract] [Full Text] [PDF]

Kristina Hoffmann, Younis Baqi, María Sol Morena, Markus Glänzel, Christa E. Müller, and Ivar von Kügelgen: Interaction of New, Very Potent Non-Nucleotide Antagonists with Arg256 of the Human Platelet P2Y₁₂ Receptor
J Pharmacol Exp Ther 2009 331: 648-655. Published online August 18, 2009; 10.1124/jpet.109.156687 [Abstract] [Full Text] [PDF]

Adam Sharp, Simon J. Crabb, Peter W. M. Johnson, Angela Hague, Ramsey Cutress, Paul A. Townsend, A. Ganesan, and Graham Packham: Thioflavin S (NSC71948) Interferes with Bcl-2-Associated Athanogene (BAG-1)-Mediated Protein-Protein Interactions
J Pharmacol Exp Ther 2009 331: 680-689. Published online August 18, 2009; 10.1124/jpet.109.153601 [Abstract] [Full Text] [PDF]

Richard A. Isbrucker, Esther A. Guzmán, Tara P. Pitts, and Amy E. Wright: Early Effects of Lasonolide A on Pancreatic Cancer Cells
J Pharmacol Exp Ther 2009 331: 733-739. Published online August 19, 2009; 10.1124/jpet.109.155531 [Abstract] [Full Text] [PDF] [Data Supplement]

Amadeu Gavaldà, Montserrat Miralpeix, Israel Ramos, Raquel Otal, Cristina Carreño, Marisa Viñals, Teresa Doménech, Carla Carcasona, Blanca Reyes, Dolors Vilella, Jordi Gras, Julio Cortijo, Esteban Morcillo, Jesús Llenas, Hamish Ryder, and Jorge Beleta: Characterization of Aclidinium Bromide, a Novel Inhaled Muscarinic Antagonist, with Long Duration of Action and a Favorable Pharmacological Profile
J Pharmacol Exp Ther 2009 331: 740-751. Published online August 26, 2009; 10.1124/jpet.109.151639 [Abstract] [Full Text] [PDF]

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Arthur Y. Shaw, Meredith C. Henderson, Gary Flynn, Betty Samulitis, Haiyong Han, Steve P. Stratton, H.-H. Sherry Chow, Laurence H. Hurley, and Robert T. Dorr: Characterization of Novel Diaryl Oxazole-Based Compounds as Potential Agents to Treat Pancreatic Cancer
J Pharmacol Exp Ther 2009 331: 636-647. Published online August 5, 2009; 10.1124/jpet.109.156406 [Abstract] [Full Text] [PDF]

ENDOCRINE AND DIABETES:

Sarah Melissa P. Jacobo, Marcy L. Guerra, and Gregory H. Hockerman: Ca_v1.2 and Ca_v1.3 Are Differentially Coupled to Glucagon-Like Peptide-1 Potentiation of Glucose-Stimulated Insulin Secretion in the Pancreatic β-Cell Line INS-1
J Pharmacol Exp Ther 2009 331: 724-732. Published online August 26, 2009; 10.1124/jpet.109.158519 [Abstract] [Full Text] [PDF]

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Ole De Backer, Ellen Elinck, Evelien Priem, Luc Leybaert, and Romain A. Lefebvre: Peroxisome Proliferator-Activated Receptor ${gamma}$ Activation Alleviates Postoperative Ileus in Mice by Inhibition of Egr-1 Expression and Its Downstream Target Genes
J Pharmacol Exp Ther 2009 331: 496-503. Published online August 5, 2009; 10.1124/jpet.109.155135 [Abstract] [Full Text] [PDF] [Data Supplement]

Anders Lehmann, Madeleine Antonsson, Ann Aurell Holmberg, L. Ashley Blackshaw, Lena Brändén, Hans Bräuner-Osborne, Bolette Christiansen, John Dent, Thomas Elebring, Britt-Marie Jacobson, Jörgen Jensen, Jan P. Mattsson, Karolina Nilsson, Simo S. Oja, Amanda J. Page, Pirjo Saransaari, and Sverker von Unge: (R)-(3-Amino-2-fluoropropyl) Phosphinic Acid (AZD3355), a Novel GABA_B Receptor Agonist, Inhibits Transient Lower Esophageal Sphincter Relaxation through a Peripheral Mode of Action
J Pharmacol Exp Ther 2009 331: 504-512. Published online July 31, 2009; 10.1124/jpet.109.153593 [Abstract] [Full Text] [PDF] [Data Supplement]

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA:

