19 August 2008

Ilka Knutter, Claudia Wollesky, Gabor Kottra, Martin Hahn, Wiebke Fischer, Katja Zebisch, Reinhard Neubert, Hannelore Daniel, and Matthias Brandsch

Transport of Angiotensin-converting Enzyme Inhibitors by H⁺/Peptide Transporters Revisited
Published August 19, 2008; doi: 10.1124/jpet.108.143339 [Abstract] [PDF]  

Donelly A van Schalkwyk, Waldemar Priebe, and Kevin J Saliba

The inhibitory effect of 2-halo derivatives of D-glucose on glycolysis and on the proliferation of the human malaria parasite Plasmodium falciparum
Published August 19, 2008; doi: 10.1124/jpet.108.141929 [Abstract] [PDF]  

15 August 2008

Bangning Yu, Jaime Becnel, Mourad Zerfaoui, Rasika Rohatgi, A Hamid Boulares, and Charles D Nichols

Serotonin 5-HT_2A receptor activation suppresses TNF--induced inflammation with extraordinary potency
Published August 15, 2008; doi: 10.1124/jpet.108.143461 [Abstract] [PDF]  

13 August 2008

Volker Nimmrich, Robert Szabo, Csaba Nykas, Ivica Granic, Klaus G Reymann, Ulrich H Schroeder, Gerhard Gross, Hans Schoemaker, Karsten Wicke, Achim Moeller, and Paul Luiten

Inhibition of calpain prevents NMDA-induced degeneration of the nucleus basalis and associated behavioral dysfunction
Published August 13, 2008; doi: 10.1124/jpet.108.142679 [Abstract] [PDF] [Data Supplement]  

Volker Rudolph, Tanja K Rudolph, Francisco J Schopfer, Gustavo Bonacci, Denise Lau, Katalin Szoecs, Anna Klinke, Thomas Meinertz, Bruce A Freeman, and Stephan Baldus

Bivalirudin decreases NO bioavailability by vascular immobilization of myeloperoxidase
Published August 13, 2008; doi: 10.1124/jpet.108.142414 [Abstract] [PDF] [Data Supplement]  

12 August 2008

Natasha T Snider, Matthew J Sikora, Chitra Sridar, Thomas J Feuerstein, James M Rae, and Paul F Hollenberg

The Endocannabinoid Anandamide is a Substrate for the Human Polymorphic Cytochrome P450 2D6
Published August 12, 2008; doi: 10.1124/jpet.108.141796 [Abstract] [PDF]  

Michael R. Tilley and Howard Gu

The effects of methylphenidate on knock-in mice with a methylphenidate resistant dopamine transporter
Published August 12, 2008; doi: 10.1124/jpet.108.141713 [Abstract] [PDF]  

11 August 2008

Byung Hak Kim, Seong Su Hong, Soon Woo Kwon, Hwa Young Lee, Hyeran Sung, In-Jeong Lee, Bang Yeon Hwang, Sukgil Song, Chong-Kil Lee, Daehyun Chung, Byeongwoo Ahn, Sang-Yoon Nam, Sang-Bae Han, and Youngsoo Kim

Diarctigenin, a Lignan Constituent from Arctium lappa, Down-Regulated Zymosan-Induced Transcription of Inflammatory Genes through Suppression of DNA Binding Ability of Nuclear Factor-B in Macrophages
Published August 11, 2008; doi: 10.1124/jpet.108.140145 [Abstract] [PDF]  

8 August 2008

Yanqi Liang, Amanda M. Shaw, Mona Boules, Siobhan Briody, Jessica Robinson, Alfredo Oliveros, Eric Blazar, Katrina Williams, Yiqun Zhang, Paul Carlier, and Elliott Richelson

Antidepressant-like pharmacological profile of a novel triple re-uptake inhibitor, PRC200-SS
Published August 8, 2008; doi: 10.1124/jpet.108.143610 [Abstract] [PDF]  

7 August 2008

Dorothee Abramowski, Karl-Heinz Wiederhold, Ulrich Furrer, Anne-Lise Jaton, Anton Neuenschwander, Marie-Josephine Runser, Simone Danner, Julia Reichwald, Domenico Ammaturo, Dieter Staab, Markus Stoeckli, Heinrich Rueeger, Ulf Neumann, and Matthias Staufenbiel

