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Fast Forward: Last updated August 19, 2008 [View by date]

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PERSPECTIVES IN PHARMACOLOGY
BEHAVIORAL PHARMACOLOGY
CARDIOVASCULAR
CELLULAR AND MOLECULAR
CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
ENDOCRINE AND DIABETES
GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
NEUROPHARMACOLOGY
TOXICOLOGY

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PERSPECTIVES IN PHARMACOLOGY

Frank J. Gonzalez and Connie Cheung: Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessment
Published August 5, 2008; doi: 10.1124/jpet.108.141242 [Abstract] [PDF]

Man Jiang and Zheng Dong: Regulation and Pathological Role of p53 in Cisplatin Nephrotoxicity
Published August 5, 2008; doi: 10.1124/jpet.108.139162 [Abstract] [PDF]

BEHAVIORAL PHARMACOLOGY

Tanuja Bordia, Carla Campos, Luping Z. Huang, and Maryka Quik: Continuous and intermittent nicotine treatment reduces L-dopa-induced dyskinesias in a rat model of Parkinson's disease
Published August 1, 2008; doi: 10.1124/jpet.108.140897 [Abstract] [PDF]

Elizabeth J Rahn, Alexander M. Zvonok, Ganesh A. Thakur, Atmaram D. Khanolkar, Alexandros Makriyannis, and Andrea G Hohmann: Selective Activation of Cannabinoid CB₂ Receptors Suppresses Neuropathic Nociception Induced by Treatment with the Chemotherapeutic Agent Paclitaxel in Rats
Published July 29, 2008; doi: 10.1124/jpet.108.141994 [Abstract] [PDF]

Anni-Maija Linden, M. Isabel Aller, Elli Leppa, Per H Rosenberg, William Wisden, and Esa R. Korpi: K⁺ channel TASK-1 knockout mice show enhanced sensitivities to ataxic and hypnotic effects of GABA_A receptor ligands
Published July 25, 2008; doi: 10.1124/jpet.108.142083 [Abstract] [PDF]

Tursun Alkam, Atsumi Nitta, Hiroyuki Mizoguchi, Akio Itoh, Rina Murai, Taku Nagai, Kiyofumi Yamada, and Toshitaka Nabeshima: The extensive nitration of neurofilament light chain in the hippocampus is associated with the cognitive impairment induced by amyloid beta in mice
Published July 11, 2008; doi: 10.1124/jpet.108.141309 [Abstract] [PDF]

CARDIOVASCULAR

Volker Rudolph, Tanja K Rudolph, Francisco J Schopfer, Gustavo Bonacci, Denise Lau, Katalin Szoecs, Anna Klinke, Thomas Meinertz, Bruce A Freeman, and Stephan Baldus: Bivalirudin decreases NO bioavailability by vascular immobilization of myeloperoxidase
Published August 13, 2008; doi: 10.1124/jpet.108.142414 [Abstract] [PDF] [Data Supplement]

Yi Xu, Bin Liu, Jay L. Zweier, and Guanglong He: Formation of Hydrogen Peroxide and Reduction of Peroxynitrite via Dismutation of Superoxide at Reperfusion Enhances Myocardial Blood Flow and Oxygen Consumption in Postischemic Mouse Heart
Published August 6, 2008; doi: 10.1124/jpet.108.142372 [Abstract] [PDF]

Lubo Zhang, Daliao Xiao, and Xiangqun Hu: Effect of cGMP on Pharmacomechanical Coupling in the Uterine Artery of Near-Term Pregnant Sheep
Published August 5, 2008; doi: 10.1124/jpet.108.141283 [Abstract] [PDF]

Pei-suen Tsou, Vamsi Krishna Addanki, and Ho-Leung Fung: Dissociation between superoxide accumulation and nitroglycerin-induced tolerance
Published July 24, 2008; doi: 10.1124/jpet.108.138784 [Abstract] [PDF]

Seta Stanbouly, Lorrie A Kirshenbaum, Doug L Jones, and Morris Karmazyn: Sodium Hydrogen Exchange 1 (NHE-1) Regulates Connexin 43 Expression in Cardiomyocytes via Reverse Mode Sodium Calcium Exchange and JNK Dependent Pathways
Published July 23, 2008; doi: 10.1124/jpet.108.140228 [Abstract] [PDF]

Eva Hoi Ching Tang and Paul M Vanhoutte: Gap junction inhibitors reduce endothelium-dependent contractions in the aorta of spontaneously hypertensive rats
Published July 16, 2008; doi: 10.1124/jpet.108.140046 [Abstract] [PDF]