Kathleen M. Gillooly, Mark A. Pattoli, Tracy L. Taylor, Laishun Chen, Lihong Cheng, Kurt R. Gregor, Gena S. Whitney, Vojkan Susulic, Scott H. Watterson, James Kempson, William J. Pitts, Hollie Booth-Lute, Guchen Yang, Paul Davies, Daniel W. Kukral, Joann Strnad, Kim W. McIntyre, Celia J. Darienzo, Luisa Salter-Cid, Zheng Yang, David B. Wang-Iverson, and James R. Burke: Periodic, Partial Inhibition of I ${kappa}$ B Kinase β-Mediated Signaling Yields Therapeutic Benefit in Preclinical Models of Rheumatoid Arthritis
J Pharmacol Exp Ther 2009 331: 349-360. Published online August 3, 2009; 10.1124/jpet.109.156018 [Abstract] [Full Text] [PDF] [Data Supplement]

Thomas B. Sundberg, Lara Swenson, Daniel R. Wahl, Anthony W. Opipari, Jr., and Gary D. Glick: Apoptotic Signaling Activated by Modulation of the F₀F₁-ATPase: Implications for Selective Killing of Autoimmune Lymphocytes
J Pharmacol Exp Ther 2009 331: 437-444. Published online August 25, 2009; 10.1124/jpet.109.156422 [Abstract] [Full Text] [PDF] [Data Supplement]

Masaki Goto, Jesse Chow, Kenzo Muramoto, Ken-ichi Chiba, Satoshi Yamamoto, Masanori Fujita, Hiroshi Obaishi, Kenji Tai, Yoshiharu Mizui, Isao Tanaka, Donna Young, Hua Yang, Yuan J. Wang, Hiroshi Shirota, and Fabian Gusovsky: E6201 [(3S,4R,5Z,8S,9S,11E)-14-(Ethylamino)-8, 9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione], a Novel Kinase Inhibitor of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase (MEK)-1 and MEK Kinase-1: In Vitro Characterization of Its Anti-Inflammatory and Antihyperproliferative Activities
J Pharmacol Exp Ther 2009 331: 485-495. Published online August 14, 2009; 10.1124/jpet.109.156554 [Abstract] [Full Text] [PDF]

Juan Sandoval, Javier Escobar, Javier Pereda, Natalia Sacilotto, José Luis Rodriguez, Luis Sabater, Luis Aparisi, Luis Franco, Gerardo López-Rodas, and Juan Sastre: Pentoxifylline Prevents Loss of PP2A Phosphatase Activity and Recruitment of Histone Acetyltransferases to Proinflammatory Genes in Acute Pancreatitis
J Pharmacol Exp Ther 2009 331: 609-617. Published online August 11, 2009; 10.1124/jpet.109.157537 [Abstract] [Full Text] [PDF]

Hideo Kohka Takahashi, Keyue Liu, Hidenori Wake, Shuji Mori, Jiyong Zhang, Rui Liu, Tadashi Yoshino, and Masahiro Nishibori: Prostaglandin E₂ Inhibits Advanced Glycation End Product-Induced Adhesion Molecule Expression, Cytokine Production, and Lymphocyte Proliferation in Human Peripheral Blood Mononuclear Cells
J Pharmacol Exp Ther 2009 331: 656-670. Published online August 21, 2009; 10.1124/jpet.109.157594 [Abstract] [Full Text] [PDF]

Delphine Carbonnelle, Muriel Duflos, Pascal Marchand, Catherine Chauvet, Jean-Yves Petit, and François Lang: A Novel Indole-3-propanamide Exerts Its Immunosuppressive Activity by Inhibiting JAK3 in T Cells
J Pharmacol Exp Ther 2009 331: 710-716. Published online August 26, 2009; 10.1124/jpet.109.155986 [Abstract] [Full Text] [PDF]

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS:

Hsia-lien Lin, Haoming Zhang, Kathleen R. Noon, and Paul F. Hollenberg: Mechanism-Based Inactivation of CYP2B1 and Its F-Helix Mutant by Two tert-Butyl Acetylenic Compounds: Covalent Modification of Prosthetic Heme Versus Apoprotein
J Pharmacol Exp Ther 2009 331: 392-403. Published online August 21, 2009; 10.1124/jpet.109.158782 [Abstract] [Full Text] [PDF]