Dynamics of A Turnover and Deposition in Different APP Transgenic Mouse Models Following Gamma-Secretase Inhibition
Published August 7, 2008; doi: 10.1124/jpet.108.140327 [Abstract] [PDF] [Data Supplement]  

6 August 2008

Yi Xu, Bin Liu, Jay L. Zweier, and Guanglong He

Formation of Hydrogen Peroxide and Reduction of Peroxynitrite via Dismutation of Superoxide at Reperfusion Enhances Myocardial Blood Flow and Oxygen Consumption in Postischemic Mouse Heart
Published August 6, 2008; doi: 10.1124/jpet.108.142372 [Abstract] [PDF]  

5 August 2008

Gracious R Ross, Bichoy H Gabra, William L Dewey, and Hamid I Akbarali

Morphine tolerance in the mouse ileum and colon
Published August 5, 2008; doi: 10.1124/jpet.108.143438 [Abstract] [PDF]  

James J Burston, Laura J Sim-Selley, John P Harloe, Anu Mahadevan, Raj K Razdan, Dana E Selley, and Jenny L. Wiley

N-Arachidonyl maleimide (NAM) potentiates the pharmacological and biochemical effects of the endocannabinoid 2-arachidonylglycerol through inhibition of monoacylglycerol lipase
Published August 5, 2008; doi: 10.1124/jpet.108.141382 [Abstract] [PDF]  

Hinako Suga, Katherine W. Figueroa, and Frederick J. Ehlert

Use of acetylcholine mustard to study allosteric interactions at the M₂ muscarinic receptor
Published August 5, 2008; doi: 10.1124/jpet.108.141234 [Abstract] [PDF]  

Lubo Zhang, Daliao Xiao, and Xiangqun Hu

Effect of cGMP on Pharmacomechanical Coupling in the Uterine Artery of Near-Term Pregnant Sheep
Published August 5, 2008; doi: 10.1124/jpet.108.141283 [Abstract] [PDF]  

Frank J. Gonzalez and Connie Cheung

Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessment
Published August 5, 2008; doi: 10.1124/jpet.108.141242 [Abstract] [PDF]  

Man Jiang and Zheng Dong

Regulation and Pathological Role of p53 in Cisplatin Nephrotoxicity
Published August 5, 2008; doi: 10.1124/jpet.108.139162 [Abstract] [PDF]  

1 August 2008

Tanuja Bordia, Carla Campos, Luping Z. Huang, and Maryka Quik

Continuous and intermittent nicotine treatment reduces L-dopa-induced dyskinesias in a rat model of Parkinson's disease
Published August 1, 2008; doi: 10.1124/jpet.108.140897 [Abstract] [PDF]  

31 July 2008

Hong-Yi Zhou, Shao-Rui Chen, Hong Chen, and Hui-Lin Pan

Sustained Inhibition of Neurotransmitter Release from non-TRPV1-Expressing Primary Afferents by [D-Ala²,N-Me-Phe⁴,Gly-ol⁵]-Enkephalin in the Spinal Cord
Published July 31, 2008; doi: 10.1124/jpet.108.141226 [Abstract] [PDF]  

29 July 2008

Neal Innocent, Phil D Livingstone, Arik Hone, Atsuko Kimura, Tracey Young, Paul Whiteaker, J. Michael McIntosh, and Susan Wonnacott

Conotoxin ArIB[V11L,V16D] is a potent and selective antagonist at rat and human native 7 nicotinic acetylcholine receptors
Published July 29, 2008; doi: 10.1124/jpet.108.142943 [Abstract] [PDF]  

Tadakatsu Matsuno, Yasushi Ito, Takamasa Ohashi, Masahiro Morise, Naoya Takeda, Kaoru Shimokata, Kazuyoshi Imaizumi, Hiroaki Kume, and Yoshinori Hasegawa

Dual pathway activated by tert-butyl hydroperoxide in human airway anion secretion
Published July 29, 2008; doi: 10.1124/jpet.108.141580 [Abstract] [PDF]  

Elizabeth J Rahn, Alexander M. Zvonok, Ganesh A. Thakur, Atmaram D. Khanolkar, Alexandros Makriyannis, and Andrea G Hohmann

Selective Activation of Cannabinoid CB₂ Receptors Suppresses Neuropathic Nociception Induced by Treatment with the Chemotherapeutic Agent Paclitaxel in Rats
Published July 29, 2008; doi: 10.1124/jpet.108.141994 [Abstract] [PDF]  