Salvatore Cuzzocrea, Rosanna Di Paola, Tiziana Genovese, Emanuela Mazzon, Emanuela Esposito, Concetta Crisafulli, Placido Bramanti, and Daniela Salvemini: Anti-inflammatory and anti-apoptotic effects of Fumonisin B1, an inhibitor of ceramide synthase, in a rodent model of splanchnic ischemia and reperfusion injury
Published July 8, 2008; doi: 10.1124/jpet.108.139808 [Abstract] [PDF]

Taeko Matsuda, Yumiko Toyohira, Susumu Ueno, Masato Tsutsui, and Nobuyuki Yanagihara: Simvastatin inhibits catecholamine secretion and synthesis induced by acetylcholine via blocking Na⁺ and Ca²⁺ influx in bovine adrenal medullary cells
Published July 1, 2008; doi: 10.1124/jpet.108.139659 [Abstract] [PDF]

CELLULAR AND MOLECULAR

Hinako Suga, Katherine W. Figueroa, and Frederick J. Ehlert: Use of acetylcholine mustard to study allosteric interactions at the M₂ muscarinic receptor
Published August 5, 2008; doi: 10.1124/jpet.108.141234 [Abstract] [PDF]

Rachel L Thomas, Rajendra Mistry, Christopher J Langmead, Martyn D Wood, and RA John Challiss: G Protein Coupling and Signaling Pathway Activation by M₁ Muscarinic Acetylcholine Receptor Orthosteric and Allosteric Agonists
Published July 29, 2008; doi: 10.1124/jpet.108.141788 [Abstract] [PDF]

Frederic G Chappe, Matthew E Loewen, John W Hanrahan, and Valerie M Chappe: VIP increases CFTR levels in the apical membrane of Calu-3 cells through a PKC-dependent mechanism
Published July 23, 2008; doi: 10.1124/jpet.108.141143 [Abstract] [PDF]

Herman D. Lim, Aldo Jongejan, Remko A. Bakker, Eric Haaksma, Iwan J. P. de Esch, and Rob Leurs: Phenylalanine¹⁶⁹ in the second extracellular loop of the human histamine H₄ receptor is responsible for the difference in agonist binding between human and mouse H₄ receptors
Published July 17, 2008; doi: 10.1124/jpet.108.140343 [Abstract] [PDF] [Data Supplement]

Lihua Jin, Maki Miyazaki, Satomi Mizuno, Miki Takigawa, Tadao Hirose, Kazuhiro Nishimura, Toshihiko Toida, Keith Williams, Keiko Kashiwagi, and Kazuei Igarashi: The Pore Region of N-Methyl-D-Aspartate Receptors Differentially Influences Stimulation and Block by Spermine
Published July 16, 2008; doi: 10.1124/jpet.108.140459 [Abstract] [PDF]

Austin Meng Guo, Ju Sheng, Gloria M Scicli, Ali S Arbab, Norman L Lehman, Paul A Edwrads, John R Falck, Richard J Roman, and Alfonso G Scicli: Expression of CYP4A1 in U251 Human Glioma Cell Induces Hyperproliferative Phenotype in vitro and Rapidly Growing Tumors in vivo
Published June 30, 2008; doi: 10.1124/jpet.108.140889 [Abstract] [PDF]

Haoyu Zeng, Earl A. Gordon, Zuojun Lin, Irina M. Lozinskaya, Robert N. Willette, and Xiaoping Xu: 1-[1-hexyl-6-(methyloxy)-1H-indazol-3-yl]-2-methyl-1-propanone (HMIMP), a Potent and Highly Selective Small Molecule Blocker of the Large-Conductance Voltage-gated and Calcium-dependent K⁺ Channel
Published June 30, 2008; doi: 10.1124/jpet.108.139733 [Abstract] [PDF]

CHEMOTHERAPY, ANTIBIOTICS, & GENE THERAPY

Cara A Rabik, Melissa L Fishel, Julianne L. Holleran, Kristen Kasza, Mark R Kelley, Merrill J. Egorin, and M. Eileen Dolan: Enhancement of cisplatin cytotoxicity by O⁶-benzylguanine involves endoplasmic reticulum stress
Published July 29, 2008; doi: 10.1124/jpet.108.141291 [Abstract] [PDF] [Data Supplement]

ENDOCRINE AND DIABETES

Alexander de Giorgio-Miller, Peter Bungay, Michelle Tutt, Julie Owen, David Goodwin, and Nick Pullen: The Translational Pharmacology Of A Novel, Potent And Selective Non-steroidal Progesterone Receptor Antagonist, PF-02367982
Published July 1, 2008; doi: 10.1124/jpet.108.140467 [Abstract] [PDF] [Data Supplement]