Kenneth T. Luu, Eric Y. Zhang, Ganesh Prasanna, Cathie Xiang, Scott Anderson, Jay Fortner, and Paolo Vicini: Pharmacokinetic-Pharmacodynamic and Response Sensitization Modeling of the Intraocular Pressure-Lowering Effect of the EP4 Agonist 5-{3-[(2S)-2-{(3R)-3-hydroxy-4-[3-(trifluoromethyl)phenyl]butyl}-5-oxopyrrolidin-1-yl]propyl}thiophene-2-carboxylate (PF-04475270)
J Pharmacol Exp Ther 2009 331: 627-635. Published online August 18, 2009; 10.1124/jpet.109.157800 [Abstract] [Full Text] [PDF]

Karen L. White, Gary Nguyen, William N. Charman, Glenn A. Edwards, W. A. (Fried) Faassen, and Christopher J. H. Porter: Lymphatic Transport of Methylnortestosterone Undecanoate (MU) and the Bioavailability of Methylnortestosterone Are Highly Sensitive to the Mass of Coadministered Lipid after Oral Administration of MU
J Pharmacol Exp Ther 2009 331: 700-709. Published online August 20, 2009; 10.1124/jpet.109.154542 [Abstract] [Full Text] [PDF]

NEUROPHARMACOLOGY:

Baskaran Thyagarajan, Natalia Krivitskaya, Joseph G. Potian, Kormakur Hognason, Carmen C. Garcia, and Joseph J. McArdle: Capsaicin Protects Mouse Neuromuscular Junctions from the Neuroparalytic Effects of Botulinum Neurotoxin A
J Pharmacol Exp Ther 2009 331: 361-371. Published online August 4, 2009; 10.1124/jpet.109.156901 [Abstract] [Full Text] [PDF] [Data Supplement]

John R. Atack, Karen A. Maubach, Keith A. Wafford, Desmond O'Connor, A. David Rodrigues, David C. Evans, F. David Tattersall, Mark S. Chambers, Angus M. MacLeod, Wai-Si Eng, Christine Ryan, Eric Hostetler, Sandra M. Sanabria, Raymond E. Gibson, Stephen Krause, H. Donald Burns, Richard J. Hargreaves, Nancy G. B. Agrawal, Ruth M. McKernan, M. Gail Murphy, Kevin Gingrich, Gerard R. Dawson, Donald G. Musson, and Kevin J. Petty: In Vitro and in Vivo Properties of 3-tert-Butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABA_A Receptor ${alpha}$ 5 Subtype-Selective Inverse Agonist
J Pharmacol Exp Ther 2009 331: 470-484. Published online August 24, 2009; 10.1124/jpet.109.157636 [Abstract] [Full Text] [PDF]

Takashi Masuko, Rie Namiki, Yuta Nemoto, Muneharu Miyake, Yasuo Kizawa, Toyofumi Suzuki, Keiko Kashiwagi, Kazuei Igarashi, and Tadashi Kusama: Neuroprotection by Tosyl-Polyamine Derivatives through the Inhibition of Ionotropic Glutamate Receptors
J Pharmacol Exp Ther 2009 331: 522-530. Published online July 30, 2009; 10.1124/jpet.109.152926 [Abstract] [Full Text] [PDF]

Carrie L. Wade, Lori L. Eskridge, H. Oanh X. Nguyen, Kelley F. Kitto, Laura S. Stone, George Wilcox, and Carolyn A. Fairbanks: Immunoneutralization of Agmatine Sensitizes Mice to µ-Opioid Receptor Tolerance
J Pharmacol Exp Ther 2009 331: 539-546. Published online August 14, 2009; 10.1124/jpet.109.155424 [Abstract] [Full Text] [PDF]

K. J. Jackson, J. M. McIntosh, D. H. Brunzell, S. S. Sanjakdar, and M. I. Damaj: The Role of ${alpha}$ 6-Containing Nicotinic Acetylcholine Receptors in Nicotine Reward and Withdrawal
J Pharmacol Exp Ther 2009 331: 547-554. Published online July 30, 2009; 10.1124/jpet.109.155457 [Abstract] [Full Text] [PDF]

Marek Schwendt, Angelica Rocha, Ronald E. See, Alejandra M. Pacchioni, Jacqueline F. McGinty, and Peter W. Kalivas: Extended Methamphetamine Self-Administration in Rats Results in a Selective Reduction of Dopamine Transporter Levels in the Prefrontal Cortex and Dorsal Striatum Not Accompanied by Marked Monoaminergic Depletion
J Pharmacol Exp Ther 2009 331: 555-562. Published online July 31, 2009; 10.1124/jpet.109.155770 [Abstract] [Full Text] [PDF]