Rachel L Thomas, Rajendra Mistry, Christopher J Langmead, Martyn D Wood, and RA John Challiss

G Protein Coupling and Signaling Pathway Activation by M₁ Muscarinic Acetylcholine Receptor Orthosteric and Allosteric Agonists
Published July 29, 2008; doi: 10.1124/jpet.108.141788 [Abstract] [PDF]  

Cara A Rabik, Melissa L Fishel, Julianne L. Holleran, Kristen Kasza, Mark R Kelley, Merrill J. Egorin, and M. Eileen Dolan

Enhancement of cisplatin cytotoxicity by O⁶-benzylguanine involves endoplasmic reticulum stress
Published July 29, 2008; doi: 10.1124/jpet.108.141291 [Abstract] [PDF] [Data Supplement]  

25 July 2008

Anni-Maija Linden, M. Isabel Aller, Elli Leppa, Per H Rosenberg, William Wisden, and Esa R. Korpi

K⁺ channel TASK-1 knockout mice show enhanced sensitivities to ataxic and hypnotic effects of GABA_A receptor ligands
Published July 25, 2008; doi: 10.1124/jpet.108.142083 [Abstract] [PDF]  

24 July 2008

Pei-suen Tsou, Vamsi Krishna Addanki, and Ho-Leung Fung

Dissociation between superoxide accumulation and nitroglycerin-induced tolerance
Published July 24, 2008; doi: 10.1124/jpet.108.138784 [Abstract] [PDF]  

23 July 2008

Seta Stanbouly, Lorrie A Kirshenbaum, Doug L Jones, and Morris Karmazyn

Sodium Hydrogen Exchange 1 (NHE-1) Regulates Connexin 43 Expression in Cardiomyocytes via Reverse Mode Sodium Calcium Exchange and JNK Dependent Pathways
Published July 23, 2008; doi: 10.1124/jpet.108.140228 [Abstract] [PDF]  

Frederic G Chappe, Matthew E Loewen, John W Hanrahan, and Valerie M Chappe

VIP increases CFTR levels in the apical membrane of Calu-3 cells through a PKC-dependent mechanism
Published July 23, 2008; doi: 10.1124/jpet.108.141143 [Abstract] [PDF]  

Jennifer B. Dennison, Michael A. Mohutsky, Robert J. Barbuch, Steven A. Wrighton, and Stephen D. Hall

Apparent high CYP3A5 expression is required for significant metabolism of vincristine by cryopreserved human hepatocytes
Published July 23, 2008; doi: 10.1124/jpet.108.139998 [Abstract] [PDF]  

17 July 2008

Herman D. Lim, Aldo Jongejan, Remko A. Bakker, Eric Haaksma, Iwan J. P. de Esch, and Rob Leurs

Phenylalanine¹⁶⁹ in the second extracellular loop of the human histamine H₄ receptor is responsible for the difference in agonist binding between human and mouse H₄ receptors
Published July 17, 2008; doi: 10.1124/jpet.108.140343 [Abstract] [PDF] [Data Supplement]  

16 July 2008

Lihua Jin, Maki Miyazaki, Satomi Mizuno, Miki Takigawa, Tadao Hirose, Kazuhiro Nishimura, Toshihiko Toida, Keith Williams, Keiko Kashiwagi, and Kazuei Igarashi

The Pore Region of N-Methyl-D-Aspartate Receptors Differentially Influences Stimulation and Block by Spermine
Published July 16, 2008; doi: 10.1124/jpet.108.140459 [Abstract] [PDF]  

Eva Hoi Ching Tang and Paul M Vanhoutte

Gap junction inhibitors reduce endothelium-dependent contractions in the aorta of spontaneously hypertensive rats
Published July 16, 2008; doi: 10.1124/jpet.108.140046 [Abstract] [PDF]  

15 July 2008

Stephen M Sims, Tom Chrones, and Harold G Preiksaitis

Calcium sensitization in human esophageal muscle: Role for RhoA kinase in maintenance of lower esophageal sphincter tone
Published July 15, 2008; doi: 10.1124/jpet.108.140806 [Abstract] [PDF]  

11 July 2008

Consuelo Amantini, Michela Mosca, Roberta Lucciarini, Marina Cecilia Perfumi, and Giorgio Santoni

Thiorphan-induced survival and proliferation of rat thymocytes by activation of Akt/Survivin pathway and inhibition of caspase-3 activity
Published July 11, 2008; doi: 10.1124/jpet.108.138719 [Abstract] [PDF]  