Yoshikazu Fujimori, Kenji Katsuno, Ikumi Nakashima, Yukiko Ishikawa-Takemura, Hideki Fujikura, and Masayuki Isaji: Remogliflozin etabonate, in a Novel Category of Selective Low-Affinity / High-Capacity Sodium Glucose Cotransporter (SGLT2) Inhibitors, Exhibits Antidiabetic Efficacy in Rodent Models
Published June 26, 2008; doi: 10.1124/jpet.108.140210 [Abstract] [PDF]

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

Gracious R Ross, Bichoy H Gabra, William L Dewey, and Hamid I Akbarali: Morphine tolerance in the mouse ileum and colon
Published August 5, 2008; doi: 10.1124/jpet.108.143438 [Abstract] [PDF]

Stephen M Sims, Tom Chrones, and Harold G Preiksaitis: Calcium sensitization in human esophageal muscle: Role for RhoA kinase in maintenance of lower esophageal sphincter tone
Published July 15, 2008; doi: 10.1124/jpet.108.140806 [Abstract] [PDF]

Shunichi Kajioka, Shinsuke Nakayama, Haruhiko Asano, Narihito Seki, Seiji Naito, and Alison F Brading: Levcromakalim and MgGDP activate small conductance K_ATP channels of Kir6.1/SUR2A in pig detrusor smooth muscle cells: Uncoupling of cAMP signal pathways
Published July 2, 2008; doi: 10.1124/jpet.108.140269 [Abstract] [PDF]

Le Yu, William KK Wu, Zhi Jie Li, Helen PS Wong, Emily KK Tai, Ya Chun Wu, Hai Tao Li, and Chi Hin Cho: EP2 receptor-mediated activation of extracellular signal-regulated kinase/activator protein-1 signaling is required for the mitogenic action of prostaglandin E2 in esophageal squamous-cell carcinoma
Published June 26, 2008; doi: 10.1124/jpet.108.141275 [Abstract] [PDF] [Data Supplement]

Gracious R Ross, Bichoy H Gabra, William L Dewey, and Hamid I Akbarali: Morphine tolerance in the mouse ileum and colon
Published August 5, 2008; doi: 10.1124/jpet.108.143438 [Abstract] [PDF]

Stephen M Sims, Tom Chrones, and Harold G Preiksaitis: Calcium sensitization in human esophageal muscle: Role for RhoA kinase in maintenance of lower esophageal sphincter tone
Published July 15, 2008; doi: 10.1124/jpet.108.140806 [Abstract] [PDF]

Shunichi Kajioka, Shinsuke Nakayama, Haruhiko Asano, Narihito Seki, Seiji Naito, and Alison F Brading: Levcromakalim and MgGDP activate small conductance K_ATP channels of Kir6.1/SUR2A in pig detrusor smooth muscle cells: Uncoupling of cAMP signal pathways
Published July 2, 2008; doi: 10.1124/jpet.108.140269 [Abstract] [PDF]

Le Yu, William KK Wu, Zhi Jie Li, Helen PS Wong, Emily KK Tai, Ya Chun Wu, Hai Tao Li, and Chi Hin Cho: EP2 receptor-mediated activation of extracellular signal-regulated kinase/activator protein-1 signaling is required for the mitogenic action of prostaglandin E2 in esophageal squamous-cell carcinoma
Published June 26, 2008; doi: 10.1124/jpet.108.141275 [Abstract] [PDF] [Data Supplement]

NEUROPHARMACOLOGY

Volker Nimmrich, Robert Szabo, Csaba Nykas, Ivica Granic, Klaus G Reymann, Ulrich H Schroeder, Gerhard Gross, Hans Schoemaker, Karsten Wicke, Achim Moeller, and Paul Luiten: Inhibition of calpain prevents NMDA-induced degeneration of the nucleus basalis and associated behavioral dysfunction
Published August 13, 2008; doi: 10.1124/jpet.108.142679 [Abstract] [PDF] [Data Supplement]

Michael R. Tilley and Howard Gu: The effects of methylphenidate on knock-in mice with a methylphenidate resistant dopamine transporter
Published August 12, 2008; doi: 10.1124/jpet.108.141713 [Abstract] [PDF]

Yanqi Liang, Amanda M. Shaw, Mona Boules, Siobhan Briody, Jessica Robinson, Alfredo Oliveros, Eric Blazar, Katrina Williams, Yiqun Zhang, Paul Carlier, and Elliott Richelson: Antidepressant-like pharmacological profile of a novel triple re-uptake inhibitor, PRC200-SS
Published August 8, 2008; doi: 10.1124/jpet.108.143610 [Abstract] [PDF]