Steven M. Grauer, Virginia L. Pulito, Rachel L. Navarra, Michele P. Kelly, Cody Kelley, Radka Graf, Barbara Langen, Sheree Logue, Julie Brennan, Lixin Jiang, Erik Charych, Ute Egerland, Feng Liu, Karen L. Marquis, Michael Malamas, Thorsten Hage, Thomas A. Comery, and Nicholas J. Brandon: Phosphodiesterase 10A Inhibitor Activity in Preclinical Models of the Positive, Cognitive, and Negative Symptoms of Schizophrenia
J Pharmacol Exp Ther 2009 331: 574-590. Published online August 6, 2009; 10.1124/jpet.109.155994 [Abstract] [Full Text] [PDF] [Data Supplement]

Bin Pan, Wei Wang, Jonathan Z. Long, Dalong Sun, Cecilia J. Hillard, Benjamin F. Cravatt, and Qing-song Liu: Blockade of 2-Arachidonoylglycerol Hydrolysis by Selective Monoacylglycerol Lipase Inhibitor 4-Nitrophenyl 4-(Dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances Retrograde Endocannabinoid Signaling
J Pharmacol Exp Ther 2009 331: 591-597. Published online August 7, 2009; 10.1124/jpet.109.158162 [Abstract] [Full Text] [PDF]

Robert L. Martone, Hua Zhou, Kevin Atchison, Thomas Comery, Jane Z. Xu, Xinyi Huang, Xioahai Gong, Mei Jin, Anthony Kreft, Boyd Harrison, Scott C. Mayer, Suzan Aschmies, Cathleen Gonzales, Margaret M. Zaleska, David R. Riddell, Erik Wagner, Peimin Lu, Shaiu-Ching Sun, June Sonnenberg-Reines, Aram Oganesian, Karissa Adkins, Michael W. Leach, David W. Clarke, Donna Huryn, Magid Abou-Gharbia, Ronald Magolda, Jonathan Bard, Glen Frick, Sangeeta Raje, S. Bradley Forlow, Carrie Balliet, Michael E. Burczynski, Peter H. Reinhart, Hong I. Wan, Menelas N. Pangalos, and J. Steven Jacobsen: Begacestat (GSI-953): A Novel, Selective Thiophene Sulfonamide Inhibitor of Amyloid Precursor Protein ${gamma}$ -Secretase for the Treatment of Alzheimer's Disease
J Pharmacol Exp Ther 2009 331: 598-608. Published online August 11, 2009; 10.1124/jpet.109.152975 [Abstract] [Full Text] [PDF]

Blaise Mathias Costa, Bihua Feng, Timur S. Tsintsadze, Richard M. Morley, Mark W. Irvine, Vera Tsintsadze, Natasha A. Lozovaya, David E. Jane, and Daniel T. Monaghan: N-Methyl-D-aspartate (NMDA) Receptor NR2 Subunit Selectivity of a Series of Novel Piperazine-2,3-dicarboxylate Derivatives: Preferential Blockade of Extrasynaptic NMDA Receptors in the Rat Hippocampal CA3-CA1 Synapse
J Pharmacol Exp Ther 2009 331: 618-626. Published online August 14, 2009; 10.1124/jpet.109.156752 [Abstract] [Full Text] [PDF]

Annabelle R Charbit, Simon Akerman, and Peter J Goadsby: Comparison of the Effects of Central and Peripheral Dopamine Receptor Activation on Evoked Firing in the Trigeminocervical Complex
J Pharmacol Exp Ther 2009 331: 752-763. Published online August 5, 2009; 10.1124/jpet.109.151951 [Abstract] [Full Text] [PDF]

TOXICOLOGY:

S. N. Lavergne, H. Wang, H. E. Callan, B. K. Park, and D. J. Naisbitt: "Danger" Conditions Increase Sulfamethoxazole-Protein Adduct Formation in Human Antigen-Presenting Cells
J Pharmacol Exp Ther 2009 331: 372-381. Published online August 7, 2009; 10.1124/jpet.109.155374 [Abstract] [Full Text] [PDF] [Data Supplement]

Daniel J. Conklin, Petra Haberzettl, Jean-Francois Lesgards, Russell A. Prough, Sanjay Srivastava, and Aruni Bhatnagar: Increased Sensitivity of Glutathione S-Transferase P-Null Mice to Cyclophosphamide-Induced Urinary Bladder Toxicity
J Pharmacol Exp Ther 2009 331: 456-469. Published online August 20, 2009; 10.1124/jpet.109.156513 [Abstract] [Full Text] [PDF]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Cover Caption:

About the cover: Homology model of the structure of the extracellular domain of the α3β4 nAChR derived from the structure of ACh binding proteins from Aplysia californica and Lymnaea stagnalis. See the article by Rana et al. on page 419 of this issue.