Tursun Alkam, Atsumi Nitta, Hiroyuki Mizoguchi, Akio Itoh, Rina Murai, Taku Nagai, Kiyofumi Yamada, and Toshitaka Nabeshima

The extensive nitration of neurofilament light chain in the hippocampus is associated with the cognitive impairment induced by amyloid beta in mice
Published July 11, 2008; doi: 10.1124/jpet.108.141309 [Abstract] [PDF]  

8 July 2008

Salvatore Cuzzocrea, Rosanna Di Paola, Tiziana Genovese, Emanuela Mazzon, Emanuela Esposito, Concetta Crisafulli, Placido Bramanti, and Daniela Salvemini

Anti-inflammatory and anti-apoptotic effects of Fumonisin B1, an inhibitor of ceramide synthase, in a rodent model of splanchnic ischemia and reperfusion injury
Published July 8, 2008; doi: 10.1124/jpet.108.139808 [Abstract] [PDF]  

Mustafa Vali, Josephina A Vossen, Manon Buijs, James M Engles, Eleni Liapi, Veronica Prieto Ventura, Afsheen Khwaja, Obele Acha-Ngwodo, Richard L Wahl, and Jean-Francois H Geschwind

Targeting of VX2 rabbit liver tumor by selective delivery of 3-bromopyruvate: a biodistribution and survival study
Published July 8, 2008; doi: 10.1124/jpet.108.141093 [Abstract] [PDF]  

7 July 2008

Kathryn T O'Leary, Neeraja Parameswaran, Louisa C Johnston, J. Michael McIntosh, Donato A Di Monte, and Maryka Quik

Paraquat exposure reduces nicotinic receptor-evoked dopamine release in monkey striatum
Published July 7, 2008; doi: 10.1124/jpet.108.141861 [Abstract] [PDF]  

Melanie A Starr, Michelle E Page, and Barry D Waterhouse

MDMA (3,4-methylenedioxymethamphetamine) – mediated distortion of somatosensory signal transmission and neurotransmitter efflux in the ventral posterior medial thalamus
Published July 7, 2008; doi: 10.1124/jpet.108.139337 [Abstract] [PDF]  

3 July 2008

Mieke Buntinx, Bart Hermans, Jan Goossens, Dieder Moechars, Ron A.H.J. Gilissen, Julien Doyon, Staf Boeckx, Erwin Coesemans, Guy Vanlommen, and Jean P Van Wauwe

Pharmacological profile of JNJ-27141491, a non-competitive and orally active antagonist of the human chemokine receptor CCR2
Published July 3, 2008; doi: 10.1124/jpet.108.140723 [Abstract] [PDF] [Data Supplement]  

2 July 2008

Shunichi Kajioka, Shinsuke Nakayama, Haruhiko Asano, Narihito Seki, Seiji Naito, and Alison F Brading

Levcromakalim and MgGDP activate small conductance K_ATP channels of Kir6.1/SUR2A in pig detrusor smooth muscle cells: Uncoupling of cAMP signal pathways
Published July 2, 2008; doi: 10.1124/jpet.108.140269 [Abstract] [PDF]  

1 July 2008

Alexander de Giorgio-Miller, Peter Bungay, Michelle Tutt, Julie Owen, David Goodwin, and Nick Pullen

The Translational Pharmacology Of A Novel, Potent And Selective Non-steroidal Progesterone Receptor Antagonist, PF-02367982
Published July 1, 2008; doi: 10.1124/jpet.108.140467 [Abstract] [PDF] [Data Supplement]  

Eduardo R. Butelman, Szymon Rus, Denise S. Simpson, Angela K.H. Wolf, Thomas E. Prisinzano, and Mary Jeanne Kreek

The effects of herkinorin, the first µ-selective ligand from a salvinorin A- derived scaffold, in a neuroendocrine biomarker assay in non-human primates
Published July 1, 2008; doi: 10.1124/jpet.108.140079 [Abstract] [PDF]  

Taeko Matsuda, Yumiko Toyohira, Susumu Ueno, Masato Tsutsui, and Nobuyuki Yanagihara

Simvastatin inhibits catecholamine secretion and synthesis induced by acetylcholine via blocking Na⁺ and Ca²⁺ influx in bovine adrenal medullary cells
Published July 1, 2008; doi: 10.1124/jpet.108.139659 [Abstract] [PDF]  