Dorothee Abramowski, Karl-Heinz Wiederhold, Ulrich Furrer, Anne-Lise Jaton, Anton Neuenschwander, Marie-Josephine Runser, Simone Danner, Julia Reichwald, Domenico Ammaturo, Dieter Staab, Markus Stoeckli, Heinrich Rueeger, Ulf Neumann, and Matthias Staufenbiel: Dynamics of A ${beta}$ Turnover and Deposition in Different APP Transgenic Mouse Models Following Gamma-Secretase Inhibition
Published August 7, 2008; doi: 10.1124/jpet.108.140327 [Abstract] [PDF] [Data Supplement]

James J Burston, Laura J Sim-Selley, John P Harloe, Anu Mahadevan, Raj K Razdan, Dana E Selley, and Jenny L. Wiley: N-Arachidonyl maleimide (NAM) potentiates the pharmacological and biochemical effects of the endocannabinoid 2-arachidonylglycerol through inhibition of monoacylglycerol lipase
Published August 5, 2008; doi: 10.1124/jpet.108.141382 [Abstract] [PDF]

Hong-Yi Zhou, Shao-Rui Chen, Hong Chen, and Hui-Lin Pan: Sustained Inhibition of Neurotransmitter Release from non-TRPV1-Expressing Primary Afferents by [D-Ala²,N-Me-Phe⁴,Gly-ol⁵]-Enkephalin in the Spinal Cord
Published July 31, 2008; doi: 10.1124/jpet.108.141226 [Abstract] [PDF]

Neal Innocent, Phil D Livingstone, Arik Hone, Atsuko Kimura, Tracey Young, Paul Whiteaker, J. Michael McIntosh, and Susan Wonnacott: ${alpha}$ Conotoxin ArIB[V11L,V16D] is a potent and selective antagonist at rat and human native ${alpha}$ 7 nicotinic acetylcholine receptors
Published July 29, 2008; doi: 10.1124/jpet.108.142943 [Abstract] [PDF]

Kathryn T O'Leary, Neeraja Parameswaran, Louisa C Johnston, J. Michael McIntosh, Donato A Di Monte, and Maryka Quik: Paraquat exposure reduces nicotinic receptor-evoked dopamine release in monkey striatum
Published July 7, 2008; doi: 10.1124/jpet.108.141861 [Abstract] [PDF]

Melanie A Starr, Michelle E Page, and Barry D Waterhouse: MDMA (3,4-methylenedioxymethamphetamine) – mediated distortion of somatosensory signal transmission and neurotransmitter efflux in the ventral posterior medial thalamus
Published July 7, 2008; doi: 10.1124/jpet.108.139337 [Abstract] [PDF]

Eduardo R. Butelman, Szymon Rus, Denise S. Simpson, Angela K.H. Wolf, Thomas E. Prisinzano, and Mary Jeanne Kreek: The effects of herkinorin, the first µ-selective ligand from a salvinorin A- derived scaffold, in a neuroendocrine biomarker assay in non-human primates
Published July 1, 2008; doi: 10.1124/jpet.108.140079 [Abstract] [PDF]

Yun Liu and Rae R Matsumoto: Alterations in fra-2 and ${sigma}$ -1 receptor gene and protein expression are associated with the development of cocaine-induced behavioral sensitization: time course and regional distribution studies
Published June 30, 2008; doi: 10.1124/jpet.108.141051 [Abstract] [PDF]

Trent Volz, Sarah Farnsworth, Shane D. Rowley, Glen R. Hanson, and Annette E. Fleckenstein: METHYLPHENIDATE-INDUCED INCREASES IN VESICULAR DOPAMINE SEQUESTRATION AND DOPAMINE RELEASE IN THE STRIATUM: THE ROLE OF MUSCARINIC AND DOPAMINE D2 RECEPTORS
Published June 30, 2008; doi: 10.1124/jpet.108.139386 [Abstract] [PDF]

Cheng Xiao, Chunyi Zhou, Kai X Li, Daryl L. Davies, and Jiang Hong Ye: P2 Receptors at GABAergic Synapses on VTA Dopamine Neurons are Targets for Ethanol Action
Published June 26, 2008; doi: 10.1124/jpet.108.139766 [Abstract] [PDF]

TOXICOLOGY

Tadakatsu Matsuno, Yasushi Ito, Takamasa Ohashi, Masahiro Morise, Naoya Takeda, Kaoru Shimokata, Kazuyoshi Imaizumi, Hiroaki Kume, and Yoshinori Hasegawa: Dual pathway activated by tert-butyl hydroperoxide in human airway anion secretion
Published July 29, 2008; doi: 10.1124/jpet.108.141580 [Abstract] [PDF]