30 June 2008

Melanie Mueller, Frank Peters, Hans Maurer, Una McCann, and George A Ricaurte

Non-linear Pharmacokinetics of MDMA ("Ecstasy") and its Major Metabolites in Squirrel Monkeys at Plasma Concentrations of MDMA that Develop After Typical Psychoactive Doses
Published June 30, 2008; doi: 10.1124/jpet.108.141366 [Abstract] [PDF]  

Yun Liu and Rae R Matsumoto

Alterations in fra-2 and -1 receptor gene and protein expression are associated with the development of cocaine-induced behavioral sensitization: time course and regional distribution studies
Published June 30, 2008; doi: 10.1124/jpet.108.141051 [Abstract] [PDF]  

Austin Meng Guo, Ju Sheng, Gloria M Scicli, Ali S Arbab, Norman L Lehman, Paul A Edwrads, John R Falck, Richard J Roman, and Alfonso G Scicli

Expression of CYP4A1 in U251 Human Glioma Cell Induces Hyperproliferative Phenotype in vitro and Rapidly Growing Tumors in vivo
Published June 30, 2008; doi: 10.1124/jpet.108.140889 [Abstract] [PDF]  

Trent Volz, Sarah Farnsworth, Shane D. Rowley, Glen R. Hanson, and Annette E. Fleckenstein

METHYLPHENIDATE-INDUCED INCREASES IN VESICULAR DOPAMINE SEQUESTRATION AND DOPAMINE RELEASE IN THE STRIATUM: THE ROLE OF MUSCARINIC AND DOPAMINE D2 RECEPTORS
Published June 30, 2008; doi: 10.1124/jpet.108.139386 [Abstract] [PDF]  

Luciana P. Coelho, Magda F. Serra, Ana Lucia de Aguiar Pires, Renato S.B. Cordeiro, Patricia M. R. Silva, Marcelo H. Santos, and Marco A. Martins

7-Epiclusianone, a tetraprenylated benzophenone, relaxes airway smooth muscle through activation of the nitric oxide-cGMP pathway
Published June 30, 2008; doi: 10.1124/jpet.108.138032 [Abstract] [PDF]  

Haoyu Zeng, Earl A. Gordon, Zuojun Lin, Irina M. Lozinskaya, Robert N. Willette, and Xiaoping Xu

1-[1-hexyl-6-(methyloxy)-1H-indazol-3-yl]-2-methyl-1-propanone (HMIMP), a Potent and Highly Selective Small Molecule Blocker of the Large-Conductance Voltage-gated and Calcium-dependent K⁺ Channel
Published June 30, 2008; doi: 10.1124/jpet.108.139733 [Abstract] [PDF]  

26 June 2008

Le Yu, William KK Wu, Zhi Jie Li, Helen PS Wong, Emily KK Tai, Ya Chun Wu, Hai Tao Li, and Chi Hin Cho

EP2 receptor-mediated activation of extracellular signal-regulated kinase/activator protein-1 signaling is required for the mitogenic action of prostaglandin E2 in esophageal squamous-cell carcinoma
Published June 26, 2008; doi: 10.1124/jpet.108.141275 [Abstract] [PDF] [Data Supplement]  

Yoshikazu Fujimori, Kenji Katsuno, Ikumi Nakashima, Yukiko Ishikawa-Takemura, Hideki Fujikura, and Masayuki Isaji

Remogliflozin etabonate, in a Novel Category of Selective Low-Affinity / High-Capacity Sodium Glucose Cotransporter (SGLT2) Inhibitors, Exhibits Antidiabetic Efficacy in Rodent Models
Published June 26, 2008; doi: 10.1124/jpet.108.140210 [Abstract] [PDF]  

Cheng Xiao, Chunyi Zhou, Kai X Li, Daryl L. Davies, and Jiang Hong Ye

P2 Receptors at GABAergic Synapses on VTA Dopamine Neurons are Targets for Ethanol Action
Published June 26, 2008; doi: 10.1124/jpet.108.139766 [Abstract] [PDF]  

Emrah Yatkin, Jenni Bernoulli, Risto Lammintausta, and Risto Santti

FISPEMIFENE, A NOVEL SERM, ATTENUATES GLANDULAR INFLAMMATION IN AN ANIMAL MODEL OF CHRONIC NONBACTERIAL PROSTATITIS
Published June 26, 2008; doi: 10.1124/jpet.108.139501 [Abstract] [PDF]  

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